Chemical Synthesis of Selenium-containing Peptides

Kainat      Ahmed; Ghayoor   Abbas   Chotana; Amir      Faisal; Rahman   Shah   Zaib Saleem
doi:10.2174/1389557522666220826140910
Abstract

Selenium (Se), a semi-metallic element, has chemical properties similar to sulfur; however, it has comparatively low electronegativity as well as a large atomic radius than sulfur. These features bestow selenium-containing compounds with extraordinary reactivity, sensitivity, and potential for several applications like chemical alteration, protein engineering, chemical (semi)synthesis, etc. Organoselenium chemistry is emerging fastly, however, examples of effective incorporation of Se into the peptides are relatively scarce. Providentially, there has been a drastic interest in synthesizing and applying selenoproteins and selenium-containing peptides over the last few decades. In this minireview, the synthetic methodologies of selenium-containing peptides and a brief description of their chemistry and biological activities are summarized. These methodologies enable access to various natural and unnatural selenium-containing peptides that have been used in a range of applications, from modulating protein characteristics to structure-activity relationship (SAR) studies for applications in nutraceuticals and drug development. This review aims at the audience interested in learning about the synthesis as well as will open new dimensions for their future research by aiding in the design of biologically interesting selenium-containing peptides.
Keywords: Selenium-containing peptides, selenoproteins, selenocysteine, selenomethionine, selenoneine, dehydroalanine.
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DOI https://dx.doi.org/10.2174/1389557522666220826140910	Print ISSN 1389-5575
Publisher Name Bentham Science Publisher	Online ISSN 1875-5607
Mini-Reviews in Medicinal Chemistry

Chemical Synthesis of Selenium-containing Peptides

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