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Reviews on Recent Clinical Trials

Editor-in-Chief

ISSN (Print): 1574-8871
ISSN (Online): 1876-1038

Review Article

Patient-Reported Outcomes for the Assessment of Sexual Health Among Patients Affected by Inflammatory Bowel Disease

Author(s): Daniela Pugliese*, Laura Parisio*, Tommaso Schepis, Giuseppe Privitera, Valentin Calvez, Antonio Gasbarrini and Alessandro Armuzzi

Volume 17, Issue 4, 2022

Published on: 23 September, 2022

Page: [250 - 258] Pages: 9

DOI: 10.2174/1574887117666220630114054

Price: $65

Abstract

Patients affected by inflammatory bowel disease (IBD) frequently report impaired quality of sexual life and complain of sexual dysfunctions. Both disease-specific features and psychological factors can be held responsible for these conditions. However, sexuality and all matters relating to sexual health are often wrongfully considered unrelated to IBD and, therefore, overlooked during medical visits. To overcome these difficulties and to best assess patients’ perceptions about their sexual health status, the use of patient-reported outcomes (PROs) could represent a valid strategy. In real-world studies, several non-IBD specific questionnaires, exploring different domains of sexuality, have been applied and validated for the IBD population.

This review summarizes the available evidence on sexual health among IBD patients and the data supporting the application of PROs to screen the quality of sexual life, as well as the rate and types of sexual dysfunctions, among IBD patients.

Keywords: Inflammatory bowel disease, sexual health, sexual dysfunction, patient-reported outcomes, IBD patients, sexual life.

[1]
Klages KL, Berlin KS, Cook JL, et al. Examining risk factors of health-related quality of life impairments among adolescents with inflam-matory bowel disease. Behav Med 2021; 47(2): 140-50.
[http://dx.doi.org/10.1080/08964289.2019.1676193] [PMID: 34048329]
[2]
Yu YR, Rodriguez JR. Clinical presentation of Crohn’s, ulcerative colitis, and indeterminate colitis: Symptoms, extraintestinal manifesta-tions, and disease phenotypes. Semin Pediatr Surg 2017; 26(6): 349-55.
[http://dx.doi.org/10.1053/j.sempedsurg.2017.10.003] [PMID: 29126502]
[3]
Marín L, Mañosa M, Garcia-Planella E, et al. Sexual function and patients’ perceptions in inflammatory bowel disease: A case-control survey. J Gastroenterol 2013; 48(6): 713-20.
[http://dx.doi.org/10.1007/s00535-012-0700-2] [PMID: 23124604]
[4]
Defining sexual health Sexual health document series Geveva: WHO 2006.
[5]
Rivière P, Zallot C, Desobry P, et al. Frequency of and factors associated with sexual dysfunction in patients with inflammatory bowel disease. J Crohn’s Colitis 2017; 11(11): 1347-52.
[http://dx.doi.org/10.1093/ecco-jcc/jjx100] [PMID: 28981625]
[6]
Fourie S, Jackson D. Dochan. These discussions aren’t happening’: Experiences of people living with inflammatory bowel disease and talking about sexual well-being with health care professionals. J Crohn’s Colitis 2021; 15(10): 1641-8.
[http://dx.doi.org/10.1093/ecco-jcc/jjab043]
[7]
Restellini S, Chao CY, Martel M, et al. Clinical parameters correlate with endoscopic activity of ulcerative colitis: A systematic review. Clin Gastroenterol Hepatol 2019; 17(7): 1265-1275.e8.
[http://dx.doi.org/10.1016/j.cgh.2018.12.021] [PMID: 30583048]
[8]
Khanna R, Zou G, D’Haens G, et al. A retrospective analysis: The development of patient reported outcome measures for the assessment of Crohn’s disease activity. Aliment Pharmacol Ther 2015; 41(1): 77-86.
[http://dx.doi.org/10.1111/apt.13001] [PMID: 25348809]
[9]
Rose M, et al. Validierung der deutschsprachigen version des >>short inflammatory bowel disease questionnaire<< (SIBDQ). Z Gastroenterol 2000; 38(4): 277-86.
[http://dx.doi.org/10.1055/s-2000-14868] [PMID: 10820859]
[10]
Czuber-Dochan W, Norton C, Bassett P, et al. Development and psychometric testing of inflammatory bowel disease fatigue (IBD-F) pa-tient self-assessment scale. J Crohn’s Colitis 2014; 8(11): 1398-406.
[http://dx.doi.org/10.1016/j.crohns.2014.04.013] [PMID: 24856864]
[11]
Tinsley A, Macklin EA, Korzenik JR, Sands BE. Validation of the functional assessment of chronic illness therapy-fatigue (FACIT-F) in patients with inflammatory bowel disease. Aliment Pharmacol Ther 2011; 34(11-12): 1328-36.
[http://dx.doi.org/10.1111/j.1365-2036.2011.04871.x] [PMID: 21999576]
[12]
Peyrin-biroulet L, et al. Development of the first disability index for inflammatory bowel disease based on the international classification of functioning, disability and health. Gut 2012; 61(2): 241-7.
[http://dx.doi.org/10.1136/gutjnl-2011-300049]
[13]
Yamamoto-Furusho JK, Sarmiento-Aguilar A, García-Alanis M, et al. Hospital anxiety and depression scale (HADS): Validation in mexi-can patients with inflammatory bowel disease. Gastroenterol Hepatol 2018; 41(8): 477-82.
[http://dx.doi.org/10.1016/j.gastrohep.2018.05.009] [PMID: 29937084]
[14]
Kroenke K, Spitzer RL, Williams JBW. The PHQ-9: Validity of a brief depression severity measure. J Gen Intern Med 2001; 16(9): 606-13.
[http://dx.doi.org/10.1046/j.1525-1497.2001.016009606.x] [PMID: 11556941]
[15]
Leenhardt R, Rivière P, Papazian P, et al. Sexual health and fertility for individuals with inflammatory bowel disease. World J Gastroenterol 2019; 25(36): 5423-33.
[http://dx.doi.org/10.3748/wjg.v25.i36.5423] [PMID: 31576090]
[16]
Knowles SR, Gass C, Macrae F. Illness perceptions in IBD influence psychological status, sexual health and satisfaction, body image and relational functioning: A preliminary exploration using structural equation modeling. J Crohn’s Colitis 2013; 7(9): e344-50.
[http://dx.doi.org/10.1016/j.crohns.2013.01.018] [PMID: 23453888]
[17]
Boudiaf R, Bouchard D, Rivière P, et al. Assessment of sexual dysfunction in patients with perianal Crohn’s disease. Colorectal Dis 2021; 23(1): 114-22.
[http://dx.doi.org/10.1111/codi.15375] [PMID: 32961618]
[18]
Zhang J, Wei S, Zeng Q, Wu X, Gan H. Prevalence and risk factors of sexual dysfunction in patients with inflammatory bowel disease: Systematic review and meta-analysis. Int J Colorectal Dis 2021; 36(9): 2027-38.
[http://dx.doi.org/10.1007/s00384-021-03958-y] [PMID: 34050786]
[19]
Aguirre MA, Vélez A, Romero M, Collantes E. Gynecomastia and sexual impotence associated with methotrexate treatment. J Rheumatol 2002; 29(8): 1793-4.
[20]
Oh JS, Heo HM, Kim YG, Lee SG, Lee CK, Yoo B. The effect of anti-tumor necrosis factor agents on sexual dysfunction in male patients with ankylosing spondylitis: A pilot study. Int J Impot Res 2009; 21(6): 372-5.
[http://dx.doi.org/10.1038/ijir.2009.44] [PMID: 19759542]
[21]
Zhao S, Wang J, Med M, Liu Y, Med M, Luo L. Inflammatory bowel diseases were associated with risk of sexual dysfunction in both sexes : A meta-analysis. Inflamm Bowel Dis 2019; 25(4): 699-707.
[http://dx.doi.org/10.1093/ibd/izy345]
[22]
Pérez-Rodríguez PK, Marqués-Lespier JM, Ortiz A, Emanuelli NI, Viñas-Joy GM, Torres EA. Sexual dysfunction in puerto rican women with inflammatory bowel disease. P R Health Sci J 2020; 39: 243-8.
[23]
Yoshida K, Araki T, Uchida K, Okita Y. Sexual activity after ileal pouch-anal anastomosis in Japanese patients with ulcerative colitis. Surgery Today 2014; 44(1): 73-9.
[http://dx.doi.org/10.1007/s00595-013-0505-9]
[24]
Kluska P, Dzika-Andrysiak K, Mik M, et al. Sexual activity in patients after proctocolectomy with ileal pouch-anal anastomosis. Polish J Surg 2020; 93(1): 19-24.
[http://dx.doi.org/10.5604/01.3001.0014.5408] [PMID: 33729170]
[25]
Gorgun E, et al. Male sexual function improves after ileal pouch anal anastomosis. Colorectal Dis 2005; 7(6): 545-50.
[http://dx.doi.org/10.1111/j.1463-1318.2005.00895.x]
[26]
Rosen RC, Riley A, Wagner G, Osterloh IH, Kirkpatrick J, Mishra A. The international index of erectile function (IIEF): A multidimen-sional scale for assessment of erectile dysfunction. Urology 1997; 49(6): 822-30.
[http://dx.doi.org/10.1016/S0090-4295(97)00238-0] [PMID: 9187685]
[27]
Rosen RC, Cappelleri JC, Iii NG. The International Index of Erectile Function (IIEF): A state-of-the-science review. Int J Impot Res 2002; 14(4): 226-44.
[28]
Rosen R, et al. The Female sexual function index (FSFI): Amultidimensional self-report instrument for the assessment of female sexualfunction the female sexual function index (FSFI): A Multidimensional Self-Report Instrument for the Assessment of Femal 2011; 0715.
[http://dx.doi.org/10.1080/009262300278597]
[29]
Lindsey I, George B, Kettlewell M, Mortensen N. Controlled trial of sildenafil (Viagra ®) for erectile dysfunction after rectal excision for cancer and inflammatory bowel disease 727-32.
[30]
Gklavas A, Kyprianou C, Exarchos G, Metaxa L, Dellis A, Papaconstantinou I. Sexual function after proctectomy in patients with inflam-matory bowel disease: A prospective study. Turk J Gastroenterol 2019; 30(11): 943-50.
[http://dx.doi.org/10.5152/tjg.2019.18676] [PMID: 31767548]
[31]
Abraham L, Symonds T, Morris MF. Psychometric validation of a sexual quality of life questionnaire for use in men with premature ejac-ulation or erectile dysfunction. J Sex Med 2008; 5(3): 595-601.
[http://dx.doi.org/10.1111/j.1743-6109.2007.00749.x] [PMID: 18208501]
[32]
Symonds T, Boolell M, Quirk F. Development of a questionnaire on sexual quality of life in women. J Sex Marital Ther 2005; 31(5): 385-97.
[http://dx.doi.org/10.1080/00926230591006502] [PMID: 16169822]
[33]
Flynn KE, et al. Development of the NIH PROMIS® sexual function and satisfaction measures in patients with cancer. J Sex Med 2013; 10: 43-52.
[http://dx.doi.org/10.1111/j.1743-6109.2012.02995.x]
[34]
Reeve BB, Wang M, Weinfurt K, Flynn KE, Usinger DS, Chen RC. Psychometric evaluation of PROMIS sexual function and satisfaction measures in a longitudinal population-based cohort of men with localized prostate cancer. J Sex Med 2018; 15(12): 1792-810.
[http://dx.doi.org/10.1016/j.jsxm.2018.09.015] [PMID: 30539735]
[35]
Reynolds CF III, Frank E, Thase ME, et al. Assessment of sexual function in depressed, impotent, and healthy men: Factor analysis of a brief sexual function questionnaire for men. Psychiatry Res 1988; 24(3): 231-50.
[http://dx.doi.org/10.1016/0165-1781(88)90106-0] [PMID: 3406241]
[36]
Taylor JF, Rosen RC, Leiblum SR. Self-report assessment of female sexual function: Psychometric evaluation of the brief index of sexual functioning for women. Arch Sex Behav 1994; 23(6): 627-43.
[http://dx.doi.org/10.1007/BF01541816] [PMID: 7872859]
[37]
Derogatis LR, Rosen R, Leiblum S, Burnett A, Heiman J. The female sexual distress scale (FSDS): Initial validation of a standardized scale for assessment of sexually related personal distress in women. J Sex Marital Ther 2002; 28(4): 317-30.
[http://dx.doi.org/10.1080/00926230290001448] [PMID: 12082670]
[38]
McGahuey CA, Gelenberg AJ, Laukes CA, et al. The arizona sexual experience scale (Asex): Reliability and validity. J Sex Marital Ther 2000; 26(1): 25-40.
[http://dx.doi.org/10.1080/009262300278623] [PMID: 10693114]
[39]
Bel LGJ, Vollebregt AM, Van der Meulen-de Jong AE, et al. Sexual dysfunctions in men and women with inflammatory bowel disease: The influence of IBD-related clinical factors and depression on sexual function. J Sex Med 2015; 12(7): 1557-67.
[http://dx.doi.org/10.1111/jsm.12913] [PMID: 26054013]
[40]
Timmer A, Bauer A, Dignass A, Rogler G. Sexual Function in Persons With Inflammatory Bowel Disease : A Survey With Matched Con-trols 2007; 87-94.
[http://dx.doi.org/10.1016/j.cgh.2006.10.018.]
[41]
Shmidt E, Suárez-Fariñas M, Mallette M, et al. A longitudinal study of sexual function in women with newly diagnosed inflammatory bowel disease. Inflamm Bowel Dis 2019; 25(7): 1262-70.
[http://dx.doi.org/10.1093/ibd/izy397] [PMID: 30726913]
[42]
Nohr EA, Nielsen J, Norgard BM, Friedman S. Sexual health in women with inflammatory bowel disease in the Danish National Birth Cohort J Crohns Colitis 2020; 14(8): 1082-9.
[http://dx.doi.org/10.1093/ecco-jcc/jjaa038]
[43]
Eluri S, Cross RK, Martin C, et al. Inflammatory bowel diseases can adversely impact domains of sexual function such as satisfaction with sex life. Dig Dis Sci 2018; 63(6): 1572-82.
[http://dx.doi.org/10.1007/s10620-018-5021-8] [PMID: 29564672]
[44]
Multicenter A, Study N, Roseira J, Magro F, Fernandes S, Simões C. Sexual quality of life in inflammatory bowel disease. Inflamm Bowel Des 2020; 26(5): 746-55.
[http://dx.doi.org/10.1093/ibd/izz185]
[45]
Crowne DP, Marlowe D. A new scale of social desirability independent of psychopathology. J Consult Psychol 1960; 24(4): 349-54.
[http://dx.doi.org/10.1037/h0047358] [PMID: 13813058]
[46]
O’Toole A, de Silva PS, Marc LG, et al. Sexual dysfunction in men with inflammatory bowel disease: A new IBD-specific scale. Inflamm Bowel Dis 2018; 24(2): 310-6.
[http://dx.doi.org/10.1093/ibd/izx053] [PMID: 29361102]

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