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Current Drug Safety

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ISSN (Print): 1574-8863
ISSN (Online): 2212-3911

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Case Report

Ascending Flaccid Paralysis Secondary to Hypokalemia in A Cancer Patient using Abiraterone - A Case Report

Author(s): Daniella Cristina Brites de Almeida*, Aline Luiza Costa, Barbara Lacerda de Oliveira Faria, Frederico Bruzzi de Carvalho and Marco Tulio Gualberto Cintra

Volume 18, Issue 1, 2023

Published on: 27 April, 2022

Page: [107 - 111] Pages: 5

DOI: 10.2174/1574886317666220425140053

Price: $65

Abstract

Background: Prostate cancer (PC) is the most common type of neoplasm in men and the fourth leading cause of mortality in Brazil. The prostate cancer refractory metastatic castration can be treated with abiraterone acetate (AA).

Case Presentation: Its use has been associated with increased survival. However, there are also side effects associated with the use of this drug, such as severe electrolyte disturbances.

Conclusion: The objective is to report the clinical case of a patient with castration-resistant metastatic prostate cancer who developed ascending flaccid paralysis secondary to severe hypokalemia, probably due to hyperaldosteronism secondary to the use of Abiraterone Acetate, despite the use of Prednisone.

Keywords: Abiraterone acetate, prostate neoplasms, hypokalemia, paralysis, case report, electrolyte disturbances.

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Graphical Abstract

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