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Current Organic Chemistry

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ISSN (Print): 1385-2728
ISSN (Online): 1875-5348

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Review Article

Dracaenone, a Novel Type of Homoisoflavone: Natural Source, Biological Activity and Chemical Synthesis

Author(s): Mei-Mei Li, Jun Lu* and Yun Deng*

Volume 26, Issue 9, 2022

Published on: 09 June, 2022

Page: [887 - 897] Pages: 11

DOI: 10.2174/1385272826666220510151029

Price: $65

Abstract

The discovery and synthesis of natural products, especially those possessing novel scaffolds, are crucial to the development of new drugs. Dracaenones are part of homoisoflavone natural products, owning a complex spiro-bridged polycyclic structure bearing benzylic quaternary carbon centers, and some of them reveal considerable biological activity. There have been continuous studies on these compounds due to the rare structure and important biological properties. However, a systematic summary and analysis for dracaenone is lacking. This review aims to generally summarize the natural source, synthetic strategies and biological activities of dracaenones, moreover, the limitations, challenges, and future prospects were discussed, wishing to provide references for the follow-up study of compounds with similar skeleton.

Keywords: Dracaenone, natural products, spiro-bridged scaffold, natural source, synthesis, biological activities.

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