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Recent Advances in Anti-Infective Drug Discovery

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ISSN (Print): 2772-4344
ISSN (Online): 2772-4352

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Cross-Sectional Study

COVID-19 Infection After Vaccination Among Healthcare Workers at a Tertiary Level Health Care Center in Northern India: A Cross-Sectional Study

Author(s): Nandita Sharma, Mahendra Singh*, Pradeep Aggarwal, Yogesh Bahurupi, Prasan Kumar Panda and Gaurika Saxena

Volume 17, Issue 3, 2022

Published on: 28 October, 2022

Page: [223 - 231] Pages: 9

DOI: 10.2174/2772434417666221011095128

Price: $65

Abstract

Background and Aims: COVID-19 vaccines are now accessible to all Indian citizens. Infection with COVID-19, on the other hand, continues to spread constantly. Our study aimed to determine the number of persons who had COVID-19 infections despite receiving the recommended number of doses of the COVID-19 vaccination at AIIMS Rishikesh, a tertiary care facility in Uttarakhand, India.

Methods: We analysed meticulously preserved data regarding COVID-19 vaccination, COVID-19 infection, clinical symptoms, and RT-PCR testing among all HCWs in our healthcare institution from 16 January 2021 to 30th June 2021.

Results: During this period, 5273 (90.3%) HCWs received two doses of the COVID-19 vaccine, while 566 (9.7%) received only one dose. 628 HCWs (10.8%) were BBV152 recipients and 5211 (89.2%) were AZD1222 (ChAdOx1-S) recipients. 423 HCWs (7.2%, confidence interval of 95% - 13.8, 22.0) reported COVID-19 infections. 274 (5.19% of total vaccinated HCWs) breakthrough infections and 149 non-breakthrough COVID-19 infections were reported in HCWs who had previously received a single dose of the COVID-19 vaccination.

Conclusion: Viral infections, especially breakthrough infections, following adequate vaccination, are a cause for concern, but there is a lack of data on these infections in the actual world. Therefore, the primary focus of research should be on the emergence of illness in India following the completion of a full vaccine course.

« Previous Next »
[1]
Sabnis R, Patil A, Shete N, Rastogi AK. Break-through COVID-19 infection rate with Indian strain in single-center healthcare Workers–A real world data. medRxiv 21258881 2021.
[http://dx.doi.org/10.1101/2021.07.02.21258881]
[2]
Sharma P, Mishra S, Basu S, Tanwar N, Kumar R. Breakthrough infection with SARS-CoV-2 and its predictors among healthcare workers in a medical college and hospital complex in Delhi, India. MedRxiv 21258447 2021.
[http://dx.doi.org/10.1101/2021.06.07.21258447]
[3]
World Health Organization. COVID-19 Vaccines. Available from: https://www.who.int/emergencies/diseases/novel-coronavirus-2019/COVID-19-vaccines [Accessed on: 8 December, 2021].
[4]
Ella R, Vadrevu KM, Jogdand H, et al. Safety and immunogenicity of an inactivated SARS-CoV-2 vaccine, BBV152: A double-blind, randomised, phase 1 trial. Lancet Infect Dis 2021; S1473-3099(20): 30942-7.
[http://dx.doi.org/10.1056/NEJMoa2105000]
[5]
Hacisuleyman E, Hale C, Saito Y, et al. Vaccine breakthrough infections with SARS-CoV-2 variants. N Engl J Med 2021; 384(23): 2212-8.
[http://dx.doi.org/10.1056/NEJMoa2105000] [PMID: 33882219]
[6]
Loconsole D, Sallustio A, Accogli M, et al. Investigation of an outbreak of symptomatic SARS-CoV-2 VOC 202012/01-lineage B.1.1.7 infection in healthcare workers, Italy. Clin Microbiol Infect 2021; 27(8): 1174.e1-4.
[http://dx.doi.org/10.1016/j.cmi.2021.05.007]
[7]
Keehner J, Horton LE, Pfeffer MA, et al. SARS-CoV-2 infection after vaccination in health care workers in California. N Engl J Med 2021; 384(18): 1774-5.
[http://dx.doi.org/10.1056/NEJMc2101927] [PMID: 33755376]
[8]
CDC. COVID-19 vaccine breakthrough case investigations team. COVID-19 vaccine breakthrough infections reported to CDC - United States, January 1-April 30, 2021. MMWR Morb Mortal Wkly Rep 2021; 70(21): 792-3.
[http://dx.doi.org/10.15585/mmwr.mm7021e3]
[9]
Philomina JB, Jolly B, John N, et al. Genomic survey of SARS-CoV-2 vaccine breakthrough infections in healthcare workers from Kerala, India. J Infect 2021; 83(2): 00260-7.
[http://dx.doi.org/10.1016/j.jinf.2021.05.018]
[10]
Tyagi K, Ghosh A, Nair D, et al. Breakthrough COVID-19 infections after vaccinations in healthcare and other workers in a chronic care medical facility in New Delhi, India. Diabetes Metab Syndr 2021; 15(3): 1007-8.
[http://dx.doi.org/10.1016/j.dsx.2021.05.001] [PMID: 33991805]
[11]
Bergwerk M, Gonen T, Lustig Y, et al. COVID-19 breakthrough infections in vaccinated health care workers. N Engl J Med 2021; 385(16): 1474-84.
[http://dx.doi.org/10.1056/NEJMoa2109072] [PMID: 34320281]
[12]
Niyas VKM, Arjun R. Breakthrough COVID-19 infections among health care workers after two doses of ChAdOx1 nCoV-19 vaccine. QJM 2021; 114(10): 757-8.
[http://dx.doi.org/10.1093/qjmed/hcab167] [PMID: 34117884]
[13]
Gupta N, Kaur H, Yadav P, et al. Clinical characterization and genomic analysis of COVID-19 breakthrough infections during second wave in different states of India. MedRxiv 21260273 2021.
[http://dx.doi.org/10.1101/2021.07.13.21260273]

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