Login Register Cart 0
Generic placeholder image

Current Stem Cell Research & Therapy

Editor-in-Chief

ISSN (Print): 1574-888X
ISSN (Online): 2212-3946

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Perspective

Modified Risk Tobacco Products and Cardiovascular Repair: Still Very “Smoky”

Author(s): Claudia Cozzolino, Vittorio Picchio, Erica Floris, Francesca Pagano, Wael Saade, Mariangela Peruzzi, Giacomo Frati and Isotta Chimenti*

Volume 18, Issue 4, 2023

Published on: 27 August, 2022

Page: [440 - 444] Pages: 5

DOI: 10.2174/1574888X17666220802142532

Abstract

Smoking habits represent a cardiovascular risk factor with a tremendous impact on health. Other than damaging differentiated and functional cells of the cardiovascular system, they also negatively affect reparative mechanisms, such as those involved in cardiac fibrosis and in endothelial progenitor cell (EPC) activation. In recent years, alternative smoking devices, dubbed modified tobacco risk products (MRPs), have been introduced, but their precise impact on human health is still under evaluation. Also, they have not been characterized yet about the possible negative effects on cardiovascular reparative and regenerative cells, such as EPCs or pluripotent stem cells. In this perspective, we critically review the still scarce available data on the effects of MRPs on molecular and cellular mechanisms of cardiovascular repair and regeneration.

Keywords: Endothelial progenitor cells, pluripotent stem cells, electronic cigarettes, modified risk products, cardiac fibrosis, cardiovascular regeneration.

« Previous Next »
Graphical Abstract

[1]
Picchio V, Bordin A, Floris E, Cozzolino C, Dhori X, Peruzzi M, et al. The dynamic facets of the cardiac stroma: From classical markers to omics and translational perspectives 2022. 14
[2]
Kisseleva T, Brenner DA. Mechanisms of fibrogenesis. Exp Biol Med (Maywood) 2008; 233(2): 109-22.
[http://dx.doi.org/10.3181/0707-MR-190] [PMID: 18222966]
[3]
Kawasaki T, Nishiwaki T, Sekine A, et al. Vascular repair by tissue-resident endothelial progenitor cells in endotoxin-induced lung injury. Am J Respir Cell Mol Biol 2015; 53(4): 500-12.
[http://dx.doi.org/10.1165/rcmb.2014-0185OC] [PMID: 25719275]
[4]
Regueiro A, Cuadrado-Godia E, Bueno-Betí C, et al. Mobilization of endothelial progenitor cells in acute cardiovascular events in the PROCELL study: Time-course after acute myocardial infarction and stroke. J Mol Cell Cardiol 2015; 80: 146-55.
[http://dx.doi.org/10.1016/j.yjmcc.2015.01.005] [PMID: 25619946]
[5]
Salahuddin S, Prabhakaran D, Roy A. Pathophysiological mechanisms of tobacco-related CVD. Glob Heart 2012; 7(2): 113-20.
[http://dx.doi.org/10.1016/j.gheart.2012.05.003] [PMID: 25691307]
[6]
Kondo T, Hayashi M, Takeshita K, et al. Smoking cessation rapidly increases circulating progenitor cells in peripheral blood in chronic smokers. Arterioscler Thromb Vasc Biol 2004; 24(8): 1442-7.
[http://dx.doi.org/10.1161/01.ATV.0000135655.52088.c5] [PMID: 15191940]
[7]
Madonna R, Van Laake LW, Davidson SM, et al. Position paper of the European society of cardiology working group cellular biology of the heart: Cell-based therapies for myocardial repair and regeneration in ischemic heart disease and heart failure. Eur Heart J 2016; 37(23): 1789-98.
[http://dx.doi.org/10.1093/eurheartj/ehw113] [PMID: 27055812]
[8]
Biondi Zoccai G, Carnevale R, Sciarretta S, Frati G. Electronic cigarette. Eur Heart J Suppl 2020; 22 (Suppl. E): E25-9.
[http://dx.doi.org/10.1093/eurheartj/suaa053] [PMID: 32523433]
[9]
Merecz-Sadowska A, Sitarek P, Zielinska-Blizniewska H, et al. A summary of in vitro and in vivo studies evaluating the impact of E-cigarette exposure on living organisms and the environment. Int J Mol Sci 2020; 21(2), E652.
[http://dx.doi.org/10.3390/ijms21020652] [PMID: 31963832]
[10]
Angelini F, Pagano F, Bordin A, Picchio V, De Falco E, Chimenti I. Getting old through the blood: Circulating molecules in aging and senescence of cardiovascular regenerative cells. Front Cardiovasc Med 2017; 4: 62.
[http://dx.doi.org/10.3389/fcvm.2017.00062] [PMID: 29057227]
[11]
Ramírez-Salazar EG, Gayosso-Gómez LV, Baez-Saldaña R, et al. Cigarette smoking alters the expression of circulating micrornas and its potential diagnostic value in female lung cancer patients. Biology (Basel) 2021; 10(8): 793.
[http://dx.doi.org/10.3390/biology10080793] [PMID: 34440025]
[12]
Solleti SK, Bhattacharya S, Ahmad A, et al. MicroRNA expression profiling defines the impact of electronic cigarettes on human airway epithelial cells. Sci Rep 2017; 7(1): 1081.
[http://dx.doi.org/10.1038/s41598-017-01167-8] [PMID: 28439113]
[13]
Singh KP, Maremanda KP, Li D, Rahman I. Exosomal microRNAs are novel circulating biomarkers in cigarette, waterpipe smokers, E-cigarette users and dual smokers. BMC Med Genomics 2020; 13(1): 128.
[http://dx.doi.org/10.1186/s12920-020-00748-3] [PMID: 32912198]
[14]
Frati G, Forte M, di Nonno F, et al. Inhibition of miR-155 attenuates detrimental vascular effects of tobacco cigarette smoking. J Am Heart Assoc 2020; 9(24), e017000.
[http://dx.doi.org/10.1161/JAHA.120.017000] [PMID: 33317369]
[15]
Albuquerque EX, Pereira EFR, Alkondon M, Rogers SW. Mammalian nicotinic acetylcholine receptors: From structure to function. Physiol Rev 2009; 89(1): 73-120.
[http://dx.doi.org/10.1152/physrev.00015.2008] [PMID: 19126755]
[16]
Jensen K, Nizamutdinov D, Guerrier M, Afroze S, Dostal D, Glaser S. General mechanisms of nicotine-induced fibrogenesis. FASEB J 2012; 26(12): 4778-87.
[http://dx.doi.org/10.1096/fj.12-206458] [PMID: 22906950]
[17]
Shan H, Zhang Y, Lu Y, et al. Downregulation of miR-133 and miR-590 contributes to nicotine-induced atrial remodelling in canines. Cardiovasc Res 2009; 83(3): 465-72.
[http://dx.doi.org/10.1093/cvr/cvp130] [PMID: 19398468]
[18]
Vang A, Clements RT, Chichger H, et al. Effect of α7 nicotinic acetylcholine receptor activation on cardiac fibroblasts: A mechanism underlying RV fibrosis associated with cigarette smoke exposure. Am J Physiol Lung Cell Mol Physiol 2017; 312(5): L748-59.
[http://dx.doi.org/10.1152/ajplung.00393.2016] [PMID: 28258105]
[19]
Porrello ER, Mahmoud AI, Simpson E, et al. Transient regenerative potential of the neonatal mouse heart. Science 2011; 331(6020): 1078-80.
[http://dx.doi.org/10.1126/science.1200708] [PMID: 21350179]
[20]
Chuang TD, Ansari A, Yu C, et al. Mechanism underlying increased cardiac extracellular matrix deposition in perinatal nicotine-exposed offspring. Am J Physiol Heart Circ Physiol 2020; 319(3): H651-60.
[http://dx.doi.org/10.1152/ajpheart.00021.2020] [PMID: 32795172]
[21]
van Rooij E, Sutherland LB, Thatcher JE, et al. Dysregulation of microRNAs after myocardial infarction reveals a role of miR-29 in cardiac fibrosis. Proc Natl Acad Sci USA 2008; 105(35): 13027-32.
[http://dx.doi.org/10.1073/pnas.0805038105] [PMID: 18723672]
[22]
Farbehi N, Patrick R, Dorison A, et al. Single-cell expression profiling reveals dynamic flux of cardiac stromal, vascular and immune cells in health and injury. eLife 2019; 8, e43882.
[http://dx.doi.org/10.7554/eLife.43882] [PMID: 30912746]
[23]
White AJ, Smith RR, Matsushita S, et al. Intrinsic cardiac origin of human cardiosphere-derived cells. Eur Heart J 2013; 34(1): 68-75.
[http://dx.doi.org/10.1093/eurheartj/ehr172] [PMID: 21659438]
[24]
Liang G, He Z, Chen Y, et al. Existence of multiple organ aging in animal model of emphysema induced by cigarette smoke extract Tob Induc Dis 2022. 20: 02.
[http://dx.doi.org/10.18332/tid/143853] [PMID: 35087358]
[25]
Plikus M v, Wang X, Sinha S, Forte E, Thompson SM, Herzog EL, et al. Fibroblasts: Origins, definitions, and functions in health and disease Cell 2021; 184: 3852-72.
[http://dx.doi.org/10.1016/j.cell.2021.06.024]
[26]
Mayyas F, Aldawod H, Alzoubi KH, Khabour O, Shihadeh A, Eissenberg T. Comparison of the cardiac effects of electronic cigarette aerosol exposure with waterpipe and combustible cigarette smoke exposure in rats. Life Sci 2020; 251, 117644.
[http://dx.doi.org/10.1016/j.lfs.2020.117644] [PMID: 32259604]
[27]
Crotty Alexander LE, Drummond CA, Hepokoski M, et al. Chronic inhalation of e-cigarette vapor containing nicotine disrupts airway barrier function and induces systemic inflammation and multiorgan fibrosis in mice. Am J Physiol Regul Integr Comp Physiol 2018; 314(6): R834-47.
[http://dx.doi.org/10.1152/ajpregu.00270.2017] [PMID: 29384700]
[28]
Rammah M, Dandachi F, Salman R, Shihadeh A, El-Sabban M. In vitro effects of waterpipe smoke condensate on endothelial cell function: A potential risk factor for vascular disease. Toxicol Lett 2013; 219(2): 133-42.
[http://dx.doi.org/10.1016/j.toxlet.2013.02.015] [PMID: 23454654]
[29]
Ejaz S. Insan-ud-din, Ashraf M, Nawaz M, Lim CW, Kim B. Cigarette smoke condensate and total particulate matter severely disrupts physiological angiogenesis. Food Chem Toxicol 2009; 47(3): 601-14.
[http://dx.doi.org/10.1016/j.fct.2008.12.018] [PMID: 19138718]
[30]
Pei C, Wang X, Lin Y, Fang L, Meng S. Inhibition of galectin-3 alleviates cigarette smoke extract-induced autophagy and dysfunction in endothelial progenitor cells. Oxid Med Cell Longev 2019; 2019, 7252943.
[http://dx.doi.org/10.1155/2019/7252943] [PMID: 31737173]
[31]
He ZH, Chen Y, Chen P, et al. Cigarette smoke extract affects methylation status and attenuates Sca-1 expression of mouse endothelial progenitor cell in vitro Tob Induc Dis 2021. 19: 08.
[http://dx.doi.org/10.18332/tid/131625] [PMID: 33542680]
[32]
Antoniewicz L, Bosson JA, Kuhl J, et al. Electronic cigarettes increase endothelial progenitor cells in the blood of healthy volunteers. Atherosclerosis 2016; 255: 179-85.
[http://dx.doi.org/10.1016/j.atherosclerosis.2016.09.064] [PMID: 27693003]
[33]
Mobarrez F, Antoniewicz L, Bosson JA, Kuhl J, Pisetsky DS, Lundbäck M. The effects of smoking on levels of endothelial progenitor cells and microparticles in the blood of healthy volunteers. PLoS One 2014; 9(2), e90314.
[http://dx.doi.org/10.1371/journal.pone.0090314] [PMID: 24587320]
[34]
Pagano F, Picchio V, Chimenti I, et al. On the road to regeneration: “Tools” and “routes” towards efficient cardiac cell therapy for ischemic cardiomyopathy. Curr Cardiol Rep 2019; 21(11): 133.
[http://dx.doi.org/10.1007/s11886-019-1226-5] [PMID: 31673821]
[35]
Greenberg JM, Carballosa CM, Cheung HS. Concise review: The deleterious effects of cigarette smoking and nicotine usage and mesenchymal stem cell function and implications for cell-based therapies. Stem Cells Transl Med 2017; 6(9): 1815-21.
[http://dx.doi.org/10.1002/sctm.17-0060] [PMID: 28696009]
[36]
Barwinska D, Traktuev DO, Merfeld-Clauss S, et al. Cigarette smoking impairs adipose stromal cell vasculogenic activity and abrogates potency to ameliorate ischemia. Stem Cells 2018; 36(6): 856-67.
[http://dx.doi.org/10.1002/stem.2813] [PMID: 29589872]
[37]
Liang Y, Li X, Zhang Y, et al. Induced pluripotent stem cells-derived mesenchymal stem cells attenuate cigarette smoke-induced cardiac remodeling and dysfunction. Front Pharmacol 2017; 8: 501.
[http://dx.doi.org/10.3389/fphar.2017.00501] [PMID: 28804458]
[38]
Yeung E, Fukunishi T, Bai Y, et al. Cardiac regeneration using human-induced pluripotent stem cell-derived biomaterial-free 3D-bioprinted cardiac patch in vivo. J Tissue Eng Regen Med 2019; 13(11): 2031-9.
[http://dx.doi.org/10.1002/term.2954] [PMID: 31408915]
[39]
Palpant NJ, Hofsteen P, Pabon L, Reinecke H, Murry CE. Cardiac development in zebrafish and human embryonic stem cells is inhibited by exposure to tobacco cigarettes and e-cigarettes. PLoS One 2015; 10(5), e0126259.
[http://dx.doi.org/10.1371/journal.pone.0126259] [PMID: 25978043]
[40]
Behar RZ, Wang Y, Talbot P. Comparing the cytotoxicity of electronic cigarette fluids, aerosols and solvents. Tob Control 2018; 27(3): 325-33.
[http://dx.doi.org/10.1136/tobaccocontrol-2016-053472] [PMID: 28596276]
[41]
Sumanasekera WK, Tran DM, Sumanasekera TU, Le N, Dao HT, Rokosh GD. Cigarette smoke adversely affects functions and cell membrane integrity in c-kit+ cardiac stem cells. Cell Biol Toxicol 2014; 30(2): 113-25.
[http://dx.doi.org/10.1007/s10565-014-9273-6] [PMID: 24633465]
[42]
Sumanasekera WK, Dao HT, Shekhovtsova V, et al. The mechanistic role of oxidative stress in cigarette smoke-induced cardiac stem cell dysfunction and prevention by ascorbic acid. Cell Biol Toxicol 2019; 35(2): 111-27.
[http://dx.doi.org/10.1007/s10565-018-9437-x] [PMID: 30006751]
[43]
Navas-Acien A, Martinez-Morata I, Hilpert M, Rule A, Shimbo D, LoIacono NJ. Early cardiovascular risk in E-cigarette users: The potential role of metals. Curr Environ Health Rep 2020; 7(4): 353-61.
[http://dx.doi.org/10.1007/s40572-020-00297-y] [PMID: 33242201]

Rights & Permissions Print Cite
Article Metrics
13
© 2024 Bentham Science Publishers | Privacy Policy