Login Register Cart 0
Generic placeholder image

Current Drug Targets

Editor-in-Chief

ISSN (Print): 1389-4501
ISSN (Online): 1873-5592

Back
Journal Home About Journal Editorial Board Journal Insight Current Issue Volumes/Issues
Subscribe
Editorial

Therapeutic Potential of Flavonoid Derivatives for Certain Neglected Tropical Diseases

Author(s): Boniface Kamdem Pone* and Elizabeth Igne Ferreira

Volume 23, Issue 7, 2022

Published on: 12 April, 2022

Page: [680 - 682] Pages: 3

DOI: 10.2174/1389450123666220309093827

Abstract

Background: Neglected tropical diseases (NTDs) are infectious diseases that mostly affect people living in tropical and subtropical regions, especially in impoverished areas. Ubiquitously found in plants, flavonoids are a group of compounds that have been reported to exhibit a wide range of biological activities against parasites (Leishmania sp., Trypanosoma cruzi, Trypanosoma brucei, Brugia malayi, etc.) that cause certain NTDs.

Aims: The present study aims to highlight and discuss our recent reports on the implication of flavonoids in drug development for NTDs, such as leishmaniasis, Chagas disease, African trypanosomiasis, filariasis, among others.

Results: Today, studies show that flavonoids exhibit in vitro antileishmanial, anti-trypanosomiasis, antifilarial activities, among others. Furthermore, the molecular hybridization of flavonoids with the triazole groups has led to the development of compounds with improved biological activity. The incorporation of chemical groups, such as NO2, F, and Cl groups, during the process of design and synthesis, leads to the enhancement of pharmacological activity.

Conclusion: Flavonoids are useful metabolites that can be prospected as potential leads for the development of new agents against certain NTDs. However, research opportunities, including cytotoxicity and in vivo studies, mechanisms of action, bioavailability of these compounds, remain to be investigated in the future.

Keywords: Neglected tropical diseases, flavonoids, triazoles, lead optimization, drug development, bioavailability.

« Previous Next »
[1]
World Health Organization (WHO). 2021. Available from: https://www.who.int/teams/control-of-neglected-tropical-diseases/overview[Accessed on 9th Feb 2022].
[2]
Jannin J, Gabrielli AF. In Handbook of Clinical Neurology 2013. Neuroparasitology and tropical neurology. Available from: https://www.sciencedirect.com/topics/medicine-and-dentistry/neglected-tropical-diseases [Accessed on 9th Feb 2022].
[3]
Joshi G, Quadir SS, Yadav KS. Road map to the treatment of neglected tropical diseases: Nanocarriers interventions. J Control Release 2021; 339: 51-74.
[http://dx.doi.org/10.1016/j.jconrel.2021.09.020] [PMID: 34555491]
[4]
Campos MRS. Bioactive compounds health benefits and potential applications. Newyork: Elsevier 2019.
[http://dx.doi.org/10.1016/C2017-0-02265-6]
[5]
Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: An overview. ScientificWorldJ 2013; 2013162750
[http://dx.doi.org/10.1155/2013/162750] [PMID: 24470791]
[6]
Boniface PK, Elizabeth FI. Flavonoid-derived privileged scaffolds in anti-Trypanosoma brucei drug discovery. Curr Drug Targets 2019; 20(12): 1295-314.
[http://dx.doi.org/10.2174/1389450120666190618114857] [PMID: 31215385]
[7]
Boniface PK, Elizabeth FI. An insight into the discovery of potent antifilarial leads against lymphatic filariasis. Curr Drug Targets 2020; 21(7): 657-80.
[http://dx.doi.org/10.2174/1389450120666191204152415] [PMID: 31800381]
[8]
Boniface PK, Sano CM, Elizabeth FI. Unveiling the targets involved in quest of antileishmanial leads using in-silico methods. Curr Drug Targets 2020; 21(7): 681-712.
[http://dx.doi.org/10.2174/1389450121666200128112948] [PMID: 32003668]
[9]
Kamdem BP, Elizabeth FI. The role of nitro (NO2-), chloro (Cl-), and fluoro (F-) substitution in the design of antileishmanial and antichagasic compounds. Curr Drug Targets 2021; 22(4): 379-98.
[http://dx.doi.org/10.2174/1389450121666201228122239] [PMID: 33371845]
[10]
Pone KB, Dalhatou S, Paumo HK, Katata-Seru LM, Ferreira EI. Triazole-containing heterocycles: Privileged scaffolds in anti-Trypanosoma cruzi drug development. Curr Drug Targets 2022; 23(1): 33-59.
[http://dx.doi.org/10.2174/1389450122666210412125643] [PMID: 33845739]
[11]
Pluta K. Morak-M;odawska B, Jele M. Recent progress in biological activities of synthesized phenothiazines. Eur J Med Chem 2011; 46(8): 3179-89.
[http://dx.doi.org/10.1016/j.ejmech.2011.05.013] [PMID: 21620536]
[12]
Subrahmanyam D. Antifilarials and their mode of action. Ciba Found Symp 1987; 127: 246-64.
[PMID: 3297557]
[13]
Sharma B. Lymphatic filariasis and chemotherapeutic targets. Biochem Anal Biochem 2014; 3(2): 1.
[http://dx.doi.org/10.4172/2161-1009.1000e147]
[14]
Polak A, Richle R. Mode of action of the 2-nitroimidazole derivative benznidazole. Ann Trop Med Parasitol 1978; 72(1): 45-54.
[http://dx.doi.org/10.1080/00034983.1978.11719278] [PMID: 418744]
[15]
Cirqueira ML. Structural studies on Trypanosoma cruzi nitroreductase enzyme: Characterization of prodrug activation mechanism for benznidazole and nifurtimox 2019. 75
[16]
Hernandes MZ, Cavalcanti SM, Moreira DR, de Azevedo Junior WF, Leite AC. Halogen atoms in the modern medicinal chemistry: Hints for the drug design. Curr Drug Targets 2010; 11(3): 303-14.
[http://dx.doi.org/10.2174/138945010790711996] [PMID: 20210755]
[17]
Gerebtzoff G, Li-Blatter X, Fischer H, Frentzel A, Seelig A. Halogenation of drugs enhances membrane binding and permeation. ChemBioChem 2004; 5(5): 676-84.
[http://dx.doi.org/10.1002/cbic.200400017] [PMID: 15122640]
[18]
Naguleswaran A, Spicher M, Vonlaufen N, et al. In vitro metacestodicidal activities of genistein and other isoflavones against Echinococcus multilocularis and Echinococcus granulosus. Antimicrob Agents Chemother 2006; 50(11): 3770-8.
[http://dx.doi.org/10.1128/AAC.00578-06] [PMID: 16954323]
[19]
Xin Q, Yuan M, Li H, Lu J, Song X, Jing T. In vitro efficacy of ampelopsin against Echinococcus granulosus and Echinococcus multilocularis. J Vet Med Sci 2019; 81(12): 1853-8.
[http://dx.doi.org/10.1292/jvms.19-0347] [PMID: 31748438]

Rights & Permissions Print Cite
Article Metrics
22
2
© 2024 Bentham Science Publishers | Privacy Policy