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Recent Patents on Nanotechnology

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ISSN (Print): 1872-2105
ISSN (Online): 2212-4020

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Mini-Review Article

Nanosponges- Versatile Platform as Drug Carrier

Author(s): Ujjwala Kandekar*, Rohini Pujari, Neha Munot, Trushal Chorge, Krishnakumar Lone, Pallavi Kamble and Khandelwal Kishanchand

Volume 17, Issue 2, 2023

Published on: 05 October, 2022

Page: [91 - 103] Pages: 13

DOI: 10.2174/1872210516666220905092202

Price: $65

Abstract

Background: Recently, nano-drug delivery systems have become an integral part of the most novel drug delivery systems and have gained considerable importance owing to various advantages such as carriers for poorly soluble drugs, targeting molecules at the desired site, protection from degradation etc.

Objective: One of the most studied areas of nanotechnology is nanosponges. The objective of this review was to extensively summarize the various strategies for the preparation, characterization and applications of nanosponges.

Methods: In the current mini-review, we conducted a systemic search of the literature and patent inventions focusing on nanosponges. The summary of the search was inclusive of various aspects of nanosponges, such as drug characteristics to be considered while incorporating in nanosponges, other crucial additives during formulation of nanosponges, methods of preparation, characterization and applications of nanosponges in pharmaceuticals.

Results: Nanosponges are nanocarriers for both lipophilic and hydrophilic drugs. These are prepared by different methods such as emulsion-solvent evaporation, solvent method, melting method, ultrasound assisted method etc., and all these methods were less time consuming, more economical and evaluated by sophisticated techniques available for routine analysis. These are among the most feasible alternative to address several formulation difficulties associated with the physicochemical properties of the drug. The porous nature and small particle size are vital properties of the nanosponges that contribute crucially to correcting the drawbacks of the drug. The properties of the nanosponges can be enhanced when combined with cyclodextrins. Extensive research work has been carried out in past to explore cyclodextrin based nanosponges. Besides, it is also used for smart targeting of tumors and for drug release in a sustainable pattern. Nanosponges can be prepared by simple methods. These can be tuned to release the drug by different routes so as to achieve the maximum benefits of the drug.

Conclusion: Huge amount of research has been carried out on nanosponges as drug carrier. The method of preparation and characterization of nanosponges are quite economical and routinely available. Owing to potential benefits and probable applications, these can be used as efficient carriers for certain drugs. The authors expect that the current review will guide the investigation of the nanosponges as nanodrug delivery systems.

Keywords: Nanosponges, solubility, targeting, sustained release, drug carrier, nanotechnology

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Graphical Abstract

[1]
Palombo M, Deshmukh M, Myers D, Gao J, Szekely Z, Sinko PJ. Pharmaceutical and toxicological properties of engineered nanomaterials for drug delivery. Annu Rev Pharmacol Toxicol 2014; 54(1): 581-98.
[http://dx.doi.org/10.1146/annurev-pharmtox-010611-134615] [PMID: 24160695]
[2]
Krishnamoorthy K, Rajappan M. Nanosponges: A novel class of drug delivery system--review. J Pharm Pharm Sci 2012; 15(1): 103-11.
[http://dx.doi.org/10.18433/J3K308] [PMID: 22365092]
[3]
Pandey P, Purohit D, Dureja H. Nanosponges–a promising novel drug delivery system. Recent Pat Nanotechnol 2018; 12(3): 180-91.
[http://dx.doi.org/10.2174/1872210512666180925102842] [PMID: 30251614]
[4]
Rajkondawar PS, Patil A. Nano-sponges: A novel carrier for delivery of chemo-therapeutic drugs. Int J Pharm Sci Res 2020; 11(1): 1040-4.
[http://dx.doi.org/10.26452/ijrps.v11i1.1933]
[5]
Clemente N, Argenziano M, Gigliotti CL, et al. Paclitaxel-loaded nanosponges inhibit growth and angiogenesis in melanoma cell models. Front Pharmacol 2019; 10: 776.
[http://dx.doi.org/10.3389/fphar.2019.00776] [PMID: 31354491]
[6]
Allahyari S, Trotta F, Valizadeh H, Jelvehgari M, Zakeri-Milani P. Cyclodextrin-based nanosponges as promising carriers for active agents. Expert Opin Drug Deliv 2019; 16(5): 467-79.
[http://dx.doi.org/10.1080/17425247.2019.1591365] [PMID: 30845847]
[7]
Trotta F, Cavalli R, Tumiatti W, Zerbinati O, Roggero C, Vallero R. Ultrasound-assisted synthesis of cyclodextrin-based nanosponges. EP1632503A1, 2006.
[8]
Swaminathan S, Pastero L, Serpe L, et al. Cyclodextrin-based nanosponges encapsulating camptothecin: Physicochemical characterization, stability and cytotoxicity. Eur J Pharm Biopharm 2010; 74(2): 193-201.
[http://dx.doi.org/10.1016/j.ejpb.2009.11.003] [PMID: 19900544]
[9]
Patel E, Oswal R. Nanosponge and micro sponges: A novel drug delivery system. Int J Res Pharm Chem 2012; 2(2): 2281-781.
[10]
Tejashri G, Amrita B, Darshana J. Cyclodextrin based nanosponges for pharmaceutical use: A review. Acta Pharm 2013; 63(3): 335-58.
[http://dx.doi.org/10.2478/acph-2013-0021] [PMID: 24152895]
[11]
Patravale VB, Mandawgade SD. Novel cosmetic delivery systems: An application update. Int J Cosmet Sci 2008; 30(1): 19-33.
[http://dx.doi.org/10.1111/j.1468-2494.2008.00416.x] [PMID: 18377627]
[12]
Jain A, Prajapati SK, Kumari A, Mody N, Bajpai M. Engineered nanosponges as versatile biodegradable carriers: An insight. J Drug Deliv Sci Technol 2020; 57: 101643.
[http://dx.doi.org/10.1016/j.jddst.2020.101643]
[13]
Singh D, Soni G, Prajapati S. Recent advances in nanosponges as drug delivery system: A review. Eur J Pharm Med Res 2016; 3(10): 364-71.
[14]
Ananya KV, Preethi S, Gowda DV, Gowda D. Recent review on nano sponge. Int J Pharm Sci Res 2020; 11(1): 1085-96.
[http://dx.doi.org/10.26452/ijrps.v11i1.1940]
[15]
Tiwari K, Bhattacharya S. The ascension of nanosponges as a drug delivery carrier: Preparation, characterization, and applications. J Mater Sci Mater Med 2022; 33(3): 28.
[http://dx.doi.org/10.1007/s10856-022-06652-9] [PMID: 35244808]
[16]
Kathe K, Kathpalia H. Film forming systems for topical and transdermal drug delivery. As. J Pharm Sci 2017; 12(6): 487-97.
[http://dx.doi.org/10.1016/j.ajps.2017.07.004] [PMID: 32104362]
[17]
Yüksel N, Tinçer T, Baykara T. Interaction between nicardipine hydrochloride and polymeric microspheres for a controlled release system. Int J Pharm 1996; 140(2): 145-54.
[http://dx.doi.org/10.1016/0378-5173(96)04560-7]
[18]
Loftsson T, Brewster ME. Pharmaceutical applications of cyclodextrins. 1. Drug solubilization and stabilization. J Pharm Sci 1996; 85(10): 1017-25.
[http://dx.doi.org/10.1021/js950534b] [PMID: 8897265]
[19]
Trotta F, Cavalli R. Characterization and applications of new hyper-cross-linked cyclodextrins. Compos Interfaces 2009; 16(1): 39-48.
[http://dx.doi.org/10.1163/156855408X379388]
[20]
Asela I, Donoso-González O, Yutronic N, Sierpe R. β- Cyclodextrin-based nanosponges functionalized with drugs and gold nanoparticles. Pharmaceutics 2021; 13(4): 513.
[http://dx.doi.org/10.3390/pharmaceutics13040513] [PMID: 33917938]
[21]
Vyas A, Saraf S. Cyclodextrin based novel drug delivery systems. J Incl Phenom Macrocycl Chem 2008; 62(1-2): 23-42.
[http://dx.doi.org/10.1007/s10847-008-9456-y]
[22]
Moin A, Roohi NKF, Rizvi SMD, et al. Design and formulation of polymeric nanosponge tablets with enhanced solubility for combination therapy. RSC Adv 2020; 10(57): 34869-84.
[http://dx.doi.org/10.1039/D0RA06611G] [PMID: 35514416]
[23]
Swaminathan S, Vavia PR, Trotta F, Torne S. Formulation of betacyclodextrin based nanosponges of itraconazole. J Incl Phenom Macrocycl Chem 2007; 57(1-4): 89-94.
[http://dx.doi.org/10.1007/s10847-006-9216-9]
[24]
Torne SJ, Ansari KA, Vavia PR, Trotta F, Cavalli R. Enhanced oral paclitaxel bioavailability after administration of paclitaxel-loaded nanosponges. Drug Deliv 2010; 17(6): 419-25.
[http://dx.doi.org/10.3109/10717541003777233] [PMID: 20429848]
[25]
Mele A, Castiglione F, Malpezzi L, et al. HR MAS NMR, powder XRD and Raman spectroscopy study of inclusion phenomena in βCD nanosponges. J Incl Phenom Macrocycl Chem 2011; 69(3-4): 403-9.
[http://dx.doi.org/10.1007/s10847-010-9772-x]
[26]
Ahmed RZ, Patil G, Zaheer Z. Nanosponges – a completely new nano-horizon: pharmaceutical applications and recent advances. Drug Dev Ind Pharm 2013; 39(9): 1263-72.
[http://dx.doi.org/10.3109/03639045.2012.694610] [PMID: 22681585]
[27]
Rossi B, Venuti V, Paciaroni A, et al. Thermal fluctuations in chemically cross-linked polymers of cyclodextrins. Soft Matter 2015; 11(11): 2183-92.
[http://dx.doi.org/10.1039/C4SM02000F] [PMID: 25639345]
[28]
Vishwakarma A, Nikam P, Mogal R, Talele S. Review on nanosponges: A benefication for novel drug delivery. Int J Pharm Tech Res 2014; 6: 11-20.
[29]
El-Osaily GH, Amer RI, Gad S. Design and optimization of topical terbinafine hydrochloride nanosponges: Application of full factorial design, in vitro and in vivo evaluation. J Adv Pharm Technol Res 2020; 11(1): 13-9.
[http://dx.doi.org/10.4103/japtr.JAPTR_85_19] [PMID: 32154153]
[30]
Lala R, Thorat A, Gargote C. Current trends in β-cyclodextrin based drug delivery systems. Int J Res Ayurveda Pharm 2011; 2(5): 1520-6.
[31]
Allahyari S, Valizadeh H, Roshangar L, et al. Preparation and characterization of cyclodextrin nanosponges for bortezomib delivery. Expert Opin Drug Deliv 2020; 17(12): 1807-16.
[http://dx.doi.org/10.1080/17425247.2020.1800637] [PMID: 32729739]
[32]
Trotta F, Shende P, Biasizzo M. Method for preparing dextrin nanosponges. WO2012147069A1, 2012.
[33]
Omar SM, Ibrahim F, Ismail A. Formulation and evaluation of cyclodextrin-based nanosponges of griseofulvin as pediatric oral liquid dosage form for enhancing bioavailability and masking bitter taste. Saudi Pharm J 2020; 28(3): 349-61.
[http://dx.doi.org/10.1016/j.jsps.2020.01.016] [PMID: 32194337]
[34]
Utzeri G, Matias PMC, Murtinho D, Valente AJM. Cyclodextrin-based nanosponges: Overview and opportunities. Front Chem 2022; 10: 859406.
[PMID: 35402388]
[35]
Kamble M, Zaheer Z, Mokale S, Zainuddin R. Formulation optimization and biopharmaceutical evaluation of imatinib mesylate loaded β-cyclodextrin nanosponges. Pharm Nanotechnol 2019; 7(5): 343-61.
[http://dx.doi.org/10.2174/2211738507666190919121445] [PMID: 31549599]
[36]
Guineo-Alvarado J, Quilaqueo M, Hermosilla J, et al. Degree of crosslinking in β-cyclodextrin-based nanosponges and their effect on piperine encapsulation. Food Chem 2021; 340: 128132.
[http://dx.doi.org/10.1016/j.foodchem.2020.128132] [PMID: 33011468]
[37]
Choi WI, Sahu A, Vilos C, et al. Bioinspired heparin nanosponge prepared by photo-crosslinking for controlled release of growth factors. Sci Rep 2017; 7(1): 14351-1.
[http://dx.doi.org/10.1038/s41598-017-14040-5] [PMID: 29084990]
[38]
Wang CH, Min SG. Method for preparing TiO2(B) nano-sponge. CN104649319A, 2016.
[39]
Lian K. Nanoparticles, nanosponges, methods of synthesis, and methods of use. U.S. Patent US14/475759, 2014.
[40]
Columbu S, Mulas M, Mundula F, Cioni R. Strategies for helium pycnometry density measurements of welded ignimbritic rocks. Measurement 2020; 173: 108640.
[41]
Zaki Rizkalla CM, latif Aziz R, Soliman II. In vitro and in vivo evaluation of hydroxyzine hydrochloride microsponges for topical delivery. AAPS Pharm Sci Tech 2011; 12(3): 989-1001.
[http://dx.doi.org/10.1208/s12249-011-9663-5] [PMID: 21800216]
[42]
Pawar AP, Gholap AP, Kuchekar AB, Bothiraja C, Mali AJ. Formulation and evaluation of optimized oxybenzone microsponge gel for topical delivery. J Drug Deliv 2015; 2015: 1-9.
[http://dx.doi.org/10.1155/2015/261068] [PMID: 25789176]
[43]
Ansari KA, Vavia PR, Trotta F, Cavalli R. Cyclodextrin-based nanosponges for delivery of resveratrol: In vitro characterisation, stability, cytotoxicity and permeation study. AAPS Pharm Sci Tech 2011; 12(1): 279-86.
[http://dx.doi.org/10.1208/s12249-011-9584-3] [PMID: 21240574]
[44]
Jeong YI, Shim YH, Kim C, Lim GT, Choi KC, Yoon C. Effect of cryoprotectants on the reconstitution of surfactant-free nanoparticles of poly(DL-lactide-co-glycolide). J Micro Encapsul 2005; 22(6): 593-601.
[http://dx.doi.org/10.1080/02652040500162659] [PMID: 16401576]
[45]
Sherje AP, Dravyakar BR, Kadam D, Jadhav M. Cyclodextrin-based nanosponges: A critical review. Carbohydr Polym 2017; 173: 37-49.
[http://dx.doi.org/10.1016/j.carbpol.2017.05.086] [PMID: 28732878]
[46]
Almutairy BK, Alshetaili A, Alali AS, Ahmed MM, Anwer MK, Aboudzadeh MA. Design of olmesartan medoxomil-loaded nanosponges for hypertension and lung cancer treatments. Polymers 2021; 13(14): 2272.
[http://dx.doi.org/10.3390/polym13142272] [PMID: 34301030]
[47]
Aldawsari HM, Badr-Eldin SM, Labib GS, El-Kamel AH. Design and formulation of a topical hydrogel integrating lemongrass-loaded nanosponges with an enhanced antifungal effect: In vitro/in vivo evaluation. Int J Nanomedicine 2015; 10: 893-902.
[PMID: 25673986]
[48]
Nokhoudchi A, Jelvehgari M, Siahi M-R, Dastmalchi S. The effect of formulation type on the release of benzoyl peroxide from micro-sponges. Iran J Pharm Sci 2005; 1(3): 131-42.
[49]
Osmani R, Aloorkar N, Kulkarni A, et al. Novel cream containing microsponges of anti-acne agent: formulation development and evaluation. Curr Drug Deliv 2015; 12(5): 504-16.
[http://dx.doi.org/10.2174/1567201812666150212122421] [PMID: 25675339]
[50]
Yaşayan G, Şatıroğlu Sert B, Tatar E, Küçükgüzel İ. Fabrication and characterisation studies of cyclodextrin-based nanosponges for sulfamethoxazole delivery. J Incl Phenom Macrocycl Chem 2020; 97(3-4): 175-86.
[http://dx.doi.org/10.1007/s10847-020-01003-z]
[51]
Sagadevan S, Koteeswari P. Analysis of structure, surface morphology, optical and electrical properties of copper nanoparticles. J Nanomed Res 2015; 2(5): 40-8.
[http://dx.doi.org/10.15406/jnmr.2015.02.00040]
[52]
Shoaib Q, Abbas N, Irfan M, et al. Development and evaluation of scaffold-based nanosponge formulation for controlled drug delivery of naproxen and ibuprofen. Trop J Pharm Res 2018; 17(8): 1465-74.
[http://dx.doi.org/10.4314/tjpr.v17i8.2]
[53]
Nadagouda MN, Varma RS. Green synthesis of silver and palladium nanoparticles at room temperature using coffee and tea extract. Green Chem 2008; 10(8): 859-62.
[http://dx.doi.org/10.1039/b804703k]
[54]
Rizvi SSB, Akhtar N, Minhas MU, Mahmood A, Khan KU. Synthesis and characterization of carboxymethyl chitosan nanosponges with cyclodextrin blends for drug solubility improvement. Gels 2022; 8(1): 55.
[http://dx.doi.org/10.3390/gels8010055] [PMID: 35049590]
[55]
Arun Rasheed. Cyclodextrins as drug carrier molecule: a review. Sci Pharm 2008; 76(4): 567-98.
[http://dx.doi.org/10.3797/scipharm.0808-05]
[56]
Penjuri SCB, Ravouru N, Damineni S, Bns S, Poreddy SR. Formulation and evaluation of lansoprazole loaded nanosponges. Turkish J Pharm Sci 2016; 13(3): 304-10.
[http://dx.doi.org/10.4274/tjps.2016.04]
[57]
Segall A. Preformulation: The use of FTIR in compatibility studies. J Innov Appl Pharm Sci 2019; 4(3): 1-6.
[58]
Silva EP, Pereira MAV, Barros LIP, et al. Compatibility study between atorvastatin and excipients using DSC and FTIR. J Therm Anal Calorim 2016; 123(2): 933-9.
[http://dx.doi.org/10.1007/s10973-015-5077-z]
[59]
Critchley L. Is Raman spectroscopy useful in nanomaterial analysis? AZoNano 2019.
[60]
Osmani RAM, Aloorkar NH, Ingale DJ, et al. Microsponges based novel drug delivery system for augmented arthritis therapy. Saudi Pharm J 2015; 23(5): 562-72.
[http://dx.doi.org/10.1016/j.jsps.2015.02.020] [PMID: 26594124]
[61]
Suryanarayanan R. X-ray powder diffractometry. In: Physical characterization of pharmaceutical solids. United States: CRC Press 1995.
[62]
Singh R, Bharti N, Madan J, Hiremath SN. Characterization of cyclodextrin inclusion complexes—a review. J Pharm Sci Technol 2010; 2(3): 171-83.
[63]
Abbas N, Parveen K, Hussain A, et al. Nanosponge-based hydrogel preparation of fluconazole for improved topical delivery. Trop J Pharm Res 2019; 18(2): 215-22.
[http://dx.doi.org/10.4314/tjpr.v18i2.1]
[64]
Amrutiya N, Bajaj A, Madan M. Development of microsponges for topical delivery of mupirocin. AAPS Pharm Sci Tech 2009; 10(2): 402-9.
[http://dx.doi.org/10.1208/s12249-009-9220-7] [PMID: 19381834]
[65]
Alongi J, Pošković M, Frache A, Trotta F. Novel flame retardants containing cyclodextrin nanosponges and phosphorus compounds to enhance EVA combustion properties. Polym Degrad Stabil 2010; 95(10): 2093-100.
[http://dx.doi.org/10.1016/j.polymdegradstab.2010.06.030]
[66]
Loganathan S, Valapa RB, Mishra RK, Pugazhenthi G, Thomas S. Thermogravimetric analysis for characterization of nanomaterials. In: Thomas S, Thomas R, Zachariah AK, Mishra RK, Eds. Thermal and rheological measurement techniques for nanomaterials characterization. United States: Elsevier 2017; pp. 67-108.
[http://dx.doi.org/10.1016/B978-0-323-46139-9.00004-9]
[67]
Pawar A. Novel techniques for solubility, dissolution rate and bioavailability enhancement of class II and IV drugs. Asian J Biomed Pharm Sci 2012; 2(13): 9-14.
[68]
Kumar S, Singh P. Various techniques for solubility enhancement: An overview. J Pharm Innov 2016; 5: 23-8.
[69]
Venkatesh DN. Enhancement of atazanavir solubility using β-cyclodextrin based nanosponges. In: Murahari M, Sundar L, Chaki S, Poongavanam V, Bhat P, Nayak U Y, Eds. Conference on Drug Design and Discovery Technologies. United States: The Royal Society of Chemistry 2020; pp. 207-11.
[70]
Pushpalatha R, Selvamuthukumar S, Kilimozhi D. Cyclodextrin nanosponge based hydrogel for the transdermal co-delivery of curcumin and resveratrol: Development, optimization, in vitro and ex vivo evaluation. J Drug Deliv Sci Technol 2019; 52: 55-64.
[http://dx.doi.org/10.1016/j.jddst.2019.04.025]
[71]
Bhavin SE, Anuradha G. Nanosponge approach-A plethora of opportunities as a promising nanocarrier for novel drug delivery. Recent Pat Nanotechnol 2022; 16(4): 271-82.
[http://dx.doi.org/10.2174/1872210515666210720141736] [PMID: 34303335]
[72]
Khalid Q, Ahmad M, Minhas MU, Batool F, Malik NS, Rehman M. Novel β-cyclodextrin nanosponges by chain growth condensation for solubility enhancement of dexibuprofen: Characterization and acute oral toxicity studies. J Drug Deliv Sci Technol 2021; 61: 102089.
[http://dx.doi.org/10.1016/j.jddst.2020.102089]
[73]
Desai D, Shende P. Drug-free cyclodextrin-based nanosponges for antimicrobial activity. J Pharm Innov 2021; 16(2): 258-68.
[http://dx.doi.org/10.1007/s12247-020-09442-4]
[74]
Banjare N, Gautam L, Behera C, Gupta PN, Vyas S, Vyas SP. Cyclodextrin nanosponges based site-retentive controlled release system for treatment of rheumatic arthritis. J Drug Deliv Sci Technol 2020; 60: 101973.
[http://dx.doi.org/10.1016/j.jddst.2020.101973]
[75]
Fontana RM, Milano N, Barbara L, Di Vincenzo A, Gallo G, Meo PL. Cyclodextrin‐calixarene nanosponges as potential platforms for pH‐dependent delivery of tetracycline. Chem Select 2019; 4(33): 9743-7.
[http://dx.doi.org/10.1002/slct.201902373]
[76]
Nait Bachir Y, Nait Bachir R, Hadj-Ziane-Zafour A. Nanodispersions stabilized by β-cyclodextrin nanosponges: Application for simultaneous enhancement of bioactivity and stability of sage essential oil. Drug Dev Ind Pharm 2019; 45(2): 333-47.
[http://dx.doi.org/10.1080/03639045.2018.1542705] [PMID: 30388376]
[77]
Silva F, Caldera F, Trotta F, Nerín C, Domingues FC. Encapsulation of coriander essential oil in cyclodextrin nanosponges: A new strategy to promote its use in controlled-release active packaging. Innov Food Sci Emerg Technol 2019; 56: 102177.
[http://dx.doi.org/10.1016/j.ifset.2019.102177]
[78]
Rafati N, Zarrabi A, Caldera F, Trotta F, Ghias N. Pyromellitic dianhydride crosslinked cyclodextrin nanosponges for curcumin controlled release; formulation, physicochemical characterization and cytotoxicity investigations. J Microencapsul 2019; 36(8): 715-27.
[http://dx.doi.org/10.1080/02652048.2019.1669728] [PMID: 31530203]
[79]
Khazaei Monfared Y, Mahmoudian M, Hoti G, et al. Cyclodextrin-based nanosponges as perse antimicrobial agents increase the activity of natural antimicrobial Peptide Nisin. Pharma 2022; 14(3): 685.
[http://dx.doi.org/10.3390/pharmaceutics14030685] [PMID: 35336058]
[80]
Sherje AP, Surve A, Shende P. CDI cross-linked β-cyclodextrin nanosponges of paliperidone: Synthesis and physicochemical characterization. J Mater Sci Mater Med 2019; 30(6): 74.
[http://dx.doi.org/10.1007/s10856-019-6268-0] [PMID: 31197491]
[81]
Dhakar NK, Caldera F, Bessone F, et al. Evaluation of solubility enhancement, antioxidant activity, and cytotoxicity studies of kynurenic acid loaded cyclodextrin nanosponge. Carbohydr Polym 2019; 224: 115168.
[http://dx.doi.org/10.1016/j.carbpol.2019.115168] [PMID: 31472867]
[82]
Rao MRP, Chaudhari J, Trotta F, Caldera F. Investigation of cyclodextrin-based nanosponges for solubility and bioavailability enhancement of rilpivirine. AAPS Pharm Sci Tech 2018; 19(5): 2358-69.
[http://dx.doi.org/10.1208/s12249-018-1064-6] [PMID: 29869305]
[83]
Gabr MM, Mortada SM, Sallam MA. Carboxylate cross-linked cyclodextrin: A nanoporous scaffold for enhancement of rosuvastatin oral bioavailability. Eur J Pharm Sci 2018; 111: 1-12.
[http://dx.doi.org/10.1016/j.ejps.2017.09.026] [PMID: 28931488]
[84]
Zidan MF, Ibrahim HM, Afouna MI, Ibrahim EA. In vitro and in vivo evaluation of cyclodextrin-based nanosponges for enhancing oral bioavailability of atorvastatin calcium. Drug Dev Ind Pharm 2018; 44(8): 1243-53.
[http://dx.doi.org/10.1080/03639045.2018.1442844] [PMID: 29452493]
[85]
Mady FM, Ibrahim SR. Cyclodextrin-based nanosponge for improvement of solubility and oral bioavailability of Ellagic acid. Pak J Pharm Sci 2018; 31(S5): 2069-76.
[PMID: 30393214]
[86]
Mendes C, Meirelles GC, Barp CG, Assreuy J, Silva MAS, Ponchel G. Cyclodextrin based nanosponge of norfloxacin: Intestinal permeation enhancement and improved antibacterial activity. Carbohydr Polym 2018; 195: 586-92.
[http://dx.doi.org/10.1016/j.carbpol.2018.05.011] [PMID: 29805015]
[87]
Rao MRP, Shirsath C. Enhancement of bioavailability of nonnucleoside reverse transciptase inhibitor using nanosponges. AAPS Pharm Sci Tech 2017; 18(5): 1728-38.
[http://dx.doi.org/10.1208/s12249-016-0636-6] [PMID: 27757921]
[88]
Dubey P, Sharma HK, Shah S, Tyagi CK, Chandekar AR, Jadon RS. Formulations and evaluation of cyclodextrin complexed ceadroxil loaded nanosponges. Int J Drug Deliv 2017; 9(3): 84-100.
[http://dx.doi.org/10.5138/09750215.2180]
[89]
Daga M, de Graaf IAM, Argenziano M, et al. Glutathione-responsive cyclodextrin-nanosponges as drug delivery systems for doxorubicin: Evaluation of toxicity and transport mechanisms in the liver. Toxicol In Vitro 2020; 65: 104800.
[http://dx.doi.org/10.1016/j.tiv.2020.104800] [PMID: 32084521]
[90]
Shringirishi M, Mahor A, Gupta R, Prajapati SK, Bansal K, Kesharwani P. Fabrication and characterization of nifedipine loaded β-cyclodextrin nanosponges: An in vitro and in vivo evaluation. J Drug Deliv Sci Technol 2017; 41: 344-50.
[http://dx.doi.org/10.1016/j.jddst.2017.08.005]
[91]
Gangadharappa HV, Chandra Prasad SM, Singh RP. Formulation, in vitro and in vivo evaluation of celecoxib nanosponge hydrogels for topical application. J Drug Deliv Sci Technol 2017; 41: 488-501.
[http://dx.doi.org/10.1016/j.jddst.2017.09.004]
[92]
Anandam S, Selvamuthukumar S. Fabrication of cyclodextrin nanosponges for quercetin delivery: Physicochemical characterization, photostability, and antioxidant effects. J Mater Sci 2014; 49(23): 8140-53.
[http://dx.doi.org/10.1007/s10853-014-8523-6]
[93]
Gilardi G, Di Nardo G, Trotta F, et al. Cyclodextrin nanosponges as a carrier for biocatalysts, and in the delivery and release of enzymes, proteins, vaccines and antibodies. European Patent WO/2009/149883, 2009.
[94]
Kumar S, Pooja , Trotta F, Rao R. Encapsulation of babchi oil in cyclodextrin-based nanosponges: Physicochemical characterization, photodegradation, and in vitro cytotoxicity studies. Pharmaceutics 2018; 10(4): 169.
[http://dx.doi.org/10.3390/pharmaceutics10040169] [PMID: 30261580]
[95]
Sapino S, Carlotti ME, Cavalli R, et al. Photochemical and antioxidant properties of gamma-oryzanol in beta-cyclodextrin-based nano-sponges. J Incl Phenom Macrocycl Chem 2013; 75(1-2): 69-76.
[http://dx.doi.org/10.1007/s10847-012-0147-3]
[96]
Cavalli R, Trotta F, Tumiatti W. Cyclodextrin-based nanosponges for drug delivery. J Incl Phenom Macrocycl Chem 2006; 56(1-2): 209-13.
[http://dx.doi.org/10.1007/s10847-006-9085-2]
[97]
Manyam N, Budideti KK, Mogili S. Formulation and in vitro evaluation of nanosponge-loaded extended release tablets of trimethoprim. UPI J Pharm Med Health Sci 2018; 1(1): 78-86.
[98]
Ahmed MM, Fatima F, Anwer MK, Ansari MJ, Das SS, Alshahrani SM. Development and characterization of ethyl cellulose nanosponges for sustained release of brigatinib for the treatment of non-small cell lung cancer. J Polym Eng 2020; 40(10): 823-32.
[http://dx.doi.org/10.1515/polyeng-2019-0365]
[99]
Chilajwar SV, Pednekar PP, Jadhav KR, Gupta GJC, Kadam VJ. Cyclodextrin-based nanosponges: A propitious platform for enhancing drug delivery. Expert Opin Drug Deliv 2014; 11(1): 111-20.
[http://dx.doi.org/10.1517/17425247.2014.865013] [PMID: 24298891]
[100]
Rao M, Bajaj A, Khole I, Munjapara G, Trotta F. In vitro and in vivo evaluation of β-cyclodextrin-based nanosponges of telmisartan. J Incl Phenom Macrocycl Chem 2013; 77(1-4): 135-45.
[http://dx.doi.org/10.1007/s10847-012-0224-7]
[101]
Olteanu AA, Aramă CC, Radu C, Mihăescu C, Monciu CM. Effect of β-cyclodextrins based nanosponges on the solubility of lipophilic pharmacological active substances (repaglinide). J Incl Phenom Macrocycl Chem 2014; 80(1-2): 17-24.
[http://dx.doi.org/10.1007/s10847-014-0406-6]
[102]
Mahant S, Kumar S, Nanda S, Rao R. Microsponges for dermatological applications: Perspectives and challenges. As. J Pharm Sci 2020; 15(3): 273-91.
[http://dx.doi.org/10.1016/j.ajps.2019.05.004] [PMID: 32636947]
[103]
Kumar S, Prasad M, Rao R. Topical delivery of clobetasol propionate loaded nanosponge hydrogel for effective treatment of psoriasis: Formulation, physicochemical characterization, antipsoriatic potential and biochemical estimation. Mater Sci Eng C 2021; 119: 111605.
[http://dx.doi.org/10.1016/j.msec.2020.111605] [PMID: 33321649]
[104]
Hayiyana Z, Choonara Y, Makgotloe A, Toit L, Kumar P, Pillay V. Ester-based hydrophilic cyclodextrin nanosponges for topical ocular drug delivery. Curr Pharm Des 2017; 22(46): 6988-97.
[http://dx.doi.org/10.2174/1381612822666161216113207] [PMID: 27981908]
[105]
Lambert WS, Carlson BJ, Ende AE, et al. Nanosponge-mediated drug delivery lowers intraocular pressure. Transl Vis Sci Technol 2015; 4(1): 1-16.
[http://dx.doi.org/10.1167/tvst.4.1.1] [PMID: 25599009]
[106]
Argenziano M, Gigliotti CL, Clemente N, et al. Improvement in the anti-tumor efficacy of doxorubicin nanosponges in in vitro and in mice bearing breast tumor models. Cancers 2020; 12(1): 162.
[http://dx.doi.org/10.3390/cancers12010162] [PMID: 31936526]
[107]
Trotta F, Tumiatti V, Cavalli R, Rogero C, Mognetti B, Berta G. Cyclodextrin-based nanosponges as a vehicle for antitumoral drugs. WO2009003656A1, 2009.

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