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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

Responsive Role of Nanomedicine in the Tumor Microenvironment and Cancer Drug Resistance

Author(s): Pratikshya Sa, Sanjeeb K. Sahoo* and Fahima Dilnawaz*

Volume 30, Issue 29, 2023

Published on: 16 November, 2022

Page: [3335 - 3355] Pages: 21

DOI: 10.2174/0929867329666220922111336

Price: $65

Abstract

Cancer remains a major worldwide health challenge. Current studies emphasize the tumor microenvironment that plays a vital role in tumor proliferation, invasion, metastasis, and drug resistance. The tumor microenvironment (TME) supports the cancer cell to evade conventional treatment such as surgery, radiotherapy, and chemotherapy. Moreover, the components of tumor microenvironments have a major contribution towards developing therapy resistance in solid tumors. Therefore, targeting the tumor microenvironment can be a novel approach for achieving advancement in cancer nanomedicine. The recent progress in understanding TME and developing TME-responsive nanoparticles offers a great advantage in treating cancer drug resistance. These nanoparticles are developed in response to TME stimuli such as low pH, redox, and hypoxia improve nanomedicine's pharmacokinetic and therapeutic efficacy. This review discusses the various components of the tumor microenvironment responsible for drug resistance and nanomedicine's role in overcoming it.

Keywords: cancer drug resistance, tumor microenvironment, nanomedicine, drug, delivery systems, pharmacokinetics

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