Abstract
Background: Active pharmaceutical ingredient to be administered in a suitable dosage form is usually incorporated with an inert substance (excipient) to achieve a necessary therapeutic effect. Pharmaceutical excipient plays a prominent role in the drug delivery system. Thus, the exploration of novel excipients is indispensable to aid in formulating the new chemical entity. This review discusses novel lipid excipient Compritol for devising as an efficient drug delivery system and its utility in the pharmaceutical and cosmeceutical industries.
Summary: In this review manuscript, the potential pharmaceutical and cosmeceutical applicability of compritol as a novel excipient has been highlighted. An extensive search of the literature was done using the existing original research papers. Furthermore, painstaking efforts were made to compile and update the information using databases viz., PubMed, Science Direct, Google Scholar, etc. The applications of various grades of compritol are enumerated in the form of tables.
Keywords: Therapeutic Regimen, optimization, sophisticated techniques, novel carrier, bioavailability, targeted delivery, lipid-based carrier system.
Graphical Abstract
[http://dx.doi.org/10.1002/jps.24299] [PMID: 25561249]
[http://dx.doi.org/10.1155/2014/801820] [PMID: 26556202]
[http://dx.doi.org/10.1016/j.ejps.2019.104967] [PMID: 31252052]
[http://dx.doi.org/10.1016/j.apsb.2013.10.001]
[http://dx.doi.org/10.1007/s11095-013-1083-7] [PMID: 23771564]
[http://dx.doi.org/10.1016/j.jddst.2018.10.012]
[http://dx.doi.org/10.3390/pharmaceutics14040831] [PMID: 35456665]
[http://dx.doi.org/10.1007/BF02915334] [PMID: 5642084]
[http://dx.doi.org/10.1002/jps.2600570206] [PMID: 5641671]
[http://dx.doi.org/10.1038/nrd2197] [PMID: 17330072]
[http://dx.doi.org/10.1081/DDC-120037477] [PMID: 15244079]
[PMID: 21589795]
[http://dx.doi.org/10.1016/B978-0-12-820007-0.00032-5]
[http://dx.doi.org/10.5772/50486]
[http://dx.doi.org/10.1186/s12944-017-0466-x] [PMID: 28403892]
[http://dx.doi.org/10.1016/j.colsurfb.2013.03.060] [PMID: 23759381]
[http://dx.doi.org/10.1007/s12272-013-0154-y] [PMID: 23695866]
[http://dx.doi.org/10.1016/j.jconrel.2014.11.013] [PMID: 25445699]
[http://dx.doi.org/10.1016/B978-0-12-813667-6.00003-6]
[http://dx.doi.org/10.4155/tde.11.62] [PMID: 22833905]
[http://dx.doi.org/10.1016/j.ijpharm.2012.10.026] [PMID: 23089578]
[http://dx.doi.org/10.22159/ijpps.2019v11i9.34194]
[http://dx.doi.org/10.4172/2472-0542.1000128]
[http://dx.doi.org/10.1517/17425247.2014.935335] [PMID: 25152197]
[http://dx.doi.org/10.3390/cosmetics8030084]
[http://dx.doi.org/10.3390/cosmetics8030089]
[http://dx.doi.org/10.1016/j.procbio.2013.08.021]
[http://dx.doi.org/10.5958/0974-360X.2018.00523.1]
[http://dx.doi.org/10.1007/s11746-010-1618-6]
[http://dx.doi.org/10.3390/pharmaceutics12121235] [PMID: 33353254]
[http://dx.doi.org/10.1155/2012/750891] [PMID: 22175030]
[PMID: 34275846]
[http://dx.doi.org/10.1208/s12249-018-1128-7] [PMID: 30094721]
[http://dx.doi.org/10.3109/03639048609065862]
[http://dx.doi.org/10.1515/acph-2015-0006] [PMID: 25781708]
[http://dx.doi.org/10.3390/lubricants2010021]
[http://dx.doi.org/10.1208/s12249-016-0504-4] [PMID: 26935562]
[http://dx.doi.org/10.1016/S1773-2247(07)50053-5]
[http://dx.doi.org/10.1111/j.1751-1097.2012.01147.x] [PMID: 22443373]
[http://dx.doi.org/10.1021/acsnano.1c04996] [PMID: 34181394]
[http://dx.doi.org/10.1080/02652040600612439] [PMID: 16854817]
[http://dx.doi.org/10.1016/j.fhfh.2021.100024]
[http://dx.doi.org/10.1016/j.ijpharm.2017.08.086] [PMID: 28842310]
[http://dx.doi.org/10.2174/1574885515999201217155123]
[http://dx.doi.org/10.1016/j.ijpharm.2006.05.052] [PMID: 16824707]
[http://dx.doi.org/10.2174/092986706778201648] [PMID: 17017910]
[http://dx.doi.org/10.1016/j.ejpb.2016.10.023] [PMID: 27815177]
[http://dx.doi.org/10.2174/1567201811310050006] [PMID: 23607649]
[http://dx.doi.org/10.22159/ijap.2019v11i1.29675]
[http://dx.doi.org/10.1016/j.ijpharm.2006.06.006] [PMID: 16837152]
[PMID: 21589801]
[http://dx.doi.org/10.4103/0250-474X.169030] [PMID: 26798179]
[http://dx.doi.org/10.3109/10837450.2013.871035] [PMID: 24354893]
[http://dx.doi.org/10.1080/10837450.2016.1245743] [PMID: 27718780]
[http://dx.doi.org/10.4103/0973-8398.154701]
[PMID: 18583254]
[http://dx.doi.org/10.3109/03639045.2011.638302] [PMID: 22149472]
[http://dx.doi.org/10.4103/0975-1483.83758] [PMID: 21897658]
[http://dx.doi.org/10.4172/pharmaceutical-sciences.1000451]
[http://dx.doi.org/10.4314/tjpr.v14i3.3]
[http://dx.doi.org/10.22270/jddt.v4i3.868]
[http://dx.doi.org/10.1208/s12249-008-9108-y] [PMID: 18686038]
[PMID: 22491314]
[http://dx.doi.org/10.3109/10837450903013576] [PMID: 19671037]
[http://dx.doi.org/10.3109/10837450.2013.805775] [PMID: 23763447]
[http://dx.doi.org/10.1208/pt0803073] [PMID: 17915823]
[http://dx.doi.org/10.3109/10837450902922744] [PMID: 19883258]
[http://dx.doi.org/10.3109/03639040903170768] [PMID: 19722915]
[http://dx.doi.org/10.1208/s12249-013-9951-3] [PMID: 23572253]
[http://dx.doi.org/10.3109/03639045.2010.546404] [PMID: 21401342]
[http://dx.doi.org/10.1016/S0939-6411(01)00173-4] [PMID: 11522491]
[http://dx.doi.org/10.1208/s12249-010-9467-z] [PMID: 20532709]
[http://dx.doi.org/10.1081/DDC-200040237] [PMID: 15595567]
[http://dx.doi.org/10.1016/j.ejpb.2010.01.007] [PMID: 20096779]
[http://dx.doi.org/10.1208/s12249-013-0007-5] [PMID: 23897035]
[http://dx.doi.org/10.1163/1568552041270563]
[http://dx.doi.org/10.1016/j.ajps.2018.08.001] [PMID: 32104473]
[http://dx.doi.org/10.1016/j.ijpharm.2018.05.002] [PMID: 29729408]
[http://dx.doi.org/10.1016/S0378-5173(03)00316-8] [PMID: 12927386]
[http://dx.doi.org/10.1080/2331205X.2018.1480572]
[http://dx.doi.org/10.5402/2012/195727] [PMID: 22830056]
[http://dx.doi.org/10.1016/j.ejps.2010.10.002] [PMID: 20971188]
[http://dx.doi.org/10.2147/IJN.S247406] [PMID: 32581538]
[http://dx.doi.org/10.1016/j.ijpharm.2008.07.028] [PMID: 18725276]
[http://dx.doi.org/10.1016/j.ejpb.2011.07.015] [PMID: 21839833]
[http://dx.doi.org/10.3390/pharmaceutics13030328] [PMID: 33802592]
[http://dx.doi.org/10.1208/s12249-009-9197-2] [PMID: 19277870]
[http://dx.doi.org/10.1016/j.jconrel.2010.02.006] [PMID: 20153385]
[http://dx.doi.org/10.2147/IJN.S33682] [PMID: 22923986]
[http://dx.doi.org/10.1002/jps.22784] [PMID: 22012873]
[http://dx.doi.org/10.5530/ijper.50.4.13]
[http://dx.doi.org/10.1016/j.ejpb.2010.05.003] [PMID: 20470882]
[http://dx.doi.org/10.4103/0975-1483.100016] [PMID: 23112531]
[http://dx.doi.org/10.1016/S0939-6411(98)00088-5] [PMID: 10234531]
[http://dx.doi.org/10.1081/DDC-100100341] [PMID: 10697753]
[http://dx.doi.org/10.1007/s11095-015-1661-y] [PMID: 25788447]
[http://dx.doi.org/10.1080/02652040010000361] [PMID: 11253932]
[http://dx.doi.org/10.3390/molecules25214887] [PMID: 33105792]
[http://dx.doi.org/10.1016/S0378-5173(03)00027-9] [PMID: 12623202]
[http://dx.doi.org/10.1016/j.jacl.2013.11.003] [PMID: 24528686]