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Endocrine, Metabolic & Immune Disorders - Drug Targets

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ISSN (Print): 1871-5303
ISSN (Online): 2212-3873

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Research Article

Erectile Dysfunction in Patients with Multiple Chronic Conditions: A Cross- Sectional Study

Author(s): Giuseppe Lisco, Nicola Bartolomeo, Maria Isabella Ramunni, Anna De Tullio, Matteo Domenico Carbone, Edoardo Guastamcchia, Giovanni De Pergola, Vincenzo Triggiani and Vito Angelo Giagulli*

Volume 23, Issue 3, 2023

Published on: 05 December, 2022

Page: [396 - 404] Pages: 9

DOI: 10.2174/1871530322666220523130212

Price: $65

Abstract

Background: The prevalence of erectile dysfunction (ED) rises with the number and severity of chronic diseases.

Aims: This cross-sectional study assessed the frequency and severity of ED in patients with multiple chronic conditions.

Methods: The 5-item International Index of Erectile Function questionnaire (IIEF-5) was used to diagnose and classify ED. The Charlson Comorbidity Index (CCI) was used to assess the burden of chronic comorbidity. The primary outcome was to assess the ED frequency according to CCI severity. The secondary outcomes included the assessment of the correlation between 1) IIEF-5 and total testosterone (TT), 2) CCI and TT, and 3) IIEF-5 and CCI. Lastly, the CCI and modified CCI (mCCI) performances were compared with each other.

Results: The overall frequency of ED increased along with the CCI score severity: 45% for CCI=0; 95% for CCI=1; 91% for CCI=2; 99% for CCI≥3 (p<.0001). CCI correlated negatively with TT levels and IIEF-5 score (r=-0.34 and -0.44; p<.0001). Compared to the CCI, a novel proposed mCCI performs well.

Discussion: The frequency and severity of ED are relevant in outpatients with sexual complaints and those with chronic comorbidities. Despite limitations, mCCI may be considered a reliable tool to assess the overall burden of multiple chronic conditions in patients with comorbidities.

Conclusion: ED is a reliable proxy of overall male health. Further studies are needed to confirm this potential application.

Keywords: Erectile dysfunction, Charlson comorbidity index, Type 2 diabetes, Comorbidities, Cross-sectional study.

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