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Current Topics in Medicinal Chemistry

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ISSN (Print): 1568-0266
ISSN (Online): 1873-4294

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Review Article

Therapeutics for the Management of Cytokine Release Syndrome in COVID-19

Author(s): Shampa Ghosh, Shantanu Durgvanshi, Sung Soo Han, Rakesh Bhaskar* and Jitendra Kumar Sinha*

Volume 23, Issue 2, 2023

Published on: 22 July, 2022

Page: [128 - 142] Pages: 15

DOI: 10.2174/1568026622666220707114121

Price: $65

Abstract

Coronavirus disease (COVID-19) is the greatest pandemic of this era and has affected more than 10 million people across 213 nations. However, the etiology, management, and treatment of COVID-19 remain unknown. A better understanding of the novel virus would help in developing accurate diagnostic methods and efficacious drugs for the treatment of patients of all age groups. To control the pandemic urgently, many drugs are being repurposed and several clinical trials are in progress for the same. As cytokine storm has been observed to be one of the common mechanisms of immune response in COVID-19 patients, several drugs are under trials to control the cytokine storm. In this review, we discuss the different categories of drugs in clinical trials for the management of cytokine storms in COVID-19 patients. Hitherto, several promising candidates such as IL-1 and IL-6 inhibitors have failed to display efficacy in the trials. Only corticosteroid therapy has shown benefit so far, albeit limited to patients on ventilator support. Thus, it is crucial to seek novel strategies to combat hyperinflammation and increase survival in COVID-19 afflicted patients.

Keywords: Cytokine storm, Pneumonia, Viral infection, Severe acute respiratory syndrome, Repurposed drugs, SARS-CoV-2.

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