Oculomotor Abnormalities during Reading in the Offspring of Late-Onset
Alzheimer’s Disease

doi:10.2174/1567205019666220413075840

摘要

引言: 阅读过程中的眼动模式得到了很好的定义和记录。每一次眼球运动都以一个固定点结束，这使大脑能够处理传入的信息并对随后的扫视进行编程。在这项研究中，我们调查了在阅读任务中，晚发性阿尔茨海默病（O-LOAD）的认知正常的中年后代是否已经存在眼动变化。方法: 18名无负荷家族史的O负荷和18名年龄匹配的健康个体参与了研究。参与者坐在一个20英寸的液晶显示器前，并在显示器上展示单个句子。用眼动跟踪器以1000Hz的采样率记录眼动。结果: 阅读过程中的眼动分析表明，与对照组相比，O-LOAD表现出更多的注视、更短的眼跳和更短的注视持续时间。结论: 目前的研究表明，在阅读过程中，O-LOAD的眼动发生了变化。O负荷眼动行为可被视为动眼神经损伤的初始迹象。因此，在阅读过程中对眼球运动的评估可能是监测明确定义的认知资源的有用工具。

关键词: 晚发、阿尔茨海默病、阅读能力、动眼神经行为、认知障碍、O负荷的后代

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DOI https://dx.doi.org/10.2174/1567205019666220413075840	Print ISSN 1567-2050
Publisher Name Bentham Science Publisher	Online ISSN 1875-5828

当代阿耳茨海默病研究

迟发性阿尔茨海默病后代阅读时的动眼神经异常

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当代阿耳茨海默病研究

迟发性阿尔茨海默病后代阅读时的动眼神经异常

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