Abstract
Enzymes are widely recognized as valuable tools for the synthesis of optically active compounds. Thus, lipasecatalysed acylation or deacylation are one of the most efficient methods for the preparation of optically active alcohols, acids and esters. In addition, other nitrogenated organic compounds can also be prepared through enzymatic aminolysis or ammonolysis reactions. Amines and their derived amides are important compounds in organic synthesis, because of the presence of theses functions in many pharmacologically active compounds. On the other hand, enantiopure amines are used in the fine chemical industry as resolving agents, chiral auxiliaries and their preparation by enzymatic acylation of amines is nowadays a well established methodology. In addition, in the last few years, many companies, especially from the pharmaceutical industry, use enzymatic aminolysis and ammonolysis processes for the preparation of enantiopure amines in a multigram scale.
Keywords: Enantioselective enzymatic desymmetrizations (EEDs), Candida antarctica B, Chemoselective Processes, Acyl Donors, Primary Monoamines, alkoxycarbonylation
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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