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Combinatorial Chemistry & High Throughput Screening

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ISSN (Print): 1386-2073
ISSN (Online): 1875-5402

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Mini-Review Article

Impact of MiRNAs and LncRNAs on Multidrug Resistance of Gastric Cancer

Author(s): Yiwen Wu, Xiaoyan Yang*, Zhizhong Xie, Haihong Hu, Xiaoyong Lei, Dun Niu, Shiyan Li and Lu Tuo

Volume 25, Issue 13, 2022

Published on: 22 April, 2022

Page: [2127 - 2140] Pages: 14

DOI: 10.2174/1386207325666220401090604

Price: $65

Abstract

Multi-drug resistance (MDR) is characterized by the resistance of tumor cells to some antitumor drugs with different structures and mechanisms after the use of a single chemotherapy drug or even the first use of the drug. Notably, MDR has become the largest obstacle to the success of gastric cancer chemotherapies. Non-coding RNAs are defined as a class of RNAs that do not have the ability to code proteins. They are widely involved in important biological functions in life activities. Multiple lines of evidence demonstrated that ncRNAs are closely related to human cancers, including gastric cancer. However, the relationship between ncRNAs and MDR in gastric cancer has been reported, yet the mechanisms are not fully clarified. Therefore, in this review, we systematically summarized the detailed molecular mechanisms of lncRNAs (long noncoding RNAs) and miRNAs (microRNAs) associated with MDR in gastric cancer. Additionally, we speculate that the abnormal expression of ncRNAs is likely to be a novel potential therapeutic target reversing MDR for gastric cancer. Future therapeutics for gastric cancer will most likely be based on noncoding RNAs (ncRNAs) that regulate MDR-related genes.

Keywords: Multidrug, resistance, gastric cancer, LncRNAs, MiRNAs, ncRNAs.

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