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Current Alzheimer Research

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Research Article

Blood Biomarkers Predict Future Cognitive Decline after Military-Related Traumatic Brain Injury

Author(s): Sara M. Lippa*, Jessica Gill, Tracey A. Brickell, Vivian A. Guedes, Louis M. French and Rael T. Lange

Volume 19, Issue 5, 2022

Published on: 11 August, 2022

Page: [351 - 363] Pages: 13

DOI: 10.2174/1567205019666220330144432

Price: $65

Abstract

Background: Traumatic brain injury (TBI) has been associated with an increased likelihood of late-life dementia; however, the mechanisms driving this relationship are elusive. Bloodbased biomarkers may provide insight into these mechanisms and serve as useful prognostic indicators of cognitive recovery or decline following a TBI.

Objective: The aim of this study was to examine blood biomarkers within one year of TBI and explore their relationship with cognitive decline.

Methods: Service members and veterans (n=224) without injury (n=77), or with a history of bodily injury (n=37), uncomplicated mild TBI (n=55), or more severe TBI (n=55), underwent a blood draw and neuropsychological assessment within one year of their injury as part of a case-control study. A subsample (n=87) completed a follow-up cognitive assessment.

Results: In the more severe TBI group, baseline glial fibrillary acidic protein (p=.008) and ubiquitin C-terminal hydrolase-L1 (p=.026) were associated with processing speed at baseline, and baseline ubiquitin C-terminal hydrolase-L1 predicted change in immediate (R2Δ=.244, p=.005) and delayed memory (R2Δ=.390, p=.003) over time. In the mild TBI group, higher baseline tau predicted greater negative change in perceptual reasoning (R2Δ=.188, p=.033) and executive functioning (R2Δ=.298, p=.007); higher baseline neurofilament light predicted greater negative change in perceptual reasoning (R2Δ=.211, p=.012).

Conclusion: Baseline ubiquitin C-terminal hydrolase-L1 strongly predicted memory decline in the more severe TBI group, while tau and neurofilament light strongly predicted decline in the mild TBI group. A panel including these biomarkers could be particularly helpful in identifying those at risk for future cognitive decline following TBI.

Keywords: Traumatic brain injury, blood biomarkers, cognition, military, dementia, proteomics.

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