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Letters in Organic Chemistry

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ISSN (Print): 1570-1786
ISSN (Online): 1875-6255

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Short Communication

Concise Synthesis of Goniothalesdiol A

Author(s): Ping Li Zeng, Junhui Zhou, Xuechao Yang, Dong Wang* and Zhibing Dong

Volume 19, Issue 12, 2022

Published on: 14 June, 2022

Page: [1145 - 1148] Pages: 4

DOI: 10.2174/1570178619666220408121439

Price: $65

Abstract

A concise and efficient synthesis of styryllactone derivative, goniothalesdiol A, has been achieved in the six longest linear steps with 17.7% overall yield. The key steps of our synthesis involved PdCl2-mediated Wacker-type oxidative cyclisation and one-pot tandem Wittig olefination- Michael addition.

Keywords: Total synthesis, goniothalesdiol A, styryllactone, L-erythrose, Wacker oxidation, Wittig olefination-Michael addition.

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