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ISSN (Print): 1573-3963
ISSN (Online): 1875-6336

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Pediatric Takayasu Arteritis: A Review of the Literature

Author(s): Fatih Haslak, Mehmet Yildiz, Sezgin Sahin, Amra Adrovic, Kenan Barut and Ozgur Kasapcopur*

Volume 18, Issue 4, 2022

Published on: 12 April, 2022

Page: [243 - 250] Pages: 8

DOI: 10.2174/1573396318666220304205518

Price: $65

Abstract

Takayasu arteritis (TA) is the third most common vasculitis of childhood and is extremely rare. It is mainly characterized by chronic, autoimmune, and granulomatous inflammation of the aorta and its major branches. Women under 40 years of age are mostly affected. It occurs for the first time in childhood in about 30% of affected individuals. Initially, it presents nonspecific constitutional findings. Since there is no specific laboratory finding, diagnosis is challenging. The gold standard imaging method for diagnosis is conventional angiography. Delay in diagnosis can cause devastating consequences. Therefore, in cases presenting with nonspecific findings, with hypertension and high acute phase reactants, the diagnosis should be suspected and confirmed with appropriate imaging method, and treatment should be started immediately. Immunosuppressive agents are the mainstay of the treatment. Biological agents are successful in refractory cases, and endovascular revascularization methods are used in the treatment of complications.

Keywords: Takayasu arteritis, systemic vasculitis, rheumatoid vasculitis, pediatrics, rheumatology, hypertension.

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Graphical Abstract

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