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Current Molecular Medicine

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ISSN (Print): 1566-5240
ISSN (Online): 1875-5666

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Review Article

The Role of Bone Morphogenetic Protein 4 in Lung Diseases

Author(s): Xiaoxiao Dong, Yimin Mao* and Pengfei Gao*

Volume 23, Issue 4, 2023

Published on: 24 June, 2022

Page: [324 - 331] Pages: 8

DOI: 10.2174/1566524022666220428110906

Price: $65

Abstract

Bone morphogenetic protein 4 (BMP4) is a multifunctional secretory protein that belongs to the transforming growth factor β superfamily. BMPs transduce their signaling to the cytoplasm by binding to membrane receptors of the serine/threonine kinase family, including BMP type I and type II receptors. BMP4 participates in various biological processes, such as embryonic development, epithelial-mesenchymal transition, and maintenance of tissue homeostasis. The interaction between BMP4 and the corresponding endogenous antagonists plays a key role in the precise regulation of BMP4 signaling. In this paper, we review the pathogenesis of BMP4-related lung diseases and the foundation on which BMP4 endogenous antagonists have been developed as potential targets.

Keywords: Bone morphogenetic protein 4, congenital pulmonary airway malformation, pulmonary artery hypertension, pulmonary fibrosis, asthma, chronic obstructive pulmonary disease, non-small cell lung cancer, endogenous antagonists.

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