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Central Nervous System Agents in Medicinal Chemistry

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ISSN (Print): 1871-5249
ISSN (Online): 1875-6166

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Research Article

Behavioral Pharmacology of Five Uncommon Passiflora Species Indicates Sedative and Anxiolytic-like Potential

Author(s): Marna Eliana Sakalem*, Ricardo Tabach, Miriane de Oliveira and Elisaldo Araújo Carlini

Volume 22, Issue 2, 2022

Published on: 21 June, 2022

Page: [125 - 138] Pages: 14

DOI: 10.2174/1871524922666220426102650

Price: $65

Abstract

Background: There are over 500 species in the Passiflora genus, and while some of them are very well known in folk medicine for their anxiolytic effects, very little is known for the other genus representants, which could also present medicinal effects.

Objective: In this study, we performed an interspecific pharmacological comparison of five investigated Passiflora species, all native to Brazil, namely P. bahiensis, P. coccinea, P. quadrangularis, P. sidaefolia, and P. vitifolia.

Methods: Extracts were administered to mice before behavioral testing, including a general pharmacological screening and anxiolytic-like effect investigation.

Results: Three of the species (P. coccinea, P. quadrangularis, and P. sidaefolia) induced a decrease in locomotor activity of mice; P. coccinea also reduced the latency to sleep. Importantly, none of the species interfered with motor coordination. Oral administration evoked no severe signs of toxicity, even at higher doses. Regarding the anxiolytic-like profile, P. sidaefolia reduced the anxious-like behavior in the Holeboard test in a similar way to the positive control, Passiflora incarnata, while not affecting total motricity.

Conclusion: These results indicated that P. coccinea, P. quadrangularis, and P. sidaefolia reduced the general activity of mice and conferred a calmative/sedative potential to these three species, which must be further elucidated by future investigations.

Keywords: Passifloreaceae, maracuja, passionflower, hole-board, pharmacological screening, phytomedicine, medicinal plants, anxiolytic-like effect.

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