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Current Pharmaceutical Design

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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Mini-Review Article

Overcoming Skin Damage from Pollution via Novel Skincare Strategies

Author(s): Alexandros Charitakis, Sulaf Assi, Sakib Yousaf and Iftikhar Khan*

Volume 28, Issue 15, 2022

Published on: 22 April, 2022

Page: [1250 - 1257] Pages: 8

DOI: 10.2174/1381612828666220331124025

Price: $65

Abstract

Urban pollution is one of the main problems encountered worldwide, with a major impact on public health as well as the environment. The health impact of urban pollution is not limited to respiratory conditions but also encompasses major skin problems, including irritation, skin ageing, and skin cancer. Toxic gases and particulate matter are the main pollutants that exhibit extensive local variability. The aforementioned pollutants are small particles that attach to the skin or penetrate it, enhancing free radicals’ production inside the inner skin layers. This urges the need to propose cosmetic products that help prevent and/or minimise pollutants’ effects on the skin, whether irritation, ageing, and cancer. Furthermore, intrinsic and extrinsic factors contribute to skin irritation and ageing. Intrinsic factors are within skin factors and include genetic and physiological characteristics of individuals. Moreover, extrinsic factors comprise environmental factors such as humidity, temperature, and smoke. Subsequently, active ingredients with anti pollutant properties addressed the intrinsic and extrinsic factors by four mechanisms: free radical neutralisation, film-forming ability, skin barrier enhancement, and fortification. Such ingredients include vitamin A derivatives, vitamin C derivatives, carbohydrates, and plantbased products. Yet, very limited studies have evaluated the effectiveness of the aforementioned active ingredients against irritation or ageing, which should be considered in future work.

Keywords: Skincare, pollutant, skin damage, skin barrier, penetration, particulate matter.

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