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Combinatorial Chemistry & High Throughput Screening

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ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

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Case Report

A Case Report of Burkholderia mallei Infection Leading to Pneumonia

Author(s): Guanfeng He, Yu Zeng, Qizhong He, Tuxuan Liu, Nanhong Li, Hui Lin, Muhong Zeng, Yonglong Li, Min Peng*, Junfen Cheng*, Wang Liu* and Weimin Yao*

Volume 26, Issue 1, 2023

Published on: 22 June, 2022

Page: [241 - 245] Pages: 5

DOI: 10.2174/1386207325666220509152221

Price: $65

Abstract

Background: Glanders is a rare zoonotic disease caused by Burkholderia mallei. Humans can be infected by B. mallei, which causes cutaneous lymphadenitis and pneumonia, leading to sepsis and death in severe cases.

Case Presentation: We report a case of a 60-year-old male who was diagnosed with glanders. The patient who had a history of diabetes presented with cough, expectoration, and fever. Computed tomography (CT) imaging showed B. mallei infection in the right upper lobe of the lung with mediastinal lymph node involvement and the lingual segment of the left lung. Moreover, the posterior basal segment of the lower lobe of both lungs had inflammation. Subsequently, B. mallei infection was confirmed by lymph node biopsy and bronchoalveolar lavage multiplex PCR-based targeted gene sequencing. After meropenem treatment, the patient was discharged, and CT imaging showed reduced absorption of pulmonary inflammatory lesions.

Conclusions: Glanders is a rare disease that can cause skin infection, lymphadenitis, and pneumonia, and in severe cases, it can be life-threatening. The diagnosis of this disease mainly relies on microbiological culture and pathological biopsy. Diagnosis is also facilitated by multiplex PCRbased targeted gene sequencing. Glanders is treated with cephalosporins, carbapenems, and other sensitive antibiotics.

Keywords: Glanders, Zoonosis, Burkholderia mallei, multiplex PCR, targeted gene sequencing, pnemonia.

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Graphical Abstract

[1]
Whitlock, G.C.; Estes, D.M.; Torres, A.G. Glanders: Off to the races with Burkholderia mallei. FEMS Microbiol. Lett., 2007, 277(2), 115-122.
[http://dx.doi.org/10.1111/j.1574-6968.2007.00949.x] [PMID: 18031330]
[2]
Van Zandt, K.E.; Greer, M.T.; Gelhaus, H.C. Glanders: An overview of infection in humans. Orphanet J. Rare Dis., 2013, 8(1), 131.
[http://dx.doi.org/10.1186/1750-1172-8-131] [PMID: 24004906]
[3]
Waag, D.M.; Chance, T.B.; Trevino, S.R.; Rossi, F.D.; Fetterer, D.P.; Amemiya, K.; Dankmeyer, J.L.; Ingavale, S.S.; Tobery, S.A.; Zeng, X.; Kern, S.J.; Worsham, P.L.; Cote, C.K.; Welkos, S.L. Comparison of three non-human primate aerosol models for glanders, caused by Burkholderia mallei. Microb. Pathog., 2021, 155, 104919.
[http://dx.doi.org/10.1016/j.micpath.2021.104919] [PMID: 33915206]
[4]
Derbyshire, J.B. The eradication of glanders in Canada. Can. Vet. J., 2002, 43(9), 722-726.
[PMID: 12240535]
[5]
Fritz, D.L.; Waag, D.M. 7 Glanders; Biodefense Research Methodology and Animal Models, 2012, p. 99.
[6]
Gregory, BC; Waag, DM GlandersMedical aspects of biological warfare, 2007, 121, p. 146.
[7]
Georgiades, C.; Fishman, E.K. Clinical image. Glanders disease of the liver and spleen: CT evaluation. J. Comput. Assist. Tomogr., 2001, 25(1), 91-93.
[http://dx.doi.org/10.1097/00004728-200101000-00016] [PMID: 11176300]
[8]
Smart, J.K. History of chemical and biological warfare: An American perspective. In: Medical aspects of chemical and biological warfare washington; Office of the surgeon general: DC, 1997, pp. 9-86.
[9]
Wheelis, M. First shots fired in biological warfare. Nature, 1998, 395(6699), 213.
[http://dx.doi.org/10.1038/26089] [PMID: 9751039]
[10]
Huber, F.G.; Kristensen, K.L.; Holden, I.K.; Andersen, P.H.; Bakir, B.; Jørgensen, A.; Lorentsson, H.J.N.; Bjorn-Mortensen, K.; Johansen, I.S.; Ravn, P. The prevalence of diabetes among tuberculosis patients in Denmark. BMC Infect. Dis., 2022, 22(1), 64.
[http://dx.doi.org/10.1186/s12879-022-07048-4] [PMID: 35045811]
[11]
Peacock, S.J.; Schweizer, H.P.; Dance, D.A.; Smith, T.L.; Gee, J.E.; Wuthiekanun, V.; DeShazer, D.; Steinmetz, I.; Tan, P.; Currie, B.J. Management of accidental laboratory exposure to Burkholderia pseudomallei and B. mallei. Emerg. Infect. Dis., 2008, 14(7), e2.
[http://dx.doi.org/10.3201/eid1407.071501] [PMID: 18598617]
[12]
Santos, Júnior ELd; Moura, JdCR; Protásio, BKPF; Parente, VAS; Veiga, MHND Clinical repercussions of Glanders (Burkholderia mallei infection) in a Brazilian child: A case report. Rev. Soc. Bras. Med. Trop., 2020, 53.
[13]
Dembek, Z.F. Medical aspects of biological warfare; Government Printing Office, 2007.
[14]
Gu, W.; Miller, S.; Chiu, C.Y. Clinical metagenomic next-generation sequencing for pathogen detection. Annu. Rev. Pathol., 2019, 14, 319-338.
[http://dx.doi.org/10.1146/annurev-pathmechdis-012418-012751] [PMID: 30355154]
[15]
Chiang, C.Y.; Zhong, Y.; Ward, M.D.; Lane, D.J.; Kenny, T.; Rosario-Acevedo, R.; Eaton, B.P.; Treviño, S.R.; Chance, T.B.; Hu, M.; Worsham, P.L.; Waag, D.M.; Moore, R.T.; Cazares, L.H.; Cote, C.K.; Zhou, Y.; Panchal, R.G. Proteomic analysis of non-human primate peripheral blood mononuclear cells during Burkholderia mallei infection reveals a role of ezrin in glanders pathogenesis. Front. Microbiol., 2021, 12, 625211.
[http://dx.doi.org/10.3389/fmicb.2021.625211] [PMID: 33967974]
[16]
Wernery, U.; Chan, E.; Raghavan, R.; Teng, J.L.L.; Syriac, G.; Siu, S.Y.; Joseph, M.; Yeung, M.L.; Jia, L.; Cai, J.P.; Chiu, T.H.; Lau, S.K.P.; Woo, P.C.Y. Development of a sensitive competitive enzyme-linked immunosorbent assay for serodiagnosis of Burkholderia mal-lei, a Tier 1 select agent. PLoS Negl. Trop. Dis., 2021, 15(12), e0010007.
[http://dx.doi.org/10.1371/journal.pntd.0010007] [PMID: 34932554]
[17]
Deurenberg, R.H.; Bathoorn, E.; Chlebowicz, M.A.; Couto, N.; Ferdous, M.; García-Cobos, S.; Kooistra-Smid, A.M.; Raangs, E.C.; Rose-ma, S.; Veloo, A.C.; Zhou, K.; Friedrich, A.W.; Rossen, J.W. Application of next generation sequencing in clinical microbiology and infec-tion prevention. J. Biotechnol., 2017, 243, 16-24.
[http://dx.doi.org/10.1016/j.jbiotec.2016.12.022] [PMID: 28042011]

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