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Protein & Peptide Letters

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Review Article

Insights into Coronavirus Papain-like Protease Structure, Function and Inhibitors

Author(s): Shujuan Jin* and Mengjiao Zhang

Volume 29, Issue 7, 2022

Published on: 21 July, 2022

Page: [574 - 583] Pages: 10

DOI: 10.2174/0929866529666220602094016

Price: $65

Abstract

The coronavirus family consists of pathogens that seriously affect human and animal health. They mostly cause respiratory or enteric diseases, which can be severe and life-threatening, such as coronavirus disease 2019 (COVID-19), severe acute respiratory syndrome (SARS), and Middle East Respiratory Syndrome (MERS) in humans. The conserved coronaviral papain-like protease is an attractive antiviral drug target because it is essential for coronaviral replication, and it also inhibits host innate immune responses. This review focuses on the latest research progress relating to the mechanism of coronavirus infection, the structural and functional characteristics of coronavirus papain-like protease, and the potent inhibitors of the protease.

Keywords: Coronavirus, papain-like protease, structure, deubiquitination, inhibitor, pathogens.

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