Recombinant Production of Hyaluronic Acid

Stephen   H.   Brown; Philip   E.   Pummill

doi:10.2174/138920108785161488

Abstract

Presently, the two main commercial sources of hyaluronic acid (HA) are rooster combs and streptococci. Harvesting from rooster combs is complex and costly. Streptococci are difficult to genetically manipulate and require complex media for growth. Both sources have potential problems with unwanted by-products, such as allergens and toxins. These problems can be solved by producing the HA with safe bacilli that are expressing a recombinant HA synthase (HAS).

Keywords: Hyaluronic Acid, Bacillus subtilis, synthase, fermentation

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Current Pharmaceutical Biotechnology

Title: Recombinant Production of Hyaluronic Acid

Volume: 9 Issue: 4

Author(s): Stephen H. Brown and Philip E. Pummill

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Keywords: Hyaluronic Acid, Bacillus subtilis, synthase, fermentation

Abstract: Presently, the two main commercial sources of hyaluronic acid (HA) are rooster combs and streptococci. Harvesting from rooster combs is complex and costly. Streptococci are difficult to genetically manipulate and require complex media for growth. Both sources have potential problems with unwanted by-products, such as allergens and toxins. These problems can be solved by producing the HA with safe bacilli that are expressing a recombinant HA synthase (HAS).

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Brown H. Stephen and Pummill E. Philip, Recombinant Production of Hyaluronic Acid, Current Pharmaceutical Biotechnology 2008; 9 (4) . https://dx.doi.org/10.2174/138920108785161488