Login Register Cart 0
Generic placeholder image

Current Drug Research Reviews

Editor-in-Chief

ISSN (Print): 2589-9775
ISSN (Online): 2589-9783

Back
Journal Home About Journal Editorial Board Current Issue Volumes/Issues
Subscribe
Clinical Trial

Effect of Evening Primrose Vaginal Capsule on Cervix Preparation and Duration of First Stage of Labor in Nulliparous Women Referred to Fatemieh Hospital in Hamadan, Iran: A Single-blind Randomized Controlled Trial

Author(s): Arezoo shayan, Seyedeh Zahra Masoumi*, Farideh Kazemi, Mansoureh Refaee, Maryam Ahmadi, Hadis Sourinezhad and Minoo Hamoun

Volume 14, Issue 3, 2022

Published on: 15 July, 2022

Page: [247 - 253] Pages: 7

DOI: 10.2174/2589977514666220418091807

Price: $65

Abstract

Background: Cervix preparation is one of the main steps in the onset of labor and is very important for success in initiating or inducing labor.

Objective: The present study aimed at investigating the effect of evening primrose vaginal capsule on the preparation of cervix and the consequences of labor in nulliparous women.

Methods: This randomized clinical trial study was conducted in 2018 on 100 nulliparous women referred to Fatemieh Hospital in Hamadan. In intervention group (50 people), one evening primrose capsule (500 mg) was used vaginally and then two hours later, another capsule was used, and placebo was used in the control group (50 people). Then, the dilatation, effacement, Bishop scores and duration of the first stage of the labor were compared in two groups after 4 hours. Statistical analysis was performed with SPSS 21. The significance level was considered to be 0.05.

Results: There was a statistically significant difference in the mean score and standard deviation of dilatation, effacement of cervix, bi-shop scores and duration of the first stage of labor four hours after the intervention in the intervention and Placebo groups by controlling the effect of potential confounding factors (P <0.001).

Conclusion: The results showed that the use of evening primrose vaginal capsules can reduce the length of the first stage of labor, improve Bishop score, and soften and ripen the cervix.

Keywords: Cervical ripening, evening primrose oil, primiparity, clinical trial, cervical ripening, first stage labor.

« Previous Next »
Graphical Abstract

[1]
Esamai, F.; Nangami, M.; Tabu, J.; Mwangi, A.; Ayuku, D.; Were, E. A system approach to improving maternal and child health care delivery in Kenya: innovations at the community and primary care facilities (a protocol). Reprod. Health, 2017, 14(1), 1-8.
[2]
Mylonas, I.; Friese, K. Indications for and risks of elective cesarean section. Dtsch. Arztebl. Int., 2015, 112(29-30), 489-495.
[http://dx.doi.org/10.3238/arztebl.2015.0489] [PMID: 26249251]
[3]
Yellon, S.M. Immunobiology of cervix ripening. Front. Immunol., 2020, 3156
[http://dx.doi.org/10.3389/fimmu.2019.03156]
[4]
Hall, H.G.; McKenna, L.G.; Griffiths, D.L. Complementary and alternative medicine for induction of labour. Women Birth, 2012, 25(3), 142-148.
[http://dx.doi.org/10.1016/j.wombi.2011.03.006] [PMID: 21524953]
[5]
Pierce, S.; Bakker, R.; Myers, D.A.; Edwards, R.K. Clinical insights for cervical ripening and labor induction using prostaglandins. AJP Rep., 2018, 8(4), e307-e314.
[http://dx.doi.org/10.1055/s-0038-1675351] [PMID: 30377555]
[6]
Souter, V; Painter, I; Sitcov, K; Caughey, AB Maternal and newborn outcomes with elective induction of labor at term. American J Obst Gynecol, 2019, 220(3), 273. e1-273. e11.
[http://dx.doi.org/10.1016/j.ajog.2019.01.223]
[7]
Greenspan, M. Acupuncture as a Means to Promote Full Term Vaginal Delivery; Yo San University: Los Angeles, California, 2015.
[8]
Faucett, A.M.; Daniels, K.; Lee, H.C.; El-Sayed, Y.Y.; Blumenfeld, Y.J. Oral misoprostol versus vaginal dinoprostone for labor induction in nulliparous women at term. J. Perinatol., 2014, 34(2), 95-99.
[http://dx.doi.org/10.1038/jp.2013.133] [PMID: 24157494]
[9]
Shoja, S.; Yousefi Sharami, S.R.; Shahgheibi, S. Contrastive analysis of vaginal misoprostol and foley catheter in cervical ripening and labor induction. J Obstetrics Gynecol Cancer Res, 2019, 4(3), 105-110.
[http://dx.doi.org/10.30699/jogcr.4.3.105]
[10]
Nauta, B.A. The use of electroacupuncture for cervical ripening in pregnant women; University of Nebraska Medical Center: Omaha, Nebraska, 2016.
[11]
Eriksson, A.; Jeppesen, S.; Krebs, L. Induction of labour in nulliparous women- quick or slow: A cohort study comparing slow-release vaginal insert with low-dose misoprostol oral tablets. BMC Pregnancy Childbirth, 2020, 20(1), 79.
[http://dx.doi.org/10.1186/s12884-020-2770-0] [PMID: 32033600]
[12]
Ghasemnezhad, A.; Honermeier, B. Effects of nitrogen and pre-harvest desiccation on seed yield and oil quality of evening primrose (Oenothera biennis L.). J. Med. Plants By-Prod., 2012, 1, 61-65.
[13]
Mahboubi, M. Evening Primrose (Oenothera biennis) oil in management of female ailments. J. Menopausal Med., 2019, 25(2), 74-82.
[http://dx.doi.org/10.6118/jmm.18190] [PMID: 31497576]
[14]
O’Mathúna, D. Evening primrose oil for symptoms of premenstrual syndrome and menopause. Alternative Medicine Alert, 2010, 13(12), 137-140.
[15]
Majdinasab, N.; Namjoyan, F.; Taghizadeh, M.; Saki, H. The effect of evening primrose oil on fatigue and quality of life in patients with multiple sclerosis. Neuropsychiatr. Dis. Treat., 2018, 14, 1505-1512.
[http://dx.doi.org/10.2147/NDT.S149403] [PMID: 29928122]
[16]
Jahdi, F Effect of oral evening primrose capsules on ripening of the cervix in nulliparous Iranian pregnant women (a randomized trial). Acta Medica Mediterranea, 2016, 32(Specia), 1273-1279.
[17]
Kalati, M.; Kashanian, M.; Jahdi, F.; Naseri, M.; Haghani, H.; Sheikhansari, N. Evening primrose oil and labour, is it effective? A randomised clinical trial. J. Obstet. Gynaecol., 2018, 38(4), 488-492.
[http://dx.doi.org/10.1080/01443615.2017.1386165] [PMID: 29426270]
[18]
Saki, M.; Akbari, S.; Saki, M.; Tarrahi, M.J.; Gholami, M.; Pirdadeh, S. The effect of primrose oil on the premenstrual syndrome among the female students in Lorestan University of Medical Sciences: A triple blind study. J Nurs Midwifery Sci, 2015, 2(1), 20-26.
[http://dx.doi.org/10.4103/2345-5756.231415]
[19]
Masoumi, Z.; Keramat, A.; Hajiaghaee, R. Systematic review on effect of herbal medicine on pain after perineal episiotomy and cesarean cutting. Faslnamah-i Giyahan-i Daruyi, 2011, 10(40), 1-16.
[20]
Shayan, A.; Masoumi, S.Z.; Shobeiri, F.; Tohidi, S.; Khalili, A. Comparing the effects of agnugol and metformin on oligomenorrhea in patients with polycystic ovary syndrome: A randomized clinical trial. J. Clin. Diagn. Res., 2016, 10(12), QC13-QC16.
[http://dx.doi.org/10.7860/JCDR/2016/22584.9040] [PMID: 28208942]
[21]
Girlie, V-M. The efficacy of evening primrose oil as a cervical ripening agent for gynecologic procedures: A single-blinded, randomized controlled trial. Philipp. J. Obstet. Gynecol., 2015, 39(1), 25-28.
[22]
Najafi, M.I.; Loripoor, M.; Saghafi, Z.; Kazemi, M. The effect of vaginal evening primrose on the Bishop score of term nulliparous women. Nursing Practice Today, 2019, 6(4), 202-211.
[http://dx.doi.org/10.18502/npt.v6i4.1942]
[23]
Shahali, S. The effect of vaginal evening primrose capsule on cervical ripening in nulliparous women with post-term pregnancy: A clinical trial. Majallah-i Zanan, Mamai va Nazai-i Iran, 2018, 21(8), 30-38.
[24]
Nonette, D.N. The effectiveness of evening primrose oil gel capsule as a cervical ripening agent during labor induction as measured by bishop score on term singleton pregnant patients. Philipp. J. Obstet. Gynecol., 2017, 41(2), 1-4.
[25]
Ty-Torredes, K.A. The effect of oral evening primrose oil on bishop score and cervical length among term gravidas. Am. J. Obstet. Gynecol., 2006, 195(6), S30.
[http://dx.doi.org/10.1016/j.ajog.2006.10.078]
[26]
Vahdat, M.; Tahermanesh, K.; Mehdizadeh Kashi, A. Evening primrose oil effect on the ease of cervical ripening and dilatation before operative hysteroscopy. Thrita, 2015, 4(3), e29876.
[http://dx.doi.org/10.5812/thrita.29876]
[27]
Marian, C. A randomized controlled trial of evening primrose oil for cervical priming prior to operative hysterroscopy. Philippine J Reprod Endocrinol Infertility, 2009, 6(2), 35-40.
[28]
González, C.A.; Salas Guerra, A.; Arroyo Llano, R. Conducta del cuello uterino durante el embarazo, parto y puerperio. Ginecol Obstet Mex, 2010, 78(2), 132-137.
[PMID: 20939217]
[29]
Hawkins, J.S.; Wing, D.A. Current pharmacotherapy options for labor induction. Expert Opin. Pharmacother., 2012, 13(14), 2005-2014.
[http://dx.doi.org/10.1517/14656566.2012.722622] [PMID: 22963686]
[30]
Umeda-Sawada, R.; Fujiwara, Y.; Ushiyama, I. Distribution and metabolism of dihomo-γ-linolenic acid (DGLA, 20:3n-6) by oral supplementation in rats. Biosci. Biotechnol. Biochem., 2006, 70(9), 2121-2130.
[http://dx.doi.org/10.1271/bbb.60057] [PMID: 16960355]
[31]
Dove, D.; Johnson, P. Oral evening primrose oil: Its effect on length of pregnancy and selected intrapartum outcomes in low-risk nulliparous women. J. Nurse Midwifery, 1999, 44(3), 320-324.
[http://dx.doi.org/10.1016/S0091-2182(99)00055-5] [PMID: 10380450]

Rights & Permissions Print Cite
Article Metrics
4
© 2024 Bentham Science Publishers | Privacy Policy