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Current Nutrition & Food Science

Editor-in-Chief

ISSN (Print): 1573-4013
ISSN (Online): 2212-3881

Mini-Review Article

Effects of Punica granatum Fruit (a Super Food) Juice on Human Health

Author(s): Luigi Ferrara, Marko Joksimovic and Stefania D'Angelo*

Volume 18, Issue 7, 2022

Published on: 12 May, 2022

Page: [618 - 628] Pages: 11

DOI: 10.2174/1573401318666220407101325

Price: $65

Abstract

Background: One of the oldest known edible fruits, the pomegranate (Punica granatum L.), is now widely consumed worldwide. Its fruits and seed are rich in many bioactive compounds, such as polyphenols, and the scientific interest in this plant has been constantly growing in recent years.

Introduction: Pomegranate fruit and its juice have been shown to have health benefits relating to their antioxidant and anti-inflammatory properties. They are used in alternative medicine as adaptogens and ergogens, protecting against many neurological, cardiovascular, gastrointestinal, liver, and skin disorders.

Methods: Given the amount of evidence, this narrative review does not seek to supply a comprehensive summary of all study findings but rather focuses on human clinical trials related to the last five years. In this regard, we have performed a check in MEDLINE, and clinical trials presented in this time are summarized.

Results: Pomegranate consumption as a table fruit or juice, which is high in polyphenols, is thus recommended in human diet for its health benefits.The consumption of pomegranate fruit symbolizes a promising therapeutic approach to avert many chronic syndromes.

Conclusion: The findings highlight the need for bigger, more thoroughly planned human clinical trials to continue research into the potential particular effects of pomegranate fruit, as well as to determine the ideal dose and duration of pomegranate juice supplementation.

Keywords: Pomegranate, polyphenols, oxidative stress, antioxidant, clinical trials, human health, performance.

Graphical Abstract

[1]
Holland D, Hatib K, Bar-Ya’akov I. Pomegranate: Botany, horticulture, breeding. In: Janick J, Ed.Horticultural Reveiws. Hoboken, NJ: John Wiley & Sons 2009; pp. 127-91.
[http://dx.doi.org/10.1002/9780470593776.ch2]
[2]
Longtin R. The pomegranate: Nature’s power fruit? J Natl Cancer Inst 2003; 95(5): 346-8.
[http://dx.doi.org/10.1093/jnci/95.5.346] [PMID: 12618495]
[3]
Levin GM. Pomegranate Roads: A Soviet Botanist’s Exile from Eden. Forestville, CA: Floreat Press 2006; pp. 15-183.
[4]
Fahan A. The leaf The flower The seedPlant Anatomy. Jerusalem: Hakkibutz Hameuhad Publishing House Ltd 1976; pp. 419-30.
[5]
Holland D, Bar-Ya’akov I. Pomegranate: Aspects concerning dynamics of health beneficial phytochemicals and therapeutic properties with respect to the tree cultivar and the environment. In: Yaniv Z, Dudai N, Eds.Medicinal and Aromatic Plants of the Middle-East Medicinal and Aromatic Plants of the World. Dordrecht: Springer 2014; pp. 225-39.
[http://dx.doi.org/10.1007/978-94-017-9276-9_12]
[6]
Lansky EP, Newman RA. Punica granatum (pomegranate) and its potential for prevention and treatment of inflammation and cancer. J Ethnopharmacol 2007; 109(2): 177-206.
[http://dx.doi.org/10.1016/j.jep.2006.09.006] [PMID: 17157465]
[7]
Viuda-Martos M, Fernández-López J, Pérez-Álvarez JA. Pomegranate and its many functional components as related to human health: A review. Compr Rev Food Sci Food Saf 2010; 9(6): 635-54.
[http://dx.doi.org/10.1111/j.1541-4337.2010.00131.x] [PMID: 33467822]
[8]
Teixeira da Silva JA, Ranac TS, Narzaryd D, Vermae N, Meshramf DT, Ranadeg SH. Pomegranate biology and biotechnology: A review. Sci Hortic (Amsterdam) 2013; 160: 85-107.
[http://dx.doi.org/10.1016/j.scienta.2013.05.017]
[9]
Wu S, Tian L. Diverse phytochemicals and bioactivities in the ancient fruit and modern functional food pomegranate (Punica granatum). Molecules 2017; 22(10): 1606.
[http://dx.doi.org/10.3390/molecules22101606] [PMID: 28946708]
[10]
Dafny-Yalin M, Glazer I, Bar-Ilan I, Kerem Z, Holland D, Amir R. Color, sugars and organic acids composition in aril juices and peel homogenates prepared from different pomegranate accessions. J Agric Food Chem 2010; 58(7): 4342-52.
[http://dx.doi.org/10.1021/jf904337t] [PMID: 20232916]
[11]
Vučić V, Grabež M, Trchounian A, Arsić A. Composition and potential health benefits of pomegranate: A review. Curr Pharm Des 2019; 25(16): 1817-27.
[http://dx.doi.org/10.2174/1381612825666190708183941] [PMID: 31298147]
[12]
Tezcan F, Uzaşçı S, Uyar G, Oztekin N, Erim FB. Determination of amino acids in pomegranate juices and fingerprint for adulteration with apple juices. Food Chem 2013; 141(2): 1187-91.
[http://dx.doi.org/10.1016/j.foodchem.2013.04.017] [PMID: 23790902]
[13]
Bar-Ya’akov I, Tian L, Amir R, Holland D. Primary metabolites, anthocyanins, and hydrolyzable tannins in the pomegranate fruit. Front Plant Sci 2019; 10: 620.
[http://dx.doi.org/10.3389/fpls.2019.00620] [PMID: 31164897]
[14]
Kalaycıoğlu Z, Erim FB. Total phenolic contents, antioxidant activities, and bioactive ingredients of juices from pomegranate cultivars worldwide. Food Chem 2017; 221: 496-507.
[http://dx.doi.org/10.1016/j.foodchem.2016.10.084] [PMID: 27979233]
[15]
Amir R, Holland D, Tian L. What can we learn about the traits of aril juice by studying wide collections of diverse pomegranate fruits? In: Siddiqui RA, Akbar M, Eds.Pomegranate: Cultivation, Composition, Antioxidant Properties, and Health Benefits. New York, NY: Nova, Medicine & Health 2018; pp. 203-31.
[16]
Hasnaoui N, Mars M, Ghaffari S, Trifi M, Melgarejo P, Hernandez F. Seed and juice characterization of pomegranate fruits grown in Tunisia: Comparison between sour and sweet cultivars revealed interesting properties for prospective industrial applications. Ind Crops Prod 2011; 33(2): 374-81.
[http://dx.doi.org/10.1016/j.indcrop.2010.11.006]
[17]
Choi DW, Kim JY, Choi SH, et al. Identification of steroid hormones in pomegranate (Punica granatum) using HPLC and GC-mass spectrometry. Food Chem 2006; 96(4): 562-71.
[http://dx.doi.org/10.1016/j.foodchem.2005.03.010]
[18]
Fischer UA, Carle R, Kammerer DR. Identification and quantification of phenolic compounds from pomegranate (Punica granatum L.) peel, mesocarp, aril and differently produced juices by HPLC-DAD-ESI/MS(n). Food Chem 2011; 127(2): 807-21.
[http://dx.doi.org/10.1016/j.foodchem.2010.12.156] [PMID: 23140740]
[19]
Ambigaipalan P, de Camargo AC, Shahidi F. Identification of phenolic antioxidants and bioactives of pomegranate seeds following juice extraction using HPLC-DAD-ESI-MSn. Food Chem 2017; 221: 1883-94.
[http://dx.doi.org/10.1016/j.foodchem.2016.10.058] [PMID: 27979177]
[20]
Tzulker R, Glazer I, Bar-Ilan I, Holland D, Aviram M, Amir R. Antioxidant activity, polyphenol content, and related compounds in different fruit juices and homogenates prepared from 29 different pomegranate accessions. J Agric Food Chem 2007; 55(23): 9559-70.
[http://dx.doi.org/10.1021/jf071413n] [PMID: 17914875]
[21]
Borochov-Neori H, Judeinstein S, Harari M, et al. Climate effects on anthocyanin accumulation and composition in the pomegranate (Punica granatum L.) fruit arils. J Agric Food Chem 2011; 59(10): 5325-34.
[http://dx.doi.org/10.1021/jf2003688] [PMID: 21506517]
[22]
Turkyilmaz M. Anthocyanin and organic acid profiles of pomegranate (Punica granatum L.) juices from registered varieties in Turkey. Int J Food Sci Technol 2013; 48: 2086-95.
[http://dx.doi.org/10.1111/ijfs.12190]
[23]
Aligourchi H, Barzegar M, Abbasi S. Anthocyanins characterisation of 15 Iranian pomegranate (Punica granatum L.) varieties and their variation after storage and pasteurization. Eur Food Res Technol 2008; 227(3): 881-7.
[http://dx.doi.org/10.1007/s00217-007-0799-1]
[24]
Ben-Simhon Z, Judeinstein S, Trainin T, et al. “White” Anthocyanin-less pomegranate (Punica granatum L.) caused by an insertion in the coding region of the leucoanthocyanidin dioxygenase (LDOX; ANS) gene. PLoS One 2015; 10(11): e0142777.
[http://dx.doi.org/10.1371/journal.pone.0142777] [PMID: 26581077]
[25]
Ferrara G, Mazzeo A, Matarrese AMS, et al. Application of abscisic acid (S-ABA) and sucrose to improve colour, anthocyanin content and antioxidant activity of cv. Crimson Seedless grape berries. Aust J Grape Wine Res 2015; 21(1): 18-29.
[http://dx.doi.org/10.1111/ajgw.12112]
[26]
Borochov-Neori H, Lazarovitch N, Judeinstein S, Patil BS, Holland D. Climate and salinity effects on color and health promoting properties in the pomegranate (Punica granatum L.) fruit arils. ACS Sympos. In book ACS Symp Ser . 2013; 1129: pp. 43-61.
[http://dx.doi.org/10.1021/bk-2013-1129.ch003]
[27]
Liu Y, Seeram NP. Liquid chromatography coupled with time-of-flight tandem mass spectrometry for comprehensive phenolic characterization of pomegranate fruit and flower extracts used as ingredients in botanical dietary supplements. J Sep Sci 2018; 41(15): 3022-33.
[http://dx.doi.org/10.1002/jssc.201800480] [PMID: 29847709]
[28]
Khomich LM, Perova IB, Eller KI. Pomegranate juice nutritional profile. Vopr Pitan 2019; 88(5): 80-92.
[http://dx.doi.org/10.24411/0042-8833-2019-10057]
[29]
Seeram NP, Henning SM, Zhang Y, Suchard M, Li Z, Heber D. Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours. J Nutr 2006; 136(10): 2481-5.
[http://dx.doi.org/10.1093/jn/136.10.2481] [PMID: 16988113]
[30]
Seeram NP, Zhang Y, McKeever R, et al. Pomegranate juice and extracts provide similar levels of plasma and urinary ellagitannin metabolites in human subjects. J Med Food 2008; 11(2): 390-4.
[http://dx.doi.org/10.1089/jmf.2007.650] [PMID: 18598186]
[31]
Kelawala NS, Ananthanarayan L. Antioxidant activity of selected foodstuffs. Int J Food Sci Nutr 2004; 55(6): 511-6.
[http://dx.doi.org/10.1080/09637480400015794] [PMID: 15762315]
[32]
Sumner MD, Elliott-Eller M, Weidner G, et al. Effects of pomegranate juice consumption on myocardial perfusion in patients with coronary heart disease. Am J Cardiol 2005; 96(6): 810-4.
[http://dx.doi.org/10.1016/j.amjcard.2005.05.026] [PMID: 16169367]
[33]
Azadzoi KM, Schulman RN, Aviram M, Siroky MB. Oxidative stress in arteriogenic erectile dysfunction: Prophylactic role of antioxidants. J Urol 2005; 174(1): 386-93.
[http://dx.doi.org/10.1097/01.ju.0000161209.39959.67] [PMID: 15947695]
[34]
Ammar A, Turki M, Chtourou H, et al. Pomegranate supplementation accelerates recovery of muscle damage and soreness and inflammatory markers after a weightlifting training session. PLoS One 2016; 11(10): e0160305.
[http://dx.doi.org/10.1371/journal.pone.0160305] [PMID: 27764091]
[35]
Sharma P, McClees SF, Afaq F. Pomegranate for prevention and treatment of cancer: An update. Molecules 2017; 22(1): E177.
[http://dx.doi.org/10.3390/molecules22010177] [PMID: 28125044]
[36]
Bassiri-Jahromi S. Punica granatum (Pomegranate) activity in health promotion and cancer prevention. Oncol Rev 2018; 12(1): 345.
[http://dx.doi.org/10.4081/oncol.2018.345] [PMID: 29441150]
[37]
Amakura Y, Okada M, Tsuji S, Tonogai Y. High-performance liquid chromatographic determination with photodiode array detection of ellagic acid in fresh and processed fruits. J Chromatogr A 2000; 896(1-2): 87-93.
[http://dx.doi.org/10.1016/S0021-9673(00)00414-3] [PMID: 11093643]
[38]
Ozbay T, Nahta R. Delphinidin inhibits HER2 and Erk1/2 signaling and suppresses growth of HER2-overexpressing and triple negative breast cancer cell lines. Breast Cancer (Auckl) 2011; 5: 143-54.
[http://dx.doi.org/10.4137/BCBCR.S7156] [PMID: 21792311]
[39]
Middha SK, Usha T, Pande V. HPLC evaluation of phenolic profile, nutritive content, and antioxidant capacity of ex-tracts obtained from Punica granatum fruit peel. Adv Pharmacol Sci 2013; 2013: 296236.
[http://dx.doi.org/10.1155/2013/296236] [PMID: 23983682]
[40]
Adams LS, Seeram NP, Aggarwal BB, Takada Y, Sand D, Heber D. Pomegranate juice, total pomegranate ellagitannins, and punicalagin suppress inflammatory cell signaling in colon cancer cells. J Agric Food Chem 2006; 54(3): 980-5.
[http://dx.doi.org/10.1021/jf052005r] [PMID: 16448212]
[41]
D’Angelo S, Rosa R. The impact of supplementation with Pomegranate fruit (Punica granatum L.) on sport performance. Sport Sci (Travnik) 2020; 13(Suppl. 1): 29-37.
[42]
D’Angelo S, Tafuri D. Nutraceutical: Their role in improving sports performance. Sport Sci (Travnik) 2020; 13(Suppl. 1): 7-12.
[43]
Harborne JB. The flavonoids: Advances in research since 1980. Berlin/Heidelberg, Germany: Springer 2013.
[44]
Bravo L. Polyphenols: Chemistry, dietary sources, metabolism, and nutritional significance. Nutr Rev 1998; 56(11): 317-33.
[http://dx.doi.org/10.1111/j.1753-4887.1998.tb01670.x] [PMID: 9838798]
[45]
Meccariello R, D’Angelo S. Impact of polyphenolic-food on longevity: An elixir of life. an overview. Antioxidants 2021; 10(4): 507.
[http://dx.doi.org/10.3390/antiox10040507] [PMID: 33805092]
[46]
Crozier A, Jaganath IB, Clifford MN. Dietary phenolics: Chemistry, bioavailability and effects on health. Nat Prod Rep 2009; 26(8): 1001-43.
[http://dx.doi.org/10.1039/b802662a] [PMID: 19636448]
[47]
D’Angelo S. Current evidence on the effect of dietary polyphenols intake on brain health. Curr Nutr Food Sci 2020; 16(8): 1170-82.
[http://dx.doi.org/10.2174/1573401316999200714160126]
[48]
Grassi D, Desideri G, Di Giosia P, et al. Tea, flavonoids, and cardiovascular health: Endothelial protection. Am J Clin Nutr 2013; 98(6)(Suppl.): 1660S-6S.
[http://dx.doi.org/10.3945/ajcn.113.058313] [PMID: 24172308]
[49]
Grassi D, Desideri G, Ferri C, Grassi D, Desideri G, Ferri C. Flavonoids: Antioxidants against atherosclerosis. Nutrients 2010; 2(8): 889-902.
[http://dx.doi.org/10.3390/nu2080889] [PMID: 22254061]
[50]
D’Angelo S, La Porta R, Napolitano M, Galletti P, Quagliuolo L, Boccellino M. Effect of Annurca apple polyphenols on human HaCaT keratinocytes proliferation. J Med Food 2012; 15(11): 1024-31.
[http://dx.doi.org/10.1089/jmf.2012.0076] [PMID: 22892038]
[51]
Nasso R, Pagliara V, D’Angelo S, Rullo R, Masullo M, Arcone R. Annurca Apple polyphenol extract affects acetyl- cholinesterase and mono-amine oxidase in vitro enzyme activity. Pharmaceuticals (Basel) 2021; 14(1): 62.
[http://dx.doi.org/10.3390/ph14010062] [PMID: 33466604]
[52]
D’Angelo S, Martino E, Ilisso CP, Bagarolo ML, Porcelli M, Cacciapuoti G. Pro-oxidant and pro-apoptotic activity of polyphenol extract from Annurca apple and its underlying mechanisms in human breast cancer cells. Int J Oncol 2017; 51(3): 939-48.
[http://dx.doi.org/10.3892/ijo.2017.4088] [PMID: 28766690]
[53]
Vuoso DC, D’Angelo S, Ferraro R, et al. Annurca apple polyphenol extract promotes mesenchymal-to-epithelial transition and inhibits migration in triple-negative breast cancer cells through ROS/JNK signaling. Sci Rep 2020; 10(1): 15921.
[http://dx.doi.org/10.1038/s41598-020-73092-2] [PMID: 32985606]
[54]
D’Angelo S, Martino E, Cacciapuoti G. Effects of Annurca apple (Malus pumila cv Annurca) polyphenols on breast cancer cells. Curr Nutr Food Sci 2019; 15(7): 745-51.
[http://dx.doi.org/10.2174/1573401315666190206142025]
[55]
Martino E, Vuoso DC, D’Angelo S, et al. Annurca apple polyphenol extract selectively kills MDA-MB-231 cells through ROS generation, sustained JNK activation and cell growth and survival inhibition. Sci Rep 2019; 9(1): 13045.
[http://dx.doi.org/10.1038/s41598-019-49631-x] [PMID: 31506575]
[56]
Boccellino M, D’Angelo S. Anti-obesity effects of polyphenol intake: Current status and future possibilities. Int J Mol Sci 2020; 21(16): 5642.
[http://dx.doi.org/10.3390/ijms21165642] [PMID: 32781724]
[57]
D’Angelo S, Cimmino A, Raimo M, Salvatore A, Zappia V, Galletti P. Effect of reddening-ripening on the antioxidant activity of polyphenol extracts from cv. ‘Annurca’ apple fruits. J Agric Food Chem 2007; 55(24): 9977-85.
[http://dx.doi.org/10.1021/jf071773a] [PMID: 17960886]
[58]
D’Angelo S, Morana A, Salvatore A, Zappia V, Galletti P. Protective effect of polyphenols from Glycyrrhiza glabra against oxidative stress in Caco-2 cells. J Med Food 2009; 12(6): 1326-33.
[http://dx.doi.org/10.1089/jmf.2008.0285] [PMID: 20041789]
[59]
Vuoso DC, Porcelli M, Cacciapuoti G, D’Angelo S. Biological activity of melannurca flesh apple biophenols. Curr Nutr Food Sci 2020; 16(8): 1149-62.
[http://dx.doi.org/10.2174/1573401316666200217113808]
[60]
D’Angelo S, Sammartino D. Protective effect of Annurca Apple extract against oxidative damage in human erythro-cytes. Curr Nutr Food Sci 2015; 11(4): 248-56.
[http://dx.doi.org/10.2174/1573401311666150610210529]
[61]
Williamson G. The role of polyphenols in modern nutrition. Nutr Bull 2017; 42(3): 226-35.
[http://dx.doi.org/10.1111/nbu.12278] [PMID: 28983192]
[62]
Motti ML. D Angelo S, Meccariello R. MicroRNAs, cancer and diet: Facts and new exciting perspectives. Curr Mol Pharmacol 2018; 11(2): 90-6.
[http://dx.doi.org/10.2174/1874467210666171013123733] [PMID: 29034844]
[63]
D’Angelo S, Scafuro M, Meccariello R. BPA and nutraceuticals, simultaneous effects on endocrine functions. Endocr Metab Immune Disord Drug Targets 2019; 19(5): 594-604.
[http://dx.doi.org/10.2174/1871530319666190101120119] [PMID: 30621569]
[64]
Alcaraz-Mármol F, Nuncio-Jáuregui N, García-Sánchez F, Martínez-Nicolás JJ, Hernández F. Characterization of twenty pomegranate (Punica granatum L.) cultivars grown in Spain: Aptitudes for fresh consumption and processing. Sci Hortic (Amsterdam) 2017; 219: 152-60.
[http://dx.doi.org/10.1016/j.scienta.2017.03.008]
[65]
Alcaraz-Mármol F, Calín-Sánchez Á, Nuncio-Jáuregui N, Carbonell-Barrachina ÁA, Hernández F, Martínez JJ. Classification of pomegranate cultivars according to their seed hardness and wood perception. J Texture Stud 2015; 46(6): 467-74.
[http://dx.doi.org/10.1111/jtxs.12145]
[66]
Alcaraz-Mármol F, Nuncio-Jáuregui N, Calín-Sánchez Á, Carbonell-Barrachina ÁA, Martínez JJ, Hernández F. Determination of fatty acid composition in arils of 20 pomegranates cultivars grown in Spain. Sci Hortic (Amsterdam) 2015; 197: 712-8.
[http://dx.doi.org/10.1016/j.scienta.2015.11.004]
[67]
Gil MI, Tomás-Barberán FA, Hess-Pierce B, Holcroft DM, Kader AA. Antioxidant activity of pomegranate juice and its relationship with phenolic composition and processing. J Agric Food Chem 2000; 48(10): 4581-9.
[http://dx.doi.org/10.1021/jf000404a] [PMID: 11052704]
[68]
Seeram NP, Adams LS, Henning SM, et al. In vitro antiproliferative, apoptotic and antioxidant activities of punicalagin, ellagic acid and a total pomegranate tannin extract are enhanced in combination with other polyphenols as found in pomegranate juice. J Nutr Biochem 2005; 16(6): 360-7.
[http://dx.doi.org/10.1016/j.jnutbio.2005.01.006] [PMID: 15936648]
[69]
Adhami VM, Khan N, Mukhtar H. Cancer chemoprevention by pomegranate: Laboratory and clinical evidence. Nutr Cancer 2009; 61(6): 811-5.
[http://dx.doi.org/10.1080/01635580903285064] [PMID: 20155621]
[70]
Abdollahzadeh Sh, Mashouf R, Mortazavi H, Moghaddam M, Roozbahani N, Vahedi M. Antibacterial and antifungal activities of Punica granatum peel extracts against oral pathogens. J Dent (Tehran) 2011; 8(1): 1-6.
[PMID: 21998800]
[71]
Bassiri-Jahromi S, Katiraee F, Hajimahmoodi M, Mostafavi E, Talebi M, Pourshafie MR. In vitro antifungal activity of various Persian cultivars of Punica granatum L. extracts against Candida species. Jundishapur J Nat Pharm Prod 2015; 10(3): e19754.
[http://dx.doi.org/10.17795/jjnpp-19754]
[72]
Mohan M, Patankar P, Ghadi P, Kasture S. Cardioprotective potential of Punica granatum extract in isoproterenol-induced myocardial infarction in Wistar rats. J Pharmacol Pharmacother 2010; 1(1): 32-7.
[http://dx.doi.org/10.4103/0976-500X.64533] [PMID: 21808588]
[73]
Abedini M, Ghasemi-Tehrani H, Tarrahi MJ, Amani R. The effect of concentrated pomegranate juice consumption on risk factors of cardiovascular diseases in women with polycystic ovary syndrome: A randomized controlled trial. Phytother Res 2021; 35(1): 442-51.
[http://dx.doi.org/10.1002/ptr.6820] [PMID: 32767710]
[74]
Barati Boldaji R, Akhlaghi M, Sagheb MM, Esmaeilinezhad Z. Pomegranate juice improves cardiometabolic risk factors, biomarkers of oxidative stress and inflammation in hemodialysis patients: A randomized crossover trial. J Sci Food Agric 2020; 100(2): 846-54.
[http://dx.doi.org/10.1002/jsfa.10096] [PMID: 31646650]
[75]
Bellone JA, Murray JR, Jorge P, et al. Pomegranate supplementation improves cognitive and functional recovery following ischemic stroke: A randomized trial. Nutr Neurosci 2019; 22(10): 738-43.
[http://dx.doi.org/10.1080/1028415X.2018.1436413] [PMID: 29433376]
[76]
Esmaeilinezhad Z, Babajafari S, Sohrabi Z, Eskandari MH, Amooee S, Barati-Boldaji R. Effect of synbiotic pomegranate juice on glycemic, sex hormone profile and anthropometric indices in PCOS: A randomized, triple blind, controlled trial. Nutr Metab Cardiovasc Dis 2019; 29(2): 201-8.
[http://dx.doi.org/10.1016/j.numecd.2018.07.002] [PMID: 30538082]
[77]
Esmaeilinezhad Z, Barati-Boldaji R, Brett NR, et al. The effect of synbiotics pomegranate juice on cardiovascular risk factors in PCOS patients: A randomized, triple-blinded, controlled trial. J Endocrinol Invest 2020; 43(4): 539-48.
[http://dx.doi.org/10.1007/s40618-019-01139-x] [PMID: 31713129]
[78]
Kerimi A, Nyambe-Silavwe H, Gauer JS, Tomás-Barberán FA, Williamson G. Pomegranate juice, but not an extract, confers a lower glycemic response on a high-glycemic index food: Randomized, crossover, controlled trials in healthy subjects. Am J Clin Nutr 2017; 106(6): 1384-93.
[http://dx.doi.org/10.3945/ajcn.117.161968] [PMID: 29021286]
[79]
Kojadinovic MI, Arsic AC, Debeljak-Martacic JD, et al. Consumption of pomegranate juice decreases blood lipid peroxidation and levels of arachidonic acid in women with metabolic syndrome. J Sci Food Agric 2017; 97(6): 1798-804.
[http://dx.doi.org/10.1002/jsfa.7977] [PMID: 27476699]
[80]
Moazzen H, Alizadeh M. Effects of pomegranate juice on cardiovascular risk factors in patients with metabolic syndrome: A double-blinded, randomized crossover controlled trial. Plant Foods Hum Nutr 2017; 72(2): 126-33.
[http://dx.doi.org/10.1007/s11130-017-0605-6] [PMID: 28303364]
[81]
Sohrab G, Ebrahimof S, Sotoudeh G, et al. Effects of pomegranate juice consumption on oxidative stress in patients with type 2 diabetes: A single-blind, randomized clinical trial. Int J Food Sci Nutr 2017; 68(2): 249-55.
[http://dx.doi.org/10.1080/09637486.2016.1229760] [PMID: 27633135]
[82]
Sohrab G, Nasrollahzadeh J, Tohidi M, Zand H, Nikpayam O. Pomegranate juice increases sirtuin1 protein in peripheral blood mononuclear cell from patients with type 2 diabetes: A randomized placebo controlled clinical trial. Metab Syndr Relat Disord 2018; 16(8): 446-51.
[http://dx.doi.org/10.1089/met.2017.0146] [PMID: 29957104]
[83]
Sohrab G, Roshan H, Ebrahimof S, Nikpayam O, Sotoudeh G, Siasi F. Effects of pomegranate juice consumption on blood pressure and lipid profile in patients with type 2 diabetes: A single-blind randomized clinical trial. Clin Nutr ESPEN 2019; 29: 30-5.
[http://dx.doi.org/10.1016/j.clnesp.2018.11.013] [PMID: 30661697]
[84]
Razani Z, Dastani M, Kazerani HR. Cardioprotective effects of pomegranate (Punica granatum) juice in patients with ischemic heart disease. Phytother Res 2017; 31(11): 1731-8.
[http://dx.doi.org/10.1002/ptr.5901] [PMID: 28913846]
[85]
Henning SM, Yang J, Lee RP, et al. Pomegranate juice and extract consumption increases the resistance to UVB-induced erythema and changes the skin microbiome in healthy women: A randomized controlled trial. Sci Rep 2019; 9(1): 14528.
[http://dx.doi.org/10.1038/s41598-019-50926-2] [PMID: 31601842]
[86]
Ammar A, Turki M, Hammouda O, et al. Effects of pomegranate juice supplementation on oxidative stress biomarkers following weightlifting exercise. Nutrients 2017; 9(8): 819.
[http://dx.doi.org/10.3390/nu9080819] [PMID: 28758938]
[87]
Ammar A, Mouna T, Trabelsi K, et al. Effects of natural polyphenol-rich pomegranate juice on the acute and delayed response of Homocysteine and steroidal hormones following weightlifting exercises: A double-blind, placebo-controlled trial. J Int Soc Sports Nutr 2020; 17(1): 15.
[http://dx.doi.org/10.1186/s12970-020-00345-w] [PMID: 32143716]
[88]
Fuster-Muñoz E, Roche E, Funes L, Martínez-Peinado P, Sempere JM, Vicente-Salar N. Effects of pomegranate juice in circulating parameters, cytokines, and oxidative stress markers in endurance-based athletes: A randomized controlled trial. Nutrition 2016; 32(5): 539-45.
[http://dx.doi.org/10.1016/j.nut.2015.11.002] [PMID: 26778544]
[89]
Lamb KL, Ranchordas MK, Johnson E, Denning J, Downing F, Lynn A. No effect of tart cherry juice or pomegranate juice on recovery from exercise-induced muscle damage in non-resistance trained men. Nutrients 2019; 11(7): 1593.
[http://dx.doi.org/10.3390/nu11071593] [PMID: 31337122]
[90]
Urbaniak A, Basta P, Ast K, et al. The impact of supplementation with pomegranate fruit (Punica granatum L.) juice on selected antioxidant parameters and markers of iron metabolism in rowers. J Int Soc Sports Nutr 2018; 15(1): 35.
[http://dx.doi.org/10.1186/s12970-018-0241-z] [PMID: 30041701]
[91]
D’Angelo S. Polyphenols and athletic performance: A review on human data. In: Soto-Hernández M, García-Mateos R, Palma Tenango M, Eds. Plant Physiological Aspects of Phenolic Compounds. London: IntechOpen Books an Open Access book 2019; pp. 1-24.
[http://dx.doi.org/10.5772/intechopen.85031]
[92]
D’Angelo S. Polyphenols: Potential beneficial effects of these phytochemicals in athletes. Curr Sports Med Rep 2020; 19(7): 260-5.
[http://dx.doi.org/10.1249/JSR.0000000000000729] [PMID: 32692061]
[93]
Ferrara L, Joksimovic M, D’Angelo S. Modulation of mitochondrial biogenesis: Action of physical activity and phytochemicals. J Phys Educ Sport 2021; 21(1): 425-33.
[http://dx.doi.org/10.7752/jpes.2021.01042]
[94]
Mankowski RT, Anton SD, Buford TW, Leeuwenburgh C. Dietary antioxidants as modifiers of physiologic adaptations to exercise. Med Sci Sports Exerc 2015; 47(9): 1857-68.
[http://dx.doi.org/10.1249/MSS.0000000000000620] [PMID: 25606815]
[95]
Oliveira CC, Ferreira D, Caetano C, et al. Nutrition and supplementation in soccer. Sports (Basel) 2017; 5(2): 28.
[http://dx.doi.org/10.3390/sports5020028] [PMID: 29910389]
[96]
Bjelakovic G, Nikolova D, Gluud LL, Simonetti RG, Gluud C. Mortality in randomized trials of antioxidant supplements for primary and secondary prevention: Systematic review and meta-analysis. JAMA 2007; 297(8): 842-57.
[http://dx.doi.org/10.1001/jama.297.8.842] [PMID: 17327526]
[97]
Braakhuis AJ, Hopkins WG. Impact of dietary antioxidants on sport performance: A review. Sports Med 2015; 45(7): 939-55.
[http://dx.doi.org/10.1007/s40279-015-0323-x] [PMID: 25790792]
[98]
Halliwell B. The antioxidant paradox. Lancet 2000; 355(9210): 1179-80.
[http://dx.doi.org/10.1016/S0140-6736(00)02075-4] [PMID: 10791396]
[99]
Powers S, Nelson WB, Larson-Meyer E. Antioxidant and vitamin D supplements for athletes: Sense or nonsense? J Sports Sci 2011; 29(Suppl. 1): S47-55.
[http://dx.doi.org/10.1080/02640414.2011.602098] [PMID: 21830999]
[100]
Abdlekawy KS, Donia AM, Elbarbry F. Effects of grapefruit and pomegranate juices on the pharmacokinetic properties of dapoxetine and midazolam in healthy subjects. Eur J Drug Metab Pharmacokinet 2017; 42(3): 397-405.
[http://dx.doi.org/10.1007/s13318-016-0352-3] [PMID: 27294349]
[101]
Banihani SA, Makahleh SM, El-Akawi ZJ. Short-term effect of fresh pomegranate juice on serum cortisol and thyroxine in patients with type 2 diabetes. Curr Mol Med 2020; 20(5): 355-60.
[http://dx.doi.org/10.2174/1566524019666191129104153] [PMID: 31782367]
[102]
Ghoochani N, Karandish M, Mowla K, Haghighizadeh MH, Jalali MT. The effect of pomegranate juice on clinical signs, matrix metalloproteinases and antioxidant status in patients with knee osteoarthritis. J Sci Food Agric 2016; 96(13): 4377-81.
[http://dx.doi.org/10.1002/jsfa.7647] [PMID: 26804926]
[103]
Matthews LG, Smyser CD, Cherkerzian S, et al. Maternal pomegranate juice intake and brain structure and function in infants with intrauterine growth restriction: A randomized controlled pilot study. PLoS One 2019; 14(8): e0219596.
[http://dx.doi.org/10.1371/journal.pone.0219596] [PMID: 31433809]
[104]
Siddarth P, Li Z, Miller KJ, et al. Randomized placebo-controlled study of the memory effects of pomegranate juice in middle-aged and older adults. Am J Clin Nutr 2020; 111(1): 170-7.
[http://dx.doi.org/10.1093/ajcn/nqz241] [PMID: 31711104]
[105]
US National Library of Medicine. Explore 405,955 research studies in all 50 states and in 220 countries. Available from: https://clinicaltrials.gov/ct2/home
[106]
US National Library of Medicine. Mediterranean Enriched Diet for Tackling Youth Obesity (MED4Youth). Available from: https://clinicaltrials.gov/ct2/show/NCT04719052?term=pomegranate&recrs=b&draw=2&rank=2
[107]
US National Library of Medicine The Beneficial Effects of Pomegranate on Hearing of Patients without Hemodialysis Available from: https://clinicaltrials.gov/ct2/show/NCT03575390?term=pomegranate&recrs=a&draw=2&rank=1
[108]
US National Library of Medicine. Pomegranate Juice in Treating Patients with Recurrent Prostate Cancer Available from: https://clinicaltrials.gov/ct2/show/NCT00060086?term=pomegranate&recrs=d&draw=2&rank=1

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