Powerful Stress Relieving Medicinal Plants for Anger, Anxiety,
Depression, and Stress During Global Pandemic

Mohamad   Hesam   Shahrajabian
doi:10.2174/1872208316666220321102216
Abstract

Consideration and improvement for anxiety and depression are important during a global pandemic. Appropriate healthcare can be obtained by paying more attention to traditional medicinal sciences. The adverse effects of stress with various symptoms can be managed by introducing plants that boost mental health. The most relevant psychological reactions in the general population related to the global pandemic are pervasive anxiety, frustration and boredom, specific and uncontrolled fear, disabling loneliness, significant lifestyle changes, and psychiatric conditions. Ginseng, chamomile, passionflower, herbal tea, lavender, saffron, kava, rose, cardamom, Chinese date, and some chief formula like yokukansan, Dan-zhi-xiao-yao-san, so-ochim-tang-gamiband, and saikokaryukotsuboreito are notable herbal treatments for mental health problems. The most common medicinal plants that have been used in Iran for the cure of stress and anxiety are Viper’s-buglosses, Dracocephalum, valerian, chamomile, common hop, hawthorns, and lavender. Medicinal plants and herbs can be used for the treatment and alleviation of the negative effects of stress, anger, and depression during the global pandemic.
Keywords: SARS-CoV-2, SARS, human coronaviruses, stress, mental health, traditional herbal medicine.
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[1] 
Ogbaji PO, Li J, Xue X, Shahrajabian MH, Egrinya EA. Impact of bio-fertilizer or nutrient solution on spinach (Spinacea oleracea) growth and yield in some province soils of P. R. China. Cercet Agron Mold  2018; 2(174): 43-52.
[http://dx.doi.org/10.2478/cerce-2018-0015] 
[2] 
Shahrajabian MH, Sun W, Cheng Q. A review of astragalus species as foodstuffs, dietary supplements, a traditional Chinese medicine and a part of modern pharmaceutical science. Appl Ecol Environ Res  2019; 17(6): 13371-82.
[http://dx.doi.org/10.15666/aeer/1706_1337113382] 
[3] 
Shahrajabian MH, Sun W, Cheng Q. DNA methylation as the most important content of epigenetics in traditional Chinese herbal medicine. J Med Plants Res  2019; 13(16): 357-69.
[http://dx.doi.org/10.5897/JMPR2019.6803] 
[4] 
Khoshkharam M, Shahrajabian MH, Sun W, Cheng Q. Survey the allelopathic effects of tobacco (Nicotiana tabacum L.) on corn (Zea mays L.) growth and germination. Cercet Agron Mold  2019; 4(180): 332-40.
[5] 
Soleymani A, Shahrajabian MH. Changes in germination and seedling growth of different cultivars of cumin to drought stress. Cercet Agron Mold  2018; 51(1): 91-100.
[http://dx.doi.org/10.2478/cerce-2018-0008] 
[6] 
Soleymani A, Shahrajabian MH. Response of different cultivars of fennel (Foeniculum vulgare) to irrigation and planting dates in Isfahan, Iran. Res Crops  2012; 13(2): 656-60.
[7] 
Ogbaji PO, Shahrajabian MH, Xue X. Changes in germination and primarily growth of three cultivars of tomato under diatomite and soil materials in auto-irrigation system. Int J Biol  2013; 5(3): 80-4.
[http://dx.doi.org/10.5539/ijb.v5n3p80] 
[8] 
Shahrajabian MH, Sun W, Cheng Q. A review of ginseng species in different regions as a multipurpose herb in traditional Chinese medicine, modern herbology and pharmacological science. J Med Plants Res  2019; 13(10): 213-26.
[9] 
Shahrajabian MH, Sun W, Cheng Q. Clinical aspects and health benefits of ginger (Zingiber officinale) in both traditional Chinese medicine and modern industry. Acta Agric Scand B Soil Plant Sci  2019; 69(6): 546-56.
[http://dx.doi.org/10.1080/09064710.2019.1606930] 
[10] 
Casteleijn D, Steel A, Bowman D, Lauche R, Wardle J. A naturalistic study of herbal medicine for self-reported depression and/or anxiety a protocol. Integr Med Res  2019; 8(2): 123-8.
[http://dx.doi.org/10.1016/j.imr.2019.04.007] [PMID:  31193603] 
[11] 
Sahoo S, Suku B. Pharmacogenomic assessment of herbal drugs in affective disorders. Biomed Pharmacother  2019; 109: 1148-62.
[http://dx.doi.org/10.1016/j.biopha.2018.10.135] [PMID:  30551365] 
[12] 
Shahrajabian MH, Sun W, Cheng Q. Chinese star anise (Illicium verum) and pyrethrum (Chrysanthemum cinerariifolium) as natural alternatives for organic farming and health care- A review. Aust J Crop Sci  2020; 14(03): 517-23.
[http://dx.doi.org/10.21475/ajcs.20.14.03.p2209] 
[13] 
Shahrajabian MH, Sun W, Cheng Q. A short review of goji berry, ginger, ginseng and astragalus in traditional Chinese and Asian medicine. Black Sea J Health Sci  2020; 3(2): 36-45.
[14] 
Shahrajabian MH, Sun W, Shen H, Cheng Q. Chinese herbal medicine for SARS and SARS-CoV-2 treatment and prevention, encouraging using herbal medicine for COVID-19 outbreak. Acta Agric Scand B Soil Plant Sci  2020; 70(5): 437-43.
[http://dx.doi.org/10.1080/09064710.2020.1763448] 
[15] 
Shahrajabian MH, Sun W, Cheng Q. Chemical components and pharmacological benefits of Basil (Ocimum basilicum): A review. Int J Food Prop  2020; 23(1): 1961-70.
[http://dx.doi.org/10.1080/10942912.2020.1828456] 
[16] 
Shahrajabian MH, Sun W, Cheng Q. Traditional herbal medicine for the prevention and treatment of cold and flu in the autumn of 2020, overlapped with COVID-19. Nat Prod Commun  2020; 15(8): 1-10.
[http://dx.doi.org/10.1177/1934578X20951431] 
[17] 
Shahrajabian MH, Wun W, Cheng Q. Chemical and pharmacological benefits of basil (Ocimum basilicum): A review. Int J Food Prop  2020; 23(1): 1961-70.
[http://dx.doi.org/10.1080/10942912.2020.1828456] 
[18] 
Sun W, Shahrajabian MH, Cheng Q. The insight and survey on medicinal properties and nutritive components of shallot. J Med Plants Res  2019; 13(18): 452-7.
[http://dx.doi.org/10.5897/JMPR2019.6836] 
[19] 
Sun W, Shahrajabian MH, Cheng Q. Anis (Pimpinella anisum l.), a dominant spice and traditional medicinal herb for both food and medicinal purposes. Cogent Biol  2019; 5(1673688): 1-25.
[http://dx.doi.org/10.1080/23312025.2019.1673688] 
[20] 
Sun N, Wei L, Shi S, et al. A qualitative study on the psychological experience of caregivers of COVID-19 patients. Am J Infect Control  2020; 48(6): 592-8.
[http://dx.doi.org/10.1016/j.ajic.2020.03.018] [PMID:  32334904] 
[21] 
Zhao Q, Li S, Xue F, et al. Structure of the main protease from a global infectious human coronavirus, HCoV-HKU1. J Virol  2008; 82(17): 8647-55.
[http://dx.doi.org/10.1128/JVI.00298-08] [PMID:  18562531] 
[22] 
Favreau DJ, Desforges M, St-Jean JR, Talbot PJ. A human coronavirus OC43 variant harboring persistence-associated mutations in the S glycoprotein differentially induces the unfolded protein response in human neurons as compared to wild-type virus. Virology  2009; 395(2): 255-67.
[http://dx.doi.org/10.1016/j.virol.2009.09.026] [PMID:  19846189] 
[23] 
Liang F-Y, Lin L-C, Ying T-H, et al. Immunoreactivity characterisation of the three structural regions of the human coronavirus OC43 nucleocapsid protein by Western blot: Implications for the diagnosis of coronavirus infection. J Virol Methods  2013; 187(2): 413-20.
[http://dx.doi.org/10.1016/j.jviromet.2012.11.009] [PMID:  23174159] 
[24] 
Bruning AHL, Aatola H, Toivola H, et al. Rapid detection and monitoring of human coronavirus infections. New Microbes New Infect  2018; 24: 52-5.
[http://dx.doi.org/10.1016/j.nmni.2018.04.007] [PMID:  29872531] 
[25] 
Killerby ME, Biggs HM, Haynes A, et al. Human coronavirus circulation in the United States 2014-2017. J Clin Virol  2018; 101: 52-6.
[http://dx.doi.org/10.1016/j.jcv.2018.01.019] [PMID:  29427907] 
[26] 
Bok M, Miño S, Rodriguez D, et al. Molecular and antigenic characterization of bovine coronavirus circulating in Argentinean cattle during 1994-2010. Vet Microbiol  2015; 181(3-4): 221-9.
[http://dx.doi.org/10.1016/j.vetmic.2015.10.017] [PMID:  26520931] 
[27] 
Kin N, Miszczak F, Diancourt L, et al. Comparative molecular epidemiology of two closely related coronaviruses, bovine coronavirus (BCoV) and human coronavirus OC43 (HCoV-OC43), reveals a different evolutionary pattern. Infect Genet Evol  2016; 40: 186-91.
[http://dx.doi.org/10.1016/j.meegid.2016.03.006] [PMID:  26969241] 
[28] 
Zhang XM, Kousoulas KG, Storz J. The hemagglutinin/esterase gene of human coronavirus strain OC43: phylogenetic relationships to bovine and murine coronaviruses and influenza C virus. Virology  1992; 186(1): 318-23.
[http://dx.doi.org/10.1016/0042-6822(92)90089-8] [PMID:  1727608] 
[29] 
Butler N, Pewe L, Trandem K, Perlman S. Murine encephalitis caused by HCoV-OC43, a human coronavirus with broad species specificity, is partly immune-mediated. Virology  2006; 347(2): 410-21.
[http://dx.doi.org/10.1016/j.virol.2005.11.044] [PMID:  16413043] 
[30] 
Lu S, Wang Y, Chen Y, et al. Discovery of a novel canine respiratory coronavirus support genetic recombination among betacoronavirus1. Virus Res  2017; 237: 7-13.
[http://dx.doi.org/10.1016/j.virusres.2017.05.006] [PMID:  28506792] 
[31] 
McIntosh K, Becker WB, Chanock RM. Growth in suckling-mouse brain of “IBV-like” viruses from patients with upper respiratory tract disease. Proc Natl Acad Sci USA  1967; 58(6): 2268-73.
[http://dx.doi.org/10.1073/pnas.58.6.2268] [PMID:  4298953] 
[32] 
Vlasak R, Luytjes W, Spaan W, Palese P. Human and bovine coronaviruses recognize sialic acid-containing receptors similar to those of influenza C viruses. Proc Natl Acad Sci USA  1988; 85(12): 4526-9.
[http://dx.doi.org/10.1073/pnas.85.12.4526] [PMID:  3380803] 
[33] 
Patrick DM, Petric M, Skowronski DM, et al. An outbreak of human coronavirus OC43 infection and serological cross-reactivity with SARS coronavirus. Can J Infect Dis Med Microbiol  2006; 17(6): 330-6.
[http://dx.doi.org/10.1155/2006/152612] [PMID:  18382647] 
[34] 
Beidas M, Chehadeh W. Effect of human coronavirus OC43 structural and accessory proteins on the transcriptional activation of antiviral response elements. Intervirology  2018; 61(1): 30-5.
[http://dx.doi.org/10.1159/000490566] [PMID:  30041172] 
[35] 
Temperton NJ, Chan PK, Simmons G, et al. Longitudinally profiling neutralizing antibody response to SARS coronavirus with pseudotypes. Emerg Infect Dis  2005; 11(3): 411-6.
[http://dx.doi.org/10.3201/eid1103.040906] [PMID:  15757556] 
[36] 
Sloots TP, Whiley DM, Lambert SB, Nissen MD. Emerging respiratory agents: New viruses for old diseases? J Clin Virol  2008; 42(3): 233-43.
[http://dx.doi.org/10.1016/j.jcv.2008.03.002] [PMID:  18406664] 
[37] 
Esper F, Ou Z, Huang YT. Human coronaviruses are uncommon in patients with gastrointestinal illness. J Clin Virol  2010; 48(2): 131-3.
[http://dx.doi.org/10.1016/j.jcv.2010.03.007] [PMID:  20362494] 
[38] 
Al-Khannaq MN, Ng KT, Oong XY, et al. Molecular epidemiology and evolutionary histories of human coronavirus OC43 and HKU1 among patients with upper respiratory tract infections in Kuala Lumpur, Malaysia. Virol J  2016; 13(1): 33.
[http://dx.doi.org/10.1186/s12985-016-0488-4] [PMID:  26916286] 
[39] 
Kahn JS, McIntosh K. History and recent advances in coronavirus discovery. Pediatr Infect Dis J  2005; 24(11)(Suppl.): S223-7.
[http://dx.doi.org/10.1097/01.inf.0000188166.17324.60] [PMID:  16378050] 
[40] 
Vabret A, Dina J, Gouarin S, Petitjean J, Corbet S, Freymuth F. Detection of the new human coronavirus HKU1: A report of 6 cases. Clin Infect Dis  2006; 42(5): 634-9.
[http://dx.doi.org/10.1086/500136] [PMID:  16447108] 
[41] 
Hays JP, Myint SH. PCR sequencing of the spike genes of geographically and chronologically distinct human coronaviruses 229E. J Virol Methods  1998; 75(2): 179-93.
[http://dx.doi.org/10.1016/S0166-0934(98)00116-5] [PMID:  9870593] 
[42] 
Herold J, Raabe T, Schelle-Prinz B, Siddell SG. Nucleotide sequence of the human coronavirus 229E RNA polymerase locus. Virology  1993; 195(2): 680-91.
[http://dx.doi.org/10.1006/viro.1993.1419] [PMID:  8337838] 
[43] 
Hofmann H, Pyrc K, van der Hoek L, Geier M, Berkhout B, Pöhlmann S. Human coronavirus NL63 employs the severe acute respiratory syndrome coronavirus receptor for cellular entry. Proc Natl Acad Sci USA  2005; 102(22): 7988-93.
[http://dx.doi.org/10.1073/pnas.0409465102] [PMID:  15897467] 
[44] 
Yeager CL, Ashmun RA, Williams RK, et al. Human aminopeptidase N is a receptor for human coronavirus 229E. Nature  1992; 357(6377): 420-2.
[http://dx.doi.org/10.1038/357420a0] [PMID:  1350662] 
[45] 
Desforges M, Miletti TC, Gagnon M, Talbot PJ. Activation of human monocytes after infection by human coronavirus 229E. Virus Res  2007; 130(1-2): 228-40.
[http://dx.doi.org/10.1016/j.virusres.2007.06.016] [PMID:  17669539] 
[46] 
Lo Y-S, Lin SY, Wang S-M, et al. Oligomerization of the carboxyl terminal domain of the human coronavirus 229E nucleocapsid protein. FEBS Lett  2013; 587(2): 120-7.
[http://dx.doi.org/10.1016/j.febslet.2012.11.016] [PMID:  23178926] 
[47] 
Wang S-M, Huang K-J, Wang C-T. BST2/CD317 counteracts human coronavirus 229E productive infection by tethering virions at the cell surface. Virology  2014; 449: 287-96.
[http://dx.doi.org/10.1016/j.virol.2013.11.030] [PMID:  24418563] 
[48] 
Yamaya M, Nishimura H, Deng X, et al. Inhibitory effects of flycopyrronium, formoterol, and budesonide on coronavirus HCoV-229E replication and cytokine production by primary cultures of human nasal and tracheal epithelial cells. Respir Investig  2020; 58(3): 155-68.
[http://dx.doi.org/10.1016/j.resinv.2019.12.005] 
[49] 
Zhang R, Wang K, Lv W, et al. The ORF4a protein of human coronavirus 229E functions as a viroporin that regulates viral production. Biochim Biophys Acta  2014; 1838(4): 1088-95.
[http://dx.doi.org/10.1016/j.bbamem.2013.07.025] [PMID:  23906728] 
[50] 
Cui L-J, Zhang C, Zhang T, et al. Human coronaviruses HCoV-NL63 and HCoV-HKU1 in hospitalized children with acute respiratory infections in Beijing, China. Adv Virol  2010; 6.
[http://dx.doi.org/10.1155/2011/129134] [PMID:  22315599] 
[51] 
Han TH, Chung J-Y, Kim SW, Hwang E-S. Human coronavirus-NL63 infections in Korean children, 2004-2006. J Clin Virol  2007; 38(1): 27-31.
[http://dx.doi.org/10.1016/j.jcv.2006.10.009] [PMID:  17137835] 
[52] 
Dijkman R, Jebbink MF, Gaunt E, et al. The dominance of human coronavirus OC43 and NL63 infections in infants. J Clin Virol  2012; 53(2): 135-9.
[http://dx.doi.org/10.1016/j.jcv.2011.11.011] [PMID:  22188723] 
[53] 
Hong X, Currier GW, Zhao X, Jiang Y, Zhou W, Wei J. Posttraumatic stress disorder in convalescent severe acute respiratory syndrome patients: A 4-year follow-up study. Gen Hosp Psychiatry  2009; 31(6): 546-54.
[http://dx.doi.org/10.1016/j.genhosppsych.2009.06.008] [PMID:  19892213] 
[54] 
Ohnishi K, Hattori Y, Kobayashi K, Akaji K. Evaluation of a non-prime site substituent and warheads combined with a decahydroisoquinolin scaffold as a SARS 3CL protease inhibitor. Bioorg Med Chem  2019; 27(2): 425-35.
[http://dx.doi.org/10.1016/j.bmc.2018.12.019] [PMID:  30558861] 
[55] 
Law PYP, Liu Y-M, Geng H, Kwan KH, Waye MM-Y, Ho Y-Y. Expression and functional characterization of the putative protein 8b of the severe acute respiratory syndrome-associated coronavirus. FEBS Lett  2006; 580(15): 3643-8.
[http://dx.doi.org/10.1016/j.febslet.2006.05.051] [PMID:  16753150] 
[56] 
Rota PA, Oberste MS, Monroe SS, et al. Characterization of a novel coronavirus associated with severe acute respiratory syndrome. Science  2003; 300(5624): 1394-9.
[http://dx.doi.org/10.1126/science.1085952] [PMID:  12730500] 
[57] 
Spiegel M, Pichlmair A, Martínez-Sobrido L, et al. Inhibition of Beta interferon induction by severe acute respiratory syndrome coronavirus suggests a two-step model for activation of interferon regulatory factor 3. J Virol  2005; 79(4): 2079-86.
[http://dx.doi.org/10.1128/JVI.79.4.2079-2086.2005] [PMID:  15681410] 
[58] 
He Y, Zhou Y, Wu H, et al. Identification of immunodominant sites on the spike protein of severe acute respiratory syndrome (SARS) coronavirus: Implication for developing SARS diagnostics and vaccines. J Immunol  2004; 173(6): 4050-7.
[http://dx.doi.org/10.4049/jimmunol.173.6.4050] [PMID:  15356154] 
[59] 
Zheng B, He M-L, Wong K-L, et al. Potent inhibition of SARS-associated coronavirus (SCOV) infection and replication by type I interferons (IFN-alpha/beta) but not by type II interferon (IFN-gamma). J Interferon Cytokine Res  2004; 24(7): 388-90.
[http://dx.doi.org/10.1089/1079990041535610] [PMID:  15296649] 
[60] 
Nieto-Torres JL, DeDiego ML, Verdiá-Báguena C, et al. Severe acute respiratory syndrome coronavirus envelope protein ion channel activity promotes virus fitness and pathogenesis. PLoS Pathog  2014; 10(5)e1004077
[http://dx.doi.org/10.1371/journal.ppat.1004077] [PMID:  24788150] 
[61] 
Ahmad A, Krumkamp R, Reintjes R. Controlling SARS: A review on China,s response compared with other SARS-affected countries. Trop Med Int Health  2009; 14(1): 36-45.
[http://dx.doi.org/10.1111/j.1365-3156.2008.02146.x] [PMID:  19017309] 
[62] 
Wong CKK, Lai V, Wong YC. Comparison of initial high resolution computed tomography features in viral pneumonia between metapneumovirus infection and severe acute respiratory syndrome. Eur J Radiol  2012; 81(5): 1083-7.
[http://dx.doi.org/10.1016/j.ejrad.2011.02.050] [PMID:  21439753] 
[63] 
Hafeez R, Aslam M, Aman S, Tahir M. Severe acute respiratory syndrome (SARS): A deadly disease. Ann King Edw Med Univ  2016; 10(1): 1130.
[http://dx.doi.org/10.21649/akemu.v10i1.1130] 
[64] 
Wang Q, Wong G, Lu G, Yan J, Gao GF. MERS-CoV spike protein: Targets for vaccines and therapeutics. Antiviral Res  2016; 133: 165-77.
[http://dx.doi.org/10.1016/j.antiviral.2016.07.015] [PMID:  27468951] 
[65] 
Demmler GJ, Ligon BL. Severe acute respiratory syndrome (SARS): A review of the history, epidemiology, prevention, and concerns for the future. Semin Pediatr Infect Dis  2003; 14(3): 240-4.
[http://dx.doi.org/10.1016/S1045-1870(03)00056-6] [PMID:  12913837] 
[66] 
Memish ZA, Zumla AI, Assiri A. Middle East respiratory syndrome coronavirus infections in health care workers. N Engl J Med  2013; 369(9): 884-6.
[http://dx.doi.org/10.1056/NEJMc1308698] [PMID:  23923992] 
[67] 
Memish ZA, Al-Tawfiq JA. Middle East respiratory syndrome coronavirus infection control: The missing piece? Am J Infect Control  2014; 42(12): 1258-60.
[http://dx.doi.org/10.1016/j.ajic.2014.08.003] [PMID:  25465252] 
[68] 
Al-Tawfiq JA, Zumla A, Memish ZA. Travel implications of emerging coronaviruses: SARS and MERS-CoV. Travel Med Infect Dis  2014; 12(5): 422-8.
[http://dx.doi.org/10.1016/j.tmaid.2014.06.007] [PMID:  25047726] 
[69] 
Noorwali AA, Turkistani AM, Asiri SI, et al. Descriptive epidemiology and characteristics of confirmed cases of Middle East respiratory syndrome coronavirus infection in the Makkah Region of Saudi Arabia, March to June 2014. Ann Saudi Med  2015; 35(3): 203-9.
[http://dx.doi.org/10.5144/0256-4947.2015.203] [PMID:  26409794] 
[70] 
Maxwell C, McGeer A, Tai KFY, Sermer M. 225-management guidelines for obstetric patients and neonates born to mothers with suspected or probable severe acute respiratory syndrome (SARS). J Obstet Gynaecol Can  2017; 39(8): e130-7.
[http://dx.doi.org/10.1016/j.jogc.2017.04.024] [PMID:  28729104] 
[71] 
Ko J-H, Kim S-H, Lee NY, et al. Effects of environmental disinfection on the isolation of vancomycin-resistant Enterococcus after a hospital-associated outbreak of Middle East respiratory syndrome. Am J Infect Control  2019; 47(12): 1516-8.
[http://dx.doi.org/10.1016/j.ajic.2019.05.032] [PMID:  31307795] 
[72] 
Assiri A, Abedi GR, Bin Saeed AA, et al. Multifacility outbreak of Middle East respiratory syndrome in Tarif. Emerg Infect Dis  2016; 22(1): 32-40.
[http://dx.doi.org/10.3201/eid2201.151370] [PMID:  26692003] 
[73] 
Inn K-S, Kim Y, Aigerim A, et al. Reduction of soluble dipeptidyl peptidase 4 levels in plasma of patients infected with Middle East respiratory syndrome coronavirus. Virology  2018; 518: 324-7.
[http://dx.doi.org/10.1016/j.virol.2018.03.015] [PMID:  29587190] 
[74] 
Corman VM, Ölschläger S, Wendtner C-M, Drexler JF, Hess M, Drosten C. Performance and clinical validation of the RealStar MERS-CoV Kit for detection of Middle East respiratory syndrome coronavirus RNA. J Clin Virol  2014; 60(2): 168-71.
[http://dx.doi.org/10.1016/j.jcv.2014.03.012] [PMID:  24726679] 
[75] 
Papaneri AB, Johnson RF, Wada J, Bollinger L, Jahrling PB, Kuhn JH. Middle East respiratory syndrome: Obstacles and prospects for vaccine development. Expert Rev Vaccines  2015; 14(7): 949-62.
[http://dx.doi.org/10.1586/14760584.2015.1036033] [PMID:  25864502] 
[76] 
Qiu H, Sun S, Xiao H, et al. Single-dose treatment with a humanized neutralizing antibody affords full protection of a human transgenic mouse model from lethal Middle East respiratory syndrome (MERS)-coronavirus infection. Antiviral Res  2016; 132: 141-8.
[http://dx.doi.org/10.1016/j.antiviral.2016.06.003] [PMID:  27312105] 
[77] 
Pallesen J, Wang N, Corbett KS, et al. Immunogenicity and structures of a rationally designed prefusion MERS-CoV spike antigen. Proc Natl Acad Sci USA  2017; 114(35): E7348-57.
[http://dx.doi.org/10.1073/pnas.1707304114] [PMID:  28807998] 
[78] 
Tang B, Bragazzi NL, Li Q, Tang S, Xiao Y, Wu J. An updated estimation of the risk of transmission of the novel coronavirus (2019-nCov). Infect Dis Model  2020; 5: 248-55.
[http://dx.doi.org/10.1016/j.idm.2020.02.001] [PMID:  32099934] 
[79] 
Kim Y. Nurses’ experiences of care for patients with Middle East respiratory syndrome-coronavirus in South Korea. Am J Infect Control  2018; 46(7): 781-7.
[http://dx.doi.org/10.1016/j.ajic.2018.01.012] [PMID:  29502886] 
[80] 
Lu G, Wang Q, Gao GF. Bat-to-human: Spike features determining ‘host jump’ of coronaviruses SARS-CoV, MERS-CoV, and beyond. Trends Microbiol  2015; 23(8): 468-78.
[http://dx.doi.org/10.1016/j.tim.2015.06.003] [PMID:  26206723] 
[81] 
Nikiforuk AM, Leung A, Cook BWM, Court DA, Kobasa D, Theriault SS. Rapid one-step construction of a Middle East Respiratory Syndrome (MERS-CoV) infectious clone system by homologous recombination. J Virol Methods  2016; 236: 178-83.
[http://dx.doi.org/10.1016/j.jviromet.2016.07.022] [PMID:  27459876] 
[82] 
Hashem AM, Al-Amri SS, Al-Subhi TL, et al. Development and validation of different indirect ELISAs for MERS-CoV serological testing. J Immunol Methods  2019; 466: 41-6.
[http://dx.doi.org/10.1016/j.jim.2019.01.005] [PMID:  30659836] 
[83] 
Ebihara H, Groseth A, Neumann G, Kawaoka Y, Feldmann H. The role of reverse genetics systems in studying viral hemorrhagic fevers. Thromb Haemost  2005; 94(2): 240-53.
[http://dx.doi.org/10.1160/TH05-05-0335] [PMID:  16113812] 
[84] 
Letko M, Miazgowicz K, McMinn R, et al. Adaptive evolution of MERS-CoV to species variation in DPP4. Cell Rep  2018; 24(7): 1730-7.
[http://dx.doi.org/10.1016/j.celrep.2018.07.045] [PMID:  30110630] 
[85] 
Mustafa S, Balkhy H, Gabere MN. Current treatment options and the role of peptides as potential therapeutic components for Middle East Respiratory Syndrome (MERS): A review. J Infect Public Health  2018; 11(1): 9-17.
[http://dx.doi.org/10.1016/j.jiph.2017.08.009] [PMID:  28864360] 
[86] 
Baharoon S, Memish ZA. MERS-CoV as an emerging respiratory illness: A review of prevention methods. Travel Med Infect Dis  2019; 32101520
[http://dx.doi.org/10.1016/j.tmaid.2019.101520] [PMID:  31730910] 
[87] 
Yuan R, Xu Q-H, Xia C-C, et al. Psychological status of parents of hospitalized children during the COVID-19 epidemic in China. Psychiatry Res  2020; 288112953
[http://dx.doi.org/10.1016/j.psychres.2020.112953] [PMID:  32302814] 
[88] 
Shereen MA, Khan S, Kazmi A, Bashir N, Siddique R. COVID-19 infection: Origin, transmission, and characteristics of human coronaviruses. J Adv Res  2020; 24: 91-8.
[http://dx.doi.org/10.1016/j.jare.2020.03.005] [PMID:  32257431] 
[89] 
Yu F, Du L, Ojcius DM, Pan C, Jiang S. Measures for diagnosing and treating infections by a novel coronavirus responsible for a pneumonia outbreak originating in Wuhan, China. Microbes Infect  2020; 22(2): 74-9.
[http://dx.doi.org/10.1016/j.micinf.2020.01.003] [PMID:  32017984] 
[90] 
Wall AC, Park Y-J, Tortoici MA, Wall A, McGuire AT, Veesler D. Structure, function, and antigenicity of the SARS-CoV-2 spike glycoprotein. Cell  2020; 181(2): 281-92.
[http://dx.doi.org/10.1016/j.cell.2020.02.058] 
[91] 
Tian S, Hu N, Lou J, et al. Characteristics of COVID-19 infection in Beijing. J Infect  2020; 80(4): 401-6.
[http://dx.doi.org/10.1016/j.jinf.2020.02.018] [PMID:  32112886] 
[92] 
Li SW, Wang Y, Yang YY, Lei XM, Yang YF. Analysis of influencing factors of anxiety and emotional disorders in children and adolescents during home isolation during the epidemic of novel coronavirus pneumonia.  Chinese J Child Health 2020; pp. 1-9.
[93] 
Grubaugh ND, Petrone ME, Holmes EC. We shouldn’t worry when a virus mutates during disease outbreaks. Nat Microbiol  2020; 5(4): 529-30.
[http://dx.doi.org/10.1038/s41564-020-0690-4] [PMID:  32071422] 
[94] 
Ghinai I, McPherson TD, Hunter JC, et al. First known person-to-person transmission of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in the USA. Lancet 2020.
[http://dx.doi.org/10.1016/S0140-6736(20)30607-3] 
[95] 
Fernandez E, Callen A, Johnson SL, Gaspar C, Kulhanek C, Jose-Bueno C. Prevalence, elicitors, and expression of anger in 21st century mass shootings. Aggress Violent Behav  2020; 55101483
[http://dx.doi.org/10.1016/j.avb.2020.101483] 
[96] 
Kosson DS, Garofalo C, McBride CK, Velotti P. Get mad: Chronic anger expression and psychopathic traits in three independent samples. J Crim Justice  2020; 67101672
[http://dx.doi.org/10.1016/j.jcrimjus.2020.101672] 
[97] 
Berkout OV, Tinsley D, Flynn M. A review of anger, hostility, and aggression from an ACT perspective. J Contextual Behav Sci  2019; 11: 34-43.
[http://dx.doi.org/10.1016/j.jcbs.2018.12.001] 
[98] 
Neale J, Kalk NJ, Parkin S, et al. Factors associated with withdrawal symptoms and anger among people resuscitated from an opioid overdose by take-home naloxone: Exploratory mixed methods analysis. J Subst Abuse Treat  2020; 117108099
[http://dx.doi.org/10.1016/j.jsat.2020.108099] [PMID:  32811629] 
[99] 
de Bles NJ, Rius Ottenheim N, van Hemert AM, et al. Trait anger and anger attacks in relation to depressive and anxiety disorders. J Affect Disord  2019; 259: 259-65.
[http://dx.doi.org/10.1016/j.jad.2019.08.023] [PMID:  31450135] 
[100] 
Stephens AN, O’Hern S, Young KL, Chambers R, Hassed C, Koppel S. Self-reported mindfulness, cyclist anger and aggression. Accid Anal Prev  2020; 144105625
[http://dx.doi.org/10.1016/j.aap.2020.105625] [PMID:  32526500] 
[101] 
Sullivan SD, Kahn JH. Individual differences in expressive suppression and the subjective experience, verbal disclosure, and behavioral expression of anger. Pers Individ Dif  2020; 155109723
[http://dx.doi.org/10.1016/j.paid.2019.109723] 
[102] 
Yip JA, Schweitzer ME. Losing your temper and your perspective: Anger reduces perspective-taking. Organ Behav Hum Decis Process  2019; 150: 28-45.
[http://dx.doi.org/10.1016/j.obhdp.2018.07.003] 
[103] 
Adam H, Brett JM. Everything in moderation: The social effects of anger depend on its perceived intensity. J Exp Soc Psychol  2018; 76: 12-8.
[http://dx.doi.org/10.1016/j.jesp.2017.11.014] 
[104] 
Sirosis MS, Bernier A, Lemelin JP. Child temperamental anger, mother-child interactions, and socio-emotional functioning at school entry. Early Child Res Q  2019; 47: 30-8.
[http://dx.doi.org/10.1016/j.ecresq.2018.10.005] 
[105] 
Dillon KH, Van Voorhees EEV, Dennis PA, et al. Anger mediates the relationship between posttraumatic stress disorder and suicidal ideation in veterans. J Affect Disord  2020; 269: 117-24.
[http://dx.doi.org/10.1016/j.jad.2020.03.053] [PMID:  32250864] 
[106] 
Gaianu PA, Giosan C, Sarbescu P. From trait anger to aggressive violations in road traffic. Transp Res, Part F Traffic Psychol Behav  2020; 70: 15-24.
[http://dx.doi.org/10.1016/j.trf.2020.02.006] 
[107] 
Ābele L, Haustein S, Møller M, Zettler I. Links between observed and self-reported driving anger, observed and self-reported aggressive driving, and personality traits. Accid Anal Prev  2020; 140105516
[http://dx.doi.org/10.1016/j.aap.2020.105516] [PMID:  32244089] 
[108] 
Robinson MD, Traurig E, Klein RJ. On looking versus leaping: A situated multilevel approach to trait anger and the anger-aggression relationship. Pers Individ Dif  2020; 164110130
[http://dx.doi.org/10.1016/j.paid.2020.110130] 
[109] 
Harris KM, Gottdiener JS, Gottlieb SS, Burg MM, Li S, Krantz DS. Impact of mental stress and anger on indices of diastolic function in patients with heart failure. J Card Fail  2020; 26(11): 1006-10.
[http://dx.doi.org/10.1016/j.cardfail.2020.07.008] [PMID:  32750485] 
[110] 
March E, Grieve R, Wagstaff D, Slocum A. Exploring anger as a moderator of narcissism and antisocial behavior on tinder. Pers Individ Dif  2020; 161109961
[http://dx.doi.org/10.1016/j.paid.2020.109961] 
[111] 
Wang X, Yang L, Yang J, et al. Trait anger and aggression: A moderated mediation model of anger rumination and moral disengagement. Pers Individ Dif  2018; 125: 44-9.
[http://dx.doi.org/10.1016/j.paid.2017.12.029] 
[112] 
Ng TWH, Sorensen KL, Zhang Y, Yim FHK. Anger, anxiety, depression, and negative affect: Convergent or divergent? J Vocat Behav  2019; 110: 186-202.
[http://dx.doi.org/10.1016/j.jvb.2018.11.014] 
[113] 
Chen Q, Liang M, Li Y, et al. Mental health care for medical staff in China during the COVID-19 outbreak. Lancet Psychiatry  2020; 7(4): e15-6.
[http://dx.doi.org/10.1016/S2215-0366(20)30078-X] [PMID:  32085839] 
[114] 
Lee SA. Coronavirus anxiety scale: A brief mental health screener for COVID-19 related anxiety. Death Stud  2020; 44(7): 393-401.
[http://dx.doi.org/10.1080/07481187.2020.1748481] [PMID:  32299304] 
[115] 
Luo M, Guo L, Yu M, Jiang W, Wang H. The psychological and mental impact of coronavirus disease 2019 (COVID-19) on medical staff and general public - A systematic review and meta-analysis. Psychiatry Res  2020; 291113190
[http://dx.doi.org/10.1016/j.psychres.2020.113190] [PMID:  32563745] 
[116] 
Khan S, Siddique R, Bai Q. Coronaviruses disease 2019 (COVID-19): Causative agent, mental health concerns and potential management option. J Infect Public Health  2020; 13(12): 1840-4.
[http://dx.doi.org/10.1016/j.jiph.2020.07.010] 
[117] 
Savitsky B, Findling Y, Ereli A, Hendel T. Anxiety and coping strategies among nursing students during the COVID-19 pandemic. Nurse Educ Pract  2020; 46102809
[http://dx.doi.org/10.1016/j.nepr.2020.102809] [PMID:  32679465] 
[118] 
Ma Y-F, Li W, Deng H-B, et al. Prevalence of depression and its association with quality of life in clinically stable patients with COVID-19. J Affect Disord  2020; 275: 145-8.
[http://dx.doi.org/10.1016/j.jad.2020.06.033] [PMID:  32658818] 
[119] 
Moghanibashi-Mansourieh A. Assessing the anxiety level of Iranian general population during COVID-19 outbreak. Asian J Psychiatr  2020; 51102076
[http://dx.doi.org/10.1016/j.ajp.2020.102076] [PMID:  32334409] 
[120] 
Yuan B, Li W, Liu H, et al. Correlation between immune response and self-reported depression during convalescence from COVID-19. Brain Behav Immun  2020; 88: 39-43.
[http://dx.doi.org/10.1016/j.bbi.2020.05.062] [PMID:  32464158] 
[121] 
Segerstrom SC, O’Connor DB. Stress, health and illness: Four challenges for the future. Psychol Health  2012; 27(2): 128-40.
[http://dx.doi.org/10.1080/08870446.2012.659516] [PMID:  22348326] 
[122] 
Toussaint L, Shields GS, Dorn G, Slavich GM. Effects of lifetime stress exposure on mental and physical health in young adulthood: How stress degrades and forgiveness protects health. J Health Psychol  2016; 21(6): 1004-14.
[http://dx.doi.org/10.1177/1359105314544132] [PMID:  25139892] 
[123] 
Clark MS, Bond MJ, Hecker JR. Environmental stress, psychological stress and allostatic load. Psychol Health Med  2007; 12(1): 18-30.
[http://dx.doi.org/10.1080/13548500500429338] [PMID:  17129930] 
[124] 
Crum AJ, Akinola M, Martin A, Fath S. The role of stress mindset in shaping cognitive, emotional, and physiological responses to challenging and threatening stress. Anxiety Stress Coping  2017; 30(4): 379-95.
[http://dx.doi.org/10.1080/10615806.2016.1275585] [PMID:  28120622] 
[125] 
Huebschmann NA, Sheets ES. The right mindset: stress mindset moderates the association between perceived stress and depressive symptoms. Anxiety Stress Coping  2020; 33(3): 248-55.
[http://dx.doi.org/10.1080/10615806.2020.1736900] [PMID:  32138538] 
[126] 
Smith L, Jacob L, Yakkundi A, et al. Correlates of symptoms of anxiety and depression and mental wellbeing associated with COVID-19: A cross-sectional study of UK-based respondents. Psychiatry Res  2020; 291113138
[http://dx.doi.org/10.1016/j.psychres.2020.113138] [PMID:  32562931] 
[127] 
Goodwin R, Wiwattanapantuwong J, Tuicomepee A, Suttiwan P, Watakakosol R. Anxiety and public responses to COVID-19: Early data from Thailand. J Psychiatr Res  2020; 129: 118-21.
[http://dx.doi.org/10.1016/j.jpsychires.2020.06.026] [PMID:  32912591] 
[128] 
Kira IA, Shuwiekh HAM, Rice KG, et al. Measuring COVID-19 as traumatic stress: Initial psychometrics and validation. J Loss Trauma  2020; 26(3): 220-37.
[http://dx.doi.org/10.1080/15325024.2020.1790160] 
[129] 
McKay D, Yang H, Elhai J, Asmundson GJG. Anxiety regarding contracting COVID-19 related to interoceptive anxiety sensations: The moderating role of disgust propensity and sensitivity. J Anxiety Disord  2020; 73102233
[http://dx.doi.org/10.1016/j.janxdis.2020.102233] [PMID:  32442880] 
[130] 
Fox HC, Sinha R. Sex differences in drug-related stress-system changes: Implications for treatment in substance-abusing women. Harv Rev Psychiatry  2009; 17(2): 103-19.
[http://dx.doi.org/10.1080/10673220902899680] [PMID:  19373619] 
[131] 
Stults-Kolehmainen MA, Tuit K, Sinha R. Lower cumulative stress is associated with better health for physically active adults in the community. Stress  2014; 17(2): 157-68.
[http://dx.doi.org/10.3109/10253890.2013.878329] [PMID:  24392966] 
[132] 
Harmsen R, Helms-Lorenz M, Maulana R, van Veen K, Veldhoven M. Measuring general and specific stress causes and stress responses among beginning secondary school teachers in the Netherlands. Int J Res Method Educ  2019; 42(1): 91-108.
[http://dx.doi.org/10.1080/1743727X.2018.1462313] 
[133] 
Tam CW, Pang EP, Lam LC, Chiu HF. Severe acute respiratory syndrome (SARS) in Hong Kong in 2003: Stress and psychological impact among frontline healthcare workers. Psychol Med  2004; 34(7): 1197-204.
[http://dx.doi.org/10.1017/S0033291704002247] [PMID:  15697046] 
[134] 
Maunder RG, Lancee WJ, Rourke S, et al. Factors associated with the psychological impact of severe acute respiratory syndrome on nurses and other hospital workers in Toronto. Psychosom Med  2004; 66(6): 938-42.
[http://dx.doi.org/10.1097/01.psy.0000145673.84698.18] [PMID:  15564361] 
[135] 
Lancee WJ, Maunder RG, Goldbloom DS. Prevalence of psychiatric disorders among Toronto hospital workers one to two years after the SARS outbreak. Psychiatr Serv  2008; 59(1): 91-5.
[http://dx.doi.org/10.1176/ps.2008.59.1.91] [PMID:  18182545] 
[136] 
Mak IW, Chu CM, Pan PC, Yiu MG, Chan VL. Long-term psychiatric morbidities among SARS survivors. Gen Hosp Psychiatry  2009; 31(4): 318-26.
[http://dx.doi.org/10.1016/j.genhosppsych.2009.03.001] [PMID:  19555791] 
[137] 
Izadinia N, Amiri M, Jahromi RG, Hamidi S. A study of relationship between suicidal ideas, depression, anxiety, resiliency, daily stresses and mental health among Tehran university students. Procedia Soc Behav Sci  2010; 5: 1515-9.
[http://dx.doi.org/10.1016/j.sbspro.2010.07.335] 
[138] 
da Silva FCT, Neto MLR. Psychiatric symptomatology associated with depression, anxiety, distress, and insomnia in health professionals working in patients affected by COVID-19: A systematic review with meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry  2021; 104110057
[http://dx.doi.org/10.1016/j.pnpbp.2020.110057] [PMID:  32777327] 
[139] 
Liang Y, Chen M, Zheng X, Liu J. Screening for Chinese medical staff mental health by SDS and SAS during the outbreak of COVID-19. J Psychosom Res  2020; 133110102
[http://dx.doi.org/10.1016/j.jpsychores.2020.110102] [PMID:  32224344] 
[140] 
Zhao Q, Niu Y, Matsumoto K, et al. Chotosan ameliorates cognitive and emotional deficits in an animal model of type 2 diabetes: Possible involvement of cholinergic and VEGF/PDGF mechanisms in the brain. BMC Complement Altern Med  2012; 12(1): 188.
[http://dx.doi.org/10.1186/1472-6882-12-188] [PMID:  23082896] 
[141] 
Percudani M, Corradin M, Moreno M, Indelicato A, Vita A. Mental health services in Lombardy during COVID-19 outbreak. Psychiatry Res  2020; 288112980
[http://dx.doi.org/10.1016/j.psychres.2020.112980] [PMID:  32315881] 
[142] 
Zhang J, Shuai L, Yu H, et al. Acute stress, behavioural symptoms and mood states among school-age children with attention-deficit/hyperactive disorder during the COVID-19 outbreak. Asian J Psychiatr  2020; 51102077
[http://dx.doi.org/10.1016/j.ajp.2020.102077] [PMID:  32315967] 
[143] 
Brooks SK, Webster RK, Smith LE, et al. The psychological impact of quarantine and how to reduce it: Rapid review of the evidence. Lancet  2020; 395(10227): 912-20.
[http://dx.doi.org/10.1016/S0140-6736(20)30460-8] [PMID:  32112714] 
[144] 
Chen W-L, Lin J-J, Wang C-T, Shen Y-C, Chen S-T, Chao Y-L. Regulating anger in different relationship contexts: A comparison between psychiatric outpatients and community controls. Heliyon  2020; 6(7)e04413
[http://dx.doi.org/10.1016/j.heliyon.2020.e04413] [PMID:  32760821] 
[145] 
Li L, Yang Z, Dang Z, et al. Propagation analysis and prediction of the COVID-19. Infect Dis Model  2020; 5: 282-92.
[http://dx.doi.org/10.1016/j.idm.2020.03.002] [PMID:  32292868] 
[146] 
Yang Y, Li W, Zhang Q, Zhang L, Cheung T, Xiang YT. Mental health services for older adults in China during the COVID-19 outbreak. Lancet Psychiatry  2020; 7(4)e19
[http://dx.doi.org/10.1016/S2215-0366(20)30079-1] [PMID:  32085843] 
[147] 
Cao W, Fang Z, Hou G, et al. The psychological impact of the COVID-19 epidemic on college students in China. Psychiatry Res  2020; 287112934
[http://dx.doi.org/10.1016/j.psychres.2020.112934] [PMID:  32229390] 
[148] 
Colizzi M, Bortoletto R, Silvestri M, et al. Medically unexplained symptoms in the times of COVID-19 pandemic: A case-report. Brain Behav Immun  2020; 5100073
[http://dx.doi.org/10.1016/j.bbih.2020.100073] [PMID:  32313886] 
[149] 
Ursano RJ, Zhang L, Li H, et al. PTSD and traumatic stress from gene to community and bench to bedside. Brain Res  2009; 1293: 2-12.
[http://dx.doi.org/10.1016/j.brainres.2009.03.030] [PMID:  19328776] 
[150] 
Yuan M, Yin W, Tao Z, Tan W, Hu Y. Association of radiologic findings with mortality of patients infected with 2019 novel coronavirus in Wuhan, China. PLoS One  2020; 15(3)e0230548
[http://dx.doi.org/10.1371/journal.pone.0230548] [PMID:  32191764] 
[151] 
Zhai Y, Du X. Addressing collegiate mental health amid COVID-19 pandemic. Psychiatry Res  2020; 288113003
[http://dx.doi.org/10.1016/j.psychres.2020.113003] [PMID:  32315885] 
[152] 
Araújo FJO, de Lima LSA, Cidade PIM, Nobre CB, Neto MLR. Impact of SARS-CoV-2 and its reverberation in global higher education and mental health. Psychiatry Res  2020; 288112977
[http://dx.doi.org/10.1016/j.psychres.2020.112977] [PMID:  32302818] 
[153] 
Sarani H, Balouchi A, Masinaeinezhad N, Ebrahimitabas E. Knowledge, attitude and practice of nurses about standard precautions for hospital-acquired infection in teaching hospitals affiliated to Zabol university of medical sciences. Glob J Health Sci  2015; 8(3): 193-8.
[http://dx.doi.org/10.5539/gjhs.v8n3p193] [PMID:  26493432] 
[154] 
Shi Y, Wang J, Yang Y, et al. Knowledge and attitudes of medical staff in Chinese psychiatric hospitals regarding COVID-19. Brain Behav Immun  2020; 4100064
[http://dx.doi.org/10.1016/j.bbih.2020.100064] [PMID:  32289123] 
[155] 
Wu D, Jiang C, He C, Li C, Yang L, Yue Y. Stressors of nurses in psychiatric hospitals during the COVID-19 outbreak. Psychiatry Res  2020; 288112956
[http://dx.doi.org/10.1016/j.psychres.2020.112956] [PMID:  32315879] 
[156] 
Babore A, Lombardi L, Viceconti ML, et al. Psychological effects of the COVID-2019 pandemic: Perceived stress and coping strategies among healthcare professionals. Psychiatry Res  2020; 293113366
[http://dx.doi.org/10.1016/j.psychres.2020.113366] [PMID:  32798932] 
[157] 
Hu D, Kong Y, Li W, et al. Frontline nurses’ burnout, anxiety, depression, and fear statuses and their associated factors during the COVID-19 outbreak in Wuhan, China: A large-scale cross-sectional study. EClinicalMedicine  2020; 24100424
[http://dx.doi.org/10.1016/j.eclinm.2020.100424] [PMID:  32766539] 
[158] 
Chan AOM, Huak CY. Psychological impact of the 2003 severe acute respiratory syndrome outbreak on health care workers in a medium size regional general hospital in Singapore. Occup Med (Lond)  2004; 54(3): 190-6.
[http://dx.doi.org/10.1093/occmed/kqh027] [PMID:  15133143] 
[159] 
Chong MY, Wang WC, Hsieh WC, et al. Psychological impact of severe acute respiratory syndrome on health workers in a tertiary hospital. Br J Psychiatry  2004; 185(2): 127-33.
[http://dx.doi.org/10.1192/bjp.185.2.127] [PMID:  15286063] 
[160] 
Chua SE, Cheung V, Cheung C, et al. Psychological effects of the SARS outbreak in Hong Kong on high-risk health care workers. Can J Psychiatry  2004; 49(6): 391-3.
[http://dx.doi.org/10.1177/070674370404900609] [PMID:  15283534] 
[161] 
Sim K, Chong PN, Chan YH, Soon WS. Severe acute respiratory syndrome-related psychiatric and posttraumatic morbidities and coping responses in medical staff within a primary health care setting in Singapore. J Clin Psychiatry  2004; 65(8): 1120-7.
[http://dx.doi.org/10.4088/JCP.v65n0815] [PMID:  15323599] 
[162] 
Chen CS, Wu HY, Yang P, Yen CF. Psychological distress of nurses in Taiwan who worked during the outbreak of SARS. Psychiatr Serv  2005; 56(1): 76-9.
[http://dx.doi.org/10.1176/appi.ps.56.1.76] [PMID:  15637196] 
[163] 
Su TP, Lien T-C, Yang C-Y, et al. Prevalence of psychiatric morbidity and psychological adaptation of the nurses in a structured SARS caring unit during outbreak: A prospective and periodic assessment study in Taiwan. J Psychiatr Res  2007; 41(1-2): 119-30.
[http://dx.doi.org/10.1016/j.jpsychires.2005.12.006] [PMID:  16460760] 
[164] 
Kwek S-K, Chew W-M, Ong K-C, et al. Quality of life and psychological status in survivors of severe acute respiratory syndrome at 3 months postdischarge. J Psychosom Res  2006; 60(5): 513-9.
[http://dx.doi.org/10.1016/j.jpsychores.2005.08.020] [PMID:  16650592] 
[165] 
Lee S-H, Juang Y-Y, Su Y-J, Lee H-L, Lin Y-H, Chao C-C. Facing SARS: Psychological impacts on SARS team nurses and psychiatric services in a Taiwan general hospital. Gen Hosp Psychiatry  2005; 27(5): 352-8.
[http://dx.doi.org/10.1016/j.genhosppsych.2005.04.007] [PMID:  16168796] 
[166] 
Jeong H, Yim HW, Song YJ, et al. Mental health status of people isolated due to Middle East respiratory syndrome. Epidemiol Health  2016; 38e2016048
[http://dx.doi.org/10.4178/epih.e2016048] [PMID:  28196409] 
[167] 
Khalid I, Khalid TJ, Qabajah MR, Barnard AG, Qushmaq IA. Healthcare workers emotions, perceived stressors and coping strategies during a MERS-CoV outbreak. Clin Med Res  2016; 14(1): 7-14.
[http://dx.doi.org/10.3121/cmr.2016.1303] [PMID:  26847480] 
[168] 
Lee SM, Kang WS, Cho A-R, Kim T, Park JK. Psychological impact of the 2015 MERS outbreak on hospital workers and quarantined hemodialysis patients. Compr Psychiatry  2018; 87: 123-7.
[http://dx.doi.org/10.1016/j.comppsych.2018.10.003] [PMID:  30343247] 
[169] 
Park J-S, Lee E-H, Park N-R, Choi YH. Mental health of nurses working at a government-designated hospital during a MERS-CoV outbreak: A cross-sectional study. Arch Psychiatr Nurs  2018; 32(1): 2-6.
[http://dx.doi.org/10.1016/j.apnu.2017.09.006] [PMID:  29413067] 
[170] 
Asmundson GJG, Taylor S. How health anxiety influences responses to viral outbreaks like COVID-19: What all decision-makers, health authorities, and health care professionals need to know. J Anxiety Disord  2020; 71102211
[http://dx.doi.org/10.1016/j.janxdis.2020.102211] [PMID:  32179380] 
[171] 
Duan L, Zhu G. Psychological interventions for people affected by the COVID-19 epidemic. Lancet Psychiatry  2020; 7(4): 300-2.
[http://dx.doi.org/10.1016/S2215-0366(20)30073-0] [PMID:  32085840] 
[172] 
Elbay RY, Kurtulmuş A, Arpacıoğlu S, Karadere E. Depression, anxiety, stress levels of physicians and associated factors in COVID-19 pandemics. Psychiatry Res  2020; 290113130
[http://dx.doi.org/10.1016/j.psychres.2020.113130] [PMID:  32497969] 
[173] 
Meng H, Xu Y, Dai J, Zhang Y, Liu B, Yang H. The psychological effect of COVID-19 on the elderly in China. Psychiatry Res  2020; 289112983
[http://dx.doi.org/10.1016/j.psychres.2020.112983] 
[174] 
Rubin GJ, Wessely S. The psychological effects of quarantining a city. BMJ  2020; 368: m313.
[http://dx.doi.org/10.1136/bmj.m313] [PMID:  31992552] 
[175] 
Wind TR, Rijkeboer M, Andersson G, Riper H. The COVID-19 pandemic: The ‘black swan’ for mental health care and a turning point for e-health. Internet Interv  2020; 20100317
[http://dx.doi.org/10.1016/j.invent.2020.100317] [PMID:  32289019] 
[176] 
Salisbury H. Helen Salisbury: Fear in the time of COVID. BMJ  2020; 368: m1286.
[http://dx.doi.org/10.1136/bmj.m1286] [PMID:  32229528] 
[177] 
Thombs BD, Tao L, Wu Y, et al. Preliminary COVID-10 fears questionnaire: Systemic sclerosis and chronic medical conditions versions. OSF Preprints 2020.
[178] 
Georgiou N, Delfabbro P, Balzan R. COVID-19-related conspiracy beliefs and their relationship with perceived stress and pre-existing conspiracy beliefs. Pers Individ Dif  2020; 166110201
[http://dx.doi.org/10.1016/j.paid.2020.110201] [PMID:  32565592] 
[179] 
Huang Y, Zhao N. Generalized anxiety disorder, depressive symptoms and sleep quality during COVID-19 outbreak in China: A web-based cross-sectional survey. Psychiatry Res  2020; 288112954
[http://dx.doi.org/10.1016/j.psychres.2020.112954] [PMID:  32325383] 
[180] 
Lu W, Wang H, Lin Y, Li L. Psychological status of medical workforce during the COVID-19 pandemic: A cross-sectional study. Psychiatry Res  2020; 288112936
[http://dx.doi.org/10.1016/j.psychres.2020.112936] [PMID:  32276196] 
[181] 
Sher L. COVID-19, anxiety, sleep disturbances and suicide. Sleep Med  2020; 70: 124.
[http://dx.doi.org/10.1016/j.sleep.2020.04.019] 
[182] 
Song M. Psychological stress responses to COVID-19 and adaptive strategies in China. World Dev  2020; 136105107
[http://dx.doi.org/10.1016/j.worlddev.2020.105107] [PMID:  32834388] 
[183] 
Caulfield KA, George MS. Treating the mental health effects of COVID-19: The need for at-home neurotherapeutics is now. Brain Stimul  2020; 13(4): 939-40.
[http://dx.doi.org/10.1016/j.brs.2020.04.005] [PMID:  32283246] 
[184] 
Husky MM, Kovess-Masfety V, Swendsen JD. Stress and anxiety among university students in France during COVID-19 mandatory confinement. Compr Psychiatry  2020; 102152191
[http://dx.doi.org/10.1016/j.comppsych.2020.152191] [PMID:  32688023] 
[185] 
Cameron EE, Joyce KM, Delaquis CP, Reynolds K, Protudjer JLP, Roos LE. Maternal psychological distress & mental health service use during the COVID-19 pandemic. J Affect Disord  2020; 276: 765-74.
[http://dx.doi.org/10.1016/j.jad.2020.07.081] [PMID:  32736186] 
[186] 
DePierro J, Lowe S, Katz C. Lessons learned from 9/11: Mental health perspectives on the COVID-19 pandemic. Psychiatry Res  2020; 288113024
[http://dx.doi.org/10.1016/j.psychres.2020.113024] [PMID:  32315874] 
[187] 
Lemke MK, Apostolopoulos Y, Sönmez S. Syndemic frameworks to understand the effects of COVID-19 on commercial driver stress, health, and safety. J Transp Health  2020; 18100877
[http://dx.doi.org/10.1016/j.jth.2020.100877] [PMID:  32501420] 
[188] 
Tian F, Li H, Tian S, Yang J, Shao J, Tian C. Psychological symptoms of ordinary Chinese citizens based on SCL-90 during the level I emergency response to COVID-19. Psychiatry Res  2020; 288112992
[http://dx.doi.org/10.1016/j.psychres.2020.112992] [PMID:  32302816] 
[189] 
Mohindra RRR, Suri V, Bhalla A, Singh SM. Issues relevant to mental health promotion in frontline health care providers managing quarantined/isolated COVID19 patients. Asian J Psychiatr  2020; 51102084
[http://dx.doi.org/10.1016/j.ajp.2020.102084] [PMID:  32289728] 
[190] 
Liu K, Chen Y, Wu D, Lin R, Wang Z, Pan L. Effects of progressive muscle relaxation on anxiety and sleep quality in patients with COVID-19. Complement Ther Clin Pract  2020; 39101132
[http://dx.doi.org/10.1016/j.ctcp.2020.101132] [PMID:  32379667] 
[191] 
Lv H, Zhu L, Chen Z, Jin H, Jin L. Physical and mental health conditions of young college students with different traditional Chinese medicine constitutions in zhejiang province of China. J Tradit Chin Med  2015; 35(6): 703-8.
[http://dx.doi.org/10.1016/S0254-6272(15)30163-1] [PMID:  26742318] 
[192] 
Fujiwara H, Tsushima R, Okada R, et al. Sansoninto, a traditional herbal medicine, ameliorates behavioral abnormalities and down-regulation of early growth response-1 expression in mice exposed to social isolation stress. J Tradit Complement Med  2017; 8(1): 81-8.
[http://dx.doi.org/10.1016/j.jtcme.2017.03.004] [PMID:  29321993] 
[193] 
Sewell RDE, Rafieian-Kopaei M. The history and ups and downs of herbal medicines usage. J Herb Med Pharmacol  2014; 3(1): 1-3.
[194] 
Saki K, Bahmani M, Rafieian-Kopaei M.  The effect   of most important medicinal plants on two importnt   psychiatric disorders (anxiety and depression)-a review.   Asian Pac J Trop Med 2014; 7S1(Suppl. 1): S34-42.
[http://dx.doi.org/10.1016/S1995-7645(14)60201-7] [PMID:  25312147] 
[195] 
Yeung KS, Hernandez M, Mao JJ, Haviland I, Gubili J. Herbal medicine for depression and anxiety: A systematic review with assessment of potential psycho-oncologic relevance. Phytother Res  2018; 32(5): 865-91.
[http://dx.doi.org/10.1002/ptr.6033] [PMID:  29464801] 
[196] 
Baek JH, Heo J-Y, Fava M, et al. Effect of Korean red ginseng in individuals exposed to high stress levels: A 6-week, double-blind, randomized, placebo-controlled trial. J Ginseng Res  2019; 43(3): 402-7.
[http://dx.doi.org/10.1016/j.jgr.2018.03.001] [PMID:  31308812] 
[197] 
Singh K. Nutrient and stress management. J Nutr Food Sci  2016; 6(4): 4.
[http://dx.doi.org/10.4172/2155-9600.1000528] 
[198] 
Han P, Han T, Peng W, Wang XR. Antidepressant-like effects of essential oil and asarone, a major essential oil component from the rhizome of Acorus tatarinowii. Pharm Biol  2013; 51(5): 589-94.
[http://dx.doi.org/10.3109/13880209.2012.751616] [PMID:  23363070] 
[199] 
Park JH, Cha HY, Seo JJ, Hong JT, Han K, Oh KW. Anxiolytic-like effects of ginseng in the elevated plus-maze model: Comparison of red ginseng and sun ginseng. Prog Neuropsychopharmacol Biol Psychiatry  2005; 29(6): 895-900.
[http://dx.doi.org/10.1016/j.pnpbp.2005.04.016] [PMID:  16002200] 
[200] 
Zheng X, Liang Y, Kang A, et al. Peripheral immunomodulation with ginsenoside Rg1 ameliorates neuroinflammation-induced behavioral deficits in rats. Neuroscience  2014; 256: 210-22.
[http://dx.doi.org/10.1016/j.neuroscience.2013.10.023] [PMID:  24161284] 
[201] 
Liu Z, Qi Y, Cheng Z, Zhu X, Fan C, Yu SY. The effects of ginsenoside Rg1 on chronic stress induced depression-like behaviors, BDNF expression and the phosphorylation of PKA and CREB in rats. Neuroscience  2016; 322: 358-69.
[http://dx.doi.org/10.1016/j.neuroscience.2016.02.050] [PMID:  26926964] 
[202] 
Lee S, Rhee D-K. Effects of ginseng on stress-related depression, anxiety, and the hypothalamic-pituitary-adrenal axis. J Ginseng Res  2017; 41(4): 589-94.
[http://dx.doi.org/10.1016/j.jgr.2017.01.010] [PMID:  29021708] 
[203] 
Baek JH, Nierenberg AA, Kinrys G. Clinical applications of herbal medicines for anxiety and insomnia; targeting patients with bipolar disorder. Aust N Z J Psychiatry  2014; 48(8): 705-15.
[http://dx.doi.org/10.1177/0004867414539198] [PMID:  24947278] 
[204] 
Di Renzo G. Ginkgo biloba and the central nervous system. Fitoterapia  2000; 71(Suppl. 1): S43-7.
[http://dx.doi.org/10.1016/S0367-326X(00)00180-5] [PMID:  10930712] 
[205] 
Woelk H, Arnoldt KH, Kieser M, Hoerr R. Ginkgo biloba special extract EGb 761 in generalized anxiety disorder and adjustment disorder with anxious mood: A randomized, double-blind, placebo-controlled trial. J Psychiatr Res  2007; 41(6): 472-80.
[http://dx.doi.org/10.1016/j.jpsychires.2006.05.004] [PMID:  16808927] 
[206] 
Chen QG, Zeng YS, Qu ZQ, et al. The effects of Rhodiola rosea extract on 5-HT level, cell proliferation and quantity of neurons at cerebral hippocampus of depressive rats. Phytomedicine  2009; 16(9): 830-8.
[http://dx.doi.org/10.1016/j.phymed.2009.03.011] [PMID:  19403286] 
[207] 
Hwang SJ, Chen FP, Jong MS, Chen YC, Kung YY, Chen TJ. Prescriptions of Chinese herbal medicines for insomnia in Taiwan during 2002. Evidence-based Complement Altern Med 2011.
[208] 
Kim CS, Han JY, Kim S, Hong JT, Oh KW. Herbs for the treatment of insomnia. Biomol Ther (Seoul)  2011; 19(3): 274-81.
[http://dx.doi.org/10.4062/biomolther.2011.19.3.274] 
[209] 
Zhou QH, Zhou XL, Xu MB, et al. Suanzaoren formulate for insomnia: Updated clinical evidence and possible mechanisms. Front Pharmacol  2018; 9: 76.
[http://dx.doi.org/10.3389/fphar.2018.00076] [PMID:  29479317] 
[210] 
Mun S, Lee S, Park K, Lee S-J, Koh B-H, Baek Y. Effect of traditional East Asian medicinal herbal tea (HT002) on insomnia: A randomized controlled pilot study. Integr Med Res  2019; 8(1): 15-20.
[http://dx.doi.org/10.1016/j.imr.2018.11.004] [PMID:  30596014] 
[211] 
Wolfson P, Hoffmann DL. An investigation into the efficacy of Scutellaria lateriflora in healthy volunteers. Altern Ther Health Med  2003; 9(2): 74-8.
[PMID:  12652886] 
[212] 
Brock C, Whitehouse J, Tewfik I, Towell T. The use of Scutellaria lateriflora: A pilot survey amongst herbal medicine practitioners. J Herb Med  2012; 2(2): 34-41.
[http://dx.doi.org/10.1016/j.hermed.2012.04.005] 
[213] 
Kleber E, Schneider W, Schäfer HL, Elstner EF. Modulation of key reactions of the catecholamine metabolism by extracts from Eschscholtzia californica and Corydalis cava. Arzneimittelforschung  1995; 45(2): 127-31.
[PMID:  7710432] 
[214] 
Rolland A, Fleurentin J, Lanhers MC, Misslin R, Mortier F. Neurophysiological effects of an extract of Eschscholzia californica Cham. (Papaveraceae). Phytother Res  2001; 15(5): 377-81.
[http://dx.doi.org/10.1002/ptr.884] [PMID:  11507727] 
[215] 
Hanus M, Lafon J, Mathieu M. Double-blind, randomised, placebo-controlled study to evaluate the efficacy and safety of a fixed combination containing two plant extracts (Crataegus oxyacantha and Eschscholtzia californica) and magnesium in mild-to-moderate anxiety disorders. Curr Med Res Opin  2004; 20(1): 63-71.
[http://dx.doi.org/10.1185/030079903125002603] [PMID:  14741074] 
[216] 
Avallone R, Zanoli P, Puia G, Kleinschnitz M, Schreier P, Baraldi M. Pharmacological profile of apigenin, a flavonoid isolated from Matricaria chamomilla. Biochem Pharmacol  2000; 59(11): 1387-94.
[http://dx.doi.org/10.1016/S0006-2952(00)00264-1] [PMID:  10751547] 
[217] 
Zanoli P, Avallone R, Baraldi M. Behavioral characterisation of the flavonoids apigenin and chrysin. Fitoterapia  2000; 71(Suppl. 1): S117-23.
[http://dx.doi.org/10.1016/S0367-326X(00)00186-6] [PMID:  10930722] 
[218] 
Awad R, Levac D, Cybulska P, Merali Z, Trudeau VL, Arnason JT. Effects of traditionally used anxiolytic botanicals on enzymes of the gamma-aminobutyric acid (GABA) system. Can J Physiol Pharmacol  2007; 85(9): 933-42.
[http://dx.doi.org/10.1139/Y07-083] [PMID:  18066140] 
[219] 
Amsterdam JD, Li Y, Soeller I, Rockwell K, Mao JJ, Shults J. A randomized, double-blind, placebo-controlled trial of oral Matricaria recutita (chamomile) extract therapy for generalized anxiety disorder. J Clin Psychopharmacol  2009; 29(4): 378-82.
[http://dx.doi.org/10.1097/JCP.0b013e3181ac935c] [PMID:  19593179] 
[220] 
Haller J, Freund TF, Pelczer KG, Füredi J, Krecsak L, Zámbori J. The anxiolytic potential and psychotropic side effects of an echinacea preparation in laboratory animals and healthy volunteers. Phytother Res  2013; 27(1): 54-61.
[http://dx.doi.org/10.1002/ptr.4677] [PMID:  22451347] 
[221] 
Akhondzadeh S, Naghavi HR, Vazirian M, Shayeganpour A, Rashidi H, Khani M. Passionflower in the treatment of generalized anxiety: A pilot double-blind randomized controlled trial with oxazepam. J Clin Pharm Ther  2001; 26(5): 363-7.
[http://dx.doi.org/10.1046/j.1365-2710.2001.00367.x] [PMID:  11679026] 
[222] 
Movafegh A, Alizadeh R, Hajimohamadi F, Esfehani F, Nejatfar M. Preoperative oral Passiflora incarnata reduces anxiety in ambulatory surgery patients: A double-blind, placebo-controlled study. Anesth Analg  2008; 106(6): 1728-32.
[http://dx.doi.org/10.1213/ane.0b013e318172c3f9] [PMID:  18499602] 
[223] 
Grundmann O, Wang J, McGregor GP, Butterweck V. Anxiolytic activity of a phytochemically characterized Passiflora incarnata extract is mediated via the GABAergic system. Planta Med  2008; 74(15): 1769-73.
[http://dx.doi.org/10.1055/s-0028-1088322] [PMID:  19006051] 
[224] 
Grundmann O, Wähling C, Staiger C, Butterweck V. Anxiolytic effects of a passion flower (Passiflora incarnata L.) extract in the elevated plus maze in mice. Pharmazie  2009; 64(1): 63-4.
[PMID:  19216234] 
[225] 
Sena LM, Zucolotto SM, Reginatto FH, Schenkel EP, De Lima TC. Neuropharmacological activity of the pericarp of Passiflora edulis flavicarpa degener: putative involvement of C-glycosylflavonoids. Exp Biol Med (Maywood)  2009; 234(8): 967-75.
[http://dx.doi.org/10.3181/0902-RM-84] [PMID:  19491371] 
[226] 
Akhondzadeh S, Fallah-Pour H, Afkham K, Jamshidi AH, Khalighi-Cigaroudi F. Comparison of Crocus sativus L. and imipramine in the treatment of mild to moderate depression: A pilot double-blind randomized trial. [ISRCTN45683816] BMC Complement Altern Med  2004; 4(1): 12.
[http://dx.doi.org/10.1186/1472-6882-4-12] [PMID:  15341662] 
[227] 
Akhondzadeh S, Tahmacebi-Pour N, Noorbala AA, et al. Crocus sativus L. in the treatment of mild to moderate depression: A double-blind, randomized and placebo-controlled trial. Phytother Res  2005; 19(2): 148-51.
[http://dx.doi.org/10.1002/ptr.1647] [PMID:  15852492] 
[228] 
Noorbala AA, Akhondzadeh S, Tahmacebi-Pour N, Jamshidi AH. Hydro-alcoholic extract of Crocus sativus L. versus fluoxetine in the treatment of mild to moderate depression: A double-blind, randomized pilot trial. J Ethnopharmacol  2005; 97(2): 281-4.
[http://dx.doi.org/10.1016/j.jep.2004.11.004] [PMID:  15707766] 
[229] 
Moshiri E, Basti AA, Noorbala AA, Jamshidi AH, Hesameddin Abbasi S, Akhondzadeh S. Crocus sativus L. (petal) in the treatment of mild-to-moderate depression: A double-blind, randomized and placebo-controlled trial. Phytomedicine  2006; 13(9-10): 607-11.
[http://dx.doi.org/10.1016/j.phymed.2006.08.006] [PMID:  16979327] 
[230] 
Schmidt M, Betti G, Hensel A. Saffron in phytotherapy: Pharmacology and clinical uses. Wien Med Wochenschr  2007; 157(13-14): 315-9.
[http://dx.doi.org/10.1007/s10354-007-0428-4] [PMID:  17704979] 
[231] 
Hosseinzadeh H, Noraei NB. Anxiolytic and hypnotic effect of Crocus sativus aqueous extract and its constituents, crocin and safranal, in mice. Phytother Res  2009; 23(6): 768-74.
[http://dx.doi.org/10.1002/ptr.2597] [PMID:  19142981] 
[232] 
Yoshitake T, Iizuka R, Yoshitake S, et al. Hypericum perforatum L (St John’s wort) preferentially increases extracellular dopamine levels in the rat prefrontal cortex. Br J Pharmacol  2004; 142(3): 414-8.
[http://dx.doi.org/10.1038/sj.bjp.0705822] [PMID:  15148244] 
[233] 
Linde K, Berner M, Egger M, Mulrow C. St John’s wort for depression: Meta-analysis of randomised controlled trials. Br J Psychiatry  2005; 186(2): 99-107.
[http://dx.doi.org/10.1192/bjp.186.2.99] [PMID:  15684231] 
[234] 
Linde K, Berner MM, Kriston L. St John’s wort for major depression. Cochrane Database Syst Rev 2008; (4): CD000448
[PMID:  18843608] 
[235] 
Rahimi R, Nikfar S, Abdollahi M. Efficacy and tolerability of Hypericum perforatum in major depressive disorder in comparison with selective serotonin reuptake inhibitors: A meta-analysis. Prog Neuropsychopharmacol Biol Psychiatry  2009; 33(1): 118-27.
[http://dx.doi.org/10.1016/j.pnpbp.2008.10.018] [PMID:  19028540] 
[236] 
Mizuki D, Qi Z, Tanaka K, et al. Butea superba-induced amelioration of cognitive and emotional deficits in olfactory bulbectomized mice and putative mechanisms underlying its actions. J Pharmacol Sci  2014; 124(4): 457-67.
[http://dx.doi.org/10.1254/jphs.13252FP] [PMID:  24646653] 
[237] 
Mizuki D, Matsumoto K, Tanaka K, et al. Antidepressant-like effect of Butea superba in mice exposed to chronic mild stress and its possible mechanism of action. J Ethnopharmacol  2014; 156: 16-25.
[http://dx.doi.org/10.1016/j.jep.2014.08.014] [PMID:  25152298] 
[238] 
Stough C, Lloyd J, Clarke J, et al. The chronic effects of an extract of Bacopa monniera (Brahmi) on cognitive function in healthy human subjects. Psychopharmacology (Berl)  2001; 156(4): 481-4.
[http://dx.doi.org/10.1007/s002130100815] [PMID:  11498727] 
[239] 
Sairam K, Dorababu M, Goel RK, Bhattacharya SK. Antidepressant activity of standardized extract of Bacopa monniera in experimental models of depression in rats. Phytomedicine  2002; 9(3): 207-11.
[http://dx.doi.org/10.1078/0944-7113-00116] [PMID:  12046860] 
[240] 
Limpeanchob N, Jaipan S, Rattanakaruna S, Phrompittayarat W, Ingkaninan K. Neuroprotective effect of Bacopa monnieri on beta-amyloid-induced cell death in primary cortical culture. J Ethnopharmacol  2008; 120(1): 112-7.
[http://dx.doi.org/10.1016/j.jep.2008.07.039] [PMID:  18755259] 
[241] 
Krishnakumar A, Nandhu MS, Paulose CS. Upregulation of 5-HT2C receptors in hippocampus of pilocarpine-induced epileptic rats: Antagonism by Bacopa monnieri. Epilepsy Behav  2009; 16(2): 225-30.
[http://dx.doi.org/10.1016/j.yebeh.2009.07.031] [PMID:  19700373] 
[242] 
Le XT, Pham HT, Do PT, et al. Bacopa monnieri ameliorates memory deficits in olfactory bulbectomized mice: Possible involvement of glutamatergic and cholinergic systems. Neurochem Res  2013; 38(10): 2201-15.
[http://dx.doi.org/10.1007/s11064-013-1129-6] [PMID:  23949198] 
[243] 
Martínez-Vázquez M, Estrada-Reyes R, Martínez-Laurrabaquio A, López-Rubalcava C, Heinze G. Neuropharmacological study of Dracocephalum moldavica L. (Lamiaceae) in mice: Sedative effect and chemical analysis of an aqueous extract. J Ethnopharmacol  2012; 141(3): 908-17.
[http://dx.doi.org/10.1016/j.jep.2012.03.028] [PMID:  22469767] 
[244] 
Saito K, Umeda S, Kawashima K, Kano Y. Pharmacological properties of traditional medicines. XXVI. Effects of Sansohnin-to on pentobarbital sleep in stressed mice. Biol Pharm Bull  2000; 23(1): 76-9.
[http://dx.doi.org/10.1248/bpb.23.76] [PMID:  10706415] 
[245] 
Mesfin M, Asres K, Shibeshi W. Evaluation of anxiolytic activity of the essential oil of the aerial part of Foeniculum vulgare miller in mice. BMC Complement Altern Med  2014; 14(1): 310.
[http://dx.doi.org/10.1186/1472-6882-14-310] [PMID:  25149087] 
[246] 
López-Rubalcava C, Estrada-Camarena E. Mexican medicinal plants with anxiolytic or antidepressant activity: Focus on preclinical research. J Ethnopharmacol  2016; 186: 377-91.
[http://dx.doi.org/10.1016/j.jep.2016.03.053] [PMID:  27021688] 
[247] 
Kennedy DO, Little W, Scholey AB. Attenuation of laboratory-induced stress in humans after acute administration of Melissa officinalis (Lemon Balm). Psychosom Med  2004; 66(4): 607-13.
[http://dx.doi.org/10.1097/01.psy.0000132877.72833.71] [PMID:  15272110] 
[248] 
Awad R, Muhammad A, Durst T, Trudeau VL, Arnason JT. Bioassay-guided fractionation of lemon balm (Melissa officinalis L.) using an in vitro measure of GABA transaminase activity. Phytother Res  2009; 23(8): 1075-81.
[http://dx.doi.org/10.1002/ptr.2712] [PMID:  19165747] 
[249] 
López V, Martín S, Gómez-Serranillos MP, Carretero ME, Jäger AK, Calvo MI. Neuroprotective and neurological properties of Melissa officinalis. Neurochem Res  2009; 34(11): 1955-61.
[http://dx.doi.org/10.1007/s11064-009-9981-0] [PMID:  19760174] 
[250] 
Atsumi T, Tonosaki K. Smelling lavender and rosemary increases free radical scavenging activity and decreases cortisol level in saliva. Psychiatry Res  2007; 150(1): 89-96.
[http://dx.doi.org/10.1016/j.psychres.2005.12.012] [PMID:  17291597] 
[251] 
Shaw D, Annett JM, Doherty B, Leslie JC. Anxiolytic effects of lavender oil inhalation on open-field behaviour in rats. Phytomedicine  2007; 14(9): 613-20.
[http://dx.doi.org/10.1016/j.phymed.2007.03.007] [PMID:  17482442] 
[252] 
Toda M, Morimoto K. Effect of lavender aroma on salivary endocrinological stress markers. Arch Oral Biol  2008; 53(10): 964-8.
[http://dx.doi.org/10.1016/j.archoralbio.2008.04.002] [PMID:  18635155] 
[253] 
Naghibi F, Mosaddegh M, Mohammadi Motamed M, Ghorbani A. Labiatae family in folk medicine in Iran: From ethnobotany to pharmacology. Iran J Pharm Res  2010; 4(2): 63-79.
[http://dx.doi.org/10.22037/IJPR.2010.619] 
[254] 
Firoozabadi A, Zarshenas MM, Salehi A, Jahanbin S, Mohagheghzadeh A. Effectiveness of Cuscuta planiflora ten. and Nepeta menthoides boiss. & Buhse in major depression: A triple-blind randomized controlled trial study. J Evid Based Complementary Altern Med  2015; 20(2): 94-7.
[http://dx.doi.org/10.1177/2156587214557359] [PMID:  25416496] 
[255] 
Kolouri S, Firoozabadi A, Salehi A, et al. Nepeta menthoides boiss. & Buhse freeze-dried aqueous extract versus sertraline in the treatment of major depression: A double blind randomized controlled trial. Complement Ther Med  2016; 26: 164-70.
[http://dx.doi.org/10.1016/j.ctim.2016.03.016] [PMID:  27261997] 
[256] 
Firoozabadi A, Kolouri S, Zarshenas MM, Salehi A, Mosavat SH, Dastgheib SA. Efficacy of a freeze-dried aqueous extract of Nepeta menthoides boiss. & buhse in the treatment of anxiety in patients with depression: A double-blind, randomized, controlled trial. J Herb Med  2017; 10: 17-23.
[http://dx.doi.org/10.1016/j.hermed.2017.08.003] 
[257] 
Darbinyan V, Aslanyan G, Amroyan E, Gabrielyan E, Malmström C, Panossian A. Clinical trial of Rhodiola rosea L. extract SHR-5 in the treatment of mild to moderate depression. Nord J Psychiatry  2007; 61(5): 343-8.
[http://dx.doi.org/10.1080/08039480701643290] [PMID:  17990195] 
[258] 
Panossian A, Wikman G, Sarris J. Rosenroot (Rhodiola rosea): Traditional use, chemical composition, pharmacology and clinical efficacy. Phytomedicine  2010; 17(7): 481-93.
[http://dx.doi.org/10.1016/j.phymed.2010.02.002] [PMID:  20378318] 
[259] 
Gerbarg PL, Brown RP. Pause menopause with Rhodiola rosea, a natural selective estrogen receptor modulator. Phytomedicine  2016; 23(7): 763-9.
[http://dx.doi.org/10.1016/j.phymed.2015.11.013] [PMID:  26776957] 
[260] 
Anghelescu I-G, Edwards D, Seifriz E, Kasper S. Stress management and the role of Rhodiolarosea: A review. Int J Psychiatry Clin Pract  2017; 22(4): 242-52.
[http://dx.doi.org/10.1080/13651501.2017.1417442] 
[261] 
Choi JH, Lee MJ, Jang M, et al. Panax ginseng exerts antidepressant-like effects by suppressing neuroinflammatory response and upregulating nuclear factor erythroid 2 related factor 2 signaling in the amygdala. J Ginseng Res  2018; 42(1): 107-15.
[http://dx.doi.org/10.1016/j.jgr.2017.04.012] [PMID:  29348729] 
[262] 
Carpenter JM, Jourdan MK, Fountain EM, et al. The effects of Sceletium tortuosum (L.) N.E. Br. extract fraction in the chick anxiety-depression model. J Ethnopharmacol  2016; 193: 329-32.
[http://dx.doi.org/10.1016/j.jep.2016.08.019] [PMID:  27553978] 
[263] 
Nazıroğlu M, Kozlu S, Yorgancıgil E, Uğuz AC, Karakuş K. Rose oil (from Rosa × damascena Mill.) vapor attenuates depression-induced oxidative toxicity in rat brain. J Nat Med  2013; 67(1): 152-8.
[http://dx.doi.org/10.1007/s11418-012-0666-7] [PMID:  22484603] 
[264] 
Mármol I, Sánchez-de-Diego C, Jiménez-Moreno N, Ancín-Azpilicueta C, Rodríguez-Yoldi MJ. Therapeutic applications of rose hips from different rosa species. Int J Mol Sci  2017; 18(6): 18.
[http://dx.doi.org/10.3390/ijms18061137] [PMID:  28587101] 
[265] 
Ueno H, Shimada A, Suemitsu S, et al. Anti-stress effects of the hydroalcoholic extract of Rosa gallica officinalis in mice. Heliyon  2019; 5(6)e01945
[http://dx.doi.org/10.1016/j.heliyon.2019.e01945] [PMID:  31431930] 
[266] 
Panossian A, Hambardzumyan M, Hovhanissyan A, Wikman G, Wikman G. The adaptogens rhodiola and schizandra modify the response to immobilization stress in rabbits by suppressing the increase of phosphorylated stress-activated protein kinase, nitric oxide and cortisol. Drug Target Insights  2007; 2: 39-54.
[http://dx.doi.org/10.1177/117739280700200011] [PMID:  21901061] 
[267] 
Panossian A, Nikoyan N, Ohanyan N, et al. Comparative study of Rhodiola preparations on behavioral despair of rats. Phytomedicine  2008; 15(1-2): 84-91.
[http://dx.doi.org/10.1016/j.phymed.2007.10.003] [PMID:  18054474] 
[268] 
Chen L-C, Chen I-C, Wang B-R, Shao C-H. Drug-use pattern of Chinese herbal medicines in insomnia: A 4-year survey in Taiwan. J Clin Pharm Ther  2009; 34(5): 555-60.
[http://dx.doi.org/10.1111/j.1365-2710.2009.01038.x] [PMID:  19753680] 
[269] 
Mattioli L, Funari C, Perfumi M. Effects of Rhodiola rosea L. extract on behavioural and physiological alterations induced by chronic mild stress in female rats. J Psychopharmacol  2009; 23(2): 130-42.
[http://dx.doi.org/10.1177/0269881108089872] [PMID:  18515456] 
[270] 
van Diermen D, Marston A, Bravo J, Reist M, Carrupt PA, Hostettmann K. Monoamine oxidase inhibition by Rhodiola rosea L. roots. J Ethnopharmacol  2009; 122(2): 397-401.
[http://dx.doi.org/10.1016/j.jep.2009.01.007] [PMID:  19168123] 
[271] 
Boskabady MH, Shafei MN, Saberi Z, Amini S. Pharmacological effects of Rosa damascena. Iran J Basic Med Sci  2011; 14(4): 295-307.
[PMID:  23493250] 
[272] 
Hongratanaworakit T. Relaxing effect of rose oil on humans. Nat Prod Commun  2009; 4(2): 291-6.
[http://dx.doi.org/10.1177/1934578X0900400226] [PMID:  19370942] 
[273] 
Hamdamian S, Nazarpour S, Simbar M, Hajian S, Mojab F, Talebi A. Effects of aromatherapy with Rosa damascena on nulliparous women’s pain and anxiety of labor during first stage of labor. J Integr Med  2018; 16(2): 120-5.
[http://dx.doi.org/10.1016/j.joim.2018.02.005] [PMID:  29526235] 
[274] 
Fazlollahpour-Rokni F, Shorofi SA, Mousavinasab N, Ghafari R, Esmaeili R. The effect of inhalation aromatherapy with rose essential oil on the anxiety of patients undergoing coronary artery bypass graft surgery. Complement Ther Clin Pract  2019; 34: 201-7.
[http://dx.doi.org/10.1016/j.ctcp.2018.11.014] [PMID:  30712728] 
[275] 
Uebelhack R, Franke L, Schewe HJ. Inhibition of platelet MAO-B by kava pyrone-enriched extract from Piper methysticum Forster (kava-kava). Pharmacopsychiatry  1998; 31(5): 187-92.
[http://dx.doi.org/10.1055/s-2007-979325] [PMID:  9832350] 
[276] 
Boonen G, Häberlein H. Influence of genuine kavapyrone enantiomers on the GABA-A binding site. Planta Med  1998; 64(6): 504-6.
[http://dx.doi.org/10.1055/s-2006-957502] [PMID:  9776662] 
[277] 
Magura EI, Kopanitsa MV, Gleitz J, Peters T, Krishtal OA. Kava extract ingredients, (+)-methysticin and (+/-)-kavain inhibit voltage-operated Na(+)-channels in rat CA1 hippocampal neurons. Neuroscience  1997; 81(2): 345-51.
[http://dx.doi.org/10.1016/S0306-4522(97)00177-2] [PMID:  9300426] 
[278] 
Pittler MH, Ernst E. Kava extract for treating anxiety. Cochrane Database Syst Rev 2003; (1): CD003383
[http://dx.doi.org/10.1002/14651858.CD003383] [PMID:  12535473] 
[279] 
Witte S, Loew D, Gaus W. Meta-analysis of the efficacy of the acetonic kava-kava extract WS1490 in patients with non-psychotic anxiety disorders. Phytother Res  2005; 19(3): 183-8.
[http://dx.doi.org/10.1002/ptr.1609] [PMID:  15934028] 
[280] 
Ashok GA, Shende MB, Chothe DS. Anti-stress activity of Ashwagandha (Withania somnifera Dunal)- A review. Int Ayurveda Med J  2014; 2(3): 386-93.
[281] 
Laura Guzman Gutierrez S, Chilpa RR, Jaime HB. Medicinal plants for the treatment of “nervios”, anxiety, and depression in Mexican traditional medicine. Rev Bras Farmacogn  2014; 24(5): 591-608.
[http://dx.doi.org/10.1016/j.bjp.2014.10.007] 
[282] 
Morishita S, Mishima Y, Hirai Y, Saito T, Shoji M. Pharmacological studies of water extract of the Zizyphus seed and the Zizyphus seed containing drug. Gen Pharmacol  1987; 18(6): 637-41.
[http://dx.doi.org/10.1016/0306-3623(87)90037-1] [PMID:  3666400] 
[283] 
Cao JX, Zhang QY, Cui SY, et al. Hypnotic effect of jujubosides from Semen ziziphi Spinosae. J Ethnopharmacol  2010; 130(1): 163-6.
[http://dx.doi.org/10.1016/j.jep.2010.03.023] [PMID:  20347951] 
[284] 
Sayyah M, Sayyah M, Kamalinejad M. A preliminary randomized double blind clinical trial on the efficacy of aqueous extract of Echium amoenum in the treatment of mild to moderate major depression. Prog Neuropsychopharmacol Biol Psychiatry  2006; 30(1): 166-9.
[http://dx.doi.org/10.1016/j.pnpbp.2005.10.005] [PMID:  16309809] 
[285] 
Rabiei Z, Setorki M. Effect of hydroalcoholic Echium amoenum extract on scopolamine-induced learning and memory impairment in rats. Pharm Biol  2018; 56(1): 672-7.
[http://dx.doi.org/10.1080/13880209.2018.1543330] [PMID:  31070534] 
[286] 
Zhou X-D, Shi D-D, Zhang Z-J. Ameliorative effects of Radix rehmanniae extract on the anxiety- and depression-like symptoms in ovariectomized mice: A behavioral and molecular study. Phytomedicine  2019; 63153012
[http://dx.doi.org/10.1016/j.phymed.2019.153012] [PMID:  31301535] 
[287] 
Najafi S, Pashandi SH, Mahmoudi H, Ebadi A, Ghaneie M. The relationship of fatigue with spirometry parameters in veterans with respiratory disorders. Iran. J War Public Health  2010; 8(2): 29-35.
[288] 
Babar A, Al-Wabel NA, Shams S, Ahamad A, Alam Khan SH, Anwar F. Essential oils used in aromatherapy: A systematic review. Asian Pac J Trop Biomed  2015; 5(8): 601-11.
[http://dx.doi.org/10.1016/j.apjtb.2015.05.007] 
[289] 
Fredriksson-Larsson U, Alsén P, Karlson BW, Brink E. Fatigue two months after myocardial infarction and its relationships with other concurrent symptoms, sleep quality and coping strategies. J Clin Nurs  2015; 24(15-16): 2192-200.
[http://dx.doi.org/10.1111/jocn.12876] [PMID:  25988847] 
[290] 
Alsén P, Brink E. Fatigue after myocardial infarction - a two-year follow-up study. J Clin Nurs  2013; 22(11-12): 1647-52.
[http://dx.doi.org/10.1111/jocn.12114] [PMID:  23444979] 
[291] 
Ji WW, Li RP, Li M, et al. Antidepressant-like effect of essential oil of Perilla frutescens in a chronic, unpredictable, mild stress-induced depression model mice. Chin J Nat Med  2014; 12(10): 753-9.
[http://dx.doi.org/10.1016/S1875-5364(14)60115-1] [PMID:  25443368] 
[292] 
Bradwejn J, Zhou Y, Koszycki D, Shlik J. A double-blind, placebo-controlled study on the effects of gotu kola (Centella asiatica) on acoustic startle response in healthy subjects. J Clin Psychopharmacol  2000; 20(6): 680-4.
[http://dx.doi.org/10.1097/00004714-200012000-00015] [PMID:  11106141] 
[293] 
Wijeweera P, Arnason JT, Koszycki D, Merali Z. Evaluation of anxiolytic properties of Gotukola--(Centella asiatica) extracts and asiaticoside in rat behavioral models. Phytomedicine  2006; 13(9-10): 668-76.
[http://dx.doi.org/10.1016/j.phymed.2006.01.011] [PMID:  16488124] 
[294] 
Jana U, Sur TK, Maity LN, Debnath PK, Bhattacharyya D. A clinical study on the management of generalized anxiety disorder with Centella asiatica. Nepal Med Coll J  2010; 12(1): 8-11.
[PMID:  20677602] 
[295] 
Rabbani M, Sajjadi SE, Vaseghi G, Jafarian A. Anxiolytic effects of Echium amoenum on the elevated plus-maze model of anxiety in mice. Fitoterapia  2004; 75(5): 457-64.
[http://dx.doi.org/10.1016/j.fitote.2004.04.004] [PMID:  15261383] 
[296] 
Kim WK, Jung JW, Ahn NY, et al. Anxiolytic-like effects of extracts from Albizzia julibrissin bark in the elevated plus-maze in rats. Life Sci  2004; 75(23): 2787-95.
[http://dx.doi.org/10.1016/j.lfs.2004.05.024] [PMID:  15464830] 
[297] 
Kim JH, Kim SY, Lee SY, Jang CG. Antidepressant-like effects of Albizzia julibrissin in mice: Involvement of the 5-HT1A receptor system. Pharmacol Biochem Behav  2007; 87(1): 41-7.
[http://dx.doi.org/10.1016/j.pbb.2007.03.018] [PMID:  17477962] 
[298] 
Jung JW, Cho JH, Ahn NY, et al. Effect of chronic Albizzia julibrissin treatment on 5-hydroxytryptamine1A receptors in rat brain. Pharmacol Biochem Behav  2005; 81(1): 205-10.
[http://dx.doi.org/10.1016/j.pbb.2005.03.014] [PMID:  15894080] 
[299] 
Masoumi-Ardakani Y, Mandegary A, Esmaeilpour K, et al. Chemical composition anticonvulsant activity, and toxicity of essential oil and methanolic extract of Elettaria cardamomum. Planta Med  2016; 82(17): 1482-6.
[http://dx.doi.org/10.1055/s-0042-106971] [PMID:  27433883] 
[300] 
Masoumi-Ardakani Y, Mahmoudvand H, Mirzaei A, et al. The effect of Elettaria cardamomum extract on anxiety-like behavior in a rat model of post-traumatic stress disorder. Biomed Pharmacother  2017; 87: 489-95.
[http://dx.doi.org/10.1016/j.biopha.2016.12.116] [PMID:  28073098] 
[301] 
Bhattacharya SK, Bhattacharya A, Sairam K, Ghosal S. Anxiolytic-antidepressant activity of Withania somnifera glycowithanolides: An experimental study. Phytomedicine  2000; 7(6): 463-9.
[http://dx.doi.org/10.1016/S0944-7113(00)80030-6] [PMID:  11194174] 
[302] 
Bhattacharya SK, Muruganandam AV. Adaptogenic activity of Withania somnifera: An experimental study using a rat model of chronic stress. Pharmacol Biochem Behav  2003; 75(3): 547-55.
[http://dx.doi.org/10.1016/S0091-3057(03)00110-2] [PMID:  12895672] 
[303] 
Sarris J, Panossian A, Schweitzer I, Stough C, Scholey A. Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence. Eur Neuropsychopharmacol  2011; 21(12): 841-60.
[http://dx.doi.org/10.1016/j.euroneuro.2011.04.002] [PMID:  21601431] 
[304] 
Zhang L, Dong Y, Sun Y, Chen T, Xu Q. Role of four major components in the effect of Si-Ni-San, a traditional Chinese prescription, against contact sensitivity in mice. J Pharm Pharmacol  2006; 58(9): 1257-64.
[http://dx.doi.org/10.1211/jpp.58.9.0013] [PMID:  16945185] 
[305] 
Takuma K, Hoshina Y, Arai S, et al. Ginkgo biloba extract EGb 761 attenuates hippocampal neuronal loss and cognitive dysfunction resulting from chronic restraint stress in ovariectomized rats. Neuroscience  2007; 149(2): 256-62.
[http://dx.doi.org/10.1016/j.neuroscience.2007.07.042] [PMID:  17869007] 
[306] 
Wang Y-T, Tan Q-R, Sun L-L, et al. Possible therapeutic effect of a traditional Chinese medicine, Sinisan, on chronic restraint stress related disorders. Neurosci Lett  2009; 449(3): 215-9.
[http://dx.doi.org/10.1016/j.neulet.2008.10.100] [PMID:  19007859] 
[307] 
Cao G-P, Gui D, Fu L-D, Guo Z-K, Fu W-J. Anxiolytic and neuroprotective effects of the traditional Chinese medicinal formulation dan-zhi-xiao-yao-san in a rat model of chronic stress. Mol Med Rep  2016; 14(2): 1247-54.
[http://dx.doi.org/10.3892/mmr.2016.5382] [PMID:  27279479] 
[308] 
Yamaguchi T, Tsujimatsu A, Kumamoto H, et al. Anxiolytic effects of yokukansan, a traditional Japanese medicine, via serotonin 5-HT1A receptors on anxiety-related behaviors in rats experienced aversive stress. J Ethnopharmacol  2012; 143(2): 533-9.
[http://dx.doi.org/10.1016/j.jep.2012.07.007] [PMID:  22819689] 
[309] 
Mizoguchi K, Yuzurihara M, Ishige A, Sasaki H, Tabira T. Saiko-ka-ryukotsu-borei-to, an herbal medicine, prevents chronic stress-induced disruption of glucocorticoid negative feedback in rats. Life Sci  2002; 72(1): 67-77.
[http://dx.doi.org/10.1016/S0024-3205(02)02199-9] [PMID:  12409146] 
[310] 
Mizoguchi K, Sun N, Jin X-L, et al. Saikokaryukotsuboreito, a herbal medicine, prevents chronic stress-induced dysfunction of glucocorticoid negative feedback system in rat brain. Pharmacol Biochem Behav  2007; 86(1): 55-61.
[http://dx.doi.org/10.1016/j.pbb.2006.12.007] [PMID:  17250881] 
[311] 
Choi JE, Park D-M, Chun E, et al. Control of stress-induced depressive disorders by So-ochim-tang-gamibang, a Korean herbal medicine. J Ethnopharmacol  2017; 196: 141-50.
[http://dx.doi.org/10.1016/j.jep.2016.12.025] [PMID:  27988398] 
[312] 
Rahmati B, Kiasalari Z, Roghani M, Khalili M, Ansari F. Antidepressant and anxiolytic activity of Lavandula officinalis aerial parts hydroalcoholic extract in scopolamine-treated rats. Pharm Biol  2017; 55(1): 958-65.
[http://dx.doi.org/10.1080/13880209.2017.1285320] [PMID:  28166686] 
[313] 
Chaves PFP, Hocayen PAS, Dallazen JL, et al. Chamomile tea: Source of a glucuronoxylan with antinociceptive, sedative and anxiolytic-like effects. Int J Biol Macromol  2020; 164: 1675-82.
[http://dx.doi.org/10.1016/j.ijbiomac.2020.08.039] [PMID:  32795578] 
[314] 
Hashikawa-Hobara N, Otsuka A, Ishikawa R, Hashikawa N. Roman chamomile inhalation combined with clomipramine treatment improves treatment-resistant depression-like behavior in mice. Biomed Pharmacother  2019; 118109263
[http://dx.doi.org/10.1016/j.biopha.2019.109263] [PMID:  31369988] 
[315] 
Ghamchini VM, Salami M, Mohammadi GR, et al. The effect of chamomile tea on anxiety and depression in cancer patients treated with chemotherapy. J Young Pharm  2019; 11(3): 309-12.
[http://dx.doi.org/10.5530/jyp.2019.11.62] 
[316] 
Cvetanovic A, Zekovic Z, Zengin G, Maskovic P, Petronijevic M, Radojkovic M. Multidirectional approaches on autofermented chamomile ligulate flowers: Antioxidant, antimicrobial, cytotoxic and enzyme inhibitory effects. S Afr J Bot  2019; 120: 112-8.
[http://dx.doi.org/10.1016/j.sajb.2018.01.003] 
[317] 
Zanoli P, Zavatti M. Pharmacognostic and pharmacological profile of Humulus lupulus L. J Ethnopharmacol  2008; 116(3): 383-96.
[http://dx.doi.org/10.1016/j.jep.2008.01.011] [PMID:  18308492] 
[318] 
Kyrou I, Christou A, Panagiotakos D, et al. Effects of a hops (Humulus lupulus L.) dry extract supplement on self-reported depression, anxiety and stress levels in apparently healthy young adults: A randomized, placebo-controlled, double-blind, crossover pilot study. Hormones (Athens)  2017; 16(2): 171-80.
[http://dx.doi.org/10.14310/horm.2002.1738] [PMID:  28742505] 
[319] 
Pouraboli I, Nazari S, Sabet N, Sharififar F, Jafari M. Antidiabetic, antioxidant, and antilipid peroxidative activities of Dracocephalum polychaetum shoot extract in streptozotocin-induced diabetic rats: In vivo and in vitro studies. Pharm Biol  2016; 54(2): 272-8.
[http://dx.doi.org/10.3109/13880209.2015.1033561] [PMID:  25901731] 
[320] 
Heydari P, Yavari M, Adibi P, et al. Medicinal properties and active constituents of Dracocephalum kotschyi and its significance in Iran: A systematic review. Evid Based Complement Alternat Med  2019; 20199465309
[http://dx.doi.org/10.1155/2019/9465309] [PMID:  31198431] 
[321] 
Alaei S. Essential oil content and composition of Dracocephalum moldavica under different irrigation regimes. Int J Hortic Sci  2019; 6(2): 167-75.
[http://dx.doi.org/10.22059/IJHST.2019.280572.294] 
[322] 
Zanoli P, Rivasi M, Zavatti M, Brusiani F, Baraldi M. New insight in the neuropharmacological activity of Humulus lupulus L. J Ethnopharmacol  2005; 102(1): 102-6.
[http://dx.doi.org/10.1016/j.jep.2005.05.040] [PMID:  16046089] 
[323] 
Tabach R, Matteri R, Carlini EL. Pharmacological evaluation of a phytotherapeutic product- CPV (dry extract of Crataegus oxyacantha L., Passiflora incarnate L. and Valeriana officinalis L.) in laboratory animals. Rev Bras Farmacogn  2009; 19(1b): 255-60.
[http://dx.doi.org/10.1590/S0102-695X2009000200013] 
[324] 
Murphy K, Kubin ZJ, Shepherd JN, Ettinger RH. Valeriana officinalis root extracts have potent anxiolytic effects in laboratory rats. Phytomedicine  2010; 17(8-9): 674-8.
[http://dx.doi.org/10.1016/j.phymed.2009.10.020] [PMID:  20042323] 
[325] 
Müller LG, Salles LA, Stein AC, et al. Antidepressant-like effect of Valeriana glechomifolia meyer (Valerianaceae) in mice. Prog Neuropsychopharmacol Biol Psychiatry  2012; 36(1): 101-9.
[http://dx.doi.org/10.1016/j.pnpbp.2011.08.015] [PMID:  21889562] 
[326] 
Hattesohl M, Feistel B, Sievers H, Lehnfeld R, Hegger M, Winterhoff H. Extracts of Valeriana officinalis L. s.l. show anxiolytic and antidepressant effects but neither and antidepressant effects but neither sedative nor myorelaxant properties. Phytomedicine  2008; 15(1-2): 2-15.
[http://dx.doi.org/10.1016/j.phymed.2007.11.027] [PMID:  18160026] 
[327] 
Neamati A, Chaman F, Hosseini M, Boskabady MH. The effects of Valeriana officinalis L. hydro-alcoholic extract on depression like behavior in ovalbumin sensitized rats. J Pharm Bioallied Sci  2014; 6(2): 97-103.
[http://dx.doi.org/10.4103/0975-7406.129174] [PMID:  24741277] 
[328] 
Jung HY, Yoo DY, Kim W, et al. Valeriana officinalis root extract suppresses physical stress by electric shock and psychological stress by nociceptive stimulation-evoked responses by decreasing the ratio of monoamine neurotransmitters to their metabolites. BMC Complement Altern Med  2014; 14(1): 476.
[http://dx.doi.org/10.1186/1472-6882-14-476] [PMID:  25495725] 
[329] 
Azizi H, Shojaii A, Hashem-Dabaghian F, et al. Effects of Valeriana officinalis (Valerian) on tension-type headache: A randomized, placebo-controlled, double-blind clinical trial. Avicenna J Phytomed  2020; 10(3): 297-304.
[PMID:  32523884] 
[330] 
Shafaghi B, Naderi N, Tahmasb L, Kamalinjad M. Anxiolytic effect of Echium amoenum in mice. Iran J Pharm Res  2002; 1: 37-41.
[331] 
Rabbani M, Sajjadi SE, Khalili S. A Lack of tolerance to the anxiolytic action of Echium amoenum. Res Pharm Sci  2011; 6(2): 101-6.
[PMID:  22224093] 
[332] 
Farajdokht F, Vosoughi A, Ziaee M, Araj-Khodaei M, Mahmoudi J, Sadigh-Eteghad S. The role of hippocampal GABAA receptors on anxiolytic effects of Echium amoenum extract in a mice model of restraint stress. Mol Biol Rep  2020; 47(9): 6487-96.
[http://dx.doi.org/10.1007/s11033-020-05699-7] [PMID:  32778988] 
[333] 
Soltani Nejad S, Zaighami M, Beirami A, Amirifar A. Effect of Echium amoenum on the anxiety of college students (Persian). Complement Med J  2020; 10(1): 46-55.
[http://dx.doi.org/10.32598/cmja.10.1.909.1] 
[334] 
Mao JJ, Li QS, Soeller I, Rockwell K, Xie SX, Amsterdam JD. Long-term chamomile therapy of generalized anxiety disorder: A study protocol for a randomized, double-blind, placebo-controlled trial. J Clin Trials  2014; 4(5): 188.
[http://dx.doi.org/10.4172/2167-0870.1000188] [PMID:  29057164] 
[335] 
Sánchez-Vidaña DI, Po KK, Fung TK, et al. Lavender essential oil ameliorates depression-like behavior and increases neurogenesis and dendritic complexity in rats. Neurosci Lett  2019; 701: 180-92.
[http://dx.doi.org/10.1016/j.neulet.2019.02.042] [PMID:  30825591] 
[336] 
Beyliklioğlu A, Arslan S. Effect of lavender oil on the anxiety of patients before breast surgery. J Perianesth Nurs  2019; 34(3): 587-93.
[http://dx.doi.org/10.1016/j.jopan.2018.10.002] [PMID:  30660371] 
[337] 
Malcolm BJ, Tallian K. Essential oil of lavender in anxiety disorders: Ready for prime time? Ment Health Clin  2018; 7(4): 147-55.
[http://dx.doi.org/10.9740/mhc.2017.07.147] [PMID:  29955514] 
[338] 
Lillehei AS, Halcón L, Gross CR, Savik K, Reis R. Well-Beijng and seld-assessment of change: Secondary analysis of and RCT that demonstrated benefit of inhaled lavender and sleep hygiene in college students with sleep problems. Explore (NY)  2016; 12(6): 427-35.
[http://dx.doi.org/10.1016/j.explore.2016.08.004] [PMID:  27659004] 
[339] 
Makhouri FR, Ghasemi JB. In silico studies in drug research against neurodegenerative disases. Curr Neuropharmacol  2018; 16(6): 664-725.
[http://dx.doi.org/10.2174/1570159X15666170823095628] [PMID:  28831921] 
[340] 
Shahrajabian MH. Medicinal herbs with anti-inflammatory activities for natural and organic healing. Curr Org Chem  2021; 25(23): 1-17.
[http://dx.doi.org/10.2174/1385272825666211110115656] 
[341] 
Yeung WF, Chung KF, Ng KY, Yu YM, Ziea ET, Ng BF. A systematic review on the efficacy, safety and types of Chinese herbal medicine for depression. J Psychiatr Res  2014; 57: 165-75.
[http://dx.doi.org/10.1016/j.jpsychires.2014.05.016] [PMID:  24974002] 
[342] 
Yeung WF, Chung KF, Poon MM, et al. Chinese herbal medicine for insomnia: A systematic review of randomized controlled trials. Sleep Med Rev  2012; 16(6): 497-507.
[http://dx.doi.org/10.1016/j.smrv.2011.12.005] [PMID:  22440393] 
[343] 
Pharmacopoeia Committee of China Chinese Pharmacopoeia. Beijing: Chemical Industry Publishing House 2005.
[344] 
Chen L, Zhang Q, Yang G, et al. Rapid purification and scale-up of honokiol and magnolol using high-capacity high-speed counter-current chromatography. J Chromatogr A  2007; 1142(2): 115-22.
[http://dx.doi.org/10.1016/j.chroma.2006.09.098] [PMID:  17222860] 
[345] 
Wang X, Wang Y, Geng Y, Li F, Zheng C. Isolation and purification of honokiol and magnolol from cortex Magnoliae officinalis by high-speed counter-current chromatography. J Chromatogr A  2004; 1036(2): 171-5.
[http://dx.doi.org/10.1016/j.chroma.2004.02.073] [PMID:  15146918] 
[346] 
Li JM, Kong LD. Advances in the study on the effect of traditional Chinese medicine on depression and anxiety. China J Chinese Materia Medica  2001; 26(12): 805-7.
[PMID:  12834251] 
[347] 
Owen A. The use of Gui Pi Tang in traditional. Chin Med 2003.
[348] 
Sun W, Shahrajabian MH, Cheng Q. Fenugreek cultivation with emphasis on historical aspects and its uses in traditional medicine and modern pharmaceutical science. Mini Rev Med Chem  2021; 21(6): 724-30.
[http://dx.doi.org/10.2174/1389557520666201127104907] [PMID:  33245271] 
[349] 
Sun W, Shahrajabian MH, Cheng Q. Barberry (Berberis vulgaris), a medicinal fruit and food with traditional and modern pharmaceutical uses. Isr J Plant Sci  2021; 68(1-2): 1-11.
[http://dx.doi.org/10.1163/22238980-bja10019] 
[350] 
Shahrajabian MH, Sun W, Cheng Q. Improving health benefits with considering traditional and modern health benefits of Peganum harmala. Clin Phytoscience  2021; 7(18): 1-9.
[http://dx.doi.org/10.1186/s40816-021-00255-7] 
[351] 
Shahrajabian MH, Sun W, Cheng Q. Asafoetida, a natural medicine for a future. Curr Nutr Food Sci  2021; 17(9): 1-10.
[http://dx.doi.org/10.2174/1573401317666210222161609] 
[352] 
Marmiit DJ, Shahrajabian MH. Plant species used in Brazil and Asia regions with toxic properties. Phytother Res  2021; 35(9): 4703-26.
[http://dx.doi.org/10.1002/ptr.7100] [PMID:  33793002] 
[353] 
Shahrajabian MH, Sun W, Marmitt DJ, Cheng Q. Diosgenin and galactomannans, natural products in the pharmaceutical sciences. Clin Phytoscience  2021; 7(1): 1-7.
[http://dx.doi.org/10.1186/s40816-021-00288-y] 
[354] 
Shahrajabian MH, Sun W, Khoshkharam M, Cheng Q. Caraway, Chinese chives and cassia as functional foods with considering nutrients and health benefits. Carpathian J Food Sci Technol  2021; 13(1): 101-9.
[http://dx.doi.org/10.34302/crpjfst/2021.13.1.9] 
[355] 
Shahrajabian MH, Sun W, Cheng Q. Different methods for molecular and rapid detection of human novel coronavirus. Curr Pharm Des  2021; 27(25): 2893-903.
[http://dx.doi.org/10.2174/1381612827666210604114411] [PMID:  34086547] 
[356] 
Shahrajabian MH, Sun W, Cheng Q. Molecular breeding and the impacts of some important genes families on agronomic traits, a review. Genet Resour Crop Evol  2021; 68(5): 1709-30.
[http://dx.doi.org/10.1007/s10722-021-01148-x] 
[357] 
Salmerón-Manzano E, Garrido-Cardenas JA, Manzano-Agugliaro F. Worldwide research trends on medicinal plants. Int J Environ Res Public Health  2020; 17(10): 3376.
[http://dx.doi.org/10.3390/ijerph17103376] [PMID:  32408690] 
[358] 
Marmitt DJ, Shahrajabian MH, Goettert MI, Rempel C. Clinical trials with plants in diabetes mellitus therapy: A systematic review. Expert Rev Clin Pharmacol  2021; 14(6): 735-47.
[http://dx.doi.org/10.1080/17512433.2021.1917380] [PMID:  33884948] 
[359] 
Shahrajabian MH, Sun W, Cheng Q. Spanish chamomile (Anacycluspyrethrum) and pyrethrum (Tanacetum cineraiifolium): Organic and natural pesticides and treasure of medicinal herbs. Not Sci Biol  2021; 13(1): 10816.
[http://dx.doi.org/10.15835/nsb13110816] 
[360] 
Shahrajabian MH, Sun W, Cheng Q. Roles of medicinal plants in organic live stock production. J Stress Physiol Biochem  2021; 17(1): 106-19.
[361] 
Sun W, Shahrajabian MH, Cheng Q. Health benefits of wolfberry (Gou Qi Zi) on the basis of ancient Chinese herbalism and western modern medicine. Avicenna J Phytomed  2021; 11(2): 109-19.
[PMID:  33907670] 
[362] 
Fitzgerald M, Heinrich M, Booker A. Medicinal plant analysis: A historical and regional discussion of emergent complex techniques. Front Pharmacol  2020; 10: 1480.
[http://dx.doi.org/10.3389/fphar.2019.01480] [PMID:  31998121] 
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DOI https://dx.doi.org/10.2174/1872208316666220321102216	Print ISSN 1872-2083
Publisher Name Bentham Science Publisher	Online ISSN 2212-4012
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