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Anti-Inflammatory & Anti-Allergy Agents in Medicinal Chemistry

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ISSN (Print): 1871-5230
ISSN (Online): 1875-614X

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Systematic Review Article

Post-COVID-19 Syndrome Clinical Manifestations: A Systematic Review

Author(s): Muhammad Abdel-Gawad, Mariam S. Zaghloul, Sherief Abd-elsalam*, Mai Hashem, Sameh A. Lashen, Aya M. Mahros, Ahmed Q. Mohammed, Amro M. Hassan, Ahmed N. Bekhit, Weam Mohammed and Mohamed Alboraie

Volume 21, Issue 2, 2022

Published on: 21 July, 2022

Page: [115 - 120] Pages: 6

DOI: 10.2174/1871523021666220328115818

Abstract

Background: Coronavirus disease-2019 (COVID-19) is a global pandemic health problem that causes a wide spectrum of clinical manifestations and considerable mortality rates. Unfortunately, recovered patients who survive COVID-19 may continue to report a wide variety of clinical manifestations of multisystem affection such as pulmonary embolism, deep vein thrombosis, acute myocardial infarction, depression, anxiety, myalgia, dyspnea, and fatigue.

Objective: We aimed to summarize the current literature regarding the prevalence of post-COVID- 19 manifestations.

Methods: We conducted a systematic review of post-COVID-19 manifestations by searching MEDLINE via PubMed, Scopus, Web of Science (WOS), EBSCO, Wily, and World health organization (WHO) databases. Screening, study selection, data extraction, data synthesis, and quality assessment were made by two independent reviewers.

Results: Of 1,371 references, 817 references remained after removing duplicates. Reviews, case reports, commentaries, and any article containing non-original information were excluded. According to the eligibility criteria for this systematic review, 12 studies were included for qualitative synthesis. The overall prevalence of post-COVID-19 manifestations ranged from 35% to 90.5%. Fatigue, dyspnea, neuropsychological disorders, and pain were the most frequent post-COVID-19 symptoms.

Conclusion: This systematic review showed that 35% to 90.5% of recovered patients who survive COVID-19 continue to have a wide variety of clinical manifestations, including fatigue, dyspnea, neuropsychological disorders, and pain as the most frequent post-COVID-19 symptoms.

Keywords: COVID-19, Coronavirus, SARS-CoV-2, Post COVID, persistence post COVID, pandemic, novel coronavirus.

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[1]
Li, Q.; Guan, X.; Wu, P.; Wang, X.; Zhou, L.; Tong, Y.; Ren, R.; Leung, K.S.M.; Lau, E.H.Y.; Wong, J.Y.; Xing, X.; Xiang, N.; Wu, Y.; Li, C.; Chen, Q.; Li, D.; Liu, T.; Zhao, J.; Liu, M.; Tu, W.; Chen, C.; Jin, L.; Yang, R.; Wang, Q.; Zhou, S.; Wang, R.; Liu, H.; Luo, Y.; Liu, Y.; Shao, G.; Li, H.; Tao, Z.; Yang, Y.; Deng, Z.; Liu, B.; Ma, Z.; Zhang, Y.; Shi, G.; Lam, T.T.Y.; Wu, J.T.; Gao, G.F.; Cowling, B.J.; Yang, B.; Leung, G.M.; Feng, Z. Early transmission dynamics in Wuhan, China, of novel coronavirus-infected pneumonia. N. Engl. J. Med., 2020, 382(13), 1199-1207.
[http://dx.doi.org/10.1056/NEJMoa2001316] [PMID: 31995857]
[2]
World Health Organization. Coronavirus disease 2019 (COVID- 19). Situation report. Available from: https://www.who.int/publications/m/item/weekly-epidemiological-update-29-december-2020
[3]
Carradori, S. Are there any Therapeutic options currently available for Wuhan coronavirus? Antiinflamm. Antiallergy Agents Med. Chem., 2020, 19(2), 85-87.
[http://dx.doi.org/10.2174/1871523019999200228100917] [PMID: 32213152]
[4]
Carfì, A.; Bernabei, R.; Landi, F.J.J. Persistent symptoms in patients after acute COVID-19. JAMA, 2020, 324(6), 603-605.
[http://dx.doi.org/10.1001/jama.2020.12603]
[5]
Jiang, D.H. Planning for the post-COVID syndrome: How payers can mitigate long-term complications of the pandemic. Igen. Inter. Med., 2020, 35(10), 3036-3039.
[6]
Assaf, G.; Davis, H.; McCorkell, L. What does COVID-19 recovery actually look like? 2020. Available from: https://patientresearchcovid19.com/research/report-1/
[7]
Halpin, S.J.; McIvor, C.; Whyatt, G.; Adams, A.; Harvey, O.; McLean, L.; Walshaw, C.; Kemp, S.; Corrado, J.; Singh, R.; Collins, T.; O’Connor, R.J.; Sivan, M. Postdischarge symptoms and rehabilitation needs in survivors of COVID-19 infection: A cross-sectional evaluation. J. Med. Virol., 2021, 93(2), 1013-1022.
[http://dx.doi.org/10.1002/jmv.26368] [PMID: 32729939]
[8]
Corrales-Medina, V.F.; Alvarez, K.N.; Weissfeld, L.A.; Angus, D.C.; Chirinos, J.A.; Chang, C-C.H.; Newman, A.; Loehr, L.; Folsom, A.R.; Elkind, M.S.; Lyles, M.F.; Kronmal, R.A.; Yende, S. Association between hospitalization for pneumonia and subsequent risk of cardiovascular disease. JAMA, 2015, 313(3), 264-274.
[http://dx.doi.org/10.1001/jama.2014.18229] [PMID: 25602997]
[9]
Mao, L.; Jin, H.; Wang, M.; Hu, Y.; Chen, S.; He, Q.; Chang, J.; Hong, C.; Zhou, Y.; Wang, D.; Miao, X.; Li, Y.; Hu, B. Neurologic manifestations of hospitalized patients with coronavirus disease 2019 in Wuhan, China. JAMA Neurol., 2020, 77(6), 683-690.
[http://dx.doi.org/10.1001/jamaneurol.2020.1127] [PMID: 32275288]
[10]
Zhang, C.; Shi, L.; Wang, F-S. Liver injury in COVID-19: Management and challenges. Lancet Gastroenterol. Hepatol., 2020, 5(5), 428-430.
[http://dx.doi.org/10.1016/S2468-1253(20)30057-1] [PMID: 32145190]
[11]
Sachdeva, M.; Gianotti, R.; Shah, M.; Bradanini, L.; Tosi, D.; Veraldi, S.; Ziv, M.; Leshem, E.; Dodiuk-Gad, R.P. Cutaneous manifestations of COVID-19: Report of three cases and a review of literature. J. Dermatol. Sci., 2020, 98(2), 75-81.
[http://dx.doi.org/10.1016/j.jdermsci.2020.04.011] [PMID: 32381430]
[12]
Hatch, R.; Young, D.; Barber, V.; Griffiths, J.; Harrison, D.A.; Watkinson, P. Anxiety, depression and post traumatic stress disorder after critical illness: A UK-wide prospective cohort study. Crit. Care, 2018, 22(1), 310.
[http://dx.doi.org/10.1186/s13054-018-2223-6] [PMID: 30466485]
[13]
Tenforde, M.W.; Kim, S.S.; Lindsell, C.J.; Billig Rose, E.; Shapiro, N.I.; Files, D.C.; Gibbs, K.W.; Erickson, H.L.; Steingrub, J.S.; Smithline, H.A.; Gong, M.N.; Aboodi, M.S.; Exline, M.C.; Henning, D.J.; Wilson, J.G.; Khan, A.; Qadir, N.; Brown, S.M.; Peltan, I.D.; Rice, T.W.; Hager, D.N.; Ginde, A.A.; Stubblefield, W.B.; Patel, M.M.; Self, W.H.; Feldstein, L.R. Symptom duration and risk factors for delayed return to usual health among outpatients with COVID-19 in a multistate health care systems network-United States, March-June 2020. Morb. Mortal. Wkly. Rep., 2020, 69(30), 993-998.
[http://dx.doi.org/10.15585/mmwr.mm6930e1] [PMID: 32730238]
[14]
Verdoni, L.; Mazza, A.; Gervasoni, A.; Martelli, L.; Ruggeri, M.; Ciuffreda, M.; Bonanomi, E.; D’Antiga, L. An outbreak of severe Kawasaki-like disease at the Italian epicentre of the SARS-CoV-2 epidemic: An observational cohort study. Lancet, 2020, 395(10239), 1771-1778.
[http://dx.doi.org/10.1016/S0140-6736(20)31103-X] [PMID: 32410760]
[15]
Savastano, A.; Crincoli, E.; Savastano, M.C.; Younis, S.; Gambini, G.; De Vico, U. Peripapillary retinal vascular involvement in early post-COVID-19 patients. J. Clin. Med., 2020, 9(9), 2895.
[http://dx.doi.org/10.3390/jcm9092895]
[16]
Roberts, L.N.; Whyte, M.B.; Georgiou, L.; Giron, G.; Czuprynska, J.; Rea, C. Post-discharge venous thromboembolism following hospital admission with COVID-19. Am. Soc. Hematol., 2020, 136(11), 1347-1350.
[http://dx.doi.org/10.1182/blood.2020008086/1751468/blood.2020008086.pdf]
[17]
Patell, R. Post-discharge thrombosis and hemorrhage in patients with COVID-19. Am. Soc. Hematol., 2020, 136(11), 1342-1346.
[http://dx.doi.org/10.1182/blood.2020007938/1752425/blood.2020007938.pdf]
[18]
Belli, S.; Balbi, B.; Prince, I.; Cattaneo, D.; Masocco, F.; Zaccaria, S. Low physical functioning and impaired performance of activities of daily life in COVID-19 patients who survived hospitalisation. The Eur. Respire. J., 2020, 56(4), 2002096.
[http://dx.doi.org/10.1183/13993003.02096-2020]
[19]
Papageorghiou, A.T.; Deruelle, P.; Gunier, R.B.; Rauch, S.; García-May, P.K.; Mhatre, M.; Usman, M.A.; Abd-Elsalam, S.; Etuk, S.; Simmons, L.E.; Napolitano, R.; Deantoni, S.; Liu, B.; Prefumo, F.; Savasi, V.; do Vale, M.S.; Baafi, E.; Zainab, G.; Nieto, R.; Maiz, N.; Aminu, M.B.; Cardona-Perez, J.A.; Craik, R.; Winsey, A.; Tavchioska, G.; Bako, B.; Oros, D.; Rego, A.; Benski, A.C.; Hassan-Hanga, F.; Savorani, M.; Giuliani, F.; Sentilhes, L.; Risso, M.; Takahashi, K.; Vecchiarelli, C.; Ikenoue, S.; Thiruvengadam, R.; Soto Conti, C.P.; Ferrazzi, E.; Cetin, I.; Nachinab, V.B.; Ernawati, E.; Duro, E.A.; Kholin, A.; Firlit, M.L.; Easter, S.R.; Sichitiu, J.; Bowale, A.; Casale, R.; Cerbo, R.M.; Cavoretto, P.I.; Eskenazi, B.; Thornton, J.G.; Bhutta, Z.A.; Kennedy, S.H.; Villar, J. Preeclampsia and COVID-19: Results from the INTERCOVID prospective longitudinal study. Am. J. Obstet. Gynecol., 2021, 225(3), 289.e1-289.e17.
[http://dx.doi.org/10.1016/j.ajog.2021.05.014] [PMID: 34187688]
[20]
Kamal, M.; Abo Omirah, M.; Hussein, A.; Saeed, H. Assessment and characterisation of post-COVID-19 manifestations. Int. J. Clin. Pract., 2020, 75(3), e13746.
[http://dx.doi.org/10.1111/ijcp.13746]
[21]
Goertz, Y.M.J.; Van Herck, M.; Delbressine, J.M.; Vaes, A.W.; Meys, R. Machado, FVC Persistent symptoms 3 months after a SARS-CoV-2 infection: The post-COVID-19 syndrome? ERJ Open Res., 2020, 6(4), 542-2020.
[http://dx.doi.org/10.1183/23120541.00542-2020]
[22]
Saloner, B.; Parish, K.; Ward, J.A.; DiLaura, G.; Dolovich, S. COVID-19 cases and deaths in federal and state prisons. JAMA, 2020, 324(6), 602-603.
[http://dx.doi.org/10.1001/jama.2020.12528]
[23]
Akter, F.; Mannan, A.; Mehedi, H.M.H.; Rob, M.A.; Ahmed, S.; Salauddin, A.; Hossain, M.S.; Hasan, M.M. Clinical characteristics and short term outcomes after recovery from COVID-19 in patients with and without diabetes in Bangladesh. Diabetes Metab. Syndr., 2020, 14(6), 2031-2038.
[http://dx.doi.org/10.1016/j.dsx.2020.10.016] [PMID: 33113469]
[24]
Axfors, C.; Schmitt, A.M.; Janiaud, P.; Van’t Hooft, J.; Abd-Elsalam, S.; Abdo, E.F.; Abella, B.S.; Akram, J.; Amaravadi, R.K.; Angus, D.C.; Arabi, Y.M.; Azhar, S.; Baden, L.R.; Baker, A.W.; Belkhir, L.; Benfield, T.; Berrevoets, M.A.H.; Chen, C.P.; Chen, T.C.; Cheng, S.H.; Cheng, C.Y.; Chung, W.S.; Cohen, Y.Z.; Cowan, L.N.; Dalgard, O.; de Almeida, E. Val, F.F.; de Lacerda, M.V.G.; de Melo, G.C.; Derde, L.; Dubee, V.; Elfakir, A.; Gordon, A.C.; Hernandez-Cardenas, C.M.; Hills, T.; Hoepelman, A.I.M.; Huang, Y.W.; Igau, B.; Jin, R.; Jurado-Camacho, F.; Khan, K.S.; Kremsner, P.G.; Kreuels, B.; Kuo, C.Y.; Le, T.; Lin, Y.C.; Lin, W.P.; Lin, T.H.; Lyngbakken, M.N.; McArthur, C.; McVerry, B.J.; Meza-Meneses, P.; Monteiro, W.M.; Morpeth, S.C.; Mourad, A.; Mulligan, M.J.; Murthy, S.; Naggie, S.; Narayanasamy, S.; Nichol, A.; Novack, L.A.; O’Brien, S.M.; Okeke, N.L.; Perez, L.; Perez-Padilla, R.; Perrin, L.; Remigio-Luna, A.; Rivera-Martinez, N.E.; Rockhold, F.W.; Rodriguez-Llamazares, S.; Rolfe, R.; Rosa, R.; Røsjø, H.; Sampaio, V.S.; Seto, T.B.; Shahzad, M.; Soliman, S.; Stout, J.E.; Thirion-Romero, I.; Troxel, A.B.; Tseng, T.Y.; Turner, N.A.; Ulrich, R.J.; Walsh, S.R.; Webb, S.A.; Weehuizen, J.M.; Velinova, M.; Wong, H.L.; Wrenn, R.; Zampieri, F.G.; Zhong, W.; Moher, D.; Goodman, S.N.; Ioannidis, J.P.A.; Hemkens, L.G. Mortality outcomes with hydroxychloroquine and chloroquine in COVID-19 from an international collaborative meta-analysis of randomized trials. Nat. Commun., 2021, 12(1), 2349.
[http://dx.doi.org/10.1038/s41467-021-22446-z] [PMID: 33859192]
[25]
Fardman, A.; Oren, D.; Berkovitch, A.; Segev, A.; Levy, Y.; Beigel, R. Post COVID-19 acute myocardial infarction rebound. Can. J. Cardiol., 2020, 36(11), 1832.e15-1832.e16.
[http://dx.doi.org/10.1016/j.cjca.2020.08.016]
[26]
Abd-Elsalam, S.; Ahmed, O.A.; Mansour, N.O.; Abdelaziz, D.H.; Salama, M.; Fouad, M.H.A.; Soliman, S.; Naguib, A.M.; Hantera, M.S.; Ibrahim, I.S.; Torky, M.; Dabbous, H.M.; El Ghafar, M.S.A.; Abdul-Baki, E.A.; Elhendawy, M. Remdesivir efficacy in COVID-19 treatment: A randomized controlled trial. Am. J. Trop. Med. Hyg., 2021, tpmd210606.
[http://dx.doi.org/10.4269/ajtmh.21-0606] [PMID: 34649223]
[27]
El-Bendary, M.; Abd-Elsalam, S.; Elbaz, T.; El-Akel, W.; Cordie, A.; Elhadidy, T.; Elalfy, H.; Farid, K.; Elegezy, M.; El-Badrawy, A.; Neamatallah, M.; Abd Elghafar, M.; Salama, M. AbdAllah, M.; Essam, M.; El-Shazly, M.; Esmat, G. Efficacy of combined Sofosbuvir and Daclatasvir in the treatment of COVID-19 patients with pneumonia: A multicenter Egyptian study. Expert Rev. Anti Infect. Ther., 2021, 1-5, 1-5.
[http://dx.doi.org/10.1080/14787210.2021.1950532] [PMID: 34225541]
[28]
Abd-Elsalam, S.; Noor, R.A.; Badawi, R.; Khalaf, M.; Esmail, E.S.; Soliman, S.; Abd El Ghafar, M.S.; Elbahnasawy, M.; Moustafa, E.F.; Hassany, S.M.; Medhat, M.A.; Ramadan, H.K.; Eldeen, M.A.S.; Alboraie, M.; Cordie, A.; Esmat, G. Clinical study evaluating the efficacy of ivermectin in COVID-19 treatment: A randomized controlled study. J. Med. Virol., 2021, 93(10), 5833-5838.
[http://dx.doi.org/10.1002/jmv.27122] [PMID: 34076901]
[29]
Abd-Elsalam, S.; Soliman, S.; Esmail, E.S.; Khalaf, M.; Mostafa, E.F.; Medhat, M.A.; Ahmed, O.A.; El Ghafar, M.S.A.; Alboraie, M.; Hassany, S.M. Do zinc supplements enhance the clinical efficacy of hydroxychloroquine?: A randomized, multicenter trial. Biol. Trace Elem. Res., 2021, 199(10), 3642-3646.
[http://dx.doi.org/10.1007/s12011-020-02512-1] [PMID: 33247380]
[30]
Mohamed, A.A.; Mohamed, N.; Mohamoud, S.; Zahran, F.E.; Khattab, R.A.; El-Damasy, D.A.; Alsayed, E.; Abd-Elsalam, S. SARS-CoV-2: The path of prevention and control. Infect. Disord. Drug Targets, 2021, 21(3), 358-362.
[http://dx.doi.org/10.2174/1871526520666200520112848] [PMID: 32433010]

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