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Current Respiratory Medicine Reviews

Editor-in-Chief

ISSN (Print): 1573-398X
ISSN (Online): 1875-6387

Research Article

Association between Red Blood Cell Distribution Width and Pulmonary Function among Iranian Employees

Author(s): Hamidreza Pouragha, Tayebeh Nasiri Ardali, Ramin Mehrdad and Gholamreza Pouryaghoub*

Volume 18, Issue 4, 2022

Published on: 06 October, 2022

Page: [275 - 282] Pages: 8

DOI: 10.2174/1573398X18666220620164456

Price: $65

Abstract

Background: RDW has been proposed as a routine test and is available as a prognosis for many diseases and disorders, especially respiratory disorders. In this study, we intend to see if the association between pulmonary function and RDW also applies to non-patients.

Methods: This study was performed on 800 people including 466 women and 344 men. Participants in the study were staff enrolled in the Tehran University of Medical Sciences cohort [TEC] study. In this study, RDW levels and pulmonary function were assessed. Elderly populations were not included in this study.

Results: The results of the univariate analysis showed that normal values versus abnormal values of RDW were significantly associated with pulmonary function index FEV1, FVC, FEV1/FVC in nonpatient individuals. On the other hand, a significant correlation was observed between RDW values and FEV1 index and FEV1/FVC ratio. Based on linear regression, there was an association between RDW and FVC [R2=0.721].

Conclusion: In this study, we found an association between RDW and FVC so we suggest that abnormal RDW may be considered as a sign of pulmonary dysfunction.

Keywords: Red blood cell distribution width, Respiratory Function Tests, Screening Approach, Occupational Health.

Graphical Abstract

[1]
Lippi, G.; Plebani, M. Red blood cell distribution width (RDW) and human pathology. One size fits all. Clin. Chem. Lab. Med., 2014, 52(9), 1247-1249.
[http://dx.doi.org/10.1515/cclm-2014-0585] [PMID: 24945432]
[2]
Salvagno, G.L.; Sanchis-Gomar, F.; Picanza, A.; Lippi, G. Red blood cell distribution width: A simple parameter with multiple clinical applications. Crit. Rev. Clin. Lab. Sci., 2015, 52(2), 86-105.
[http://dx.doi.org/10.3109/10408363.2014.992064] [PMID: 25535770]
[3]
Felker, G.M.; Allen, L.A.; Pocock, S.J. Red cell distribution width as a novel prognostic marker in heart failure: Data from the CHARM program and the duke databank. J. Am. Coll. Cardiol., 2007, 50(1), 40-47.
[http://dx.doi.org/10.1016/j.jacc.2007.02.067] [PMID: 17601544]
[4]
Tonelli, M.; Sacks, F.; Arnold, M.; Moye, L.; Davis, B.; Pfeffer, M. Relation between red blood cell distribution width and cardiovascular event rate in people with coronary disease. Circulation, 2008, 117(2), 163-168.
[http://dx.doi.org/10.1161/CIRCULATIONAHA.107.727545] [PMID: 18172029]
[5]
Lippi, G.; Targher, G.; Montagnana, M.; Salvagno, G.L.; Zoppini, G.; Guidi, G.C. Relation between red blood cell distribution width and inflammatory biomarkers in a large cohort of unselected outpatients. Arch. Pathol. Lab. Med., 2009, 133(4), 628-632.
[http://dx.doi.org/10.5858/133.4.628] [PMID: 19391664]
[6]
Perlstein, T.S.; Weuve, J.; Pfeffer, M.A.; Beckman, J.A. Red blood cell distribution width and mortality risk in a community-based prospective cohort. Arch. Intern. Med., 2009, 169(6), 588-594.
[http://dx.doi.org/10.1001/archinternmed.2009.55] [PMID: 19307522]
[7]
Patel, K.V.; Ferrucci, L.; Ershler, W.B.; Longo, D.L.; Guralnik, J.M. Red blood cell distribution width and the risk of death in middle-aged and older adults. Arch. Intern. Med., 2009, 169(5), 515-523.
[http://dx.doi.org/10.1001/archinternmed.2009.11] [PMID: 19273783]
[8]
Akboga, M.K.; Yayla, C.; Yilmaz, S. Increased red cell distribution width predicts occlusion of the infarct-related artery in STEMI. Scand. Cardiovasc. J., 2016, 50(2), 114-118.
[http://dx.doi.org/10.3109/14017431.2015.1119303] [PMID: 26651498]
[9]
Loprinzi, P.D. Comparative evaluation of red blood cell distribution width and high sensitivity C-reactive protein in predicting all-cause mortality and coronary heart disease mortality. Int. J. Cardiol., 2016, 223, 72-73.
[http://dx.doi.org/10.1016/j.ijcard.2016.08.156] [PMID: 27543696]
[10]
Wan, H.; Yang, Y.; Zhu, J. The relationship between elevated red cell distribution width and long-term outcomes among patients with atrial fibrillation. Clin. Biochem., 2015, 48(12), 762-767.
[http://dx.doi.org/10.1016/j.clinbiochem.2015.06.001] [PMID: 26054582]
[11]
Lee, K.H.; Park, H.W.; Cho, J.G. Red cell distribution width as a novel predictor for clinical outcomes in patients with paroxysmal atrial fibrillation. Europace, 2015, 17(Suppl. 2), ii83-ii88.
[http://dx.doi.org/10.1093/europace/euv210] [PMID: 26842121]
[12]
Bonaque, J.C.; Pascual-Figal, D.A.; Manzano-Fernández, S. Red blood cell distribution width adds prognostic value for outpatients with chronic heart failure. Rev. Esp. Cardiol. (Engl. Ed.), 2012, 65(7), 606-612.
[http://dx.doi.org/10.1016/j.rec.2011.12.007] [PMID: 22440296]
[13]
Turcato, G.; Zorzi, E.; Prati, D. Early in-hospital variation of red blood cell distribution width predicts mortality in patients with acute heart failure. Int. J. Cardiol., 2017, 243, 306-310.
[http://dx.doi.org/10.1016/j.ijcard.2017.05.023] [PMID: 28506551]
[14]
Huang, Y-L.; Hu, Z-D.; Liu, S-J. Prognostic value of red blood cell distribution width for patients with heart failure: A systematic review and meta-analysis of cohort studies. PLoS One, 2014, 9(8), e104861.
[http://dx.doi.org/10.1371/journal.pone.0104861] [PMID: 25133510]
[15]
Shao, Q.; Li, L.; Li, G.; Liu, T. Prognostic value of red blood cell distribution width in heart failure patients: A meta-analysis. Int. J. Cardiol., 2015, 179, 495-499.
[http://dx.doi.org/10.1016/j.ijcard.2014.11.042] [PMID: 25465815]
[16]
Hampole, C.V.; Mehrotra, A.K.; Thenappan, T.; Gomberg-Maitland, M.; Shah, S.J. Usefulness of red cell distribution width as a prognostic marker in pulmonary hypertension. Am. J. Cardiol., 2009, 104(6), 868-872.
[http://dx.doi.org/10.1016/j.amjcard.2009.05.016] [PMID: 19733726]
[17]
Allen, L.A.; Felker, G.M.; Mehra, M.R. Validation and potential mechanisms of red cell distribution width as a prognostic marker in heart failure. J. Card. Fail., 2010, 16(3), 230-238.
[http://dx.doi.org/10.1016/j.cardfail.2009.11.003] [PMID: 20206898]
[18]
Patel, K.V.; Semba, R.D.; Ferrucci, L. Red cell distribution width and mortality in older adults: A meta-analysis. Journals of Gerontology Series A: Biomedical Sciences and Medical Sciences, 2010, 65(3), 258-265.
[http://dx.doi.org/10.1093/gerona/glp163] [PMID: 19880817]
[19]
Lippi, G.; Plebani, M. Biomarker research and leading causes of death worldwide: A rather feeble relationship. Clin. Chem. Lab. Med., 2013, 51(9), 1691-1693.
[http://dx.doi.org/10.1515/cclm-2013-0210] [PMID: 23612670]
[20]
Lee, J.H.; Chung, H.J.; Kim, K. Red cell distribution width as a prognostic marker in patients with community-acquired pneumonia. Am. J. Emerg. Med., 2013, 31(1), 72-79.
[http://dx.doi.org/10.1016/j.ajem.2012.06.004] [PMID: 22867824]
[21]
Topaz, G.; Kitay-Cohen, Y.; Peled, L. The association between red cell distribution width and poor outcomes in hospitalized patients with influenza. J. Crit. Care, 2017, 41, 166-169.
[http://dx.doi.org/10.1016/j.jcrc.2017.05.014] [PMID: 28554095]
[22]
Seo, S-G.; Lee, M-Y.; Park, S.H. The association between red cell distribution width and incident hypertension in Korean adults. Hypertens. Res., 2020, 43(1), 55-61.
[http://dx.doi.org/10.1038/s41440-019-0334-3] [PMID: 31551565]
[23]
Karampitsakos, T.; Dimakou, K.; Papaioannou, O. The role of increased red cell distribution width as a negative prognostic marker in patients with COPD. Pulm. Pharmacol. Ther., 2020, 60, 101877.
[http://dx.doi.org/10.1016/j.pupt.2019.101877] [PMID: 31843703]
[24]
Monasta, L.; Ronfani, L. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980-2017: A systematic analysis for the global burden of disease study 2017. Lancet, 2018, 392(10159), 1736-1788.
[http://dx.doi.org/10.1016/S0140-6736(18)32203-7] [PMID: 30496103]
[25]
Miravitlles, M.; Ribera, A. Understanding the impact of symptoms on the burden of COPD. Respir. Res., 2017, 18(1), 67.
[http://dx.doi.org/10.1186/s12931-017-0548-3] [PMID: 28431503]
[26]
Kourlaba, G.; Hillas, G.; Vassilakopoulos, T.; Maniadakis, N. The disease burden of chronic obstructive pulmonary disease in Greece. Int. J. Chron. Obstruct. Pulmon. Dis., 2016, 11, 2179-2189.
[http://dx.doi.org/10.2147/COPD.S110373] [PMID: 27672323]
[27]
Lee, H.M.; Le, H.; Lee, B.T.; Lopez, V.A.; Wong, N.D. Forced vital capacity paired with Framingham Risk Score for prediction of all-cause mortality. Eur. Respir. J., 2010, 36(5), 1002-1006.
[http://dx.doi.org/10.1183/09031936.00042410] [PMID: 20562119]
[28]
Sin, D.D.; Wu, L.; Man, S.F. The relationship between reduced lung function and cardiovascular mortality: A population-based study and a systematic review of the literature. Chest, 2005, 127(6), 1952-1959.
[http://dx.doi.org/10.1378/chest.127.6.1952] [PMID: 15947307]
[29]
Subhashree, A.R.; Shanthi, B.; Parameaswari, P.J. The red cell distribution width as a sensitive biomarker for assessing the pulmonary function in automobile welders- a cross sectional study. J. Clin. Diagn. Res., 2013, 7(1), 89-92.
[http://dx.doi.org/10.7860/JCDR/2012/5051.2678] [PMID: 23449620]
[30]
Tertemiz, K.C.; Ozgen Alpaydin, A.; Sevinc, C.; Ellidokuz, H.; Acara, A.C.; Cimrin, A. Could “red cell distribution width” predict COPD severity? Rev. Port. Pneumol., 2016, 22(4), 196-201.
[http://dx.doi.org/10.1016/j.rppnen.2015.11.006] [PMID: 26809230]
[31]
Hu, G.P.; Zhou, Y.M.; Wu, Z.L. Red blood cell distribution width is an independent predictor of mortality for an acute exacerbation of COPD. Int. J. Tuberc. Lung Dis., 2019, 23(7), 817-823.
[http://dx.doi.org/10.5588/ijtld.18.0429] [PMID: 31439113]
[32]
Bai, Y.; Tao, X.N. Mean platelet volume combined red cell distribution width as biomarker of chronic obstructive pulmonary disease with pulmonary heart disease. Clin. Respir. J., 2020, 14(12), 1122-1130.
[http://dx.doi.org/10.1111/crj.13248] [PMID: 32772499]
[33]
Koma, Y.; Onishi, A.; Matsuoka, H. Increased red blood cell distribution width associates with cancer stage and prognosis in patients with lung cancer. PLoS One, 2013, 8(11), e80240.
[http://dx.doi.org/10.1371/journal.pone.0080240] [PMID: 24244659]
[34]
Sincer, I; Zorlu, A; Yilmaz, MB; Dogan, OT; Ege, MR; Amioglu, G Relationship between red cell distribution width and right ventricular dysfunction in patients with chronic obstructive pulmonary disease heart & lung, 2012, 41(3), 238-243.
[35]
Karampitsakos, T.; Bouros, E.; Papaioannou, O.; Tsipilis, S.; Antonou, C.; Ntassiou, M. Increased monocyte count and red cell distribution width represent negative prognostic markers in patients with Hypersensitivity Pneumonitis; Eur Respiratory Soc, 2020.
[http://dx.doi.org/10.1183/13993003.congress-2020.1077]
[36]
Kaya, AG; Özyürek, BA; Özdemirel, TŞ; Öz, M; Erdoğan, Y Prognostic significance of red cell distribution width in idiopathic pulmonary fibrosis and combined pulmonary fibrosis emphysema. Med. Princ. Pract., 29(6), 514-519.
[37]
Nedjat, S.; Mehrdad, R.; Yunesian, M.; Pouragha, H.; Biagi, V.; Monazzam-Esmaeelpour, M.R. Prospective cohort study on the social determinants of health: Tehran University of Medical Sciences employeescohort (TEC) study protocol. BMC Public Health, 2020, 20(1), 1-7.
[http://dx.doi.org/10.1186/s12889-020-09798-9] [PMID: 31898494]
[38]
McPherson, R.A. Henry’s Clinical Diagnosis and Management by Laboratory Methods: First South Asia Edition_e-BookIndia; Elsevier, 2017.
[39]
Culver, B.H.; Graham, B.L.; Coates, A.L. Recommendations for a standardized pulmonary function report. An official American Thoracic Society technical statement. Am. J. Respir. Crit. Care Med., 2017, 196(11), 1463-1472.
[http://dx.doi.org/10.1164/rccm.201710-1981ST] [PMID: 29192835]
[40]
Organization, WH Waist circumference and waist-hip ratio: Report of a WHO expert consultationGeneva , 2011; pp. 8-11.
[41]
Feng, X.; Qian, Z.; Zhang, B. Number of cigarettes smoked per day, smoking index, and intracranial aneurysm rupture: A case–control study. Front. Neurol., 2018, 9, 380.
[http://dx.doi.org/10.3389/fneur.2018.00380] [PMID: 29904368]
[42]
Redlich, C.A.; Tarlo, S.M.; Hankinson, J.L. Official American Thoracic Society technical standards: Spirometry in the occupational setting. Am. J. Respir. Crit. Care Med., 2014, 189(8), 983-993.
[http://dx.doi.org/10.1164/rccm.201402-0337ST] [PMID: 24735032]
[43]
Townsend, M.C. Spirometry in occupational health-2020. J. Occup. Environ. Med., 2020, 62(5), e208-e230.
[http://dx.doi.org/10.1097/JOM.0000000000001851] [PMID: 32398505]
[44]
Vigeh, M.; Mazaheri, M. Occupational medicine in Iran. Occup. Med. (Lond.), 2009, 59(1), 66.
[http://dx.doi.org/10.1093/occmed/kqn085] [PMID: 19114431]
[45]
Chen, Y.; Wang, Y.; Zhang, Z.; Liang, Z.; Zheng, J. The correlation between blood routine test parameters and severity of patients with acute exacerbation of chronic obstructive pulmonary diseaseC40 predicting outcomes and new therapies in chronic obstructive lung disease; American Thoracic Society, 2020, p. 5057.
[46]
Ravi, D; Sharma, N; Ochieng, P Red cell distribution width as a marker for pulmonary hypertension in COPD: A systematic review B58 BIOMARKERS AND IMAGING IN PULMONARY VASCULAR DISEASE: CLINICAL 2020, 38632.
[47]
Grant, B.J.; Kudalkar, D.P.; Muti, P. Relation between lung function and RBC distribution width in a population-based study. Chest, 2003, 124(2), 494-500.
[http://dx.doi.org/10.1378/chest.124.2.494] [PMID: 12907534]

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