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Current Medicinal Chemistry

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ISSN (Print): 0929-8673
ISSN (Online): 1875-533X

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Review Article

Chaperone-Mediated Autophagy: A Potential Target for Metabolic Diseases

Author(s): Ming Yang, Shilu Luo, Wei Chen, Li Zhao and Xi Wang*

Volume 30, Issue 16, 2023

Published on: 04 October, 2022

Page: [1887 - 1899] Pages: 13

DOI: 10.2174/0929867329666220811141955

Price: $65

Abstract

Autophagy is the process by which cells selectively remove damaged organelles or proteins. Chaperone-mediated autophagy (CMA) is a type of autophagy that degrades proteins containing the KFERQ pentapeptide in cells. CMA can degrade damaged or excess proteins and therefore plays an important role in maintaining protein balance in cells. CMA can also play a regulatory role by degrading key proteins in life activities, such as lipid and glucose metabolism. This review introduces the CMA process and describes the current commonly used CMA detection methods. In addition, we describe the role of CMA in glucose and lipid metabolism. Finally, we summarize the current role of CMA in metabolic diseases such as diabetic nephropathy (DN), alcoholic liver disease (ALD) and nonalcoholic fatty liver disease (NAFLD) and discuss the role of CMA as a potential therapeutic target for metabolic diseases.

Keywords: Chaperone-mediated autophagy (CMA), metabolic diseases, autophagy, diabetic nephropathy (DN), LAMP2A, HSC70.

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