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当代阿耳茨海默病研究

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ISSN (Print): 1567-2050
ISSN (Online): 1875-5828

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Clinical Trial

16周的有氧运动不会改变阿尔茨海默病患者楔前叶的静息状态连通性

卷 19, 期 2, 2022

发表于: 14 March, 2022

页: [171 - 177] 页: 7

弟呕挨: 10.2174/1567205019666220304091241

价格: $65

摘要

简介：在健康的老年人和轻度认知障碍患者中，体育锻炼可以增加通过静息状态功能磁共振成像（rs-fMRI）测量的默认模式网络（DMN）中的功能性大脑连接。然而，到目前为止，还没有研究体育锻炼对阿尔茨海默病（AD）患者DMN功能性静止状态连接的影响。 目的：在一项单盲随机对照试验中，我们使用静息态功能磁共振成像评估了16周体育锻炼的有氧运动干预对AD患者的DMN连通性的影响。 方法：45名患者被随机分配到对照组或运动组。该运动小组每周进行三次60分钟的有氧运动，为期16周。所有患者在3T、基线检查时和16周后都接受了全脑静息态功能磁共振成像。由于后扣带回皮质（PCC）和邻近的楔前叶构成DMN的中心枢纽，因此该顶叶区域被定义为感兴趣区，并用作静息态功能磁共振成像数据的功能连通性分析的种子区域，将年龄和性别作为协变量。, 结果：无论是基于PCC/楔前区的种子点的分析，还是以DMN网络组成部分为重点的基于ICA的分析，都没有显示从基线到随访期间运动诱导的静息状态连接功能的变化。 结论：16周的有氧运动不会改变AD患者PCC/楔前区的功能连接。可能需要更长时间的干预来显示运动对大脑连接的影响。

关键词: 体育锻炼，运动，阿尔茨海默病，默认模式网络，静息状态，功能性磁共振成像

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