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Current Molecular Medicine

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ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

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Mini-Review Article

Molecular Mechanisms of miR-214 Involved in Cancer and Drug Resistance

Author(s): Elham Karimi, Aghdas Dehghani, Hanieh Azari, Mahboobeh Zarei, Mohammad Shekari and Pegah Mousavi*

Volume 23, Issue 7, 2023

Published on: 07 September, 2022

Page: [589 - 605] Pages: 17

DOI: 10.2174/1566524022666220428112744

Price: $65

Abstract

As a transcriptional regulation element, the microRNA plays a crucial role in many aspects of molecular biological processes, like cellular metabolism, cell division, cell death, cell movement, intracellular signaling, and immunity. Previous studies suggested that microRNA-214 (miR-214) is probably a valuable cancer marker. In this study, a brief updated overview of the vital dual role of miR-214 in cancer as a tumor suppressor or oncogene was provided. We also examined target genes and signaling pathways related to the dysregulation of miR-214 reported in previous experimental research on various human diseases. To highlight the critical function of miR-214 in the prognostic, diagnostic, and pathogenesis of cancer diseases, we focused on the probable clinical biomarker and drug resistance function of miR-214. The current research provides a comprehensive perspective of the regulatory mechanisms governed by miR-214 in human disease pathogenesis and a list of probable candidates for future study.

Keywords: microRNA, miR-214, target genes, cancer diseases, RNAs, miRNA

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