Role of TGF- β in the Tumor Stroma

H.   P.H.   Naber; P.      ten Dijke; E.      Pardali

doi:10.2174/156800908785699342

Abstract

Recent findings have demonstrated that the tumor stroma actively contributes to tumorigenesis. The communication of malignant cells and tumor stromal components is orchestrated in part by a network of growth factors. One of these growth factors is transforming growth factor-β (TGF-β), a secreted multifunctional protein that acts in a highly cellular contextual manner. TGF-β can either stimulate or inhibit the tumor-promoting effects of the different components of the tumor stroma. In this review, we discuss our current understanding on how TGF-β influences different stromal compartments.

Keywords: TGF-β, tumor stroma, CAF, angiogenesis, immune cells

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