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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Case Report

A Case Report of Concurrent Graves’ Disease and Subacute Thyroiditis Following SARS-CoV-2 Vaccination: An Autoimmune/Inflammatory Syndrome (ASIA)

Author(s): Işılay Taşkaldıran*, Feride Pınar Altay, Yusuf Bozkuş, Özlem Turhan İyidir, Aslı Nar and Neslihan Başçıl Tütüncü

Volume 23, Issue 2, 2023

Published on: 26 August, 2022

Page: [242 - 246] Pages: 5

DOI: 10.2174/1871530322666220621101209

Price: $65

Abstract

Background: The response against adjuvants in vaccines is presented as autoimmune/inflammatory syndrome (ASIA). In this case report, we presented both SAT and Graves’ disease in a patient as ASIA following the BNT162b2 mRNA COVID-19 vaccination.

Case Presentation: A 31-year-old woman was admitted to the endocrinology outpatient clinic with the complaint of neck pain following the second dose of the BNT162B2 SARS-CoV-2 (Pfizer/BioNTech) vaccine. On physical examination, her thyroid gland was tender on palpation. Her thyroid function tests were compatible with hyperthyroidism, and inflammatory markers were high. In the thyroid ultrasonography (US) examination, we observed bilateral diffuse hypoechoic areas in the thyroid gland and increased vascularity in some parts of the thyroid. Anti-thyroid stimulating hormone receptor antibodies (TRAB) were positive. Overall, we considered concurrent subacute thyroiditis (SAT) and Graves’ disease.

Conclusion: The present study may be the first report to evaluate SAT and Graves’ disease as ASIA following mRNA COVID-19 vaccination. Clinicians should be aware of possible vaccine-related complications.

Keywords: ASIA, COVID-19, vaccine, Graves’ disease, subacute thyroiditis, SARS CoV-2.

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