Abstract
Background: Obesity is a prominent disorder that has a drastic effect on lots of individuals. It is a consequence of non-equilibrium in the energy expenditure and intake of energy, while other etiological factors can be genetic, epigenetic, and physiological.
Objective: The aim is to explore the multiple aspects reported for its management based on controlled metabolic approaches as well as surgical approaches.
Results: It has been reviewed that medical interventions for obesity are lifestyle-altering interventions that include appropriate diet and exercise. Furthermore, pharmacotherapy is also proving to be efficient for the management of obesity. Drugs allowed by the competent authority of the US are for long-term such as orlistat and phentermine for the short-term obesity treatment. Surgical approaches involve restrictive, malabsorptive as well as mixed bariatric procedures and these procedures show evidence to alleviate obesity and its comorbidities.
Conclusion: This review explored various treatment options for obesity.
Keywords: Obesity, nutrition, treatment modalities, management, orlistat, bariatric procedures.
[http://dx.doi.org/10.1210/jc.2004-0535] [PMID: 15181027]
[http://dx.doi.org/10.1111/j.1467-789X.2009.00708.x] [PMID: 20059703]
[http://dx.doi.org/10.1542/peds.2014-0063] [PMID: 24709935]
[http://dx.doi.org/10.2337/dci15-0008] [PMID: 26494806]
[http://dx.doi.org/10.1016/j.jhealeco.2011.10.003] [PMID: 22094013]
[http://dx.doi.org/10.1097/JOM.0b013e3181a39180] [PMID: 19339899]
[http://dx.doi.org/10.1016/j.mce.2014.09.002] [PMID: 25218215]
[http://dx.doi.org/10.1038/sj.ijo.0803326] [PMID: 16801930]
[http://dx.doi.org/10.1097/HCR.0000000000000112] [PMID: 25714749]
[http://dx.doi.org/10.3810/pgm.2011.01.2243] [PMID: 21293082]
[http://dx.doi.org/10.1038/oby.2002.204] [PMID: 12490660]
[http://dx.doi.org/10.1186/1475-2891-3-3] [PMID: 15084221]
[http://dx.doi.org/10.1038/oby.2001.130] [PMID: 11707553]
[http://dx.doi.org/10.1056/NEJMoa0804748] [PMID: 19246357]
[http://dx.doi.org/10.1093/aje/kws264] [PMID: 23035144]
[http://dx.doi.org/10.1001/jama.2014.10397] [PMID: 25182101]
[http://dx.doi.org/10.1038/ejcn.2014.243] [PMID: 25369829]
[http://dx.doi.org/10.1056/NEJMoa1200303] [PMID: 23432189]
[http://dx.doi.org/10.1001/archinte.161.13.1599] [PMID: 11434791]
[http://dx.doi.org/10.1159/000090961] [PMID: 16418540]
[http://dx.doi.org/10.1001/jama.1991.03470110081037] [PMID: 1880885]
[http://dx.doi.org/10.1016/j.cct.2009.07.003] [PMID: 19665588]
[http://dx.doi.org/10.1093/ajcn/66.2.239] [PMID: 9250100]
[http://dx.doi.org/10.1093/ajcn/49.5.1115] [PMID: 2655416]
[http://dx.doi.org/10.7326/0003-4819-119-7_Part_2-199310011-00015] [PMID: 8363201]
[http://dx.doi.org/10.1001/jama.1995.03520290054029] [PMID: 7823386]
[http://dx.doi.org/10.1093/phr/115.1.89] [PMID: 10968589]
[http://dx.doi.org/10.1111/j.1547-5069.2011.01424.x] [PMID: 22018175]
[http://dx.doi.org/10.1136/jcp.56.1.17] [PMID: 12499427]
[http://dx.doi.org/10.1161/CIR.0b013e3181e8edf1] [PMID: 20625115]
[http://dx.doi.org/10.1038/oby.2007.368] [PMID: 18198319]
[http://dx.doi.org/10.1037/h0029874]
[http://dx.doi.org/10.1016/j.psc.2004.09.008] [PMID: 15733617]
[http://dx.doi.org/10.1056/NEJMoa050156] [PMID: 16291981]
[http://dx.doi.org/10.1016/j.amepre.2004.04.019] [PMID: 15275677]
[http://dx.doi.org/10.1037/0022-006X.62.1.165] [PMID: 8034818]
[http://dx.doi.org/10.1037/0022-006X.56.4.529] [PMID: 2848874]
[http://dx.doi.org/10.1016/j.neubiorev.2012.11.008] [PMID: 23261403]
[http://dx.doi.org/10.1016/j.neuroimage.2003.09.063] [PMID: 14980581]
[http://dx.doi.org/10.1038/oby.2001.92] [PMID: 11707534]
[http://dx.doi.org/10.2337/diabetes.49.5.838] [PMID: 10905495]
[http://dx.doi.org/10.1073/pnas.96.8.4569] [PMID: 10200303]
[http://dx.doi.org/10.1038/sj.ijo.0802558] [PMID: 14676847]
[http://dx.doi.org/10.1093/ajcn/84.4.725] [PMID: 17023697]
[http://dx.doi.org/10.1093/ajcn/86.3.573] [PMID: 17823419]
[http://dx.doi.org/10.1080/07315724.2009.10719799] [PMID: 20516266]
[http://dx.doi.org/10.1146/annurev.clinpsy.2.022305.095249] [PMID: 17716074]
[http://dx.doi.org/10.1016/j.brs.2008.06.004] [PMID: 20633386]
[http://dx.doi.org/10.1016/j.tics.2005.09.001] [PMID: 16182596]
[http://dx.doi.org/10.1016/j.nicl.2015.03.016] [PMID: 26110109]
[http://dx.doi.org/10.1016/j.appet.2014.03.010] [PMID: 24656950]
[http://dx.doi.org/10.1016/j.appet.2011.02.013] [PMID: 21352881]
[http://dx.doi.org/10.1016/j.appet.2007.09.016] [PMID: 18243412]
[http://dx.doi.org/10.3945/ajcn.113.075481] [PMID: 25099550]
[http://dx.doi.org/10.1016/j.appet.2014.08.005] [PMID: 25128836]
[http://dx.doi.org/10.1161/01.cir.0000437739.71477.ee]
[http://dx.doi.org/10.1111/j.1467-789X.2004.00125.x] [PMID: 14969507]
[http://dx.doi.org/10.1136/bmj.39385.413113.25] [PMID: 18006966]
[http://dx.doi.org/10.1172/JCI17953] [PMID: 12618507]
[http://dx.doi.org/10.1002/oby.20584] [PMID: 24136928]
[http://dx.doi.org/10.1016/j.gtc.2010.01.001] [PMID: 20202580]
[http://dx.doi.org/10.1016/j.pcad.2013.09.005] [PMID: 24438739]
[http://dx.doi.org/10.1038/oby.2011.330] [PMID: 22051941]
[http://dx.doi.org/10.1016/S0140-6736(11)60205-5] [PMID: 21481449]
[http://dx.doi.org/10.3945/ajcn.111.024927] [PMID: 22158731]
[http://dx.doi.org/10.1056/NEJMoa0909809] [PMID: 20647200]
[http://dx.doi.org/10.1210/jc.2011-1256] [PMID: 21795446]
[http://dx.doi.org/10.1002/1098-2396(20010101)39:1<32:AID-SYN5>3.0.CO;2-3] [PMID: 11071707]
[http://dx.doi.org/10.1517/14728214.2011.609168] [PMID: 21834735]
[http://dx.doi.org/10.1136/bmj.1.5588.352] [PMID: 15508204]
[http://dx.doi.org/10.1016/j.mcna.2017.08.010] [PMID: 29156182]
[http://dx.doi.org/10.1056/NEJMoa1411892] [PMID: 26132939]
[http://dx.doi.org/10.1001/jama.2015.9676] [PMID: 26284720]
[http://dx.doi.org/10.1161/CIRCULATIONAHA.111.040139] [PMID: 22869859]
[http://dx.doi.org/10.1001/jama.299.3.316] [PMID: 18212316]
[http://dx.doi.org/10.1097/SLA.0b013e3181b92480] [PMID: 19730234]
[http://dx.doi.org/10.1016/j.amjmed.2008.05.036] [PMID: 18823860]
[http://dx.doi.org/10.1016/S0140-6736(12)60401-2] [PMID: 22683132]
[http://dx.doi.org/10.1016/j.soard.2010.07.011] [PMID: 20947447]
[http://dx.doi.org/10.1002/bjs.1800660906] [PMID: 497645]
[http://dx.doi.org/10.1159/000363480] [PMID: 26288594]
[http://dx.doi.org/10.1007/s11695-011-0496-9] [PMID: 21874519]
[http://dx.doi.org/10.3945/ajcn.2009.27583] [PMID: 19439456]
[http://dx.doi.org/10.1381/0960892053268264]
[http://dx.doi.org/10.1007/s11695-008-9762-x] [PMID: 19002740]
[http://dx.doi.org/10.1007/s00464-012-2510-2] [PMID: 22936440]
[http://dx.doi.org/10.1097/00000658-197710000-00012] [PMID: 907395]
[http://dx.doi.org/10.3945/ajcn.2010.29870] [PMID: 20739420]
[http://dx.doi.org/10.1055/s-0032-1328594]
[http://dx.doi.org/10.1007/s11695-008-9489-8] [PMID: 18369680]
[http://dx.doi.org/10.1097/SLA.0b013e3182a5034b] [PMID: 24018646]