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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Review Article

Insulin Resistance and Diabetes Mellitus in Patients with Systemic Lupus Erythematosus

Author(s): Mario García-Carrasco*, Claudia Mendoza-Pinto, Pamela Munguía-Realpozo, Ivet Etchegaray-Morales, Sandra Karina Vélez-Pelcastre, Socorro Méndez-Martínez, Irma Zamora-Ginez, Luis Guillermo Vázquez de Lara, José Luis Gálvez-Romero and Marco Escamilla-Márquez

Volume 23, Issue 4, 2023

Published on: 02 November, 2022

Page: [503 - 514] Pages: 12

DOI: 10.2174/1871530322666220908154253

Price: $65

Abstract

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by damage to multiple systems and a higher risk of cardiovascular disease. In addition, several studies have found that insulin resistance (IR) is more prevalent in SLE patients than controls, increasing the risk of prediabetes, type 2 diabetes mellitus (T2DM) and morbidity. The objective of this review article was to summarize the most relevant evidence about the relationship among IR, T2DM and SLE, including the effects of proinflammatory states, acute-phase proteins, pro-inflammatory cytokines, and pharmacological SLE treatment. A better understanding of the mechanisms involved in these comorbidities will allow better treatment strategies.

Keywords: Systemic lupus erythematosus, insulin resistance, diabetes mellitus, T2DM

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