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Review Article

针对肠屏障功能障碍诱导焦虑所涉及的各个方面的联合方法

卷 23, 期 11, 2022

发表于: 21 June, 2022

页: [1085 - 1098] 页: 14

弟呕挨: 10.2174/1389450123666220428093419

价格: $65

摘要

焦虑症是最常见的精神疾病之一。共患胃肠道疾病和焦虑症的高患病率，以及当前治疗的各种局限性，使得有必要寻找替代技术。肠脑轴是肠道和大脑之间的连接纽带。导致HPA轴刺激和焦虑的肠脑轴故障的原因之一是肠屏障功能障碍。肠道微生物，脂多糖和其他因素可以刺激这种肠道屏障的破坏。紧密连接蛋白、上皮屏障、粘膜、拓领样受体/骨髓分化因子88途径、激活的免疫系统和HPA轴都可能成为肠道屏障破坏引起的焦虑的潜在靶标。槲皮素和瑞巴派特，小檗碱和阿戈美拉汀，血管紧张素II受体1型阻断剂和卢比前列酮可以作用于这些靶标以提供抗焦虑作用。

关键词: 焦虑，肠屏障功能障碍，肠脑轴，紧密连接蛋白，免疫系统，HPA轴，皮质醇。

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