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Review Article

The Interaction Network of MicroRNAs with Cytokines and Signaling Pathways in Allergic Asthma

Author(s): Ali Farmanzadeh*, Durdi Qujeq and Tooba Yousefi

Volume 11, Issue 2, 2022

Published on: 23 August, 2022

Page: [104 - 117] Pages: 14

DOI: 10.2174/2211536611666220428134324

Price: $65

Abstract

Allergic asthma is a complicated disease that is affected by many factors. Numerous cytokines and signaling pathways are attributed to the cause of asthma symptoms. MicroRNAs (miRNAs) are a group of small non-coding single-stranded RNA molecules that are involved in gene silencing and posttranscriptional regulation of gene expression by targeting mRNAs. In pathological conditions, altered expression of microRNAs differentially regulates cytokines and signaling pathways and therefore, can be the underlying reason for the pathogenesis of allergic asthma. Indeed, microRNAs participate in airway inflammation via inducing airway structural cells and activating immune responses by targeting cytokines and signaling pathways. Thus, to make a complete understanding of allergic asthma, it is necessary to investigate the communication network of microRNAs with cytokines and signaling pathways which is contributed to the pathogenesis of allergic asthma. Here, we shed light on this aspect of asthma pathology by Summarizing our current knowledge of this topic.

Keywords: Allergic asthma, microRNAs, cytokines, signaling pathways

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Graphical Abstract

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