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ISSN (Print): 1381-6128
ISSN (Online): 1873-4286

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Review Article

FER1L4: A Long Non-coding RNA with Multiple Roles in the Occurrence and Development of Tumors

Author(s): Jie Mou, Bei Wang, Yuling Liu, Fengnan Zhao, Yinxin Wu, Wen Xu, Deyuan Zeng, Qi Zhang and Chengfu Yuan*

Volume 28, Issue 16, 2022

Published on: 20 May, 2022

Page: [1334 - 1341] Pages: 8

DOI: 10.2174/1381612828666220324141016

Price: $65

Abstract

Background: FER-1 family member 4 (FER1L4), a 6.7 kb lncRNA located at 20q11.22, plays an important biological function in a variety of tumor diseases. The purpose of this review is to clarify the pathophysiological mechanism and potential biological function of FER1L4 in different tumors.

Methods: By searching the relevant literature in PubMed, the specific pathophysiological mechanism of FER1L4 in different tumors was summarized.

Results: LncRNA FER1L4 is one of the key factors in tumorigenesis and is abnormally down-regulated in many tumors, including osteosarcoma, lung cancer, laryngeal squamous cell carcinoma, laryngeal cancer, colorectal cancer, ovarian cancer, prostate cancer, esophageal cancer, gastric cancer, endometrial cancer, osteoarthritis, rheumatoid arthritis, and so on. However, FER1L4 is downregulated in breast cancer, glioma, oral squamous cell carcinoma, renal clear cell carcinoma, and periodontitis, and plays a protective role in orthodontic teeth. In addition, as a tumor suppressor gene or oncogene, FER1L4 affects tumor proliferation, invasion, migration, and apoptosis.

Conclusion: LncRNA FER1L4 has a good application prospect in the treatment and diagnosis of various tumors.

Keywords: Long non-coding RNA, FER1L4, biological marker, target, diagnosis, malignancy, prognosis, mechanism.

« Previous Next »
[1]
Kumar S, Gonzalez EA, Rameshwar P, Etchegaray JP. Non-coding RNAs as mediators of epigenetic changes in malignancies. Cancers (Basel) 2020; 12(12): 12.
[http://dx.doi.org/10.3390/cancers12123657] [PMID: 33291485]
[2]
de Sousa VML, Carvalho L. Heterogeneity in lung cancer. Pathobiology 2018; 85(1-2): 96-107.
[http://dx.doi.org/10.1159/000487440] [PMID: 29635240]
[3]
Ritter J, Bielack SS. Osteosarcoma. Ann Oncol 2010; 21(Suppl. 7): vii320-5.
[http://dx.doi.org/10.1093/annonc/mdq276] [PMID: 20943636]
[4]
Hartke J, Johnson M, Ghabril M. The diagnosis and treatment of hepatocellular carcinoma. Semin Diagn Pathol 2017; 34(2): 153-9.
[http://dx.doi.org/10.1053/j.semdp.2016.12.011] [PMID: 28108047]
[5]
Thomas AC, Hubbard-Turner T, Wikstrom EA, Palmieri-Smith RM. Epidemiology of posttraumatic osteoarthritis. J Athl Train 2017; 52(6): 491-6.
[http://dx.doi.org/10.4085/1062-6050-51.5.08] [PMID: 27145096]
[6]
Meng WX, Wang BS. Epigenetic regulations in laryngeal squamous cell carcinoma. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi 2018; 32(22): 1958-762.
[PMID: 30716813]
[7]
Labianca R, Beretta GD, Kildani B, et al. Colon cancer. Crit Rev Oncol Hematol 2010; 74(2): 106-33.
[http://dx.doi.org/10.1016/j.critrevonc.2010.01.010] [PMID: 20138539]
[8]
Haraldsdottir S, Einarsdottir HM, Smaradottir A, Gunnlaugsson A, Halfdanarson TR. Colorectal cancer - review. Laeknabladid 2014; 100(2): 75-82.
[PMID: 24639430]
[9]
Scott DL, Wolfe F, Huizinga TWJ. Rheumatoid arthritis. Lancet 2010; 376(9746): 1094-108.
[http://dx.doi.org/10.1016/S0140-6736(10)60826-4] [PMID: 20870100]
[10]
Stewart C, Ralyea C, Lockwood S. Ovarian cancer: An integrated review. Semin Oncol Nurs 2019; 35(2): 151-6.
[http://dx.doi.org/10.1016/j.soncn.2019.02.001] [PMID: 30867104]
[11]
Murillo_Kypta_Nature_Reviews_Urology_accepted version.pdf
[12]
Huang FL, Yu SJ. Esophageal cancer: Risk factors, genetic association, and treatment. Asian J Surg 2018; 41(3): 210-5.
[http://dx.doi.org/10.1016/j.asjsur.2016.10.005] [PMID: 27986415]
[13]
Song Z, Wu Y, Yang J, Yang D, Fang X. Progress in the treatment of advanced gastric cancer. Tumour Biol 2017; 39(7): 1010428317714626.
[http://dx.doi.org/10.1177/1010428317714626] [PMID: 28671042]
[14]
Bell DW, Ellenson LH. Molecular genetics of endometrial carcinoma. Annu Rev Pathol 2019; 14(1): 339-67.
[http://dx.doi.org/10.1146/annurev-pathol-020117-043609] [PMID: 30332563]
[15]
Fan L, Strasser-Weippl K, Li J-J, et al. Breast cancer in China. Lancet Oncol 2014; 15(7): e279-89.
[http://dx.doi.org/10.1016/S1470-2045(13)70567-9] [PMID: 24872111]
[16]
Wesseling P, Capper D. WHO 2016 Classification of gliomas. Neuropathol Appl Neurobiol 2018; 44(2): 139-50.
[http://dx.doi.org/10.1111/nan.12432] [PMID: 28815663]
[17]
Panarese I, Aquino G, Ronchi A, et al. Oral and oropharyngeal squamous cell carcinoma: Prognostic and predictive parameters in the etiopathogenetic route. Expert Rev Anticancer Ther 2019; 19(2): 105-19.
[http://dx.doi.org/10.1080/14737140.2019.1561288] [PMID: 30582397]
[18]
Zhao J, Eyzaguirre E. Clear cell papillary renal cell carcinoma. Arch Pathol Lab Med 2019; 143(9): 1154-8.
[http://dx.doi.org/10.5858/arpa.2018-0121-RS] [PMID: 30672334]
[19]
Slots J. Periodontitis: Facts, fallacies and the future. Periodontol 2000 2017; 75(1): 7-23.
[http://dx.doi.org/10.1111/prd.12221] [PMID: 28758294]
[20]
Rossini G, Parrini S, Castroflorio T, Deregibus A, Debernardi CL. Efficacy of clear aligners in controlling orthodontic tooth movement: A systematic review. Angle Orthod 2015; 85(5): 881-9.
[http://dx.doi.org/10.2319/061614-436.1] [PMID: 25412265]
[21]
You Z, Ge A, Pang D, Zhao Y, Xu S. Long noncoding RNA FER1L4 acts as an oncogenic driver in human pan-cancer. J Cell Physiol 2020; 235(2): 1795-807.
[http://dx.doi.org/10.1002/jcp.29098] [PMID: 31332783]
[22]
Chen ZX, Chen CP, Zhang N, Wang TX. Low-expression of lncRNA FER1L4 might be a prognostic marker in osteosarcoma. Eur Rev Med Pharmacol Sci 2018; 22(8): 2310-4.
[PMID: 29762833]
[23]
Fei D, Zhang X, Liu J, et al. Long noncoding RNA FER1L4 suppresses tumorigenesis by regulating the expression of PTEN targeting mir-18a-5p in osteosarcoma. Cell Physiol Biochem 2018; 51(3): 1364-75.
[http://dx.doi.org/10.1159/000495554] [PMID: 30481787]
[24]
Ye F, Tian L, Zhou Q, Feng D. LncRNA FER1L4 induces apoptosis and suppresses EMT and the activation of PI3K/AKT pathway in osteosarcoma cells via inhibiting miR-18a-5p to promote SOCS5. Gene 2019; 721: 144093.
[http://dx.doi.org/10.1016/j.gene.2019.144093] [PMID: 31473323]
[25]
Han J, Shen X. Long noncoding RNAs in osteosarcoma via various signaling pathways. J Clin Lab Anal 2020; 34(6): e23317.
[http://dx.doi.org/10.1002/jcla.23317] [PMID: 32249459]
[26]
Ma L, Zhang L, Guo A, et al. Overexpression of FER1L4 promotes the apoptosis and suppresses epithelial-mesenchymal transition and stemness markers via activating PI3K/AKT signaling pathway in osteosarcoma cells. Pathol Res Pract 2019; 215(6): 152412.
[http://dx.doi.org/10.1016/j.prp.2019.04.004] [PMID: 31000382]
[27]
Gao X, Wang N, Wu S, Cui H, An X, Yang Y. Long non coding RNA FER1L4 inhibits cell proliferation and metastasis through regulation of the PI3K/AKT signaling pathway in lung cancer cells. Mol Med Rep 2019; 20(1): 182-90.
[http://dx.doi.org/10.3892/mmr.2019.10219] [PMID: 31115514]
[28]
Wu J, Huang J, Wang W, et al. Long non-coding RNA Fer-1-like protein 4 acts as a tumor suppressor via miR-106a-5p and predicts good prognosis in hepatocellular carcinoma. Cancer Biomark 2017; 20(1): 55-65.
[http://dx.doi.org/10.3233/CBM-170090] [PMID: 28759956]
[29]
Wang X, Dong K, Jin Q, Ma Y, Yin S, Wang S. Upregulation of lncRNA FER1L4 suppresses the proliferation and migration of the hepatocellular carcinoma via regulating PI3K/AKT signal pathway. J Cell Biochem 2019; 120(4): 6781-8.
[http://dx.doi.org/10.1002/jcb.27980] [PMID: 30382631]
[30]
He J, Wang L, Ding Y, Liu H, Zou G. lncRNA FER1L4 is dysregulated in osteoarthritis and regulates IL-6 expression in human chondrocyte cells. Sci Rep 2021; 11(1): 13032.
[http://dx.doi.org/10.1038/s41598-021-92474-8] [PMID: 34158566]
[31]
Jiao L, Liu S, Liu L, et al. Long non coding RNA fer 1 like family member 4 serves as a tumor suppressor in laryngeal squamous cell carcinoma cells via regulating the AKT/ERK signaling pathway. Mol Med Rep 2020; 22(6): 5304-12.
[http://dx.doi.org/10.3892/mmr.2020.11598] [PMID: 33174027]
[32]
Ding F, Tang H, Nie D, Xia L. Long non-coding RNA Fer-1-like family member 4 is overexpressed in human glioblastoma and regulates the tumorigenicity of glioma cells. Oncol Lett 2017; 14(2): 2379-84.
[http://dx.doi.org/10.3892/ol.2017.6403] [PMID: 28789454]
[33]
Xia L, Nie D, Wang G, Sun C, Chen G. FER1L4/miR-372/E2F1 works as a ceRNA system to regulate the proliferation and cell cycle of glioma cells. J Cell Mol Med 2019; 23(5): 3224-33.
[http://dx.doi.org/10.1111/jcmm.14198] [PMID: 30887657]
[34]
Yue B, Sun B, Liu C, et al. Long non-coding RNA Fer-1-like protein 4 suppresses oncogenesis and exhibits prognostic value by associating with miR-106a-5p in colon cancer. Cancer Sci 2015; 106(10): 1323-32.
[http://dx.doi.org/10.1111/cas.12759] [PMID: 26224446]
[35]
Ostovarpour M, Khalaj-Kondori M, Ghasemi T. Correlation between expression levels of lncRNA FER1L4 and RB1 in patients with colorectal cancer. Mol Biol Rep 2021; 48(5): 4581-9.
[http://dx.doi.org/10.1007/s11033-021-06488-6] [PMID: 34132945]
[36]
Zhang N, Zeng L, Wang S, et al. LncRNA FER1L4 promotes oral squamous cell carcinoma progression via targeting miR-133a-5p/Prx1 axis. OncoTargets Ther 2021; 14: 795-806.
[http://dx.doi.org/10.2147/OTT.S277351] [PMID: 33568918]
[37]
Liu YR, Yang L, Xu QQ, et al. Long noncoding RNA MEG3 regulates rheumatoid arthritis by targeting NLRC5. J Cell Physiol 2019; 234(8): 14270-84.
[http://dx.doi.org/10.1002/jcp.28126] [PMID: 30644097]
[38]
Liu S, Zou B, Tian T, et al. Overexpression of the lncRNA FER1L4 inhibits paclitaxel tolerance of ovarian cancer cells via the regulation of the MAPK signaling pathway. J Cell Biochem 2019; 120(5): 7581-9.
[PMID: 30444026]
[39]
Huo W, Qi F, Wang K. Long non-coding RNA FER1L4 inhibits prostate cancer progression via sponging miR-92a-3p and upregulation of FBXW7. Cancer Cell Int 2020; 20(1): 64.
[http://dx.doi.org/10.1186/s12935-020-1143-0] [PMID: 32140077]
[40]
Jonasch E, Walker CL, Rathmell WK. Clear cell renal cell carcinoma ontogeny and mechanisms of lethality. Nat Rev Nephrol 2021; 17(4): 245-61.
[http://dx.doi.org/10.1038/s41581-020-00359-2] [PMID: 33144689]
[41]
Cox A, Tolkach Y, Kristiansen G, Ritter M, Ellinger J. The lncRNA Fer1L4 is an adverse prognostic parameter in clear-cell renal-cell carcinoma. Clin Transl Oncol 2020; 22(9): 1524-31.
[http://dx.doi.org/10.1007/s12094-020-02291-0] [PMID: 31965534]
[42]
Ma W, Zhang CQ, Li HL, et al. LncRNA FER1L4 suppressed cancer cell growth and invasion in esophageal squamous cell carcinoma. Eur Rev Med Pharmacol Sci 2018; 22(9): 2638-45.
[PMID: 29771417]
[43]
Song H, Sun W, Ye G, et al. Long non-coding RNA expression profile in human gastric cancer and its clinical significances. J Transl Med 2013; 11(1): 225.
[http://dx.doi.org/10.1186/1479-5876-11-225] [PMID: 24063685]
[44]
Liu Z, Shao Y, Tan L, Shi H, Chen S, Guo J. Clinical significance of the low expression of FER1L4 in gastric cancer patients. Tumour Biol 2014; 35(10): 9613-7.
[http://dx.doi.org/10.1007/s13277-014-2259-4] [PMID: 24961353]
[45]
Sun W, Yang Y, Xu C, Xie Y, Guo J. Roles of long noncoding RNAs in gastric cancer and their clinical applications. J Cancer Res Clin Oncol 2016; 142(11): 2231-7.
[http://dx.doi.org/10.1007/s00432-016-2183-7] [PMID: 27246953]
[46]
Xia T, Chen S, Jiang Z, et al. Long noncoding RNA FER1L4 suppresses cancer cell growth by acting as a competing endogenous RNA and regulating PTEN expression. Sci Rep 2015; 5(1): 13445.
[http://dx.doi.org/10.1038/srep13445] [PMID: 26306906]
[47]
Xia T, Liao Q, Jiang X, et al. Long noncoding RNA associated-competing endogenous RNAs in gastric cancer. Sci Rep 2014; 4(1): 6088.
[http://dx.doi.org/10.1038/srep06088] [PMID: 25124853]
[48]
Huang Y, Han Y, Guo R, et al. Long non-coding RNA FER1L4 promotes osteogenic differentiation of human periodontal ligament stromal cells via miR-874-3p and vascular endothelial growth factor A. Stem Cell Res Ther 2020; 11(1): 5.
[http://dx.doi.org/10.1186/s13287-019-1519-z] [PMID: 31900200]
[49]
Huang Y, Zhang Y, Li X, et al. The long non-coding RNA landscape of periodontal ligament stem cells subjected to compressive force. Eur J Orthod 2019; 41(4): 333-42.
[http://dx.doi.org/10.1093/ejo/cjy057] [PMID: 30169774]
[50]
Huang Y, Liu H, Guo R, et al. Long Non-coding RNA FER1L4 mediates the autophagy of periodontal ligament stem cells under orthodontic compressive force via AKT/FOXO3 pathway. Front Cell Dev Biol 2021; 9: 631181.
[http://dx.doi.org/10.3389/fcell.2021.631181] [PMID: 33604341]
[51]
Dong P, Xiong Y, Yue J, et al. Exploring lncRNA-mediated regulatory networks in endometrial cancer cells and the tumor microenvironment: Advances and challenges. Cancers (Basel) 2019; 11(2): 234.
[52]
Kong Y, Ren Z. Overexpression of LncRNA FER1L4 in endometrial carcinoma is associated with favorable survival outcome. Eur Rev Med Pharmacol Sci 2018; 22(23): 8113-8.
[PMID: 30556848]
[53]
Qiao Q, Li H. LncRNA FER1L4 suppresses cancer cell proliferation and cycle by regulating PTEN expression in endometrial carcinoma. Biochem Biophys Res Commun 2016; 478(2): 507-12.
[http://dx.doi.org/10.1016/j.bbrc.2016.06.160] [PMID: 27381864]

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