Cobalt Ferrite Nanoparticle’s Safety in Biomedical and Agricultural
Applications: A Review of Recent Progress

Md   Salman   Shakil; Md   Simul   Bhuiya; Md   Reaz   Morshed; Golap      Babu; Mahruba   Sultana   Niloy; Md   Sakib   Hossen; Md   Asiful   Islam
doi:10.2174/0929867329666221007113951
Abstract

Cobalt ferrite nanoparticles (CFN) have drawn attention as a theranostic agent. Unique physicochemical features of CFN and magnetic properties make CFN an outstanding candidate for biomedical, agricultural, and environmental applications. The extensive use of CFN may result in intentional inoculation of humans for disease diagnosis and therapeutic purposes or unintentional penetration of CFN via inhalation, ingestion, adsorption, or other means. Therefore, understanding the potential cytotoxicity of CFN may pave the way for their future biomedical and agricultural applications. This review scrutinized CFN biocompatibility, possible effects, and cytotoxic mechanisms in different biological systems. Literature indicates CFN toxicity is linked with their size, synthesizing methods, coating materials, exposure time, route of administration, and test concentrations. Some in vitro cytotoxicity tests showed misleading results of CFN potency; this might be due to the interaction of CFN with cytotoxicity assay regents. To date, published research indicates that the biocompatibility of CFN outweighed its cytotoxic effects in plant or animal models, but the opposite outcomes were observed in aquatic Zebrafish.
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DOI https://dx.doi.org/10.2174/0929867329666221007113951	Print ISSN 0929-8673
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Current Medicinal Chemistry

Cobalt Ferrite Nanoparticle’s Safety in Biomedical and Agricultural Applications: A Review of Recent Progress

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