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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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General Review Article

Putative Therapeutic Impact of Inflammasome Inhibitors against COVID-19-Induced ARDS

Author(s): Seyed Fazel Nabavi, Adeleh Sahebnasagh, Ahad Shahbazi, Seyed Mohammad Nabavi*, Saeid Azimi, Malihe Khayat Kashani, Solomon Habtemariam, Mojde Rahmani, Mohadese Badiee, Javad Hashemi, Fatemeh Saghafi, Kiumarth Amini, Mina Azimi and Aysa Rezabakhsh*

Volume 30, Issue 12, 2023

Published on: 02 November, 2022

Page: [1406 - 1419] Pages: 14

DOI: 10.2174/0929867329666220906111550

Price: $65

Abstract

Given the importance of COVID-19-induced ARDS, recently, researchers have strived to determine underlying mechanisms involved in the inflammatory responses. In this regard, inflammasomes possess a distinct priority for cytokine storm occurrence and, subsequently, ARDS progression in ill patients with SARS-CoV-2 infection. In this minireview, the characteristics of known inflammasome inhibitors and designed research in this field were concretely deciphered.

Keywords: ARDS, COVID-19, Inflammasome, Inhibitors, NLRP3, SARS-CoV-2.

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