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Current Molecular Medicine

Editor-in-Chief

ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

New Costimulatory Families: Signaling Lymphocytic Activation Molecule in Adaptive Allergic Responses

Author(s): Samir S. Makani, Kai Y. Jen and Patricia W. Finn

Volume 8, Issue 5, 2008

Page: [359 - 364] Pages: 6

DOI: 10.2174/156652408785161005

Price: $65

Abstract

The generation of an allergic immune response requires at least two signals for complete activation of T cells. Costimulatory molecules are integral to the second signal. In this review, we analyze the costimulatory molecule signaling lymphocytic activation molecule (SLAM) and other recently described SLAM family members. We highlight recent findings that position SLAM as critical for allergic inflammation and its role in modulation of cytokine secretion. Furthermore, a possible role of SLAM as a link between the adaptive and innate immune response is also discussed. Understanding the role of costimulatory molecules, including SLAM and SLAM family members, may elucidate mechanisms involved in the allergic immune response, and suggest potential therapeutic opportunities.

Keywords: Allergy, SLAM, SAP, XLP, costimulatory molecules


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