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Review Article

A Comprehensive Review on COVID-19: Emphasis on Current Vaccination and Nanotechnology Aspects

Author(s): Akriti Rai, Kamal Shah, Rajiv Sharma and Hitesh Kumar Dewangan*

Volume 17, Issue 4, 2023

Published on: 19 September, 2022

Page: [359 - 377] Pages: 19

DOI: 10.2174/1872210516666220819104853

Price: $65

Abstract

COVID-19, caused by the SARS-CoV-2 virus, has been expanding. SARS-CoV caused an outbreak in early 2000, while MERS-CoV had a similar expansion of illness in early 2010. Nanotechnology has been employed for nasal delivery of drugs to conquer a variety of challenges that emerge during mucosal administration. The role of nanotechnology is highly relevant to counter this “virus” nano enemy. This technique directs the safe and effective distribution of accessible therapeutic choices using tailored nanocarriers, as well as the interruption of virion assembly, by preventing the early contact of viral spike glycoprotein with host cell surface receptors. This study summarises what we know about earlier SARS-CoV and MERS-CoV illnesses, with the goal of better understanding the recently discovered SARS-CoV-2 virus. It also explains the progress made so far in creating COVID-19 vaccines/ treatments using existing methods. Furthermore, we studied nanotechnology- based vaccinations and therapeutic medications that are now undergoing clinical trials and other alternatives.

Keywords: COVID-19, SARS-CoV-2, MERS-CoV, immune system, nanotechnology, treatment.

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