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Letters in Drug Design & Discovery

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ISSN (Print): 1570-1808
ISSN (Online): 1875-628X

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Research Article

Design and Optimization of Sustained-Release Trihexyphenidyl Hydrochloride Nanoparticles: Design of the Experiment Approach

Author(s): Ajaygiri Kamalgiri Goswami, Premraj Ramesh Patil and Nitin Rajendra Shirsath*

Volume 20, Issue 3, 2023

Published on: 15 July, 2022

Page: [343 - 352] Pages: 10

DOI: 10.2174/1570180819666220512103016

Price: $65

Abstract

Background: Trihexyphenidyl chloride (THP) is an antidyskinetic medication used in single and combination therapy to symptomatically treat Parkinson's disease. Due to its fast metabolism and short elimination of half-life, it causes changes in plasma concentrations and requires frequent dosage.

Objective: The aim of this study was to prepare a sustained release formulation of Trihexyphenidyl chloride (THP).

Materials and Methods: Using chitosan as the natural polymer, the polymeric nanoparticles were prepared by using the ionic gelation method. A 32 response surface methodology was used to optimize the effects of independent variables, such as the amount of polymer (X1mg) and the amount of copolymer (X2mg), on dependent variables, such as entrapment efficiency (% EE) (Y1) and drug release (% DR) (Y2).

Results: The prepared formulations were evaluated for Fourier transform-infrared (FTIR), X-ray Diffraction, Field scanning micrographs (FESEM), and In vitro drug release. Higher drug entrapment efficiency was observed for batch T11. FTIR confirmed the loading of trihexyphenidyl drug into the chitosan matrix. X-ray diffraction pattern indicated that the degree of crystallinity of pure drug was reduced in the formulated NPs.

Conclusion: The drug release from the formulated batches (T1-T13) showed sustained-release action for around 9-14 hrs. The technique reduced the dosing frequencies and possible side effects of trihexyphenidyl chloride.

Keywords: Trihexyphenidyl chloride, nanoparticles, 32 response surface methodology, drug release, sustained release, chitosan.

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Graphical Abstract

[1]
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[http://dx.doi.org/10.5530/ijper.53.4s.149]
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Sagar, R. Pardeshi, Harshal A. Mistari, and Nitin R. Shirsath, Development and optimization of sustained release moxifloxacin hydrochloride loaded nanoemulsion for ophthalmic drug delivery: A 32 factorial design approach. Micro Nanosyst., 2020, 12, 1.
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Shirsath, N.R.; Goswami, A.K. Design and development of sustained release vildagliptin-loaded silica nanoparticles for enhancing oral bioavailability. Bionanoscience, 2021, 11(2), 324-335.
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[14]
Shirsath, N.R.; Goswami, A.K. Design and development of solid dispersion of valsartan by a lyophilization technique: A 32 factorial design approach. Micro Nanosyst., 2021, 13(1), 90-102.
[http://dx.doi.org/10.2174/1876402912666200206155430]

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