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ISSN (Print): 1574-8871
ISSN (Online): 1876-1038

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The Gut Microbiota-Brain Axis in Acute Neurological Disease: Focus on Stroke

Author(s): Angela Saviano*, Gunawardena Gayani, Alessio Migneco, Marcello Candelli, Francesco Franceschi, Veronica Ojetti, Christian Zanza and Yaroslava Longhitano

Volume 17, Issue 4, 2022

Published on: 11 April, 2022

Page: [240 - 244] Pages: 5

DOI: 10.2174/1574887117666220321155508

Price: $65

Abstract

The gut microbiota is one of the great innovations of modern medicine. In the modern microbiota revolution era, more comprehensive and in-depth studies have been performed regarding the microbial gut communities and their impact on acute and chronic diseases, including those of the nervous system as acute neurological diseases. The microbiota has changed our knowledge of medical conditions; in particular, considering stroke (both ischemic and hemorrhagic), literature studies, experimental and clinical researches indicate that the individual’s risk and outcomes are substantially impacted by the gut microbiota. The aim of our review article is to investigate and discuss the recent insights into the emerging role of this complex “gut microbiota-brain axis” in affecting some acute neurological diseases, such as stroke, responsible for a significant number of deaths worldwide.

We performed electronic research on PubMed® and collected articles published in the last ten years, finding that changes in the gut microbiota composition could affect various aspects of stroke pathophysiology and individual predisposition, risk, and outcomes. Our review article suggests that there is a strong connection between the gut microbiota and the brain, both in health and in acute neurological diseases such as stroke. Investigating and exploring this relationship can be a challenge useful to learn more about this disabling/deadly condition, and it can be a useful tool to identify novel potential therapeutic approaches, improving an individual’s outcomes and life.

Keywords: Gut microbiota-brain axis, stroke, emergency department, acute neurological disease, microbiota, brain.

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[1]
Battaglini D, Pimentel-Coelho PM, Robba C, et al. Gut microbiota in acute ischemic stroke: From pathophysiology to therapeutic implications. Front Neurol 2020; 11: 598.
[http://dx.doi.org/10.3389/fneur.2020.00598] [PMID: 32670191]
[2]
Zhao L, Yang L, Guo Y, Xiao J, Zhang J, Xu S. New insights into stroke prevention and treatment: Gut microbiome. Cell Mol Neurobiol 2022; 42(2): 455-72.
[http://dx.doi.org/10.1007/s10571-021-01047-w] [PMID: 33635417]
[3]
Singh V, Roth S, Llovera G, et al. Microbiota dysbiosis controls the neuroinflammatory response after stroke. J Neurosci 2016; 36(28): 7428-40.
[http://dx.doi.org/10.1523/JNEUROSCI.1114-16.2016] [PMID: 27413153]
[4]
Singh V, Sadler R, Heindl S, et al. The gut microbiome primes a cerebroprotective immune response after stroke. J Cereb Blood Flow Metab 2018; 38(8): 1293-8.
[http://dx.doi.org/10.1177/0271678X18780130] [PMID: 29846130]
[5]
Sadler R, Cramer JV, Heindl S, et al. Short-chain fatty acids improve poststroke recovery via immunological mechanisms. J Neurosci 2020; 40(5): 1162-73.
[http://dx.doi.org/10.1523/JNEUROSCI.1359-19.2019] [PMID: 31889008]
[6]
Pluta R, Januszewski S, Czuczwar SJ. The role of gut microbiota in an ischemic stroke. Int J Mol Sci 2021; 22(2): 915.
[http://dx.doi.org/10.3390/ijms22020915] [PMID: 33477609]
[7]
Sampson TR, Mazmanian SK. Control of brain development, function, and behavior by the microbiome. Cell Host Microbe 2015; 17(5): 565-76.
[http://dx.doi.org/10.1016/j.chom.2015.04.011] [PMID: 25974299]
[8]
Zhu S, Jiang Y, Xu K, et al. The progress of gut microbiome research related to brain disorders. J Neuroinflammation 2020; 17(1): 25.
[http://dx.doi.org/10.1186/s12974-020-1705-z] [PMID: 31952509]
[9]
Cryan JF, O’Riordan KJ, Cowan CSM, et al. The microbiota-gut-brain axis. Physiol Rev 2019; 99(4): 1877-2013.
[http://dx.doi.org/10.1152/physrev.00018.2018] [PMID: 31460832]
[10]
Sinagra E, Utzeri E, Morreale GC, Fabbri C, Pace F, Anderloni A. Microbiota-gut-brain axis and its affect inflammatory bowel disease: Pathophysiological concepts and insights for clinicians. World J Clin Cases 2020; 8(6): 1013-25.
[http://dx.doi.org/10.12998/wjcc.v8.i6.1013] [PMID: 32258072]
[11]
Zhang J, Tang Q, Zhu L. Could the gut microbiota serve as a therapeutic target in ischemic stroke? Evid Based Complement Alternat Med 2021; 2021: 1391384.
[http://dx.doi.org/10.1155/2021/1391384] [PMID: 33959182]
[12]
Delgado Jiménez R, Benakis C. The gut ecosystem: A critical player in stroke. Neuromolecular Med 2021; 23(2): 236-41.
[http://dx.doi.org/10.1007/s12017-020-08633-z] [PMID: 33206321]
[13]
Benakis C, Martin-Gallausiaux C, Trezzi J-P, Melton P, Liesz A, Wilmes P. The microbiome-gut-brain axis in acute and chronic brain diseases. Curr Opin Neurobiol 2020; 61: 1-9.
[http://dx.doi.org/10.1016/j.conb.2019.11.009] [PMID: 31812830]
[14]
Yin J, Liao SX, He Y,, et al. Dysbiosis of gut microbiota with reduced trimethylamine-n-oxide level in patients with large-artery atherosclerotic stroke or transient ischemic attack. J Am Heart Assoc 2015; 4(11): e002699.
[http://dx.doi.org/10.1161/JAHA.115.002699] [PMID: 26597155]
[15]
Zeng X, Gao X, Peng Y, et al. Higher risk of stroke is correlated with increased opportunistic pathogen load and reduced levels of butyrate-producing bacteria in the gut. Front Cell Infect Microbiol 2019; 9: 4.
[http://dx.doi.org/10.3389/fcimb.2019.00004] [PMID: 30778376]
[16]
Li N, Wang X, Sun C, et al. Change of intestinal microbiota in cerebral ischemic stroke patients. BMC Microbiol 2019; 19(1): 191.
[http://dx.doi.org/10.1186/s12866-019-1552-1] [PMID: 31426765]
[17]
Ji W, Zhu Y, Kan P, et al. Analysis of intestinal microbial communities of cerebral infarction and ischemia patients based on high throughput sequencing technology and glucose and lipid metabolism. Mol Med Rep 2017; 16(4): 5413-7.
[http://dx.doi.org/10.3892/mmr.2017.7227] [PMID: 28849032]
[18]
Zheng L, Kelly CJ, Battista KD, et al. Microbial-derived butyrate promotes epithelial barrier function through IL-10 receptor-dependent repression of claudin-2. J Immunol 2017; 199(8): 2976-84.
[http://dx.doi.org/10.4049/jimmunol.1700105] [PMID: 28893958]
[19]
Lukovac S, Belzer C, Pellis L, et al. Differential modulation by Akkermansia muciniphila and Faecalibacterium prausnitzii of host peripheral lipid metabolism and histone acetylation in mouse gut organoids. MBio 2014; 5(4): e01438-14.
[http://dx.doi.org/10.1128/mBio.01438-14] [PMID: 25118238]
[20]
Dimidi E, Cox SR, Rossi M, Whelan K. Fermented foods: Definitions and characteristics, impact on the gut microbiota and effects on gastrointestinal health and disease. Nutrients 2019; 11(8): 1806.
[http://dx.doi.org/10.3390/nu11081806] [PMID: 31387262]
[21]
Pascale A, Marchesi N, Marelli C, et al. Microbiota and metabolic diseases. Endocrine 2018; 61(3): 357-71.
[http://dx.doi.org/10.1007/s12020-018-1605-5] [PMID: 29721802]
[22]
Parker A, Fonseca S, Carding SR. Gut microbes and metabolites as modulators of blood-brain barrier integrity and brain health. Gut Microbes 2020; 11(2): 135-57.
[http://dx.doi.org/10.1080/19490976.2019.1638722] [PMID: 31368397]
[23]
de Jong PR, González-Navajas JM, Jansen NJ. The digestive tract as the origin of systemic inflammation. Crit Care 2016; 20(1): 279.
[http://dx.doi.org/10.1186/s13054-016-1458-3] [PMID: 27751165]
[24]
Xu R, Tan C, Zhu J, et al. Dysbiosis of the intestinal microbiota in neurocritically ill patients and the risk for death. Crit Care 2019; 23(1): 195.
[http://dx.doi.org/10.1186/s13054-019-2488-4] [PMID: 31151471]

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