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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Patent News

Novel Proline Derivatives for Treating COVID-19

Author(s): Surya K. De*

Volume 30, Issue 12, 2023

Published on: 27 October, 2022

Page: [1458 - 1461] Pages: 4

DOI: 10.2174/0929867329666220922095343

Price: $65

Abstract

COVID-19 is a contagious disease. Paxlovid, a combination of Nirmatrelvir and Ritonavir, was granted emergency use authorization by the United States Food and Drug Administration (FDA) for the treatment of COVID-19 on December 22, 2021. These are peptidomimetic coronavirus main protease inhibitors. Nirmatrelvir is a proline derivative. The present patent describes similar proline- like compounds, their preparation, use, pharmaceutical composition, and treatment.

Keywords: COVID-19, Proline derivatives, Protease inhibitors, Picornavirus, Norovirus, Single-stranded RNA virus

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