Childhood Obesity: An Updated Review

Alexander   K.C.   Leung; Alex   H.C.   Wong; Kam   Lun   Hon
doi:10.2174/1573396318666220801093225
Abstract

Background: Childhood obesity is an important and serious public health problem worldwide.
Objective: This article aims to familiarize physicians with the evaluation, management, and prevention of childhood.
Methods: A PubMed search was conducted in May, 2021, in Clinical Queries using the key terms "obesity" OR “obese”. The search included clinical trials, randomized controlled trials, case-control studies, cohort studies, meta-analyses, observational studies, clinical guidelines, case reports, case series, and reviews. The search was restricted to English literature and children. The information retrieved from the above search was used in the compilation of the present article.
Results: Most obese children have exogenous obesity characterized by a growth rate for height above the 50th percentile, normal intelligence, normal genitalia, and lack of historical or physical evidence of an endocrine abnormality or a congenital syndrome. Obese children are at risk for dyslipidemia, hypertension, diabetes mellitus, non-alcoholic fatty liver disease, obstructive sleep apnea, psychosocial disturbances, impaired quality of life, and shorter life expectancy. The multitude of serious comorbidities necessitates effective treatment modalities. Dietary modification, therapeutic exercise, and behavioral modification are the fundamentals of treatment. Pharmacotherapy and/or bariatric surgery should be considered for obese individuals who do not respond to the above measures and suffer from a serious comorbid condition.
Conclusion: Childhood obesity, once established, is often refractory to treatment. Most treatment programs lead to a brief period of weight loss, followed by rapid re-accumulation of the lost weight after the termination of therapy. As such, preventive activity is the key to solving the problem of childhood obesity. Childhood obesity can be prevented by promoting a healthy diet, regular physical activity, and lifestyle modification. Parents should be encouraged to get involved in school and community programs that improve their children's nutritional status and physical activity.
Keywords: diabetes mellitus, dyslipidemia, hypertension, non-alcoholic fatty liver disease, obesity, obstructive sleep apnea, overweight
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Graphical Abstract

[1]
Leung AK, Robson WL. Childhood obesity. Postgrad Med  1990; 87(4): 123-130, 133.
 [http://dx.doi.org/10.1080/00325481.1990.11704600] [PMID:  2315241]

[2]
Leung AKC, Robson WL. Childhood obesity Nutrition Research at the Leading Edge.  New York: Nova Science Publishers, Inc. 2008; pp. 53-93.

[3]
González-Álvarez MA, Lázaro-Alquézar A, Simón-Fernández MB. Global trends in child obesity: Are figures converging? Int J Environ Res Public Health  2020; 17(24): 9252.
 [http://dx.doi.org/10.3390/ijerph17249252] [PMID:  33321991]

[4]
Klish WJ, Skelton JA. Definition, epidemiology, and etiology of obesity in children and adolescents UpToDate. Netherlands: Wolters Kluwer 2022.

[5]
Gahagan S. Child and adolescent obesity. Curr Probl Pediatr Adolesc Health Care  2004; 34(1): 6-43.
 [http://dx.doi.org/10.1016/j.cppeds.2003.09.001] [PMID:  14685151]

[6]
Binns HJ, Ariza AJ. Guidelines help clinicians identify risk factors for overweight in children. Pediatr Ann  2004; 33(1): 18-22.
 [http://dx.doi.org/10.3928/0090-4481-20040101-08] [PMID:  14981865]

[7]
Chia DJ, Boston BA. Childhood obesity and the metabolic syndrome. Adv Pediatr  2006; 53: 23-53.
 [http://dx.doi.org/10.1016/j.yapd.2006.04.005] [PMID:  17089862]

[8]
Hall DM, Cole TJ. What use is the BMI? Arch Dis Child  2006; 91(4): 283-6.
 [http://dx.doi.org/10.1136/adc.2005.077339] [PMID:  16551784]

[9]
Ichikawa G, Arisaka O, Nakayama K, Koyama S, Yoshihara S. Increase of body mass index is a useful predictor of childhood obesity. J Pediatr  2019; 215: 284-5.
 [http://dx.doi.org/10.1016/j.jpeds.2019.08.011] [PMID:  31542155]

[10]
Lake AM. Pediatric obesity: Preventive measures in early childhood. JPEN J Parenter Enteral Nutr  2012; 36(1): 76S-80S.
 [http://dx.doi.org/10.1177/0148607111423915] [PMID:  22237881]

[11]
Styne DM, Arslanian SA, Connor EL, et al. Pediatric obesity-assessment, treatment, and prevention: An endocrine society clinical practice guideline. J Clin Endocrinol Metab  2017; 102(3): 709-57.
 [http://dx.doi.org/10.1210/jc.2016-2573] [PMID:  28359099]

[12]
Tyson N, Frank M. Childhood and adolescent obesity definitions as related to BMI, evaluation and management options. Best Pract Res Clin Obstet Gynaecol  2018; 48: 158-64.
 [http://dx.doi.org/10.1016/j.bpobgyn.2017.06.003] [PMID:  28838829]

[13]
Greydanus DE, Agana M, Kamboj MK, et al. Pediatric obesity: Current concepts. Dis Mon  2018; 64(4): 98-156.
 [http://dx.doi.org/10.1016/j.disamonth.2017.12.001] [PMID:  29329689]

[14]
Bjerregaard LG. Are we approaching a better definition of childhood obesity? Lancet Child Adolesc Health  2019; 3(11): 752-4.
 [http://dx.doi.org/10.1016/S2352-4642(19)30248-2] [PMID:  31451395]

[15]
Chinn S. Definitions of childhood obesity: Current practice. Eur J Clin Nutr  2006; 60(10): 1189-94.
 [http://dx.doi.org/10.1038/sj.ejcn.1602436] [PMID:  16639415]

[16]
Reilly JJ. Obesity in childhood and adolescence: Evidence based clinical and public health perspectives. Postgrad Med J  2006; 82(969): 429-37.
 [http://dx.doi.org/10.1136/pgmj.2005.043836] [PMID:  16822919]

[17]
Vanderwall C, Randall Clark R, Eickhoff J, Carrel AL. BMI is a poor predictor of adiposity in young overweight and obese children. BMC Pediatr  2017; 17(1): 135.
 [http://dx.doi.org/10.1186/s12887-017-0891-z] [PMID:  28577356]

[18]
Bass JL, Bhatia A, Boas FE, Sansary J, Rauch D. Validation of a body mass index nomogram for children as an obesity screening tool in young children. Clin Pediatr (Phila)  2006; 45(8): 718-24.
 [http://dx.doi.org/10.1177/0009922806292784] [PMID:  16968957]

[19]
Expert panel on the identification, evaluation, and treatment of overweight in adults. clinical guidelines on the identification, evaluation, and treatment of overweight and obesity in adults: Executive summary. Am J Clin Nutr  1998; 68(4): 899-917.
 [http://dx.doi.org/10.1093/ajcn/68.4.899] [PMID:  9771869]

[20]
Must A, Dallal GE, Dietz WH. Reference data for obesity: 85th and 95th percentiles of body mass index (wt/ht2) and triceps skinfold thickness. Am J Clin Nutr  1991; 53(4): 839-46.
 [http://dx.doi.org/10.1093/ajcn/53.4.839] [PMID:  2008861]

[21]
Troiano RP, Flegal KM. Overweight children and adolescents: Description, epidemiology, and demographics. Pediatrics  1998; 101(3 Pt 2): 497-504.
 [http://dx.doi.org/10.1542/peds.101.S2.497] [PMID:  12224656]

[22]
Dobashi K. Evaluation of obesity in school-age children. J Atheroscler Thromb  2016; 23(1): 32-8.
 [http://dx.doi.org/10.5551/jat.29397] [PMID:  26510873]

[23]
Franzosi MG. Should we continue to use BMI as a cardiovascular risk factor? Lancet  2006; 368(9536): 624-5.
 [http://dx.doi.org/10.1016/S0140-6736(06)69222-2] [PMID:  16920449]

[24]
Güngör NK. Overweight and obesity in children and adolescents. J Clin Res Pediatr Endocrinol  2014; 6(3): 129-43.
 [http://dx.doi.org/10.4274/jcrpe.1471] [PMID:  25241606]

[25]
Aggarwal B, Jain V. Obesity in children: Definition, etiology and approach. Indian J Pediatr  2018; 85(6): 463-71.
 [http://dx.doi.org/10.1007/s12098-017-2531-x] [PMID:  29177599]

[26]
Yusuf S, Hawken S, Ounpuu S, et al. Effect of potentially modifiable risk factors associated with myocardial infarction in 52 countries (the INTERHEART study): Case-control study. Lancet  2004; 364(9438): 937-52.
 [http://dx.doi.org/10.1016/S0140-6736(04)17018-9] [PMID:  15364185]

[27]
Simmonds M, Llewellyn A, Owen CG, Woolacott N. Simple tests for the diagnosis of childhood obesity: A systematic review and meta-analysis. Obes Rev  2016; 17(12): 1301-15.
 [http://dx.doi.org/10.1111/obr.12462] [PMID:  27653184]

[28]
Sopher AB, Thornton JC, Wang J, Pierson RN Jr, Heymsfield SB, Horlick M. Measurement of percentage of body fat in 411 children and adolescents: A comparison of dual-energy X-ray absorptiometry with a four-compartment model. Pediatrics  2004; 113(5): 1285-90.
 [http://dx.doi.org/10.1542/peds.113.5.1285] [PMID:  15121943]

[29]
Ajlouni K, Khader Y, Batieha A, Jaddou H, El-Khateeb M. An alarmingly high and increasing prevalence of obesity in Jordan. Epidemiol Health  2020; 42: e2020040.
 [http://dx.doi.org/10.4178/epih.e2020040] [PMID:  32512659]

[30]
Miller J, Rosenbloom A, Silverstein J. Childhood obesity. J Clin Endocrinol Metab  2004; 89(9): 4211-8.
 [http://dx.doi.org/10.1210/jc.2004-0284] [PMID:  15356008]

[31]
Bushaw A. Call for action: Addressing obesity in early childhood. Nurse Pract  2019; 44(9): 11-4.
 [http://dx.doi.org/10.1097/01.NPR.0000577956.19725.11] [PMID:  31436588]

[32]
Kumar S, Kelly AS. Review of childhood obesity: From epidemiology, etiology, and comorbidities to clinical assessment and treatment. Mayo Clin Proc  2017; 92(2): 251-65.
 [http://dx.doi.org/10.1016/j.mayocp.2016.09.017] [PMID:  28065514]

[33]
Philippas NG, Lo CW. Childhood obesity: Etiology, prevention, and treatment. Nutr Clin Care  2005; 8(2): 77-88.
 [PMID:  16013226]

[34]
Reilly JJ, Wilson D. ABC of obesity. Childhood obesity. BMJ  2006; 333(7580): 1207-10.
 [http://dx.doi.org/10.1136/bmj.39048.503750.BE] [PMID:  17158388]

[35]
Wang Y, Lobstein T. Worldwide trends in childhood overweight and obesity. Int J Pediatr Obes  2006; 1(1): 11-25.
 [http://dx.doi.org/10.1080/17477160600586747] [PMID:  17902211]

[36]
Anderson PM, Butcher KF, Schanzenbach DW. Understanding recent trends in childhood obesity in the United States. Econ Hum Biol  2019; 34: 16-25.
 [http://dx.doi.org/10.1016/j.ehb.2019.02.002] [PMID:  30910341]

[37]
Ogden CL, Flegal KM, Carroll MD, Johnson CL. Prevalence and trends in overweight among US children and adolescents, 1999-2000. JAMA  2002; 288(14): 1728-32.
 [http://dx.doi.org/10.1001/jama.288.14.1728] [PMID:  12365956]

[38]
Xanthakos SA, Inge TH. Extreme pediatric obesity: Weighing the health dangers. J Pediatr  2007; 150(1): 3-5.
 [http://dx.doi.org/10.1016/j.jpeds.2006.11.040] [PMID:  17188602]

[39]
Brown CL, Halvorson EE, Cohen GM, Lazorick S, Skelton JA. Addressing childhood obesity: Opportunities for prevention. Pediatr Clin North Am  2015; 62(5): 1241-61.
 [http://dx.doi.org/10.1016/j.pcl.2015.05.013] [PMID:  26318950]

[40]
Kohut T, Robbins J, Panganiban J. Update on childhood/adolescent obesity and its sequela. Curr Opin Pediatr  2019; 31(5): 645-53.
 [http://dx.doi.org/10.1097/MOP.0000000000000786] [PMID:  31145127]

[41]
McBride DL. Childhood obesity: Influential factors and interventions. J Pediatr Nurs  2018; 42: 122-3.
 [http://dx.doi.org/10.1016/j.pedn.2018.02.011] [PMID:  29487027]

[42]
Rao DP, Kropac E, Do MT, Roberts KC, Jayaraman GC. Childhood overweight and obesity trends in Canada. Health Promot Chronic Dis Prev Can  2016; 36(9): 194-8.
 [http://dx.doi.org/10.24095/hpcdp.36.9.03] [PMID:  27670922]

[43]
Wright N, Wales J. Assessment and management of severely obese children and adolescents. Arch Dis Child  2016; 101(12): 1161-7.
 [http://dx.doi.org/10.1136/archdischild-2015-309103] [PMID:  27312003]

[44]
Poskitt EM. Tackling childhood obesity: Diet, physical activity or lifestyle change? Acta Paediatr  2005; 94(4): 396-8.
 [http://dx.doi.org/10.1080/08035250510026733] [PMID:  16092449]

[45]
Veugelers PJ, Fitzgerald AL. Prevalence of and risk factors for childhood overweight and obesity. CMAJ  2005; 173(6): 607-13.
 [http://dx.doi.org/10.1503/cmaj.050445] [PMID:  16157724]

[46]
Alaimo K, Olson CM, Frongillo EA Jr. Low family income and food insufficiency in relation to overweight in US children: Is there a paradox? Arch Pediatr Adolesc Med  2001; 155(10): 1161-7.
 [http://dx.doi.org/10.1001/archpedi.155.10.1161] [PMID:  11576013]

[47]
Casey PH, Simpson PM, Gossett JM, et al. The association of child and household food insecurity with childhood overweight status. Pediatrics  2006; 118(5): e1406-13.
 [http://dx.doi.org/10.1542/peds.2006-0097] [PMID:  17079542]

[48]
Morales Camacho WJ, Molina Díaz JM, Plata Ortiz S, Plata Ortiz JE, Morales Camacho MA, Calderón BP. Childhood obesity: Aetiology, comorbidities, and treatment. Diabetes Metab Res Rev  2019; 35(8): e3203.
 [http://dx.doi.org/10.1002/dmrr.3203] [PMID:  31299135]

[49]
Agras WS, Hammer LD, McNicholas F, Kraemer HC. Risk factors for childhood overweight: A prospective study from birth to 9.5 years. J Pediatr  2004; 145(1): 20-5.
 [http://dx.doi.org/10.1016/j.jpeds.2004.03.023] [PMID:  15238901]

[50]
Danielzik S, Czerwinski-Mast M, Langnäse K, Dilba B, Müller MJ. Parental overweight, socioeconomic status and high birth weight are the major determinants of overweight and obesity in 5-7 y-old children: Baseline data of the Kiel Obesity Prevention Study (KOPS). Int J Obes Relat Metab Disord  2004; 28(11): 1494-502.
 [http://dx.doi.org/10.1038/sj.ijo.0802756] [PMID:  15326465]

[51]
Reinehr T. Long-term effects of adolescent obesity: Time to act. Nat Rev Endocrinol  2018; 14(3): 183-8.
 [http://dx.doi.org/10.1038/nrendo.2017.147] [PMID:  29170543]

[52]
Whitaker RC, Wright JA, Pepe MS, Seidel KD, Dietz WH. Predicting obesity in young adulthood from childhood and parental obesity. N Engl J Med  1997; 337(13): 869-73.
 [http://dx.doi.org/10.1056/NEJM199709253371301] [PMID:  9302300]

[53]
Dorosty AR, Emmett PM. Cowin Sd, Reilly JJ. Factors associated with early adiposity rebound. ALSPAC Study Team Pediatrics  2000; 105(5): 1115-8.

[54]
Grummer-Strawn LM, Mei Z. Does breastfeeding protect against pediatric overweight? Analysis of longitudinal data from the Centers for Disease Control and Prevention Pediatric Nutrition Surveillance System. Pediatrics  2004; 113(2): e81-6.
 [http://dx.doi.org/10.1542/peds.113.2.e81] [PMID:  14754976]

[55]
Lang Morović M, Musić Milanović S. Breastfeeding duration as a predictor of childhood lifestyle habits, Overweight and obesity in second- and third-grade schoolchildren in Croatia. Acta Clin Croat  2019; 58(3): 481-90.
 [http://dx.doi.org/10.20471/acc.2019.58.03.12] [PMID:  31969761]

[56]
Leung AK, Sauve RS. Breast is best for babies. J Natl Med Assoc  2005; 97(7): 1010-9.
 [PMID:  16080672]

[57]
Owen CG, Martin RM, Whincup PH, Smith GD, Cook DG. Effect of infant feeding on the risk of obesity across the life course: A quantitative review of published evidence. Pediatrics  2005; 115(5): 1367-77.
 [http://dx.doi.org/10.1542/peds.2004-1176] [PMID:  15867049]

[58]
Toschke AM, Vignerova J, Lhotska L, Osancova K, Koletzko B, Von Kries R. Overweight and obesity in 6- to 14-year-old Czech children in 1991: Protective effect of breast-feeding. J Pediatr  2002; 141(6): 764-9.
 [http://dx.doi.org/10.1067/mpd.2002.128890] [PMID:  12461491]

[59]
Wang L, Collins C, Ratliff M, Xie B, Wang Y. Breastfeeding reduces childhood obesity risks. Child Obes  2017; 13(3): 197-204.
 [http://dx.doi.org/10.1089/chi.2016.0210] [PMID:  28398851]

[60]
von Kries R, Koletzko B, Sauerwald T, et al. Breast feeding and obesity: Cross sectional study. BMJ  1999; 319(7203): 147-50.
 [http://dx.doi.org/10.1136/bmj.319.7203.147] [PMID:  10406746]

[61]
Harder T, Bergmann R, Kallischnigg G, Plagemann A. Duration of breastfeeding and risk of overweight: A meta-analysis. Am J Epidemiol  2005; 162(5): 397-403.
 [http://dx.doi.org/10.1093/aje/kwi222] [PMID:  16076830]

[62]
Martin RM, Gunnell D, Smith GD. Breastfeeding in infancy and blood pressure in later life: Systematic review and meta-analysis. Am J Epidemiol  2005; 161(1): 15-26.
 [http://dx.doi.org/10.1093/aje/kwh338] [PMID:  15615909]

[63]
Bradshaw JM, Ensor SJA, Lorenz HAL. Gestational diabetes and childhood obesity. JAMA  2019; 321(7): 708.
 [http://dx.doi.org/10.1001/jama.2018.19750] [PMID:  30778593]

[64]
Freemark M. Determinants of risk for childhood obesity. N Engl J Med  2018; 379(14): 1371-2.
 [http://dx.doi.org/10.1056/NEJMe1811305] [PMID:  30281997]

[65]
Langley-Evans SC, Moran VH. Childhood obesity: Risk factors, prevention and management. Matern Child Nutr  2014; 10(4): 453-5.
 [http://dx.doi.org/10.1111/mcn.12140] [PMID:  25263514]

[66]
Langley-Evans SC, Moran VH. Childhood obesity: Risk factors, prevention and management. J Hum Nutr Diet  2014; 27(5): 411-2.
 [http://dx.doi.org/10.1111/jhn.12254] [PMID:  25250902]

[67]
Larqué E, Labayen I, Flodmark CE, et al. From conception to infancy - early risk factors for childhood obesity. Nat Rev Endocrinol  2019; 15(8): 456-78.
 [http://dx.doi.org/10.1038/s41574-019-0219-1] [PMID:  31270440]

[68]
Rayfield S, Plugge E. Systematic review and meta-analysis of the association between maternal smoking in pregnancy and childhood overweight and obesity. J Epidemiol Community Health  2017; 71(2): 162-73.
 [http://dx.doi.org/10.1136/jech-2016-207376] [PMID:  27480843]

[69]
Spruijt-Metz D, Li C, Cohen E, Birch L, Goran M. Longitudinal influence of mother’s child-feeding practices on adiposity in children. J Pediatr  2006; 148(3): 314-20.
 [http://dx.doi.org/10.1016/j.jpeds.2005.10.035] [PMID:  16615957]

[70]
Seth A, Sharma R. Childhood obesity. Indian J Pediatr  2013; 80(4): 309-17.
 [http://dx.doi.org/10.1007/s12098-012-0931-5] [PMID:  23255079]

[71]
Bowman SA, Gortmaker SL, Ebbeling CB, Pereira MA, Ludwig DS. Effects of fast-food consumption on energy intake and diet quality among children in a national household survey. Pediatrics  2004; 113(1 Pt 1): 112-8.
 [http://dx.doi.org/10.1542/peds.113.1.112] [PMID:  14702458]

[72]
Thompson OM, Ballew C, Resnicow K, et al. Food purchased away from home as a predictor of change in BMI z-score among girls. Int J Obes Relat Metab Disord  2004; 28(2): 282-9.
 [http://dx.doi.org/10.1038/sj.ijo.0802538] [PMID:  14647177]

[73]
Fox MK, Reidy K, Novak T, Ziegler P. Sources of energy and nutrients in the diets of infants and toddlers. J Am Diet Assoc  2006; 106 (Suppl. 1): S28-42.
 [http://dx.doi.org/10.1016/j.jada.2005.09.034] [PMID:  16376628]

[74]
Ludwig DS, Peterson KE, Gortmaker SL. Relation between consumption of sugar-sweetened drinks and childhood obesity: A prospective, observational analysis. Lancet  2001; 357(9255): 505-8.
 [http://dx.doi.org/10.1016/S0140-6736(00)04041-1] [PMID:  11229668]

[75]
Striegel-Moore RH, Thompson D, Affenito SG, et al. Correlates of beverage intake in adolescent girls: The National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr  2006; 148(2): 183-7.
 [http://dx.doi.org/10.1016/j.jpeds.2005.11.025] [PMID:  16492426]

[76]
Bradwisch SA, Smith EM, Mooney C, Scaccia D. Obesity in children and adolescents: An overview. Nursing  2020; 50(11): 60-6.
 [http://dx.doi.org/10.1097/01.NURSE.0000718908.20119.01] [PMID:  33105431]

[77]
Wickham EP III, DeBoer MD. Evaluation and treatment of severe obesity in childhood. Clin Pediatr (Phila)  2015; 54(10): 929-40.
 [http://dx.doi.org/10.1177/0009922814565886] [PMID:  25567296]

[78]
Aguirre Castaneda RL, Kumar S, Voigt RG, et al. Childhood attention-deficit/hyperactivity disorder, sex, and obesity: A longitudinal population-based study. Mayo Clin Proc  2016; 91(3): 352-61.
 [http://dx.doi.org/10.1016/j.mayocp.2015.09.017] [PMID:  26853710]

[79]
Chen Q, Hartman CA, Kuja-Halkola R, Faraone SV, Almqvist C, Larsson H. Attention-deficit/hyperactivity disorder and clinically diagnosed obesity in adolescence and young adulthood: A register-based study in Sweden. Psychol Med  2019; 49(11): 1841-9.
 [http://dx.doi.org/10.1017/S0033291718002532] [PMID:  30220266]

[80]
Egbert AH, Wilfley DE, Eddy KT, et al. Attention-deficit/hyperactivity disorder symptoms are associated with overeating with and without loss of control in youth with overweight/obesity. Child Obes  2018; 14(1): 50-7.
 [http://dx.doi.org/10.1089/chi.2017.0114] [PMID:  28945463]

[81]
Hanć T. ADHD as a risk factor for obesity. Current state of research. Psychiatr Pol  2018; 52(2): 309-22.
 [http://dx.doi.org/10.12740/PP/70388] [PMID:  29975369]

[82]
Leung AK, Lemay JF. Attention deficit hyperactivity disorder: An update. Adv Ther  2003; 20(6): 305-18.
 [http://dx.doi.org/10.1007/BF02849796] [PMID:  15058747]

[83]
Leung AK, Hon KL. Attention-deficit/hyperactivity disorder. Adv Pediatr  2016; 63(1): 255-80.
 [http://dx.doi.org/10.1016/j.yapd.2016.04.017] [PMID:  27426904]

[84]
Fliers EA, Buitelaar JK, Maras A, et al. ADHD is a risk factor for overweight and obesity in children. J Dev Behav Pediatr  2013; 34(8): 566-74.
 [http://dx.doi.org/10.1097/DBP.0b013e3182a50a67] [PMID:  24131879]

[85]
Patrick K, Norman GJ, Calfas KJ, et al. Diet, physical activity, and sedentary behaviors as risk factors for overweight in adolescence. Arch Pediatr Adolesc Med  2004; 158(4): 385-90.
 [http://dx.doi.org/10.1001/archpedi.158.4.385] [PMID:  15066880]

[86]
Salbe AD, Weyer C, Harper I, Lindsay RS, Ravussin E, Tataranni PA. Assessing risk factors for obesity between childhood and adolescence: II. Energy metabolism and physical activity. Pediatrics  2002; 110(2 Pt 1): 307-14.
 [http://dx.doi.org/10.1542/peds.110.2.307] [PMID:  12165583]

[87]
Leung AK, Fagan JE, Cho H, Lim SH, Robson WM. Children and television. Am Fam Physician  1994; 50(5): 909-912, 915-918.
 [PMID:  7942409]

[88]
Schneider MB, Brill SR. Obesity in children and adolescents. Pediatr Rev  2005; 26(5): 155-62.
 [http://dx.doi.org/10.1542/pir.26.5.155] [PMID:  15863625]

[89]
Taveras EM, Sandora TJ, Shih MC, Ross-Degnan D, Goldmann DA, Gillman MW. The association of television and video viewing with fast food intake by preschool-age children. Obesity (Silver Spring)  2006; 14(11): 2034-41.
 [http://dx.doi.org/10.1038/oby.2006.238] [PMID:  17135621]

[90]
Marshall SJ, Biddle SJ, Gorely T, Cameron N, Murdey I. Relationships between media use, body fatness and physical activity in children and youth: A meta-analysis. Int J Obes Relat Metab Disord  2004; 28(10): 1238-46.
 [http://dx.doi.org/10.1038/sj.ijo.0802706] [PMID:  15314635]

[91]
Proctor MH, Moore LL, Gao D, et al. Television viewing and change in body fat from preschool to early adolescence: The Framingham Children’s Study. Int J Obes Relat Metab Disord  2003; 27(7): 827-33.
 [http://dx.doi.org/10.1038/sj.ijo.0802294] [PMID:  12821969]

[92]
Fatima Y, Doi SA, Mamun AA. Sleep quality and obesity in young subjects: A meta-analysis. Obes Rev  2016; 17(11): 1154-66.
 [http://dx.doi.org/10.1111/obr.12444] [PMID:  27417913]

[93]
Li L, Zhang S, Huang Y, Chen K. Sleep duration and obesity in children: A systematic review and meta-analysis of prospective cohort studies. J Paediatr Child Health  2017; 53(4): 378-85.
 [http://dx.doi.org/10.1111/jpc.13434] [PMID:  28073179]

[94]
Sluggett L, Wagner SL, Harris RL. Sleep duration and obesity in children and adolescents. Can J Diabetes  2019; 43(2): 146-52.
 [http://dx.doi.org/10.1016/j.jcjd.2018.06.006] [PMID:  30266216]

[95]
Shedlock K, Susi A, Gorman GH, Hisle-Gorman E, Erdie-Lalena CR, Nylund CM. Autism spectrum disorders and metabolic complications of obesity. J Pediatr  2016; 178: 183-187.e1.
 [http://dx.doi.org/10.1016/j.jpeds.2016.07.055] [PMID:  27592097]

[96]
Farooqi IS, O’Rahilly S. Recent advances in the genetics of severe childhood obesity. Arch Dis Child  2000; 83(1): 31-4.
 [http://dx.doi.org/10.1136/adc.83.1.31] [PMID:  10868996]

[97]
Wardle J. Understanding the aetiology of childhood obesity: Implications for treatment. Proc Nutr Soc  2005; 64(1): 73-9.
 [http://dx.doi.org/10.1079/PNS2004411] [PMID:  15877925]

[98]
Strauss RS, Pollack HA. Social marginalization of overweight children. Arch Pediatr Adolesc Med  2003; 157(8): 746-52.
 [http://dx.doi.org/10.1001/archpedi.157.8.746] [PMID:  12912779]

[99]
Manco M, Dallapiccola B. Genetics of pediatric obesity. Pediatrics  2012; 130(1): 123-33.
 [http://dx.doi.org/10.1542/peds.2011-2717] [PMID:  22665408]

[100]
Stunkard AJ, Foch TT, Hrubec Z. A twin study of human obesity. JAMA  1986; 256(1): 51-4.
 [http://dx.doi.org/10.1001/jama.1986.03380010055024] [PMID:  3712713]

[101]
Stunkard AJ, Sørensen TI, Hanis C, et al. An adoption study of human obesity. N Engl J Med  1986; 314(4): 193-8.
 [http://dx.doi.org/10.1056/NEJM198601233140401] [PMID:  3941707]

[102]
Sun M, Gower BA, Bartolucci AA, Hunter GR, Figueroa-Colon R, Goran MI. A longitudinal study of resting energy expenditure relative to body composition during puberty in African American and white children. Am J Clin Nutr  2001; 73(2): 308-15.
 [http://dx.doi.org/10.1093/ajcn/73.2.308] [PMID:  11157329]

[103]
Barsh GS, Farooqi IS, O’Rahilly S. Genetics of body-weight regulation. Nature  2000; 404(6778): 644-51.
 [http://dx.doi.org/10.1038/35007519] [PMID:  10766251]

[104]
Chesi A, Grant SFA. The genetics of pediatric obesity. Trends Endocrinol Metab  2015; 26(12): 711-21.
 [http://dx.doi.org/10.1016/j.tem.2015.08.008] [PMID:  26439977]

[105]
Kostovski M, Tasic V, Laban N, Polenakovic M, Danilovski D, Gucev Z. Obesity in childhood and adolescence, genetic factors. Prilozi (Makedon Akad Nauk Umet Odd Med Nauki)  2017; 38(3): 121-33.
 [http://dx.doi.org/10.2478/prilozi-2018-0013] [PMID:  29668472]

[106]
Martos-Moreno GA, Argente J. Molecular basis of human obesity. J Pediatr Endocrinol Metab  2005; 18 (Suppl. 1): 1187-97.
 [http://dx.doi.org/10.1515/JPEM.2005.18.S1.1187] [PMID:  16398449]

[107]
Savona-Ventura C, Savona-Ventura S. The inheritance of obesity. Best Pract Res Clin Obstet Gynaecol  2015; 29(3): 300-8.
 [http://dx.doi.org/10.1016/j.bpobgyn.2014.07.023] [PMID:  25457854]

[108]
Leung AK, McArthur RG, Ross SA, McMillan DD, Sauve RS. Thyroxine-binding globulin deficiency in Beckwith syndrome. J Pediatr  1979; 95(5 Pt 1): 752-4.
 [http://dx.doi.org/10.1016/S0022-3476(79)80730-1] [PMID:  114616]

[109]
Leung AK, Robson WL. Recurrent panniculitis in an adolescent boy with Prader-Willi syndrome. J Natl Med Assoc  2006; 98(10): 1700-1.
 [PMID:  17052066]

[110]
Yoshii K, Isojima T, Piedvache A, Morisaki N, Tanaka T, Nagata S. Reduced pubertal growth in children with obesity regardless of pubertal timing. Endocr J  2020; 67(4): 477-84.
 [http://dx.doi.org/10.1507/endocrj.EJ19-0359] [PMID:  32009029]

[111]
Brown T, Moore TH, Hooper L, et al. Interventions for preventing obesity in children. Cochrane Database Syst Rev  2019; 7(7): CD001871.
 [PMID:  31332776]

[112]
Bereket A, Kiess W, Lustig RH, et al. Hypothalamic obesity in children. Obes Rev  2012; 13(9): 780-98.
 [http://dx.doi.org/10.1111/j.1467-789X.2012.01004.x] [PMID:  22577758]

[113]
Hon KL, Fung GPG, Leung AKC, Leung KKY, Ng DKK. Ondine’s curse of congenital central hypoventilation syndrome in children: The Hong Kong perspectives. Hong Kong Med J 2022. [Epub ahead of print].

[114]
Leung AKC, Lam JM, Leong KF. Childhood Langerhans cell histiocytosis: A disease with many faces. World J Pediatr  2019; 15(6): 536-45.
 [http://dx.doi.org/10.1007/s12519-019-00304-9] [PMID:  31456157]

[115]
Sudi KM, Gallistl S, Tafeit E, Möller R, Borkenstein MH. The relationship between different subcutaneous adipose tissue layers, fat mass and leptin in obese children and adolescents. J Pediatr Endocrinol Metab  2000; 13(5): 505-12.
 [http://dx.doi.org/10.1515/JPEM.2000.13.5.505] [PMID:  10803868]

[116]
Someshwar J, Someshwar S, Perkins KC. The obese adolescent. Pediatr Ann  2006; 35(3): 180-6.
 [http://dx.doi.org/10.3928/0090-4481-20060301-11] [PMID:  16570484]

[117]
Liu H, Du T, Li C, Yang G. STAT3 phosphorylation in central leptin resistance. Nutr Metab (Lond)  2021; 18(1): 39.
 [http://dx.doi.org/10.1186/s12986-021-00569-w] [PMID:  33849593]

[118]
ElSaeed G, Mousa N, El-Mougy F, et al. Monogenic leptin deficiency in early childhood obesity. Pediatr Obes  2020; 15(1): e12574.
 [http://dx.doi.org/10.1111/ijpo.12574] [PMID:  31483094]

[119]
Diamond FB Jr, Cuthbertson D, Hanna S, Eichler D. Correlates of adiponectin and the leptin/adiponectin ratio in obese and non-obese children. J Pediatr Endocrinol Metab  2004; 17(8): 1069-75.
 [http://dx.doi.org/10.1515/JPEM.2004.17.8.1069] [PMID:  15379417]

[120]
Artz E, Haqq A, Freemark M. Hormonal and metabolic consequences of childhood obesity. Endocrinol Metab Clin North Am  2005; 34(3): 643-58.
 [http://dx.doi.org/10.1016/j.ecl.2005.04.004] [PMID:  16085164]

[121]
de Groot CJ, van den Berg A, Ballieux BEPB, et al. Determinants of advanced bone age in childhood obesity. Horm Res Paediatr  2017; 87(4): 254-63.
 [http://dx.doi.org/10.1159/000467393] [PMID:  28365712]

[122]
Skelton JA, Klish WJ. Clinical evaluation of the child or adolescent with obesity UpToDate. Netherlands: Wolters Kluwer 2022.

[123]
Hilgers KK, Akridge M, Scheetz JP, Kinane DE. Childhood obesity and dental development. Pediatr Dent  2006; 28(1): 18-22.
 [PMID:  16615371]

[124]
Leung AK, Barankin B. Physiological striae atrophicae of adolescence with involvement of the upper back. Case Rep Pediatr  2013; 2013: 386094.
 [http://dx.doi.org/10.1155/2013/386094] [PMID:  23956908]

[125]
Leung AKC, Barankin B. Physiological striae atrophicae of adolescence with involvement of the axillae and proximal rms. Case Rep Pediatr  2017; 2017: 7678086.
 [http://dx.doi.org/10.1155/2017/7678086] [PMID:  28593064]

[126]
Biro FM, Khoury P, Morrison JA. Influence of obesity on timing of puberty. Int J Androl  2006; 29(1): 272-7.
 [http://dx.doi.org/10.1111/j.1365-2605.2005.00602.x] [PMID:  16371114]

[127]
Unni JC. Onset of puberty in relation to obesity. Indian Pediatr  2016; 53(5): 379-80.
 [http://dx.doi.org/10.1007/s13312-016-0856-6] [PMID:  27254042]

[128]
Wang Y. Is obesity associated with early sexual maturation? A comparison of the association in American boys versus girls. Pediatrics  2002; 110(5): 903-10.
 [http://dx.doi.org/10.1542/peds.110.5.903] [PMID:  12415028]

[129]
Leung AKC, Leung AAC. Gynecomastia in infants, children, and adolescents. Recent Pat Endocr Metab Immune Drug Discov  2017; 10(2): 127-37.
 [http://dx.doi.org/10.2174/1872214811666170301124033] [PMID:  28260521]

[130]
Harper MG. Childhood obesity: Strategies for prevention. Fam Community Health  2006; 29(4): 288-98.
 [http://dx.doi.org/10.1097/00003727-200610000-00007] [PMID:  16980804]

[131]
Fisberg M, Baur L, Chen W, et al. Obesity in children and adolescents: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr  2004; 39 (Suppl. 2): S678-87.
 [http://dx.doi.org/10.1097/00005176-200406002-00015] [PMID:  15184769]

[132]
Meixner L, Cohrdes C, Schienkiewitz A, Mensink GBM. Health-related quality of life in children and adolescents with overweight and obesity: Results from the German KIGGS survey. BMC Public Health  2020; 20(1): 1722.
 [http://dx.doi.org/10.1186/s12889-020-09834-8] [PMID:  33198705]

[133]
Taylor VH, Forhan M, Vigod SN, McIntyre RS, Morrison KM. The impact of obesity on quality of life. Best Pract Res Clin Endocrinol Metab  2013; 27(2): 139-46.
 [http://dx.doi.org/10.1016/j.beem.2013.04.004] [PMID:  23731876]

[134]
Salwen JK, Hymowitz GF, Vivian D, O’Leary KD. Childhood abuse, adult interpersonal abuse, and depression in individuals with extreme obesity. Child Abuse Negl  2014; 38(3): 425-33.
 [http://dx.doi.org/10.1016/j.chiabu.2013.12.005] [PMID:  24412223]

[135]
Janssen I, Craig WM, Boyce WF, Pickett W. Associations between overweight and obesity with bullying behaviors in school-aged children. Pediatrics  2004; 113(5): 1187-94.
 [http://dx.doi.org/10.1542/peds.113.5.1187] [PMID:  15121928]

[136]
Fonseca H, Palmeira AL, Martins SC, Falcato L, Quaresma A. Managing paediatric obesity: A multidisciplinary intervention including peers in the therapeutic process. BMC Pediatr  2014; 14: 89.
 [http://dx.doi.org/10.1186/1471-2431-14-89] [PMID:  24693926]

[137]
Gow ML, Tee MSY, Garnett SP, et al. Pediatric obesity treatment, self-esteem, and body image: A systematic review with meta-analysis. Pediatr Obes  2020; 15(3): e12600.
 [http://dx.doi.org/10.1111/ijpo.12600] [PMID:  32020780]

[138]
Slabá Š, Málková I, Wagenknecht M, et al. Psychological aspects of obesity. Cas Lek Cesk  2020; 159(3-4): 118-24.
 [PMID:  33297686]

[139]
Franklin J, Denyer G, Steinbeck KS, Caterson ID, Hill AJ. Obesity and risk of low self-esteem: A statewide survey of Australian children. Pediatrics  2006; 118(6): 2481-7.
 [http://dx.doi.org/10.1542/peds.2006-0511] [PMID:  17142534]

[140]
Erickson SJ, Robinson TN, Haydel KF, Killen JD. Are overweight children unhappy?: Body mass index, depressive symptoms, and overweight concerns in elementary school children. Arch Pediatr Adolesc Med  2000; 154(9): 931-5.
 [http://dx.doi.org/10.1001/archpedi.154.9.931] [PMID:  10980798]

[141]
Mustillo S, Worthman C, Erkanli A, Keeler G, Angold A, Costello EJ. Obesity and psychiatric disorder: Developmental trajectories. Pediatrics  2003; 111(4 Pt 1): 851-9.
 [http://dx.doi.org/10.1542/peds.111.4.851] [PMID:  12671123]

[142]
Richardson LP, Davis R, Poulton R, et al. A longitudinal evaluation of adolescent depression and adult obesity. Arch Pediatr Adolesc Med  2003; 157(8): 739-45.
 [http://dx.doi.org/10.1001/archpedi.157.8.739] [PMID:  12912778]

[143]
Robinson TN, Chang JY, Haydel KF, Killen JD. Overweight concerns and body dissatisfaction among third-grade children: The impacts of ethnicity and socioeconomic status. J Pediatr  2001; 138(2): 181-7.
 [http://dx.doi.org/10.1067/mpd.2001.110526] [PMID:  11174614]

[144]
Striegel-Moore RH. Body image concerns among children. J Pediatr  2001; 138(2): 158-60.
 [http://dx.doi.org/10.1067/mpd.2001.112901] [PMID:  11174609]

[145]
An R, Yan H, Shi X, Yang Y. Childhood obesity and school absenteeism: A systematic review and meta-analysis. Obes Rev  2017; 18(12): 1412-24.
 [http://dx.doi.org/10.1111/obr.12599] [PMID:  28925105]

[146]
Gill N, Gjelsvik A, Mercurio LY, Amanullah S. Childhood obesity is associated with poor academic skills and coping mechanisms. J Pediatr  2021; 228: 278-84.
 [http://dx.doi.org/10.1016/j.jpeds.2020.09.004] [PMID:  32896554]

[147]
Ma L, Gao L, Chiu DT, Ding Y, Wang Y, Wang W. Overweight and obesity impair academic performance in adolescence: A national cohort study of 10, 279 adolescents in China. Obesity (Silver Spring)  2020; 28(7): 1301-9.
 [http://dx.doi.org/10.1002/oby.22801] [PMID:  32447840]

[148]
Raine LB, Khan NA, Drollette ES, Pontifex MB, Kramer AF, Hillman CH. Obesity, visceral adipose tissue, and cognitive function in childhood. J Pediatr  2017; 187: 134-140.e3.
 [http://dx.doi.org/10.1016/j.jpeds.2017.05.023] [PMID:  28622956]

[149]
Santana CCA, Hill JO, Azevedo LB, Gunnarsdottir T, Prado WL. The association between obesity and academic performance in youth: A systematic review. Obes Rev  2017; 18(10): 1191-9.
 [http://dx.doi.org/10.1111/obr.12582] [PMID:  28742946]

[150]
Washington R. Negative association between obesity and academic performance-Physical fitness may help mediate the effects. J Pediatr  2018; 198: 2-3.
 [http://dx.doi.org/10.1016/j.jpeds.2018.04.064] [PMID:  29936959]

[151]
Kolotkin RL, Binks M, Crosby RD, Østbye T, Gress RE, Adams TD. Obesity and sexual quality of life. Obesity (Silver Spring)  2006; 14(3): 472-9.
 [http://dx.doi.org/10.1038/oby.2006.62] [PMID:  16648619]

[152]
van Vuuren CL, Wachter GG, Veenstra R, et al. Associations between overweight and mental health problems among adolescents, and the mediating role of victimization. BMC Public Health  2019; 19(1): 612.
 [http://dx.doi.org/10.1186/s12889-019-6832-z] [PMID:  31113424]

[153]
Freedman DS, Khan LK, Dietz WH, Srinivasan SR, Berenson GS. Relationship of childhood obesity to coronary heart disease risk factors in adulthood: The Bogalusa Heart Study. Pediatrics  2001; 108(3): 712-8.
 [http://dx.doi.org/10.1542/peds.108.3.712] [PMID:  11533341]

[154]
Hubert HB, Feinleib M, McNamara PM, Castelli WP. Obesity as an independent risk factor for cardiovascular disease: A 26-year follow-up of participants in the Framingham Heart Study. Circulation  1983; 67(5): 968-77.
 [http://dx.doi.org/10.1161/01.CIR.67.5.968] [PMID:  6219830]

[155]
Freedman DS, Mei Z, Srinivasan SR, Berenson GS, Dietz WH. Cardiovascular risk factors and excess adiposity among overweight children and adolescents: The Bogalusa Heart Study. J Pediatr  2007; 150(1): 12-17.e2.
 [http://dx.doi.org/10.1016/j.jpeds.2006.08.042] [PMID:  17188605]

[156]
Elmaoğulları S, Tepe D, Uçaktürk SA, Karaca Kara F, Demirel F. Prevalence of dyslipidemia and associated factors in obese children and adolescents. J Clin Res Pediatr Endocrinol  2015; 7(3): 228-34.
 [http://dx.doi.org/10.4274/jcrpe.1867] [PMID:  26831558]

[157]
Radaelli G, Sausen G, Cesa CC, Portal VL, Pellanda LC. Secondary dyslipidemia in obese children - Is there evidence for pharmacological treatment? Arq Bras Cardiol  2018; 111(3): 356-61.
 [http://dx.doi.org/10.5935/abc.20180155] [PMID:  30156604]

[158]
Boyd GS, Koenigsberg J, Falkner B, Gidding S, Hassink S. Effect of obesity and high blood pressure on plasma lipid levels in children and adolescents. Pediatrics  2005; 116(2): 442-6.
 [http://dx.doi.org/10.1542/peds.2004-1877] [PMID:  16061601]

[159]
Klish WJ, Skelton JA. Overview of the health consequences of obesity in children and adolescents UpToDate. Netherlands: Wolters Kluwer 2022.

[160]
Srinivasan SR, Myers L, Berenson GS. Distribution and correlates of non-high-density lipoprotein cholesterol in children: The Bogalusa Heart Study. Pediatrics  2002; 110(3): e29.
 [http://dx.doi.org/10.1542/peds.110.3.e29] [PMID:  12205279]

[161]
Steinberger J, Moran A, Hong CP, Jacobs DR Jr, Sinaiko AR. Adiposity in childhood predicts obesity and insulin resistance in young adulthood. J Pediatr  2001; 138(4): 469-73.
 [http://dx.doi.org/10.1067/mpd.2001.112658] [PMID:  11295707]

[162]
Thompson DR, Obarzanek E, Franko DL, et al. Childhood overweight and cardiovascular disease risk factors: The National Heart, Lung, and Blood Institute Growth and Health Study. J Pediatr  2007; 150(1): 18-25.
 [http://dx.doi.org/10.1016/j.jpeds.2006.09.039] [PMID:  17188606]

[163]
Berenson GS, Srinivasan SR, Bao W, Newman WP III, Tracy RE, Wattigney WA. Association between multiple cardiovascular risk factors and atherosclerosis in children and young adults. The Bogalusa Heart Study. N Engl J Med  1998; 338(23): 1650-6.
 [http://dx.doi.org/10.1056/NEJM199806043382302] [PMID:  9614255]

[164]
Berenson GS. Childhood risk factors predict adult risk associated with subclinical cardiovascular disease. The Bogalusa Heart Study. Am J Cardiol  2002; 90(10C): 3L-7L.
 [http://dx.doi.org/10.1016/S0002-9149(02)02953-3] [PMID:  12459418]

[165]
Newman WP III, Freedman DS, Voors AW, et al. Relation of serum lipoprotein levels and systolic blood pressure to early atherosclerosis. The Bogalusa Heart Study. N Engl J Med  1986; 314(3): 138-44.
 [http://dx.doi.org/10.1056/NEJM198601163140302] [PMID:  3455748]

[166]
Ayer J, Charakida M, Deanfield JE, Celermajer DS. Lifetime risk: Childhood obesity and cardiovascular risk. Eur Heart J  2015; 36(22): 1371-6.
 [http://dx.doi.org/10.1093/eurheartj/ehv089] [PMID:  25810456]

[167]
Barton M. Childhood obesity: A life-long health risk. Acta Pharmacol Sin  2012; 33(2): 189-93.
 [http://dx.doi.org/10.1038/aps.2011.204] [PMID:  22301858]

[168]
Li S, Chen W, Srinivasan SR, et al. Childhood cardiovascular risk factors and carotid vascular changes in adulthood: The Bogalusa Heart Study. JAMA  2003; 290(17): 2271-6.
 [http://dx.doi.org/10.1001/jama.290.17.2271] [PMID:  14600185]

[169]
McCrindle BW. Cardiovascular consequences of paediatric obesity: Will there be a future epidemic of premature cardiovascular disease? Paediatr Child Health  2007; 12(3): 175-7.
 [PMID:  19030355]

[170]
Saner C, Simonetti GD, Wühl E, Mullis PE, Janner M. Increased ambulatory arterial stiffness index in obese children. Atherosclerosis  2015; 238(2): 185-9.
 [http://dx.doi.org/10.1016/j.atherosclerosis.2014.12.009] [PMID:  25528426]

[171]
McCrindle BW. Cardiovascular consequences of childhood obesity. Can J Cardiol  2015; 31(2): 124-30.
 [http://dx.doi.org/10.1016/j.cjca.2014.08.017] [PMID:  25661547]

[172]
Badeli H, Hassankhani A, Naeemi Z, et al. Prevalence of hypertension and obesity-related hypertension in urban school-aged children in Rasht. Iran J. Iran J Kidney Dis  2016; 10(6): 364-8.
 [PMID:  27903995]

[173]
Chang CJ, Jian DY, Lin MW, Zhao JZ, Ho LT, Juan CC. Evidence in obese children: Contribution of hyperlipidemia, obesity-inflammation, and insulin sensitivity. PLoS One  2015; 10(5): e0125935.
 [http://dx.doi.org/10.1371/journal.pone.0125935] [PMID:  26011530]

[174]
Falkner B, Gidding SS, Ramirez-Garnica G, Wiltrout SA, West D, Rappaport EB. The relationship of body mass index and blood pressure in primary care pediatric patients. J Pediatr  2006; 148(2): 195-200.
 [http://dx.doi.org/10.1016/j.jpeds.2005.10.030] [PMID:  16492428]

[175]
Sorof JM, Lai D, Turner J, Poffenbarger T, Portman RJ. Overweight, ethnicity, and the prevalence of hypertension in school-aged children. Pediatrics  2004; 113(3 Pt 1): 475-82.
 [http://dx.doi.org/10.1542/peds.113.3.475] [PMID:  14993537]

[176]
Robson WL, Leung AK. Hypertension in young patients. Postgrad Med  1991; 90(3): 191-200.
 [http://dx.doi.org/10.1080/00325481.1991.11701045] [PMID:  1881854]

[177]
Rosaneli CF, Baena CP, Auler F, et al. Elevated blood pressure and obesity in childhood: A cross-sectional evaluation of 4, 609 schoolchildren. Arq Bras Cardiol  2014; 103(3): 238-44.
 [http://dx.doi.org/10.5935/abc.20140104] [PMID:  25076178]

[178]
Wühl E. Hypertension in childhood obesity. Acta Paediatr  2019; 108(1): 37-43.
 [http://dx.doi.org/10.1111/apa.14551] [PMID:  30144170]

[179]
Kinlen D, Cody D, O’Shea D. Complications of obesity. QJM  2018; 111(7): 437-43.
 [http://dx.doi.org/10.1093/qjmed/hcx152] [PMID:  29025162]

[180]
Atabek ME, Vatansev H, Erkul I. Oxidative stress in childhood obesity. J Pediatr Endocrinol Metab  2004; 17(8): 1063-8.
 [http://dx.doi.org/10.1515/JPEM.2004.17.8.1063] [PMID:  15379416]

[181]
Bauersachs J, Fleming I, Fraccarollo D, Busse R, Ertl G. Prevention of endothelial dysfunction in heart failure by vitamin E: Attenuation of vascular superoxide anion formation and increase in soluble guanylyl cyclase expression. Cardiovasc Res  2001; 51(2): 344-50.
 [http://dx.doi.org/10.1016/S0008-6363(01)00319-4] [PMID:  11470474]

[182]
Doshi SN, McDowell IF, Moat SJ, et al. Folate improves endothelial function in coronary artery disease: An effect mediated by reduction of intracellular superoxide? Arterioscler Thromb Vasc Biol  2001; 21(7): 1196-202.
 [http://dx.doi.org/10.1161/hq0701.092000] [PMID:  11451751]

[183]
Chinali M, de Simone G, Roman MJ, et al. Impact of obesity on cardiac geometry and function in a population of adolescents: The Strong Heart Study. J Am Coll Cardiol  2006; 47(11): 2267-73.
 [http://dx.doi.org/10.1016/j.jacc.2006.03.004] [PMID:  16750694]

[184]
Üner A. Doğan M, Epcacan Z, Epçaçan S. The effect of childhood obesity on cardiac functions. J Pediatr Endocrinol Metab  2014; 27(3-4): 261-71.
 [http://dx.doi.org/10.1515/jpem-2013-0157] [PMID:  24150205]

[185]
Zhang Y, Zhao M, Bovet P, Xi B. Association of abdominal obesity and high blood pressure with left ventricular hypertrophy and geometric remodeling in Chinese children. Nutr Metab Cardiovasc Dis  2021; 31(1): 306-13.
 [http://dx.doi.org/10.1016/j.numecd.2020.09.007] [PMID:  33500107]

[186]
Pulgaron ER, Delamater AM. Obesity and type 2 diabetes in children: Epidemiology and treatment. Curr Diab Rep  2014; 14(8): 508.
 [http://dx.doi.org/10.1007/s11892-014-0508-y] [PMID:  24919749]

[187]
Tagi VM, Chiarelli F. Obesity and insulin resistance in children. Curr Opin Pediatr  2020; 32(4): 582-8.
 [http://dx.doi.org/10.1097/MOP.0000000000000913] [PMID:  32520824]

[188]
Twig G, Zucker I, Afek A, et al. Adolescent obesity and early-onset type 2 diabetes. Diabetes Care  2020; 43(7): 1487-95.
 [http://dx.doi.org/10.2337/dc19-1988] [PMID:  32321731]

[189]
Weihrauch-Blüher S, Kromeyer-Hauschild K, Graf C, et al. Current guidelines for obesity prevention in childhood and adolescence. Obes Facts  2018; 11(3): 263-76.
 [http://dx.doi.org/10.1159/000486512] [PMID:  29969778]

[190]
Hannon TS, Rao G, Arslanian SA. Childhood obesity and type 2 diabetes mellitus. Pediatrics  2005; 116(2): 473-80.
 [http://dx.doi.org/10.1542/peds.2004-2536] [PMID:  16061606]

[191]
Weiss AL, Mooney A, Gonzalvo JP. Bariatric surgery: The future of obesity management in adolescents. Adv Pediatr  2017; 64(1): 269-83.
 [http://dx.doi.org/10.1016/j.yapd.2017.03.005] [PMID:  28688592]

[192]
Boden G, Shulman GI. Free fatty acids in obesity and type 2 diabetes: Defining their role in the development of insulin resistance and beta-cell dysfunction. Eur J Clin Invest  2002; 32 (Suppl. 3): 14-23.
 [http://dx.doi.org/10.1046/j.1365-2362.32.s3.3.x] [PMID:  12028371]

[193]
Kashyap S, Belfort R, Gastaldelli A, et al. A sustained increase in plasma free fatty acids impairs insulin secretion in nondiabetic subjects genetically predisposed to develop type 2 diabetes. Diabetes  2003; 52(10): 2461-74.
 [http://dx.doi.org/10.2337/diabetes.52.10.2461] [PMID:  14514628]

[194]
Silverstein JH, Rosenbloom AL. Type 2 diabetes in children. Curr Diab Rep  2001; 1(1): 19-27.
 [http://dx.doi.org/10.1007/s11892-001-0006-x] [PMID:  12762953]

[195]
Edelstein SL, Knowler WC, Bain RP, et al. Predictors of progression from impaired glucose tolerance to NIDDM: An analysis of six prospective studies. Diabetes  1997; 46(4): 701-10.
 [http://dx.doi.org/10.2337/diab.46.4.701] [PMID:  9075814]

[196]
Weiss R, Taksali SE, Tamborlane WV, Burgert TS, Savoye M, Caprio S. Predictors of changes in glucose tolerance status in obese youth. Diabetes Care  2005; 28(4): 902-9.
 [http://dx.doi.org/10.2337/diacare.28.4.902] [PMID:  15793193]

[197]
Nevin MA. Pediatric obesity, metabolic syndrome, and obstructive sleep apnea syndrome. Pediatr Ann  2013; 42(10): 205-10.
 [http://dx.doi.org/10.3928/00904481-20130924-11] [PMID:  24126983]

[198]
Owens S, Galloway R. Childhood obesity and the metabolic syndrome. Curr Atheroscler Rep  2014; 16(9): 436.
 [http://dx.doi.org/10.1007/s11883-014-0436-y] [PMID:  25037582]

[199]
Ortega-González C, Luna S, Hernández L, et al. Responses of serum androgen and insulin resistance to metformin and pioglitazone in obese, insulin-resistant women with polycystic ovary syndrome. J Clin Endocrinol Metab  2005; 90(3): 1360-5.
 [http://dx.doi.org/10.1210/jc.2004-1965] [PMID:  15598674]

[200]
Dunaif A. Insulin resistance and the polycystic ovary syndrome: Mechanism and implications for pathogenesis. Endocr Rev  1997; 18(6): 774-800.
 [PMID:  9408743]

[201]
Bideci A, Cinaz P, Hasanoglu A, Elbeg S. Serum levels of insulin-like growth factor-I and insulin-like growth factor binding protein-3 in obese children. J Pediatr Endocrinol Metab  1997; 10(3): 295-9.
 [http://dx.doi.org/10.1515/JPEM.1997.10.3.295] [PMID:  9388822]

[202]
Leung AK, Robson WL. Premature adrenarche. J Pediatr Health Care  2008; 22(4): 230-3.
 [http://dx.doi.org/10.1016/j.pedhc.2007.07.002] [PMID:  18590867]

[203]
Witchel SF, Smith R, Tomboc M, Aston CE. Candidate gene analysis in premature pubarche and adolescent hyperandrogenism. Fertil Steril  2001; 75(4): 724-30.
 [http://dx.doi.org/10.1016/S0015-0282(00)01798-2] [PMID:  11287026]

[204]
Chiumello G, Brambilla P, Guarneri MP, Russo G, Manzoni P, Sgaramella P. Precocious puberty and body composition: Effects of GnRH analog treatment. J Pediatr Endocrinol Metab  2000; 13 (Suppl. 1): 791-4.
 [http://dx.doi.org/10.1515/JPEM.2000.13.S1.791] [PMID:  10969923]

[205]
Dimartino-Nardi J. Premature adrenarche: Findings in prepubertal African-American and Caribbean-Hispanic girls. Acta Paediatr Suppl  1999; 88(433): 67-72.
 [http://dx.doi.org/10.1111/j.1651-2227.1999.tb14406.x] [PMID:  10626548]

[206]
Leung AK. Gynecomastia. Am Fam Physician  1989; 39(4): 215-22.
 [PMID:  2650505]

[207]
Marcovecchio ML, Chiarelli F. Obesity and growth during childhood and puberty. World Rev Nutr Diet  2013; 106: 135-41.
 [http://dx.doi.org/10.1159/000342545] [PMID:  23428692]

[208]
Dayal D, Kumar TS. High prevalence of thyroid dysfunction in children with simple obesity. Indian Pediatr  2019; 56(4): 331.
 [http://dx.doi.org/10.1007/s13312-019-1527-1] [PMID:  31064907]

[209]
Atamna A, Elis A, Gilady E, Gitter-Azulay L, Bishara J. How obesity impacts outcomes of infectious diseases. Eur J Clin Microbiol Infect Dis  2017; 36(3): 585-91.
 [http://dx.doi.org/10.1007/s10096-016-2835-1] [PMID:  27864622]

[210]
Dixon AE, Peters U. The effect of obesity on lung function. Expert Rev Respir Med  2018; 12(9): 755-67.
 [http://dx.doi.org/10.1080/17476348.2018.1506331] [PMID:  30056777]

[211]
Tracey VV, De NC, Harper JR. Obesity and respiratory infection in infants and young children. BMJ  1971; 1(5739): 16-8.
 [http://dx.doi.org/10.1136/bmj.1.5739.16] [PMID:  5539136]

[212]
Kassim R, Harris MA, Leong GM, Heussler H. Obstructive sleep apnoea in children with obesity. J Paediatr Child Health  2016; 52(3): 284-90.
 [http://dx.doi.org/10.1111/jpc.13009] [PMID:  26748912]

[213]
Leung AK, Robson WL. The ABZzzzs of snoring. Postgrad Med  1992; 92(3): 217-22.
 [http://dx.doi.org/10.1080/00325481.1992.11701451] [PMID:  1518755]

[214]
Wing YK, Hui SH, Pak WM, et al. A controlled study of sleep related disordered breathing in obese children. Arch Dis Child  2003; 88(12): 1043-7.
 [http://dx.doi.org/10.1136/adc.88.12.1043] [PMID:  14670764]

[215]
Xanthopoulos M, Tapia IE. Obesity and common respiratory diseases in children. Paediatr Respir Rev  2017; 23: 68-71.
 [PMID:  27838161]

[216]
Katz SL, Pillar G. Obstructive sleep apnea, obesity, and endothelial dysfunction in children. Am J Respir Crit Care Med  2016; 194(9): 1046-7.
 [http://dx.doi.org/10.1164/rccm.201605-0911ED] [PMID:  27797619]

[217]
Li AM, Chan MH, Chan DF, et al. Insulin and obstructive sleep apnea in obese Chinese children. Pediatr Pulmonol  2006; 41(12): 1175-81.
 [http://dx.doi.org/10.1002/ppul.20508] [PMID:  17034061]

[218]
Lang JE, Bunnell HT, Hossain MJ, et al. Being overweight or obese and the development of asthma. Pediatrics  2018; 142(6): e20182119.
 [http://dx.doi.org/10.1542/peds.2018-2119] [PMID:  30478238]

[219]
Pulgarón ER. Childhood obesity: A review of increased risk for physical and psychological comorbidities. Clin Ther  2013; 35(1): A18-32.
 [http://dx.doi.org/10.1016/j.clinthera.2012.12.014] [PMID:  23328273]

[220]
de Almeida AHS, Filho EAR, Costa EL, et al. Obesity is a risk factor for exercise-induced bronchospasm in asthmatic adolescents. Pediatr Pulmonol  2020; 55(8): 1916-23.
 [http://dx.doi.org/10.1002/ppul.24875] [PMID:  32462822]

[221]
Permaul P, Kanchongkittiphon W, Phipatanakul W. Childhood asthma and obesity--what is the true link? Ann Allergy Asthma Immunol  2014; 113(3): 244-6.
 [http://dx.doi.org/10.1016/j.anai.2014.07.001] [PMID:  25091715]

[222]
Raj D, Kabra SK, Lodha R. Childhood obesity and risk of allergy or asthma. Immunol Allergy Clin North Am  2014; 34(4): 753-65.
 [http://dx.doi.org/10.1016/j.iac.2014.07.001] [PMID:  25282288]

[223]
Jiménez SJ, Espinet FJH, Garrido JMM, et al. Asthma and insulin resistance in obese children and adolescents. Pediatr Allergy Immunol  2014; 25(7): 699-705.
 [http://dx.doi.org/10.1111/pai.12294] [PMID:  25348132]

[224]
Vijayakanthi N, Greally JM, Rastogi D. Pediatric obesity-related asthma: The role of metabolic dysregulation. Pediatrics  2016; 137(5): e20150812.
 [http://dx.doi.org/10.1542/peds.2015-0812] [PMID:  27244776]

[225]
Jesus JPV, Lima-Matos AS, Almeida PCA, et al. Obesity and asthma: Clinical and laboratory characterization of a common combination. J Bras Pneumol  2018; 44(3): 207-12.
 [http://dx.doi.org/10.1590/s1806-37562017000000034] [PMID:  30043887]

[226]
de Sá Pinto AL, de Barros Holanda PM, Radu AS, Villares SM, Lima FR. Musculoskeletal findings in obese children. J Paediatr Child Health  2006; 42(6): 341-4.
 [http://dx.doi.org/10.1111/j.1440-1754.2006.00869.x] [PMID:  16737474]

[227]
Perry DC, Metcalfe D, Lane S, Turner S. Childhood obesity and slipped capital femoral epiphysis. Pediatrics  2018; 142(5): e20181067.
 [http://dx.doi.org/10.1542/peds.2018-1067] [PMID:  30348751]

[228]
Cheng J, East P, Blanco E, et al. Obesity leads to declines in motor skills across childhood. Child Care Health Dev  2016; 42(3): 343-50.
 [http://dx.doi.org/10.1111/cch.12336] [PMID:  27059409]

[229]
Baran RT, Atar M, Pirgon Ö, Filiz S, Filiz M. Restless legs syndrome and poor sleep quality in obese children and adolescents. J Clin Res Pediatr Endocrinol  2018; 10(2): 131-8.
 [http://dx.doi.org/10.4274/jcrpe.5165] [PMID:  29175807]

[230]
Witt CE, Arbabi S, Nathens AB, Vavilala MS, Rivara FP. Obesity in pediatric trauma. J Pediatr Surg  2017; 52(4): 628-32.
 [http://dx.doi.org/10.1016/j.jpedsurg.2016.11.037] [PMID:  27914588]

[231]
Kim JE, Hsieh MH, Soni BK, Zayzafoon M, Allison DB. Childhood obesity as a risk factor for bone fracture: A mechanistic study. Obesity (Silver Spring)  2013; 21(7): 1459-66.
 [http://dx.doi.org/10.1002/oby.20355] [PMID:  23512354]

[232]
Andrews LE, Liu GT, Ko MW. Idiopathic intracranial hypertension and obesity. Horm Res Paediatr  2014; 81(4): 217-25.
 [http://dx.doi.org/10.1159/000357730] [PMID:  24642712]

[233]
Cuzmar V, Alberti G, Uauy R, et al. Early obesity: Risk factor for fatty liver disease. J Pediatr Gastroenterol Nutr  2020; 70(1): 93-8.
 [http://dx.doi.org/10.1097/MPG.0000000000002523] [PMID:  31880680]

[234]
Schwimmer JB, McGreal N, Deutsch R, Finegold MJ, Lavine JE. Influence of gender, race, and ethnicity on suspected fatty liver in obese adolescents. Pediatrics  2005; 115(5): e561-5.
 [http://dx.doi.org/10.1542/peds.2004-1832] [PMID:  15867021]

[235]
Schwimmer JB, Deutsch R, Rauch JB, Behling C, Newbury R, Lavine JE. Obesity, insulin resistance, and other clinicopathological correlates of pediatric nonalcoholic fatty liver disease. J Pediatr  2003; 143(4): 500-5.
 [http://dx.doi.org/10.1067/S0022-3476(03)00325-1] [PMID:  14571229]

[236]
Sokol RJ. The chronic disease of childhood obesity: The sleeping giant has awakened. J Pediatr  2000; 136(6): 711-3.
 [http://dx.doi.org/10.1067/mpd.2000.107787]

[237]
Kaechele V, Wabitsch M, Thiere D, et al. Prevalence of gallbladder stone disease in obese children and adolescents: Influence of the degree of obesity, sex, and pubertal development. J Pediatr Gastroenterol Nutr  2006; 42(1): 66-70.
 [http://dx.doi.org/10.1097/01.mpg.0000187816.31213.06] [PMID:  16385256]

[238]
Koebnick C, Smith N, Black MH, et al. Pediatric obesity and gallstone disease. J Pediatr Gastroenterol Nutr  2012; 55(3): 328-33.
 [http://dx.doi.org/10.1097/MPG.0b013e31824d256f] [PMID:  22314396]

[239]
Kwak BO, Lee MJ, Park HW, Kim KS, Chung S. A case of recurrent acute pancreatitis in an obese child. Nutrition  2014; 30(10): 1213-6.
 [http://dx.doi.org/10.1016/j.nut.2014.04.002] [PMID:  25194617]

[240]
Thavamani A, Umapathi KK, Roy A, Krishna SG. The increasing prevalence and adverse impact of morbid obesity in paediatric acute pancreatitis. Pediatr Obes  2020; 15(8): e12643.
 [http://dx.doi.org/10.1111/ijpo.12643] [PMID:  32406194]

[241]
Everhart JE. Contributions of obesity and weight loss to gallstone disease. Ann Intern Med  1993; 119(10): 1029-35.
 [http://dx.doi.org/10.7326/0003-4819-119-10-199311150-00010] [PMID:  8214980]

[242]
Poddighe D, Sazonov V. Acute acalculous cholecystitis in children. World J Gastroenterol  2018; 24(43): 4870-9.
 [http://dx.doi.org/10.3748/wjg.v24.i43.4870] [PMID:  30487697]

[243]
Leung AK, Hon KL. Gastroesophageal reflux in children: An updated review. Drugs Context  2019; 8: 212591.
 [http://dx.doi.org/10.7573/dic.212591] [PMID:  31258618]

[244]
Phatak UP, Pashankar DS. Obesity and gastrointestinal disorders in children. J Pediatr Gastroenterol Nutr  2015; 60(4): 441-5.
 [http://dx.doi.org/10.1097/MPG.0000000000000670] [PMID:  25493349]

[245]
Fishman L, Lenders C, Fortunato C, Noonan C, Nurko S. Increased prevalence of constipation and fecal soiling in a population of obese children. J Pediatr  2004; 145(2): 253-4.
 [http://dx.doi.org/10.1016/j.jpeds.2004.04.022] [PMID:  15289779]

[246]
Leung AK, Chan PY, Cho HY. Constipation in children. Am Fam Physician  1996; 54(2): 611-8.

[247]
Leung AK, Hon KL. Paediatrics: How to manage functional constipation. Drugs Context  2021; 10: 2021-11-2.
 [PMID:  33828605]

[248]
Sims MA, Hasler WL, Chey WD, Kim MS, Owyang C. Hyperglycemia inhibits mechanoreceptor-mediated gastrocolonic responses and colonic peristaltic reflexes in healthy humans. Gastroenterology  1995; 108(2): 350-9.
 [http://dx.doi.org/10.1016/0016-5085(95)90060-8] [PMID:  7835576]

[249]
van der Sijp JR, Kamm MA, Nightingale JM, et al. Circulating gastrointestinal hormone abnormalities in patients with severe idiopathic constipation. Am J Gastroenterol  1998; 93(8): 1351-6.
 [http://dx.doi.org/10.1111/j.1572-0241.1998.00345.x] [PMID:  9707064]

[250]
Dong Y, Berens S, Eich W, Schaefert R, Tesarz J. Is body mass index associated with symptom severity and health-related quality of life in irritable bowel syndrome? A cross-sectional study. BMJ Open  2018; 8(10): e019453.
 [http://dx.doi.org/10.1136/bmjopen-2017-019453] [PMID:  30337304]

[251]
Więch P, Chmiel Z, Bazaliński D, et al. The relationship between body composition and a gluten free diet in children with celiac disease. Nutrients  2018; 10(11): 1817.
 [http://dx.doi.org/10.3390/nu10111817] [PMID: 30469383]

[252]
Ahmed S, Arjmand E, Sidell D. Role of obesity in otitis media in children. Curr Allergy Asthma Rep  2014; 14(11): 469.
 [http://dx.doi.org/10.1007/s11882-014-0469-x] [PMID:  25183362]

[253]
Leung AKC, Wong AHC. Acute otitis media in children. Recent Pat Inflamm Allergy Drug Discov  2017; 11(1): 32-40.
 [http://dx.doi.org/10.2174/1874609810666170712145332] [PMID:  28707578]

[254]
Fan W, Chen XF, Shen C, Guo ZR, Dong C. Hepatitis B vaccine response in obesity: A meta-analysis. Vaccine  2016; 34(40): 4835-41.
 [http://dx.doi.org/10.1016/j.vaccine.2016.08.027] [PMID:  27546877]

[255]
Green WD, Beck MA. Obesity impairs the adaptive immune response to influenza virus. Ann Am Thorac Soc  2017; 14 (Suppl. 5): S406-9.
 [http://dx.doi.org/10.1513/AnnalsATS.201706-447AW] [PMID:  29161078]

[256]
Neidich SD, Green WD, Rebeles J, et al. Increased risk of influenza among vaccinated adults who are obese. Int J Obes  2017; 41(9): 1324-30.
 [http://dx.doi.org/10.1038/ijo.2017.131] [PMID:  28584297]

[257]
Gutmark-Little I, Shah KN. Obesity and the metabolic syndrome in pediatric psoriasis. Clin Dermatol  2015; 33(3): 305-15.
 [http://dx.doi.org/10.1016/j.clindermatol.2014.12.006] [PMID:  25889131]

[258]
Leung AK. Obesity and nevocellular nevi. Br J Clin Pract  1988; 42(4): 172-3.
 [PMID:  3207585]

[259]
Lopez-Alvarenga JC, Chittoor G, Paul SFD, et al. Acanthosis nigricans as a composite marker of cardiometabolic risk and its complex association with obesity and insulin resistance in Mexican American children. PLoS One  2020; 15(10): e0240467.
 [http://dx.doi.org/10.1371/journal.pone.0240467] [PMID:  33057385]

[260]
Mirmirani P, Carpenter DM. Skin disorders associated with obesity in children and adolescents: A population-based study. Pediatr Dermatol  2014; 31(2): 183-90.
 [http://dx.doi.org/10.1111/pde.12271] [PMID:  24329996]

[261]
Ng HY, Young JH, Huen KF, Chan LT. Acanthosis nigricans in obese Chinese children. Hong Kong Med J  2014; 20(4): 290-6.
 [PMID:  24762331]

[262]
Salama RH, Al-Shobaili HA, Al Robaee AA, Alzolibani AA. Psoriasin: A novel marker linked obesity with psoriasis. Dis Markers  2013; 34(1): 33-9.
 [http://dx.doi.org/10.1155/2013/659864] [PMID:  23151615]

[263]
Leung AK, Chan KW. Iron deficiency anemia. Adv Pediatr  2001; 48: 385-408.
 [PMID:  11480764]

[264]
Nead KG, Halterman JS, Kaczorowski JM, Auinger P, Weitzman M. Overweight children and adolescents: A risk group for iron deficiency. Pediatrics  2004; 114(1): 104-8.
 [http://dx.doi.org/10.1542/peds.114.1.104] [PMID:  15231915]

[265]
Pinhas-Hamiel O, Newfield RS, Koren I, Agmon A, Lilos P, Phillip M. Greater prevalence of iron deficiency in overweight and obese children and adolescents. Int J Obes Relat Metab Disord  2003; 27(3): 416-8.
 [http://dx.doi.org/10.1038/sj.ijo.0802224] [PMID:  12629572]

[266]
Sal E, Yenicesu I, Celik N, et al. Relationship between obesity and iron deficiency anemia: Is there a role of hepcidin? Hematology  2018; 23(8): 542-8.
 [http://dx.doi.org/10.1080/10245332.2018.1423671] [PMID:  29318945]

[267]
Siyaram D, Bhatia P, Dayal D, Bhalla AK, Marathe R. Hypoferremic state in overweight and obese children. Indian Pediatr  2018; 55(1): 72-3.
 [PMID:  29396942]

[268]
Zhao L, Zhang X, Shen Y, Fang X, Wang Y, Wang F. Obesity and iron deficiency: A quantitative meta-analysis. Obes Rev  2015; 16(12): 1081-93.
 [http://dx.doi.org/10.1111/obr.12323] [PMID:  26395622]

[269]
Cepeda-Lopez AC, Baye K. Obesity, iron deficiency and anaemia: A complex relationship. Public Health Nutr  2020; 23(10): 1703-4.
 [http://dx.doi.org/10.1017/S1368980019004981] [PMID:  32345389]

[270]
Yıldırım Ö, Demircan T, Tüfekçi Ö, et al. Anemia and its effect on cardiovascular findings in obese adolescents. Turk J Haematol  2018; 35(3): 192-6.
 [PMID: 29666035]

[271]
Frischmuth T, Hindberg K, Gabrielsen ME, Brumpton BM, Hveem K, Brækkan SK, et al. Joint effect of multiple prothrombotic genotypes and obesity on the risk of incident venous thromboembolism. Thromb Haemost 2021. [Online ahead of print].
 [http://dx.doi.org/10.1055/a-1497-9777] [PMID:  33940655]

[272]
Halvorson EE, Ervin SE, Russell TB, Skelton JA, Davis S, Spangler J. Association of obesity and pediatric venous thromboembolism. Hosp Pediatr  2016; 6(1): 22-6.
 [http://dx.doi.org/10.1542/hpeds.2015-0039] [PMID:  26675300]

[273]
Correia-Costa L, Azevedo A, Caldas Afonso A. Childhood obesity and impact on the kidney. Nephron  2019; 143(1): 8-11.
 [http://dx.doi.org/10.1159/000492826] [PMID:  30359981]

[274]
Franchini S, Savino A, Marcovecchio ML, Tumini S, Chiarelli F, Mohn A. The effect of obesity and type 1 diabetes on renal function in children and adolescents. Pediatr Diabetes  2015; 16(6): 427-33.
 [http://dx.doi.org/10.1111/pedi.12196] [PMID:  25131409]

[275]
Koch VH. The effects of obesity on kidney function: A challenge for nephrologists. J Bras Nefrol  2019; 41(2): 162-5.
 [http://dx.doi.org/10.1590/2175-8239-jbn-2019-0064] [PMID:  31173042]

[276]
Nehus E. Obesity and chronic kidney disease. Curr Opin Pediatr  2018; 30(2): 241-6.
 [http://dx.doi.org/10.1097/MOP.0000000000000586] [PMID:  29346138]

[277]
Wang Y, Chen X, Klag MJ, Caballero B. Epidemic of childhood obesity: Implications for kidney disease. Adv Chronic Kidney Dis  2006; 13(4): 336-51.
 [http://dx.doi.org/10.1053/j.ackd.2006.07.016] [PMID:  17045220]

[278]
Adelman RD, Restaino IG, Alon US, Blowey DL. Proteinuria and focal segmental glomerulosclerosis in severely obese adolescents. J Pediatr  2001; 138(4): 481-5.
 [http://dx.doi.org/10.1067/mpd.2001.113006] [PMID:  11295709]

[279]
Faustinella F, Uzoh C, Sheikh-Hamad D, Truong LD, Olivero JJ. Glomerulomegaly and proteinuria in a patient with idiopathic pulmonary hypertension. J Am Soc Nephrol  1997; 8(12): 1966-70.
 [http://dx.doi.org/10.1681/ASN.V8121966] [PMID:  9402101]

[280]
Praga M, Morales E, Herrero JC, et al. Absence of hypoalbuminemia despite massive proteinuria in focal segmental glomerulosclerosis secondary to hyperfiltration. Am J Kidney Dis  1999; 33(1): 52-8.
 [http://dx.doi.org/10.1016/S0272-6386(99)70257-X] [PMID:  9915267]

[281]
Shimomura Y, Murakami M, Shimizu H, et al. Improvement of nephrotic syndrome in a massively obese patient after weight loss and treatment with an anti-allergic drug. J Med  1990; 21(6): 337-47.
 [PMID:  2093099]

[282]
Weisinger JR, Kempson RL, Eldridge FL, Swenson RS. The nephrotic syndrome: A complication of massive obesity. Ann Intern Med  1974; 81(4): 440-7.
 [http://dx.doi.org/10.7326/0003-4819-81-4-440] [PMID:  4416380]

[283]
Welch TR, Daniels SR. Yet another target organ of obesity. J Pediatr  2001; 138(4): 455-6.
 [http://dx.doi.org/10.1067/mpd.2001.114028] [PMID:  11295703]

[284]
Tikkinen KA, Auvinen A, Huhtala H, Tammela TL. Nocturia and obesity: A population-based study in Finland. Am J Epidemiol  2006; 163(11): 1003-11.
 [http://dx.doi.org/10.1093/aje/kwj139] [PMID:  16597705]

[285]
Ma Y, Shen Y, Liu X. Association between enuresis and obesity in children with primary monosymptomatic nocturnal enuresis. Int Braz J Urol  2019; 45(4): 790-7.
 [http://dx.doi.org/10.1590/s1677-5538.ibju.2018.0603] [PMID:  31184451]

[286]
Robson WL, Leung AK. Secondary nocturnal enuresis. Clin Pediatr (Phila)  2000; 39(7): 379-85.
 [http://dx.doi.org/10.1177/000992280003900701] [PMID:  10914301]

[287]
Robson WL, Leung AK, Van Howe R. Primary and secondary nocturnal enuresis: Similarities in presentation. Pediatrics  2005; 115(4): 956-9.
 [http://dx.doi.org/10.1542/peds.2004-1402] [PMID:  15805370]

[288]
Zhang A, Li S, Zhang Y, Jiang F, Jin X, Ma J. Nocturnal enuresis in obese children: A nation-wide epidemiological study from China. Sci Rep  2019; 9(1): 8414.
 [http://dx.doi.org/10.1038/s41598-019-44532-5] [PMID:  31182742]

[289]
Grier WR, Kratimenos P, Singh S, Guaghan JP, Koutroulis I. Obesity as a risk factor for urinary tract infection in children. Clin Pediatr (Phila)  2016; 55(10): 952-6.
 [http://dx.doi.org/10.1177/0009922815617974] [PMID:  26810625]

[290]
Hsu PC, Chen SJ. Obesity and risk of urinary tract infection in young children presenting with fever. Medicine (Baltimore)  2018; 97(49): e13006.
 [http://dx.doi.org/10.1097/MD.0000000000013006] [PMID:  30544371]

[291]
Leung AK, Robson WL. Urinary tract infection in infancy and childhood. Adv Pediatr  1991; 38: 257-85.
 [PMID:  1927703]

[292]
Leung AKC, Wong AHC, Leung AAM, Hon KL. Urinary tract infection in children. Recent Pat Inflamm Allergy Drug Discov  2019; 13(1): 2-18.
 [http://dx.doi.org/10.2174/1872213X13666181228154940] [PMID:  30592257]

[293]
Mahyar A, Ayazi P, Gholmohammadi P, Moshiri SA, Oveisi S, Esmaeily S. The role of overweight and obesity in urinary tract infection in children. Infez Med  2016; 24(1): 38-42.
 [PMID:  27031895]

[294]
Colak R, Anil M, Yasar F, et al. Metabolic disturbances and cardiovascular risk factors in obese children with vitamin D deficiency. Arch Pediatr  2020; 27(3): 140-5.
 [http://dx.doi.org/10.1016/j.arcped.2019.12.005] [PMID:  31955958]

[295]
Plesner JL, Dahl M, Fonvig CE, et al. Obesity is associated with vitamin D deficiency in Danish children and adolescents. J Pediatr Endocrinol Metab  2018; 31(1): 53-61.
 [http://dx.doi.org/10.1515/jpem-2017-0246] [PMID:  29197860]

[296]
Rusconi RE, De Cosmi V, Gianluca G, Giavoli C, Agostoni C. Vitamin D insufficiency in obese children and relation with lipid profile. Int J Food Sci Nutr  2015; 66(2): 132-4.
 [http://dx.doi.org/10.3109/09637486.2014.959902] [PMID:  25657099]

[297]
Theriot JA, Sayat J, Franco S, Buchino JJ. Childhood obesity: A risk factor for omental torsion. Pediatrics  2003; 112(6 Pt 1): e460.
 [http://dx.doi.org/10.1542/peds.112.6.e460] [PMID:  14654645]

[298]
Kadia BM, Chichom-Mefire A, Halle-Ekane GE. Exploring the role of obesity and overweight in predicting postoperative outcome of abdominal surgery in a sub-Saharan African setting: A prospective cohort study. BMC Res Notes  2018; 11(1): 742.
 [http://dx.doi.org/10.1186/s13104-018-3853-0] [PMID:  30340649]

[299]
Lian J, Patel NK, Nickoli M, et al. Obesity is associated with significant morbidity after multiligament knee surgery. J Knee Surg  2020; 33(6): 525-30.
 [http://dx.doi.org/10.1055/s-0039-1681027] [PMID:  30822784]

[300]
Mortensen A, Lenz K, Abildstrøm H, Lauritsen TL. Anesthetizing the obese child. Paediatr Anaesth  2011; 21(6): 623-9.
 [http://dx.doi.org/10.1111/j.1460-9592.2011.03559.x] [PMID:  21429056]

[301]
Philippi-Höhne C. Anaesthesia in the obese child. Baillieres Best Pract Res Clin Anaesthesiol  2011; 25(1): 53-60.
 [http://dx.doi.org/10.1016/j.bpa.2010.12.004] [PMID:  21516913]

[302]
Sabharwal S, Root MZ. Impact of obesity on orthopaedics. J Bone Joint Surg Am  2012; 94(11): 1045-52.
 [http://dx.doi.org/10.2106/JBJS.K.00330] [PMID:  22637211]

[303]
Houdek MT, Griffin AM, Ferguson PC, Wunder JS. Morbid obesity increases the risk of postoperative wound complications, infection, and repeat surgical procedures following upper extremity limb salvage surgery for soft tissue sarcoma. Hand (N Y)  2019; 14(1): 114-20.
 [http://dx.doi.org/10.1177/1558944718797336] [PMID:  30145914]

[304]
Li LW, Wong HM, McGrath CP. Longitudinal association between obesity and dental caries in adolescents. J Pediatr  2017; 189: 149-154.e5.
 [http://dx.doi.org/10.1016/j.jpeds.2017.06.050] [PMID:  28728812]

[305]
Mohamed RN, Basha S, Al-Thomali Y, AlZahrani FS, Ashour AA, Almutair NE. Association between dental caries and obesity among children with special health care needs. Oral Health Prev Dent  2021; 19(1): 101-6.
 [PMID:  33511824]

[306]
Manohar N, Hayen A, Fahey P, Arora A. Obesity and dental caries in early childhood: A systematic review and meta-analyses. Obes Rev  2020; 21(3): e12960.
 [http://dx.doi.org/10.1111/obr.12960] [PMID:  31721413]

[307]
Ravaghi V, Rezaee A, Pallan M, Morris AJ. Childhood obesity and dental caries: An ecological investigation of the shape and moderators of the association. BMC Oral Health  2020; 20(1): 338.
 [http://dx.doi.org/10.1186/s12903-020-01329-7] [PMID:  33238971]

[308]
Willershausen B, Haas G, Krummenauer F, Hohenfellner K. Relationship between high weight and caries frequency in German elementary school children. Eur J Med Res  2004; 9(8): 400-4.
 [PMID:  15337630]

[309]
Khan S, Barrington G, Bettiol S, Barnett T, Crocombe L. Is overweight/obesity a risk factor for periodontitis in young adults and adolescents?: A systematic review. Obes Rev  2018; 19(6): 852-83.
 [http://dx.doi.org/10.1111/obr.12668] [PMID:  29349893]

[310]
Elizondo-Montemayor L, Hernández-Escobar C, Lara-Torre E, Nieblas B, Gómez-Carmona M. Gynecologic and obstetric consequences of obesity in adolescent girls. J Pediatr Adolesc Gynecol  2017; 30(2): 156-68.
 [http://dx.doi.org/10.1016/j.jpag.2016.02.007] [PMID:  26915924]

[311]
Sirimi N, Goulis DG. Obesity in pregnancy. Hormones (Athens)  2010; 9(4): 299-306.
 [http://dx.doi.org/10.14310/horm.2002.1280] [PMID:  21112860]

[312]
Wood PL, Bauman D. Gynaecological issues affecting the obese adolescent. Best Pract Res Clin Obstet Gynaecol  2015; 29(4): 453-65.
 [http://dx.doi.org/10.1016/j.bpobgyn.2014.10.015] [PMID:  25481559]

[313]
Dennedy MC, Avalos G, O’Reilly MW, O’Sullivan EP, Dunne FP. The impact of maternal obesity on gestational outcomes. Ir Med J  2012; 105(5): 23-5.
 [PMID:  22838105]

[314]
Jungheim ES, Travieso JL, Carson KR, Moley KH. Obesity and reproductive function. Obstet Gynecol Clin North Am  2012; 39(4): 479-93.
 [http://dx.doi.org/10.1016/j.ogc.2012.09.002] [PMID:  23182555]

[315]
Marshall NE, Spong CY. Obesity, pregnancy complications, and birth outcomes. Semin Reprod Med  2012; 30(6): 465-71.
 [http://dx.doi.org/10.1055/s-0032-1328874] [PMID:  23074004]

[316]
Santangeli L, Sattar N, Huda SS. Impact of maternal obesity on perinatal and childhood outcomes. Best Pract Res Clin Obstet Gynaecol  2015; 29(3): 438-48.
 [http://dx.doi.org/10.1016/j.bpobgyn.2014.10.009] [PMID:  25497183]

[317]
Sermondade N, Faure C, Fezeu L, et al. BMI in relation to sperm count: An updated systematic review and collaborative meta-analysis. Hum Reprod Update  2013; 19(3): 221-31.
 [http://dx.doi.org/10.1093/humupd/dms050] [PMID:  23242914]

[318]
Shamloul R, Ghanem H. Erectile dysfunction. Lancet  2013; 381(9861): 153-65.
 [http://dx.doi.org/10.1016/S0140-6736(12)60520-0] [PMID:  23040455]

[319]
Calle EE, Rodriguez C, Walker-Thurmond K, Thun MJ. Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med  2003; 348(17): 1625-38.
 [http://dx.doi.org/10.1056/NEJMoa021423] [PMID:  12711737]

[320]
Conroy MJ, Dunne MR, Donohoe CL, Reynolds JV. Obesity-associated cancer: An immunological perspective. Proc Nutr Soc  2016; 75(2): 125-38.
 [http://dx.doi.org/10.1017/S0029665115004176] [PMID:  26567898]

[321]
Krupa-Kotara K, Dakowska D. Impact of obesity on risk of cancer. Cent Eur J Public Health  2021; 29(1): 38-44.
 [http://dx.doi.org/10.21101/cejph.a5913] [PMID:  33831285]

[322]
Reinehr T. Obesity in adolescents and cancer risk: Causal relationship or epiphenomenon? Lancet Diabetes Endocrinol  2020; 8(3): 179-80.
 [http://dx.doi.org/10.1016/S2213-8587(20)30028-0] [PMID:  32027850]

[323]
Song M, Choi JY, Yang JJ, et al. Obesity at adolescence and gastric cancer risk. Cancer Causes Control  2015; 26(2): 247-56.
 [http://dx.doi.org/10.1007/s10552-014-0506-z] [PMID:  25471061]

[324]
Weihrauch-Blüher S, Schwarz P, Klusmann JH. Childhood obesity: Increased risk for cardiometabolic disease and cancer in adulthood. Metabolism  2019; 92: 147-52.
 [http://dx.doi.org/10.1016/j.metabol.2018.12.001] [PMID:  30529454]

[325]
Wise J. Teenage obesity is linked to bowel cancer in later life. BMJ  2015; 350: h2838.
 [http://dx.doi.org/10.1136/bmj.h2838] [PMID:  26019280]

[326]
American Dietetic Association (ADA). Position of the American Dietetic Association: Individual-, family-, school-, and community-based interventions for pediatric overweight. J Am Diet Assoc  2006; 106(6): 925-45.
 [http://dx.doi.org/10.1016/j.jada.2006.03.001] [PMID:  16812927]

[327]
Alvarado-Terrones EG, Perea-Cabrera M, Klünder-Klünder M, et al. Maternal obesity as a risk factor for the development of total anomalous pulmonary venous connection in their offspring. Arch Med Res  2018; 49(2): 109-13.
 [http://dx.doi.org/10.1016/j.arcmed.2018.06.001] [PMID:  29907426]

[328]
Brite J, Laughon SK, Troendle J, Mills J. Maternal overweight and obesity and risk of congenital heart defects in offspring. Int J Obes  2014; 38(6): 878-82.
 [http://dx.doi.org/10.1038/ijo.2013.244] [PMID:  24362506]

[329]
Moore LL, Singer MR, Bradlee ML, Rothman KJ, Milunsky A. A prospective study of the risk of congenital defects associated with maternal obesity and diabetes mellitus. Epidemiology  2000; 11(6): 689-94.
 [http://dx.doi.org/10.1097/00001648-200011000-00013] [PMID:  11055631]

[330]
Shaw GM, Nelson V, Moore CA. Prepregnancy body mass index and risk of multiple congenital anomalies. Am J Med Genet  2002; 107(3): 253-5.
 [http://dx.doi.org/10.1002/ajmg.10164] [PMID:  11807910]

[331]
Waller DK, Mills JL, Simpson JL, et al. Are obese women at higher risk for producing malformed offspring? Am J Obstet Gynecol  1994; 170(2): 541-8.
 [http://dx.doi.org/10.1016/S0002-9378(94)70224-1] [PMID:  8116710]

[332]
Watkins ML, Rasmussen SA, Honein MA, Botto LD, Moore CA. Maternal obesity and risk for birth defects. Pediatrics  2003; 111(5 Pt 2): 1152-8.
 [http://dx.doi.org/10.1542/peds.111.S1.1152] [PMID:  12728129]

[333]
Kendrick JG, Carr RR, Ensom MH. Pediatric obesity: Pharmacokinetics and implications for drug dosing. Clin Ther  2015; 37(9): 1897-923.
 [http://dx.doi.org/10.1016/j.clinthera.2015.05.495] [PMID:  26361823]

[334]
Vaughns JD, Conklin LS, Long Y, et al. Obesity and pediatric drug development. J Clin Pharmacol  2018; 58(5): 650-61.
 [http://dx.doi.org/10.1002/jcph.1054] [PMID:  29350758]

[335]
Anderson BJ, Holford NH. Getting the dose right for obese children. Arch Dis Child  2017; 102(1): 54-5.
 [http://dx.doi.org/10.1136/archdischild-2016-311696] [PMID:  27655657]

[336]
Collier H, Nasim M, Gandhi A. Prescribing in obese children: How good are paediatricians? Arch Dis Child  2017; 102(1): 61-2.
 [http://dx.doi.org/10.1136/archdischild-2016-310603] [PMID:  27461279]

[337]
Kyler KE, Wagner J, Hosey-Cojocari C, Watt K, Shakhnovich V. Drug dose selection in pediatric obesity: Available information for the most commonly prescribed drugs to children. Paediatr Drugs  2019; 21(5): 357-69.
 [http://dx.doi.org/10.1007/s40272-019-00352-8] [PMID:  31432433]

[338]
Tsai AG, Williamson DF, Glick HA. Direct medical cost of overweight and obesity in the USA: A quantitative systematic review. Obes Rev  2011; 12(1): 50-61.
 [http://dx.doi.org/10.1111/j.1467-789X.2009.00708.x] [PMID:  20059703]

[339]
Lehnert T, Sonntag D, Konnopka A, Riedel-Heller S, König HH. Economic costs of overweight and obesity. Best Pract Res Clin Endocrinol Metab  2013; 27(2): 105-15.
 [http://dx.doi.org/10.1016/j.beem.2013.01.002] [PMID:  23731873]

[340]
Huang Y, Chen J, Wang X, Li Y, Yang S, Qu S. The clinical characteristics of obese patients with acanthosis nigricans and its independent risk factors. Exp Clin Endocrinol Diabetes  2017; 125(3): 191-5.
 [http://dx.doi.org/10.1055/s-0042-123035] [PMID:  28081576]

[341]
Dietz WH, Robinson TN. Clinical practice. Overweight children and adolescents. N Engl J Med  2005; 352(20): 2100-9.
 [http://dx.doi.org/10.1056/NEJMcp043052] [PMID:  15901863]

[342]
An R. Diet quality and physical activity in relation to childhood obesity. Int J Adolesc Med Health  2017; 29(2): /j/ijamh.2017.29.
 [http://dx.doi.org/10.1515/ijamh-2015-0045]

[343]
Browne AF. Therapeutic options to treat pediatric obesity. Gastrointest Endosc Clin N Am  2017; 27(2): 313-26.
 [http://dx.doi.org/10.1016/j.giec.2017.01.003] [PMID:  28292409]

[344]
Kumaran A, Sakka S, Dias RP. Obesity in children: Recent NICE guidance. Arch Dis Child Educ Pract Ed  2017; 102(2): 84-8.
 [http://dx.doi.org/10.1136/archdischild-2015-309729] [PMID:  27821434]

[345]
De Miguel-Etayo P, Bueno G, Garagorri JM, Moreno LA. Interventions for treating obesity in children. World Rev Nutr Diet  2013; 108: 98-106.
 [http://dx.doi.org/10.1159/000351493] [PMID:  24029793]

[346]
Lifshitz F, Moses N. Growth failure. A complication of dietary treatment of hypercholesterolemia. Am J Dis Child  1989; 143(5): 537-42.
 [http://dx.doi.org/10.1001/archpedi.1989.02150170035015] [PMID:  2718985]

[347]
Pradinuk M, Chanoine JP, Goldman RD. Obesity and physical activity in children. Can Fam Physician  2011; 57(7): 779-82.
 [PMID:  21753100]

[348]
Dolinsky DH, Armstrong SC, Kinra S. The clinical treatment of childhood obesity. Indian J Pediatr  2013; 80 (Suppl. 1): S48-54.
 [http://dx.doi.org/10.1007/s12098-012-0766-0] [PMID:  22669690]

[349]
Owens S, Gutin B, Allison J, et al. Effect of physical training on total and visceral fat in obese children. Med Sci Sports Exerc  1999; 31(1): 143-8.
 [http://dx.doi.org/10.1097/00005768-199901000-00022] [PMID:  9927022]

[350]
Epstein LH, Wing RR, Penner BC, Kress MJ. Effect of diet and controlled exercise on weight loss in obese children. J Pediatr  1985; 107(3): 358-61.
 [http://dx.doi.org/10.1016/S0022-3476(85)80506-0] [PMID:  4032130]

[351]
Watts K, Beye P, Siafarikas A, et al. Effects of exercise training on vascular function in obese children. J Pediatr  2004; 144(5): 620-5.
 [http://dx.doi.org/10.1016/j.jpeds.2004.02.027] [PMID:  15126996]

[352]
Woo KS, Chook P, Yu CW, et al. Effects of diet and exercise on obesity-related vascular dysfunction in children. Circulation  2004; 109(16): 1981-6.
 [http://dx.doi.org/10.1161/01.CIR.0000126599.47470.BE] [PMID:  15066949]

[353]
Centers for Disease Control and Prevention (CDC). Prevalence of physical activity, including lifestyle activities among adults--United States, 2000-2001. MMWR Morb Mortal Wkly Rep  2003; 52(32): 764-9.
 [PMID:  12917582]

[354]
Lau DC, Douketis JD, Morrison KM, Hramiak IM, Sharma AM, Ur E. 2006 Canadian clinical practice guidelines on the management and prevention of obesity in adults and children [summary]. CMAJ  2007; 176(8): S1-S13.
 [http://dx.doi.org/10.1503/cmaj.061409] [PMID:  17420481]

[355]
Skelton JA. Management of childhood obesity in the primary care setting UpToDate. Netherlands: Wolters Kluwer 2022.

[356]
American Academy of Pediatrics Committee on Communications. Children, adolescents, and television. Pediatrics  1995; 96(4 Pt 1): 786-7.
 [PMID:  7567350]

[357]
Wilson K. Obesity: Lifestyle modification and behavior interventions. FP Essent  2020; 492: 19-24.
 [PMID:  32383844]

[358]
Durant N, Cox J. Current treatment approaches to overweight in adolescents. Curr Opin Pediatr  2005; 17(4): 454-9.
 [http://dx.doi.org/10.1097/01.mop.0000170515.35272.9e] [PMID:  16012255]

[359]
Nerud K, Samra HA. Make a move intervention to reduce childhood obesity. J Sch Nurs  2017; 33(3): 205-13.
 [http://dx.doi.org/10.1177/1059840516665217] [PMID:  27573416]

[360]
Kennedy E, Powell R. Changing eating patterns of American children: A view from 1996. J Am Coll Nutr  1997; 16(6): 524-9.
 [PMID:  9430079]

[361]
Krebs-Smith SM, Cook A, Subar AF, Cleveland L, Friday J, Kahle LL. Fruit and vegetable intakes of children and adolescents in the United States. Arch Pediatr Adolesc Med  1996; 150(1): 81-6.
 [http://dx.doi.org/10.1001/archpedi.1996.02170260085014] [PMID:  8542012]

[362]
Wrotniak BH, Epstein LH, Paluch RA, Roemmich JN. Parent weight change as a predictor of child weight change in family-based behavioral obesity treatment. Arch Pediatr Adolesc Med  2004; 158(4): 342-7.
 [http://dx.doi.org/10.1001/archpedi.158.4.342] [PMID:  15066873]

[363]
Chao AM, Wadden TA, Berkowitz RI. The safety of pharmacologic treatment for pediatric obesity. Expert Opin Drug Saf  2018; 17(4): 379-85.
 [http://dx.doi.org/10.1080/14740338.2018.1437143] [PMID:  29411652]

[364]
Boland CL, Harris JB, Harris KB. Pharmacological management of obesity in pediatric patients. Ann Pharmacother  2015; 49(2): 220-32.
 [http://dx.doi.org/10.1177/1060028014557859] [PMID:  25366340]

[365]
Kelly AS, Fox CK, Rudser KD, Gross AC, Ryder JR. Pediatric obesity pharmacotherapy: Current state of the field, review of the literature and clinical trial considerations. Int J Obes  2016; 40(7): 1043-50.
 [http://dx.doi.org/10.1038/ijo.2016.69] [PMID:  27113643]

[366]
Kelly AS, Fox CK. Pharmacotherapy in the management of pediatric obesity. Curr Diab Rep  2017; 17(8): 55.
 [http://dx.doi.org/10.1007/s11892-017-0886-z] [PMID:  28646356]

[367]
Lenders CM. Paediatric obesity: Can medications help. Curr Opin Endocrinol Diabetes Obes  2015; 22(5): 331-9.
 [http://dx.doi.org/10.1097/MED.0000000000000183] [PMID:  26218173]

[368]
Grant-Guimaraes J, Feinstein R, Laber E, Kosoy J. Childhood overweight and obesity. Gastroenterol Clin North Am  2016; 45(4): 715-28.
 [http://dx.doi.org/10.1016/j.gtc.2016.07.007] [PMID:  27837784]

[369]
Hundal RS, Inzucchi SE. Metformin: New understandings, new uses. Drugs  2003; 63(18): 1879-94.
 [http://dx.doi.org/10.2165/00003495-200363180-00001] [PMID:  12930161]

[370]
Webb E, Viner R. Should metformin be prescribed to overweight adolescents in whom dietary/behavioural modifications have not helped? Arch Dis Child  2006; 91(9): 793-4.
 [http://dx.doi.org/10.1136/adc.2006.098962] [PMID:  16923867]

[371]
Freemark M, Bursey D. The effects of metformin on body mass index and glucose tolerance in obese adolescents with fasting hyperinsulinemia and a family history of type 2 diabetes. Pediatrics  2001; 107(4): E55.
 [http://dx.doi.org/10.1542/peds.107.4.e55] [PMID:  11335776]

[372]
Sabin MA, Kiess W. Childhood obesity: Current and novel approaches. Best Pract Res Clin Endocrinol Metab  2015; 29(3): 327-38.
 [http://dx.doi.org/10.1016/j.beem.2015.04.003] [PMID:  26051294]

[373]
Warnakulasuriya LS, Fernando MMA, Adikaram AVN, et al. Metformin in the management of childhood obesity: A randomized control trial. Child Obes  2018; 14(8): 553-65.
 [http://dx.doi.org/10.1089/chi.2018.0043] [PMID:  30070925]

[374]
Holterman MJ, Le Holterman AX, Browne AF. Pediatric obesity. Surg Clin North Am  2012; 92(3): 559-82.
 [http://dx.doi.org/10.1016/j.suc.2012.03.007] [PMID:  22595709]

[375]
Zitsman JL, Inge TH, Reichard KW, Browne AF, Harmon CM, Michalsky MP. Pediatric and adolescent obesity: Management, options for surgery, and outcomes. J Pediatr Surg  2014; 49(3): 491-4.
 [http://dx.doi.org/10.1016/j.jpedsurg.2013.11.067] [PMID:  24650484]

[376]
Inge TH, Krebs NF, Garcia VF, et al. Bariatric surgery for severely overweight adolescents: Concerns and recommendations. Pediatrics  2004; 114(1): 217-23.
 [http://dx.doi.org/10.1542/peds.114.1.217] [PMID:  15231931]

[377]
Inge TH.  Surgical management of severe obesity in adolescents. UpToDate.

[378]
Singhal V, Youssef S, Misra M. Use of sleeve gastrectomy in adolescents and young adults with severe obesity. Curr Opin Pediatr  2020; 32(4): 547-53.
 [http://dx.doi.org/10.1097/MOP.0000000000000927] [PMID:  32692052]

[379]
Moore BF, Harrall KK, Sauder KA, Glueck DH, Dabelea D. Neonatal adiposity and childhood obesity. Pediatrics  2020; 146(3): e20200737.
 [http://dx.doi.org/10.1542/peds.2020-0737] [PMID:  32796097]

[380]
Ong KK, Loos RJ. Rapid infancy weight gain and subsequent obesity: Systematic reviews and hopeful suggestions. Acta Paediatr  2006; 95(8): 904-8.
 [http://dx.doi.org/10.1080/08035250600719754] [PMID:  16882560]

[381]
Salsberry PJ, Reagan PB. Dynamics of early childhood overweight. Pediatrics  2005; 116(6): 1329-38.
 [http://dx.doi.org/10.1542/peds.2004-2583] [PMID:  16322155]

[382]
Smego A, Woo JG, Klein J, et al. High body mass index in infancy may predict severe obesity in early childhood. J Pediatr  2017; 183: 87-93.e1.
 [http://dx.doi.org/10.1016/j.jpeds.2016.11.020] [PMID:  27916426]

[383]
Freedman DS, Khan LK, Serdula MK, Dietz WH, Srinivasan SR, Berenson GS. The relation of childhood BMI to adult adiposity: The Bogalusa Heart Study. Pediatrics  2005; 115(1): 22-7.
 [http://dx.doi.org/10.1542/peds.2004-0220] [PMID:  15629977]

[384]
Laitinen J, Power C, Järvelin MR. Family social class, maternal body mass index, childhood body mass index, and age at menarche as predictors of adult obesity. Am J Clin Nutr  2001; 74(3): 287-94.
 [http://dx.doi.org/10.1093/ajcn/74.3.287] [PMID:  11522550]

[385]
Serdula MK, Ivery D, Coates RJ, Freedman DS, Williamson DF, Byers T. Do obese children become obese adults? A review of the literature. Prev Med  1993; 22(2): 167-77.
 [http://dx.doi.org/10.1006/pmed.1993.1014] [PMID:  8483856]

[386]
Krassas GE, Tzotzas T. Do obese children become obese adults: Childhood predictors of adult disease. Pediatr Endocrinol Rev  2004; 1 (Suppl. 3): 455-9.
 [PMID:  16444174]

[387]
Aranceta-Bartrina J, Pérez-Rodrigo C. Childhood obesity: An unresolved issue. Rev Esp Cardiol (Engl Ed)  2018; 71(11): 888-91.
 [http://dx.doi.org/10.1016/j.rec.2018.05.042] [PMID:  30190188]

[388]
Bleich SN, Vercammen KA, Zatz LY, Frelier JM, Ebbeling CB, Peeters A. Interventions to prevent global childhood overweight and obesity: A systematic review. Lancet Diabetes Endocrinol  2018; 6(4): 332-46.
 [http://dx.doi.org/10.1016/S2213-8587(17)30358-3] [PMID:  29066096]

[389]
Psaltopoulou T, Tzanninis S, Ntanasis-Stathopoulos I, et al. Prevention and treatment of childhood and adolescent obesity: A systematic review of meta-analyses. World J Pediatr  2019; 15(4): 350-81.
 [http://dx.doi.org/10.1007/s12519-019-00266-y] [PMID:  31313240]

[390]
Rush E, Simmons D. Physical activity in children: Prevention of obesity and type 2 diabetes. Med Sport Sci  2014; 60: 113-21.
 [http://dx.doi.org/10.1159/000357341] [PMID:  25226806]

[391]
Thury C, de Matos CV. Prevention of childhood obesity: A review of the current guidelines and supporting evidence. S D Med  2015; (Spec No): 18-23.
 [PMID:  25985603]

[392]
Jin J. Screening for obesity in children and adolescents. JAMA  2017; 317(23): 2460.
 [http://dx.doi.org/10.1001/jama.2017.7044] [PMID:  28632868]

[393]
Whaley SE, Koleilat M, Leonard S, Whaley M. Breastfeeding is associated with reduced obesity in Hispanic 2- to 5-year-olds served by WIC. J Nutr Educ Behav  2017; 49(7)(Suppl. 2): S144-50.e1, 150.e1.
 [http://dx.doi.org/10.1016/j.jneb.2017.03.007] [PMID: 28689551]

[394]
Dennison BA, Boyer PS. Risk evaluation in pediatric practice aids in prevention of childhood overweight. Pediatr Ann  2004; 33(1): 25-30.
 [http://dx.doi.org/10.3928/0090-4481-20040101-09] [PMID:  14981866]

[395]
Mack I, Bayer C, Schäffeler N, et al. Chances and limitations of video games in the fight against childhood obesity - A systematic review. Eur Eat Disord Rev  2017; 25(4): 237-67.
 [http://dx.doi.org/10.1002/erv.2514] [PMID:  28467004]

[396]
American Diabetes Association. Type 2 diabetes in children and adolescents. Diabetes Care  2000; 23(3): 381-9.
 [http://dx.doi.org/10.2337/diacare.23.3.381] [PMID:  10868870]

[397]
Moreno LA, Bel-Serrat S, Santaliestra-Pasías AM, Rodríguez G. Obesity prevention in children. World Rev Nutr Diet  2013; 106: 119-26.
 [http://dx.doi.org/10.1159/000342560] [PMID:  23428690]
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DOI https://dx.doi.org/10.2174/1573396318666220801093225	Print ISSN 1573-3963
Publisher Name Bentham Science Publisher	Online ISSN 1875-6336
Current Pediatric Reviews

Childhood Obesity: An Updated Review

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