Abstract
Liposome nanoparticles (LNPs), as a promising platform in drug delivery, combine the advantages of both liposomes and inorganic/organic nanoparticles into a single system. Both liposomes and nanoparticles have demonstrated optimized drug efficacy in the clinic. LNPs are proven to be multifunctional systems and thus utilized in various research applications (e.g., spatiotemporal control of drug release, hyperthermia, photothermal therapy, and biological imaging). The type of nanoparticles involved in LNPs largely affects the features of LNPs. Besides, diverse nanoparticles enable liposomes to overcome the defects such as poor stability, few functions, and rapid elimination from blood circulation. In this review, multiple nanoparticles materials and further prepared LNPs as well as their structure, physicochemical properties, manipulation and the latest applications in biomedical field are introduced. Future directions in advancing of LNPs are also discussed in the end.
Keywords: Liposome nanoparticles, nanostructure, drug delivery system, controlled drug release, combination therapy, imaging.
Graphical Abstract
[http://dx.doi.org/10.3390/molecules26041077] [PMID: 33670668]
[http://dx.doi.org/10.1016/j.msec.2018.05.018] [PMID: 29853147]
[http://dx.doi.org/10.1080/17435390.2020.1860265] [PMID: 33337941]
[http://dx.doi.org/10.1002/adma.201902333] [PMID: 31353752]
[http://dx.doi.org/10.1302/0301-620X.96B5.33606]
[http://dx.doi.org/10.3390/molecules25153542] [PMID: 32756410]
[http://dx.doi.org/10.1186/s12951-019-0514-y] [PMID: 31291960]
[PMID: 30611991]
[http://dx.doi.org/10.2174/1389450117666160401124624] [PMID: 27033191]
[http://dx.doi.org/10.1080/17425247.2018.1504018] [PMID: 30064267]
[http://dx.doi.org/10.1016/j.carbpol.2020.117108] [PMID: 33142645]
[http://dx.doi.org/10.1002/cplu.202000496] [PMID: 32864902]
[http://dx.doi.org/10.3390/molecules25071605] [PMID: 32244513]
[http://dx.doi.org/10.2174/1389200211314050005] [PMID: 23687925]
[http://dx.doi.org/10.1615/CritRevTherDrugCarrierSyst.2013006955] [PMID: 23662604]
[http://dx.doi.org/10.1002/wnan.1450] [PMID: 28198148]
[http://dx.doi.org/10.1080/10717544.2016.1177136] [PMID: 27145899]
[http://dx.doi.org/10.1016/j.addr.2012.09.037] [PMID: 23036225]
[http://dx.doi.org/10.3109/08982104.2015.1117490] [PMID: 26784833]
[http://dx.doi.org/10.1021/ar200105p] [PMID: 21812415]
[http://dx.doi.org/10.3390/pharmaceutics10030139] [PMID: 30154315]
[http://dx.doi.org/10.1517/17425240802652309] [PMID: 19236209]
[http://dx.doi.org/10.1080/17425247.2016.1182485] [PMID: 27116988]
[http://dx.doi.org/10.1080/17425247.2019.1669558] [PMID: 31530041]
[http://dx.doi.org/10.1039/C8TB03084G] [PMID: 30740226]
[PMID: 23872180]
[http://dx.doi.org/10.2217/17435889.2.1.85] [PMID: 17716195]
[http://dx.doi.org/10.1039/C3CS60299K] [PMID: 24100581]
[http://dx.doi.org/10.1016/j.msec.2019.01.129] [PMID: 30889738]
[http://dx.doi.org/10.3390/molecules25163731] [PMID: 32824172]
[http://dx.doi.org/10.1002/adhm.201901058] [PMID: 32196144]
[http://dx.doi.org/10.3390/ijms19071979] [PMID: 29986450]
[http://dx.doi.org/10.2147/IJN.S138624] [PMID: 28814860]
[PMID: 28061404]
[PMID: 33035830]
[http://dx.doi.org/10.1016/j.drudis.2019.01.013] [PMID: 30703542]
[http://dx.doi.org/10.3390/ijms19113564] [PMID: 30424535]
[http://dx.doi.org/10.1080/21691401.2020.1817052] [PMID: 32930615]
[http://dx.doi.org/10.1016/j.bios.2019.111919] [PMID: 31787449]
[http://dx.doi.org/10.1016/j.biomaterials.2010.12.043] [PMID: 21269689]
[http://dx.doi.org/10.1088/1748-605X/ab5f1a] [PMID: 31805539]
[PMID: 28370555]
[http://dx.doi.org/10.2147/IJN.S266006] [PMID: 33268986]
[http://dx.doi.org/10.1080/17425247.2019.1575806] [PMID: 30686075]
[http://dx.doi.org/10.3390/pharmaceutics10030118] [PMID: 30082647]
[http://dx.doi.org/10.1016/j.nano.2014.09.014] [PMID: 25461284]
[http://dx.doi.org/10.1002/adma.201104763] [PMID: 22378538]
[http://dx.doi.org/10.1016/j.apsb.2018.01.007] [PMID: 29719777]
[http://dx.doi.org/10.1002/anie.200604488] [PMID: 17854012]
[http://dx.doi.org/10.1016/j.ijpharm.2018.10.026] [PMID: 30316004]
[http://dx.doi.org/10.1039/c2cs15308d] [PMID: 22441299]
[http://dx.doi.org/10.1021/nn901376h] [PMID: 20731423]
[PMID: 33962002]
[http://dx.doi.org/10.1021/nn204102q] [PMID: 22309035]
[PMID: 23517784]
[http://dx.doi.org/10.1021/acsnano.6b02819] [PMID: 27419663]
[http://dx.doi.org/10.1021/ja808018y] [PMID: 19173660]
[http://dx.doi.org/10.1166/jbn.2011.1201] [PMID: 21485803]
[http://dx.doi.org/10.1021/acsnano.5b07781] [PMID: 26835979]
[http://dx.doi.org/10.1002/jps.24448] [PMID: 25873019]
[http://dx.doi.org/10.1002/elps.201700286] [PMID: 29235657]
[PMID: 26780591]
[http://dx.doi.org/10.1038/nmat2992] [PMID: 21499315]
[http://dx.doi.org/10.1021/acsami.8b15390] [PMID: 30609348]
[http://dx.doi.org/10.1186/s12951-020-00677-4] [PMID: 32811502]
[http://dx.doi.org/10.1016/j.ijpharm.2020.119576] [PMID: 32603839]
[PMID: 31518679]
[http://dx.doi.org/10.1021/acs.molpharmaceut.8b01073] [PMID: 30525641]
[http://dx.doi.org/10.1038/nrgastro.2012.115] [PMID: 22710569]
[http://dx.doi.org/10.1056/NEJMoa1304369] [PMID: 24131140]
[http://dx.doi.org/10.1021/acsnano.5b00510] [PMID: 25776964]
[http://dx.doi.org/10.1021/acs.molpharmaceut.7b00519] [PMID: 28737925]
[http://dx.doi.org/10.1021/acsami.7b13651] [PMID: 29276824]
[http://dx.doi.org/10.2174/1381612821666150901095722] [PMID: 26323432]
[http://dx.doi.org/10.2174/1381612822666160720145328] [PMID: 27510479]
[http://dx.doi.org/10.1021/acscentsci.6b00172] [PMID: 27725960]
[http://dx.doi.org/10.1002/adhm.201700759] [PMID: 28945015]
[http://dx.doi.org/10.1039/C8TB01114A] [PMID: 32254972]
[http://dx.doi.org/10.2147/IJN.S198353] [PMID: 30936695]
[http://dx.doi.org/10.3390/pharmaceutics13081291] [PMID: 34452251]
[http://dx.doi.org/10.3390/md18040201] [PMID: 32283782]
[http://dx.doi.org/10.1016/j.apsb.2019.10.002] [PMID: 32963951]
[http://dx.doi.org/10.1080/10717544.2020.1831105] [PMID: 33100057]
[http://dx.doi.org/10.1007/s13346-019-00616-3] [PMID: 30652257]
[http://dx.doi.org/10.1016/j.addr.2007.05.006] [PMID: 17618704]
[http://dx.doi.org/10.1080/10717544.2017.1311968] [PMID: 28436702]
[http://dx.doi.org/10.3390/pharmaceutics12070607] [PMID: 32629827]
[http://dx.doi.org/10.1016/j.ijpharm.2020.119246] [PMID: 32205141]
[http://dx.doi.org/10.1080/10717544.2020.1837294] [PMID: 33118428]
[http://dx.doi.org/10.1088/1361-6528/ab4241] [PMID: 31491782]
[http://dx.doi.org/10.2217/nnm-2016-0316] [PMID: 27876448]
[http://dx.doi.org/10.1007/s00604-019-3410-0] [PMID: 31037494]
[http://dx.doi.org/10.1021/ar200085c] [PMID: 21823593]
[http://dx.doi.org/10.1039/C8CP03016B] [PMID: 29923574]
[http://dx.doi.org/10.1248/cpb.34.4253] [PMID: 3829157]
[http://dx.doi.org/10.3390/ijms22179268] [PMID: 34502176]
[http://dx.doi.org/10.1002/cmmi.1697] [PMID: 27307214]
[http://dx.doi.org/10.1016/j.colsurfb.2016.07.002] [PMID: 27429294]
[PMID: 27090165]
[http://dx.doi.org/10.2147/IJN.S157082] [PMID: 29559778]
[http://dx.doi.org/10.1016/j.msec.2020.111116] [PMID: 32600717]
[http://dx.doi.org/10.1073/pnas.2136683100] [PMID: 14676325]
[http://dx.doi.org/10.2217/nnm-2018-0115] [PMID: 30265184]
[PMID: 19819275]
[http://dx.doi.org/10.1007/978-1-60327-360-2_19] [PMID: 20072888]
[http://dx.doi.org/10.1016/j.colsurfb.2017.03.008] [PMID: 28329728]
[http://dx.doi.org/10.1248/bpb.b17-00563] [PMID: 28966298]
[PMID: 30200551]
[PMID: 28784989]
[http://dx.doi.org/10.1088/0957-4484/27/8/085105] [PMID: 26820520]
[http://dx.doi.org/10.1515/znc-2017-0110] [PMID: 29894307]
[http://dx.doi.org/10.1016/j.colsurfb.2012.02.029] [PMID: 22521681]
[http://dx.doi.org/10.1002/ijc.24864] [PMID: 19711342]
[http://dx.doi.org/10.1021/nn506949t] [PMID: 25695371]
[http://dx.doi.org/10.1016/j.jphotobiol.2012.05.009] [PMID: 22854225]
[PMID: 32707876]
[http://dx.doi.org/10.1039/C8TB02684J] [PMID: 32254777]
[http://dx.doi.org/10.1002/smsc.202000055]
[http://dx.doi.org/10.2217/nnm.14.169] [PMID: 25600972]
[http://dx.doi.org/10.1021/nl052396o] [PMID: 16608261]
[http://dx.doi.org/10.3389/fchem.2019.00167] [PMID: 31024882]
[http://dx.doi.org/10.1177/153303460400300104] [PMID: 14750891]
[http://dx.doi.org/10.1016/j.biomaterials.2019.01.034] [PMID: 30703743]
[http://dx.doi.org/10.1021/acs.langmuir.8b03550] [PMID: 30517012]
[http://dx.doi.org/10.1016/j.nano.2009.04.009] [PMID: 19447206]
[http://dx.doi.org/10.1021/nl5045378] [PMID: 25554860]
[http://dx.doi.org/10.1007/s12291-013-0355-7] [PMID: 24966479]
[http://dx.doi.org/10.1016/j.nano.2017.03.012] [PMID: 28363771]
[http://dx.doi.org/10.1021/acs.langmuir.8b02553] [PMID: 30350687]
[http://dx.doi.org/10.1021/acs.nanolett.6b03588]
[http://dx.doi.org/10.1021/acs.jpcb.7b01702]
[http://dx.doi.org/10.1021/ja802656d] [PMID: 18543914]
[http://dx.doi.org/10.1007/s40259-018-0290-5]
[http://dx.doi.org/10.1016/j.biomaterials.2012.06.063] [PMID: 22795856]
[http://dx.doi.org/10.1080/21691401.2018.1436553] [PMID: 29405791]
[http://dx.doi.org/10.1088/1361-6528/aad358] [PMID: 30004030]
[http://dx.doi.org/10.1002/jbio.201600241] [PMID: 28417560]
[http://dx.doi.org/10.1039/C9BM00932A] [PMID: 31309204]
[http://dx.doi.org/10.1080/21691401.2018.1559177] [PMID: 30724609]
[http://dx.doi.org/10.2147/IJN.S156240] [PMID: 29692611]
[http://dx.doi.org/10.1016/j.jconrel.2015.02.028] [PMID: 25701610]
[http://dx.doi.org/10.1021/acs.langmuir.6b00716] [PMID: 27089512]
[http://dx.doi.org/10.2147/IJN.S241055] [PMID: 32368056]
[http://dx.doi.org/10.1021/bc5005679] [PMID: 25565445]
[PMID: 28345887]
[PMID: 27767252]
[http://dx.doi.org/10.1021/ja411339f] [PMID: 24417287]
[http://dx.doi.org/10.1039/C8NR05877F] [PMID: 30226255]
[http://dx.doi.org/10.1021/la703775a] [PMID: 18564860]
[PMID: 22619515]
[PMID: 30954619]
[http://dx.doi.org/10.1021/acsami.9b18388] [PMID: 31747243]
[http://dx.doi.org/10.1021/acsami.9b00294] [PMID: 30788951]
[http://dx.doi.org/10.1038/nri3902] [PMID: 26471778]
[http://dx.doi.org/10.7150/thno.18069] [PMID: 28255364]
[http://dx.doi.org/10.1021/acs.nanolett.9b03817] [PMID: 31671946]
[http://dx.doi.org/10.1039/C9NR05647E] [PMID: 31513215]
[PMID: 30458644]
[http://dx.doi.org/10.1016/j.colsurfb.2018.11.041] [PMID: 30476792]
[http://dx.doi.org/10.1016/j.talanta.2018.01.069] [PMID: 29501158]
[http://dx.doi.org/10.1042/BA20080007] [PMID: 18257745]
[http://dx.doi.org/10.1021/ja0546525] [PMID: 16144396]
[http://dx.doi.org/10.1002/chem.201800674] [PMID: 29512833]
[http://dx.doi.org/10.2174/1567201815666181031162208] [PMID: 30381073]
[http://dx.doi.org/10.1016/j.actbio.2017.10.040] [PMID: 29109030]
[http://dx.doi.org/10.1016/j.msec.2019.109860] [PMID: 31349463]
[http://dx.doi.org/10.1038/srep42767] [PMID: 28218295]
[http://dx.doi.org/10.1007/s41061-019-0278-8] [PMID: 31938922]
[http://dx.doi.org/10.1038/nbt0708-774] [PMID: 18612299]
[http://dx.doi.org/10.1016/j.ijpharm.2017.06.043] [PMID: 28627453]
[http://dx.doi.org/10.1007/s11095-015-1707-1] [PMID: 26085038]
[http://dx.doi.org/10.1177/0885328214543211] [PMID: 25033825]
[http://dx.doi.org/10.3109/1061186X.2014.931405] [PMID: 24964053]
[http://dx.doi.org/10.1021/acsnano.0c08790] [PMID: 33749240]
[http://dx.doi.org/10.1073/pnas.0308198101] [PMID: 15133147]
[http://dx.doi.org/10.1016/j.biomaterials.2012.10.053] [PMID: 23146432]
[http://dx.doi.org/10.1371/journal.pone.0114985] [PMID: 25501573]
[http://dx.doi.org/10.1016/j.ijpharm.2018.07.036] [PMID: 30016671]
[http://dx.doi.org/10.2334/josnusd.17-0488] [PMID: 30918207]
[http://dx.doi.org/10.1163/092050611X570644] [PMID: 21605505]
[http://dx.doi.org/10.1021/mp200028w] [PMID: 21557579]
[http://dx.doi.org/10.1002/biot.202000005] [PMID: 32330358]
[http://dx.doi.org/10.3390/nano7110351] [PMID: 29072630]
[PMID: 31074196]
[PMID: 31641713]