Abstract
The biological importance and activity of glycostructures in cellular interactions is focus of numerous investigations to date. Aim is to probe the activity of diverse natural- and non-natural glycoconjugates in order to identify and correlate structure-activity relationships. The complexity of glycostructures and their synthetic realization has been a major obstacle, since synthetic methodologies are used on a case by case basis; hence access to a variety of complex glycostructures has been limited. Combinatorial chemistry is a powerful tool for the study of structure-function relationship of e.g. proteins and nucleic acids and small molecules, but has been little regarded within the recent decade in the field of carbohydrate chemistry. This paper focuses on combinatorial glycosylation strategy attempts from partially protected glycosyl acceptors, to the development of solution phase glyco-combinatorial chemistry using entirely unprotected non-reducing acceptors to generate random libraries of regioisomeric oligosaccharides.
Keywords: Oligosaccharide, Random Glycosylation, glycoconjugates, structure-activity relationships, Combinatorial chemistry
Call for Papers in Thematic Issues
Catalytic C-H bond activation as a tool for functionalization of heterocycles
The major topic is the functionalization of heterocycles through catalyzed C-H bond activation. The strategies based on C-H activation not only provide straightforward formation of C-C or C-X bonds but, more importantly, allow for the avoidance of pre-functionalization of one or two of the cross-coupling partners. The beneficial impact of ...read more
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