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Current Pharmaceutical Biotechnology

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ISSN (Print): 1389-2010
ISSN (Online): 1873-4316

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Review Article

Nanoengineered Therapeutic Scaffolds for Burn Wound Management

Author(s): Ziauddin, Tanveer Hussain, Ahsan Nazir, Urwa Mahmood, Misbah Hameed, Seeram Ramakrishna and Sharjeel Abid*

Volume 23, Issue 12, 2022

Published on: 13 May, 2022

Page: [1417 - 1435] Pages: 19

DOI: 10.2174/1389201023666220329162910

Price: $65

Abstract

Background: Wound healing is a complex process, and selecting an appropriate treatment is crucial and varies from one wound to another. Among injuries, burn wounds are more challenging to treat. Different dressings and scaffolds come into play when skin is injured. These scaffolds provide the optimum environment for wound healing. With the advancements in nanoengineering, scaffolds have been engineered to improve wound healing with lower fatality rates.

Objectives: Nanoengineered systems have emerged as one of the most promising candidates for burn wound management. This review paper aims to provide an in-depth understanding of burn wounds and the role of nanoengineering in burn wound management. The advantages of nanoengineered scaffolds, their properties, and their proven effectiveness have been discussed. Nanoparticles and nanofibers-based nanoengineered therapeutic scaffolds provide optimum protection, infection management, and accelerated wound healing due to their unique characteristics. These scaffolds increase cell attachment and proliferation for desired results.

Results: The literature review suggested that the utilization of nanoengineered scaffolds has accelerated burn wound healing. Nanofibers provide better cell attachment and proliferation among different nanoengineered scaffolds because their 3D structure mimics the body's extracellular matrix.

Conclusion: With these advanced nanoengineered scaffolds, better burn wound management is possible due to sustained drug delivery, better cell attachment, and an infection-free environment.

Keywords: Burn wound, nanomedicine, nanoengineering, scaffolds, nanofibers, therapeutic medicine.

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